Zika structural genes determine the virulence of African and Asian lineages

References

• Fauci AS, Morens DM. Zika virus in the Americas — yet another Arbovirus threat. N Engl J Med. 2016;374:601–604.
   PubMed Web of Science ®Google Scholar
• Azevedo RSS, de Sousa JR, Araujo MT, et al. In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus. Sci Rep. 2018;8(1):1–11.
   PubMed Web of Science ®Google Scholar
• Lindenbach B, Murray C, Thiel H, et al. Flaviviridae. In: Knipe D, Howley P, editor. Fields Virology. Philadelphia: LIPPINCOTT WILLIAMS & WILKINS; 2013. p. 712–743.
   Google Scholar
• Lanciotti RS, Kosoy OL, Laven JJ, et al. Genetic and Serologic Properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14:1232–1239.
   PubMed Web of Science ®Google Scholar
• Hayes EB. Zika virus Outside Africa. Emerg Infect Dis. 2009;15:1347–1350.
   PubMed Web of Science ®Google Scholar
• Faria NR, Quick J, Claro IM, et al. Establishment and cryptic transmission of Zika virus in Brazil and the Americas. Nature. 2017;546:406–410.
   PubMed Web of Science ®Google Scholar
• Liu Y, Liu J, Du S, et al. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature. 2017;545:482–486.
   PubMed Web of Science ®Google Scholar
• Neal JW. Flaviviruses are neurotropic, but how do they invade the CNS? J Infect. 2014;69:203–215.
   PubMed Web of Science ®Google Scholar
• Yuan L, Huang X-Y, Liu Z-Y, et al. A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. Science. 2017;358:933–936.
   PubMed Web of Science ®Google Scholar
• Lazear HM, Govero J, Smith AM, et al. A mouse model of Zika virus pathogenesis. Cell Host Microbe. 2016;19:720–730.
   PubMed Web of Science ®Google Scholar
• Rossi SL, Tesh RB, Azar SR, et al. Characterization of a Novel Murine model to study Zika virus. Am J Trop Med Hyg. 2016;94:1362–1369.
   PubMed Web of Science ®Google Scholar
• Zmurko J, Marques RE, Schols D, et al. The viral polymerase inhibitor 7-Deaza-2’-C-Methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a Robust mouse infection model. PLoS Negl Trop Dis. 2016;10:e0004695.
   PubMed Web of Science ®Google Scholar
• Gorman MJ, Caine EA, Zaitsev K, et al. An immunocompetent mouse model of Zika virus infection. Cell Host Microbe. 2018;23:672–685.e6.
   PubMed Web of Science ®Google Scholar
• Shan C, Xie X, Muruato AE, et al. An infectious cDNA clone of Zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors. Cell Host Microbe. 2016;19:891–900.
   PubMed Web of Science ®Google Scholar
• Ladner JT, Wiley MR, Prieto K, et al. Complete genome sequences of five Zika virus isolates: TABLE 1 . Genome Announc. 2016;4:1–2.
   Google Scholar
• Shi P-Y, Tilgner M, Lo MK. Construction and characterization of subgenomic replicons of new york strain of West Nile virus. Virology. 2002;296:219–233.
   PubMed Web of Science ®Google Scholar
• Xie X, Yang Y, Muruato AE, et al. Understanding Zika virus stability and developing a chimeric vaccine through functional analysis. MBio. 2017;8:1–14.
   Web of Science ®Google Scholar
• Shan C, Muruato AE, Nunes BTD, et al. A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models. Nat Med. 2017;23:763–767.
   PubMed Web of Science ®Google Scholar
• Shan C, Muruato AE, Jagger BW, et al. A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage. Nat Commun. 2017;8:676.
   PubMed Web of Science ®Google Scholar
• Xie X, Kum DB, Xia H, et al. A single-dose live-attenuated Zika virus vaccine with controlled infection rounds that protects against vertical transmission. Cell Host Microbe. 2018;24:487–499.e5.
   PubMed Web of Science ®Google Scholar
• Heang V, Yasuda CY, Sovann L, et al. Zika virus infection, Cambodia, 2010. Emerg Infect Dis. 2012;18:349–351.
   PubMed Web of Science ®Google Scholar
• Duggal NK, Ritter JM, McDonald EM, et al. Differential neurovirulence of African and Asian genotype Zika virus isolates in outbred immunocompetent mice. Am J Trop Med Hyg. 2017;97:1410–1417.
   PubMed Web of Science ®Google Scholar
• França GVA, Schuler-Faccini L, Oliveira WK, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet. 2016;388:891–897.
   PubMed Web of Science ®Google Scholar
• Faye O, Freire CCM, Iamarino A, et al. Molecular evolution of Zika virus during its emergence in the 20th century. PLoS Negl Trop Dis. 2014;8:e2636.
