2,563
Views
16
CrossRef citations to date
0
Altmetric
Articles

Non-walled spherical Acinetobacter baumannii is an important type of persister upon β-lactam antibiotic treatment

, , , , , & ORCID Icon show all
Pages 1149-1159 | Received 18 Feb 2020, Accepted 13 May 2020, Published online: 02 Jun 2020

References

  • Bigger JW. Treatment of Staphylococcal infections with penicillin by intermittent sterilisation. The Lancet. 1944;244(6320):479–500. doi: 10.1016/S0140-6736(00)74210-3
  • Hall-Stoodley L, Costerton JW, Stoodley P. Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol. 2004 Feb;2(2):95–108. doi: 10.1038/nrmicro821
  • Lewis K. Persister cells. Annu Rev Microbiol. 2010;64:357–372. doi: 10.1146/annurev.micro.112408.134306
  • Gollan B, Grabe G, Michaux C, et al. Bacterial persisters and infection: past, present, and progressing. Annu Rev Microbiol. 2019 Sep 8;73:359–385. doi: 10.1146/annurev-micro-020518-115650
  • Fisher RA, Gollan B, Helaine S. Persistent bacterial infections and persister cells. Nat Rev Microbiol. 2017 Aug;15(8):453–464. doi: 10.1038/nrmicro.2017.42
  • Levin-Reisman I, Ronin I, Gefen O, et al. Antibiotic tolerance facilitates the evolution of resistance. Science. 2017 Feb 24;355(6327):826–830. doi: 10.1126/science.aaj2191
  • Cohen NR, Lobritz MA, Collins JJ. Microbial persistence and the road to drug resistance. Cell Host Microbe. 2013 Jun 12;13(6):632–642. doi: 10.1016/j.chom.2013.05.009
  • Liu J, Gefen O, Ronin I, et al. Effect of tolerance on the evolution of antibiotic resistance under drug combinations. Science. 2020 Jan 10;367(6474):200–204.
  • Windels EM, Michiels JE, Fauvart M, et al. Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates. ISME J. 2019 May;13(5):1239–1251. doi: 10.1038/s41396-019-0344-9
  • Fauvart M, De Groote VN, Michiels J. Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies. J Med Microbiol. 2011 Jun;60(Pt 6):699–709. doi: 10.1099/jmm.0.030932-0
  • Yan J, Bassler BL. Surviving as a community: antibiotic tolerance and persistence in bacterial biofilms. Cell Host Microbe. 2019 Jul 10;26(1):15–21. doi: 10.1016/j.chom.2019.06.002
  • Balaban NQ, Gerdes K, Lewis K, et al. A problem of persistence: still more questions than answers? Nat Rev Microbiol. 2013 Aug;11(8):587–591. doi: 10.1038/nrmicro3076
  • Pu Y, Ke Y, Bai F. Active efflux in dormant bacterial cells – new insights into antibiotic persistence. Drug Resist Updat. 2017 Jan;30:7–14. doi: 10.1016/j.drup.2016.11.002
  • Pu Y, Zhao Z, Li Y, et al. Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells. Mol Cell. 2016 Apr 21;62(2):284–294. doi: 10.1016/j.molcel.2016.03.035
  • Dijkshoorn L, Nemec A, Seifert H. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol. 2007 Dec;5(12):939–951. doi: 10.1038/nrmicro1789
  • McConnell MJ, Actis L, Pachon J. Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models. Fems Microbiol Rev. 2013 Mar;37(2):130–155. doi: 10.1111/j.1574-6976.2012.00344.x
  • Antunes LC, Visca P, Towner KJ. Acinetobacter baumannii: evolution of a global pathogen. Pathog Dis. 2014;71(3):292–301. doi: 10.1111/2049-632X.12125
  • Xie R, Zhang XD, Zhao Q, et al. Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries. Emerg Microbes Infect. 2018 Mar 14;7(1):31.
