Advanced search
Publication Cover
Emerging Microbes & Infections Volume 9, 2020 - Issue 1
Submit an article Journal homepage
7,686
Views
93
CrossRef citations to date
0
Altmetric
Letter

Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae

Juan Baoa Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Nannan Wua Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Yigang Zenga Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Liguang Chena Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Linlin Lia Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Lan Yanga Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Yiyuan Zhanga Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Mingquan Guoa Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Lisha Lib Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
,
Jie Lia Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Demeng Tana Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Mengjun Chenga Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Jingmin Gua Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Jinghong Qina Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China;b Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-6712-9472View further author information
ORCID Icon,
Jiazheng Liuc Department of Microbiology, Army Medical University, Chongqing, People’s Republic of ChinaView further author information
,
Shiru Lic Department of Microbiology, Army Medical University, Chongqing, People’s Republic of ChinaView further author information
,
Guangqiang Pand Department of Pathology, The Second Affiliated Hospital of Army Medical University, Chongqing, People’s Republic of ChinaView further author information
,
Xin Jina Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Bangxin Yaoe Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Xiaokui Guoa Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China;b Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
,
Tongyu Zhua Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China;f Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Shuai Lea Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China;c Department of Microbiology, Army Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3748-5454View further author information
ORCID Icon show all
Pages 771-774 | Received 01 Feb 2020, Accepted 23 Mar 2020, Published online: 02 Apr 2020

References

  • Muller LM, Gorter KJ, Hak E, et al. Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus. Clin Infect Dis. 2005;41(3):281–288. doi: 10.1086/431587
  • Hollyer I, Ison MG. The challenge of urinary tract infections in renal transplant recipients. Transpl Infect Dis. 2018;20(2):e12828. doi: 10.1111/tid.12828
  • Wyres KL, Lam MMC, Holt KE. Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol. 2020 Feb 13. doi:10.1038/s41579-019-0315-1 [Epub ahead of print].
  • Kortright KE, Chan BK, Koff JL, et al. Phage therapy: a renewed approach to Combat antibiotic-resistant bacteria. Cell Host Microbe. 2019;25(2):219–232. doi: 10.1016/j.chom.2019.01.014
  • Sybesma W, Zbinden R, Chanishvili N, et al. Bacteriophages as potential treatment for urinary tract infections. Front Microbiol. 2016;7:465. doi: 10.3389/fmicb.2016.00465
  • Jault P, Leclerc T, Jennes S, et al. Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial. Lancet Infect Dis. 2018;19(1):35–45. doi: 10.1016/S1473-3099(18)30482-1
  • Dedrick RM, Guerrero-Bustamante CA, Garlena RA, et al. Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus. Nat Med. 2019;25(5):730–733. doi: 10.1038/s41591-019-0437-z
  • Azam AH, Tanji Y. Bacteriophage-host arm race: an update on the mechanism of phage resistance in bacteria and revenge of the phage with the perspective for phage therapy. Appl Microbiol Biotechnol. 2019;103(5):2121–2131. doi: 10.1007/s00253-019-09629-x
  • Rohde C, et al. Expert opinion on three phage therapy Related Topics: bacterial phage resistance, phage training and Prophages in bacterial Production strains. Viruses. 2018 Apr 5;10(4):178. doi: 10.3390/v10040178
  • Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International clinical Practice Guidelines from the infectious Diseases society of America. Clin Infect Dis. 2010;50(5):625–663. doi: 10.1086/650482
  • Shen M, Zhang H, Shen W, et al. Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation. Nucleic Acids Res. 2018;46(9):4505–4514. doi: 10.1093/nar/gky160
  • Roach DR, et al. Synergy between the host immune system and bacteriophage is essential for successful phage therapy against an acute Respiratory pathogen. Cell Host Microbe. 2017;22(1):38–47.e4. doi: 10.1016/j.chom.2017.06.018
  • Kuipers S, et al. A Dutch case report of successful treatment of chronic relapsing urinary tract infection with bacteriophages in a renal transplant patient. Antimicrob Agents Chemother. 2019 2019 Dec 20;64(1). pii: e01281–19. doi:10.1128/AAC.01281-19.
  • Yang Y, Shen W, Zhong Q, et al. Development of a bacteriophage cocktail to constrain the emergence of phage-resistant Pseudomonas aeruginosa. Front Microbiol. 2020;11:327. doi: 10.3389/fmicb.2020.00327
  • Hesse S, Rajaure M, Wall E, et al. Phage resistance in multidrug-resistant Klebsiella pneumoniae ST258 evolves via diverse mutations that Culminate in impaired adsorption. mBio. 2020;11(1). doi: 10.1128/mBio.02530-19

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.