   PubMed Web of Science ®Google Scholar
• Jun S-R, Wassenaar TM, Wanchai V, et al. Suggested mechanisms for Zika virus causing microcephaly: what do the genomes tell us? BMC Bioinform. 2017;18:471.
   PubMed Web of Science ®Google Scholar
• Hamel R, Ferraris P, Wichit S, et al. African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes. Infect Genet Evol. 2017;49:134–137.
   PubMed Web of Science ®Google Scholar
• Vielle NJ, Zumkehr B, García-Nicolás O, et al. Silent infection of human dendritic cells by African and Asian strains of Zika virus. Sci Rep. 2018;8:5440.
   PubMed Web of Science ®Google Scholar
• Gabriel E, Ramani A, Karow U, et al. Recent Zika virus isolates induce premature differentiation of neural progenitors in human brain organoids. Cell Stem Cell. 2017;20:397–406.e5.
   PubMed Web of Science ®Google Scholar
• Vermillion MS, Lei J, Shabi Y, et al. Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes. Nat Commun. 2017;8:14575.
   PubMed Web of Science ®Google Scholar
• Simonin Y, Loustalot F, Desmetz C, et al. Zika virus strains potentially display different infectious profiles in human neural cells. EBioMedicine. 2016;12:161–169.
   PubMed Web of Science ®Google Scholar
• Anfasa F, Siegers JY, van der Kroeg M, et al. Phenotypic differences between Asian and African lineage Zika viruses in human neural progenitor cells. mSphere. 2017;2:1–10.
   Web of Science ®Google Scholar
• Sheridan MA, Yunusov D, Balaraman V, et al. Vulnerability of primitive human placental trophoblast to Zika virus. Proc Natl Acad Sci. 2017;114:E1587–E1596.
   PubMed Web of Science ®Google Scholar
• Dowall SD, Graham VA, Rayner E, et al. Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice. PLoS Negl Trop Dis. 2017;11:e0005704.
   PubMed Web of Science ®Google Scholar
• Govero J, Esakky P, Scheaffer SM, et al. Zika virus infection damages the testes in mice. Nature. 2016;540:438–442.
   PubMed Web of Science ®Google Scholar
• Tripathi S, Balasubramaniam VRMT, Brown JA, et al. A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLOS Pathog. 2017;13:e1006258.
   PubMed Web of Science ®Google Scholar
• Kulesh DA, Smith DR, Bellanca SA, et al. African and Asian Zika virus isolates display phenotypic differences both in vitro and in vivo. Am J Trop Med Hyg. 2018;98:432–444.
   PubMed Web of Science ®Google Scholar
• Chiu CY, Sánchez-San Martín C, Bouquet J, et al. Experimental Zika virus inoculation in a new world monkey model reproduces key features of the human infection. Sci Rep. 2017;7:17126.
   PubMed Web of Science ®Google Scholar
• Udenze D, Trus I, Berube N, et al. The African strain of Zika virus causes more severe in utero infection than Asian strain in a porcine fetal transmission model. Emerg Microbes Infect. 2019;8:1098–1107.
   PubMed Web of Science ®Google Scholar
• Jaeger AS, Murrieta RA, Goren LR, et al. Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission. PLoS Negl Trop Dis. 2019;13:e0007343.
   PubMed Web of Science ®Google Scholar
• Koide F, Goebel S, Snyder B, et al. Development of a Zika virus infection model in cynomolgus macaques. Front Microbiol. 2016;7:1–8.
   PubMed Web of Science ®Google Scholar
• Morrison TE, Diamond MS. Animal models of Zika virus infection, pathogenesis, and immunity. J Virol. 2017;91:1–15.
   Web of Science ®Google Scholar
• Li P, Wei Y, Mei M, et al. Integrative analysis of Zika virus genome RNA structure reveals critical determinants of viral infectivity. Cell Host Microbe. 2018;24:875–886.e5.
   PubMed Web of Science ®Google Scholar
• Nambala P, Su W-C. Role of Zika virus prM protein in viral pathogenicity and use in vaccine development. Front Microbiol. 2018;9.
   PubMed Web of Science ®Google Scholar
• Fontes-Garfias CR, Shan C, Luo H, et al. Functional analysis of glycosylation of Zika virus envelope protein. Cell Rep. 2017;21:1180–1190.
   PubMed Web of Science ®Google Scholar
• Fontaine KA, Leon KE, Khalid MM, et al. The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein. MBio. 2018;9.
   PubMed Web of Science ®Google Scholar
• Slomnicki LP, Chung D-H, Parker A, et al. Ribosomal stress and Tp53-mediated neuronal apoptosis in response to capsid protein of the Zika virus. Sci Rep. 2017;7:16652.
   PubMed Web of Science ®Google Scholar
• de Sousa JR, Azevedo RdSdS, Martins Filho AJ, et al. In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases. Cytokine. 2018;111:255–264.
   PubMed Web of Science ®Google Scholar