  • WHO publishes list of bacteria for which new antibiotics are urgently needed 2017. Available from: http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/
  • Barth VC Jr., Rodrigues BA, Bonatto GD, et al. Heterogeneous persister cells formation in Acinetobacter baumannii. PLoS One. 2013;8(12):e84361. doi: 10.1371/journal.pone.0084361
  • Alkasir R, Ma Y, Liu F, et al. Characterization and transcriptome analysis of Acinetobacter baumannii persister cells. Microb Drug Resist. 2018 Dec;24(10):1466–1474. doi: 10.1089/mdr.2017.0341
  • Nicol M, Mlouka MAB, Berthe T, et al. Anti-persister activity of squalamine against Acinetobacter baumannii. Int J Antimicrob Agents. 2019 Mar;53(3):337–342. doi: 10.1016/j.ijantimicag.2018.11.004
  • Kaur A, Sharma P, Capalash N. Curcumin alleviates persistence of Acinetobacter baumannii against colistin. Sci Rep. 2018 Jul 23;8(1):11029. doi: 10.1038/s41598-018-29291-z
  • Donamore BK, Gallo SW, Abreu Ferreira PM, et al. Levels of persisters influenced by aeration in Acinetobacter calcoaceticus-baumannii. Future Microbiol. 2018 Feb;13:209–219. doi: 10.2217/fmb-2017-0153
  • Zheng J, Tung SL, Leung KY. Regulation of a type III and a putative secretion system in Edwardsiella tarda by EsrC is under the control of a two-component system, EsrA-EsrB. Infect Immun. 2005 Jul;73(7):4127–4137. doi: 10.1128/IAI.73.7.4127-4137.2005
  • Basler M, Pilhofer M, Henderson GP, et al. Type VI secretion requires a dynamic contractile phage tail-like structure. Nature. 2012 Feb 26;483(7388):182–186. doi: 10.1038/nature10846
  • Zou J, Zhang W, Zhang H, et al. Studies on aminoglycoside susceptibility identify a novel function of KsgA to secure translational fidelity during antibiotic stress. Antimicrob Agents Chemother. 2018 Oct;62(10):e853–e818. doi: 10.1128/AAC.00853-18
  • Peleg AY, Jara S, Monga D, et al. Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics. Antimicrob Agents Chemother. 2009 Jun;53(6):2605–2609. doi: 10.1128/AAC.01533-08
  • Kawai Y, Mickiewicz K, Errington J. Lysozyme counteracts beta-lactam antibiotics by promoting the emergence of L-form bacteria. Cell. 2018 Feb 22;172(5):1038–1049. e10. doi: 10.1016/j.cell.2018.01.021
  • Khalil MAF, Moawad SS, Hefzy EM. In vivo activity of co-trimoxazole combined with colistin against Acinetobacter baumannii producing OXA-23 in a Galleria mellonella model. J Med Microbiol. 2019 Jan;68(1):52–59. doi: 10.1099/jmm.0.000872
  • Brauner A, Fridman O, Gefen O, et al. Distinguishing between resistance, tolerance and persistence to antibiotic treatment. Nat Rev Microbiol. 2016 Apr;14(5):320–330. doi: 10.1038/nrmicro.2016.34
  • Harms A, Maisonneuve E, Gerdes K. Mechanisms of bacterial persistence during stress and antibiotic exposure. Science. 2016 Dec 16;354(6318):aaf4268. doi: 10.1126/science.aaf4268
  • Dorr T, Davis BM, Waldor MK. Endopeptidase-mediated beta lactam tolerance. PLoS Pathog. 2015 Apr;11(4):e1004850. doi: 10.1371/journal.ppat.1004850
  • Cardoso K, Gandra RF, Wisniewski ES, et al. Dnak and GroEL are induced in response to antibiotic and heat shock in Acinetobacter baumannii. J Med Microbiol. 2010 Sep;59(Pt 9):1061–1068. doi: 10.1099/jmm.0.020339-0
  • Kuru E, Tekkam S, Hall E, et al. Synthesis of fluorescent D-amino acids and their use for probing peptidoglycan synthesis and bacterial growth in situ. Nat Protoc. 2015 Jan;10(1):33–52. doi: 10.1038/nprot.2014.197
  • Hornsey M, Wareham DW. In vivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infection. Antimicrob Agents Chemother. 2011 Jul;55(7):3534–3537. doi: 10.1128/AAC.00230-11
  • Hornsey M, Phee L, Longshaw C, et al. In vivo efficacy of telavancin/colistin combination therapy in a Galleria mellonella model of Acinetobacter baumannii infection. Int J Antimicrob Agents. 2013 Mar;41(3):285–287. doi: 10.1016/j.ijantimicag.2012.11.013
  • Gupta S, Govil D, Kakar PN, et al. Colistin and polymyxin B: a re-emergence. Indian J Crit Care Med. 2009 Apr–Jun;13(2):49–53. doi: 10.4103/0972-5229.56048
  • Loho T, Dharmayanti A. Colistin: an antibiotic and its role in multiresistant gram-negative infections. Acta Med Indones. 2015 Apr;47(2):157–168.
  • Falla TJ, Chopra I. Joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli results from overexpression of hipA. Antimicrob Agents Chemother. 1998 Dec;42(12):3282–3284. doi: 10.1128/AAC.42.12.3282
  • Hall AM, Gollan B, Helaine S. Toxin-antitoxin systems: reversible toxicity. Curr Opin Microbiol. 2017 Apr;36:102–110. doi: 10.1016/j.mib.2017.02.003
  • Hansen S, Vulic M, Min J, et al. Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. PLoS One. 2012;7(6):e39185. doi: 10.1371/journal.pone.0039185
  • Tsilibaris V, Maenhaut-Michel G, Van Melderen L. Biological roles of the Lon ATP-dependent protease. Res Microbiol. 2006 Oct;157(8):701–713. doi: 10.1016/j.resmic.2006.05.004
  • Germain E, Castro-Roa D, Zenkin N, et al. Molecular mechanism of bacterial persistence by HipA. Mol Cell. 2013 Oct 24;52(2):248–254. doi: 10.1016/j.molcel.2013.08.045
  • Semanjski M, Germain E, Bratl K, et al. The kinases HipA and HipA7 phosphorylate different substrate pools in Escherichia coli to promote multidrug tolerance. Sci Signal. 2018 Sep 11;11(547):eaat5750. doi: 10.1126/scisignal.aat5750
  • Ronneau S, Helaine S. Clarifying the link between toxin-antitoxin modules and bacterial persistence. J Mol Biol. 2019 Aug 23;431(18):3462–3471. doi: 10.1016/j.jmb.2019.03.019
  • Pu Y, Li Y, Jin X, et al. ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance. Mol Cell. 2019 Jan 3;73(1):143–156. e4. doi: 10.1016/j.molcel.2018.10.022
  • Shan Y, Brown Gandt A, Rowe SE, et al. ATP-dependent persister formation in Escherichia coli. MBio. 2017 Feb 7;8(1):e02267–16. doi: 10.1128/mBio.02267-16
  • Errington J, Mickiewicz K, Kawai Y, et al. L-form bacteria, chronic diseases and the origins of life. Philos Trans R Soc Lond B Biol Sci. 2016 Nov 5;371(1707):20150494. doi: 10.1098/rstb.2015.0494
  • Monahan LG, Turnbull L, Osvath SR, et al. Rapid conversion of Pseudomonas aeruginosa to a spherical cell morphotype facilitates tolerance to carbapenems and penicillins but increases susceptibility to antimicrobial peptides. Antimicrob Agents Chemother. 2014;58(4):1956–1962. doi: 10.1128/AAC.01901-13
  • Roberts D, Higgs E, Rutman A, et al. Isolation of spheroplastic forms of Haemophilus influenzae from sputum in conventionally treated chronic bronchial sepsis using selective medium supplemented with N-acetyl-D-glucosamine: possible reservoir for re-emergence of infection. Br Med J (Clin Res Ed). 1984 Nov 24;289(6456):1409–1412. doi: 10.1136/bmj.289.6456.1409
  • Cross T, Ransegnola B, Shin JH, et al. Spheroplast-mediated carbapenem tolerance in gram-negative pathogens. Antimicrob Agents Chemother. 2019 Sep;63(9):e00756–19. doi: 10.1128/AAC.00756-19
  • Rojas ER, Billings G, Odermatt PD, et al. The outer membrane is an essential load-bearing element in gram-negative bacteria. Nature. 2018 Jul;559(7715):617–621. doi: 10.1038/s41586-018-0344-3
  • Osawa M, Erickson HP. L form bacteria growth in low-osmolality medium. Microbiology. 2019 Aug;165(8):842–851. doi: 10.1099/mic.0.000799
  • Mercier R, Kawai Y, Errington J. Excess membrane synthesis drives a primitive mode of cell proliferation. Cell. 2013 Feb 28;152(5):997–1007. doi: 10.1016/j.cell.2013.01.043
  • Chung ES, Ko KS. Eradication of persister cells of Acinetobacter baumannii through combination of colistin and amikacin antibiotics. J Antimicrob Chemother. 2019 May 1;74(5):1277–1283. doi: 10.1093/jac/dkz034
  • Ji X, Zou J, Peng H, et al. Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9578–9585. doi: 10.1073/pnas.1822026116