5,622
Views
91
CrossRef citations to date
0
Altmetric
Letter

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

, , , , , , , , , , ORCID Icon, & ORCID Icon show all
Pages 1170-1173 | Received 18 Mar 2020, Published online: 02 Jun 2020

References

  • Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G. 2020. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. DOI:10.1038/s41422-020-0282-0.
  • Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. DOI:10.1038/s41586-020-2012-7.
  • Shin HJ, Kim C, Cho S. Gemcitabine and nucleos(t)ide synthesis inhibitors are broad-spectrum antiviral drugs that activate innate immunity. Viruses. 2018;10(4):211. doi: 10.3390/v10040211
  • Dyall J, Coleman CM, Hart BJ, Venkataraman T, Holbrook MR, Kindrachuk J, Johnson RF, Olinger GG, Jr., Jahrling PB, Laidlaw M, Johansen LM, Lear-Rooney CM, Glass PJ, Hensley LE, Frieman MB. 2014. Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother 58:4885-93. doi: 10.1128/AAC.03036-14
  • Kuivanen S, Bespalov MM, Nandania J, et al. Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism. Antiviral Res. 2017;139:117–128. doi: 10.1016/j.antiviral.2016.12.022
  • Denisova OV, Kakkola L, Feng L, et al. Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. J Biol Chem. 2012;287:35324–32. doi: 10.1074/jbc.M112.392142
  • Lee K, Kim DE, Jang KS, et al. Gemcitabine, a broad-spectrum antiviral drug, suppresses enterovirus infections through innate immunity induced by the inhibition of pyrimidine biosynthesis and nucleotide depletion. Oncotarget. 2017;8:115315–115325. doi: 10.18632/oncotarget.23258
  • Alharbi AF, Kratzke RA, D’Cunha J, et al. Gemcitabine and metabolite pharmacokinetics in advanced NSCLC patients after bronchial artery infusion and intravenous infusion. Cancer Chemother Pharmacol. 2019;83:387–391. doi: 10.1007/s00280-018-3757-7
  • Qi FH, Wang ZX, Cai PP, et al. Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection. Drug Discov Ther. 2013;7:212–24. doi: 10.5582/ddt.2013.v7.6.212
  • Yao XQ, Zhang YH, Long W, et al. Oxysophoridine suppresses the growth of hepatocellular carcinoma in mice: in vivo and cDNA microarray studies. Chin J Integr Med. 2012;18:209–13. doi: 10.1007/s11655-012-1001-6
  • Jin SJ, Yang Y, Ma L, et al. In vivo and in vitro induction of the apoptotic effects of oxysophoridine on colorectal cancer cells via the Bcl-2/Bax/caspase-3 signaling pathway. Oncol Lett. 2017;14:8000–8006.
  • Cao Z, Chen L, Liu Y, et al. Oxysophoridine rescues spinal cord injury via antiinflammatory, antioxidative stress and antiapoptosis effects. Mol Med Rep. 2018;17:2523–2528.
  • Liu J, Yang Y, Xu Y, et al. Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication. Virol J. 2011;8:483. doi: 10.1186/1743-422X-8-483
  • He J, Qi WB, Wang L, et al. Amaryllidaceae alkaloids inhibit nuclear-to-cytoplasmic export of ribonucleoprotein (RNP) complex of highly pathogenic avian influenza virus H5N1. Infl Other Respir Viruses. 2013;7:922–31. doi: 10.1111/irv.12035
  • Wang H, Guo T, Yang Y, et al. Lycorine derivative LY-55 inhibits EV71 and CVA16 replication through downregulating autophagy. Front Cell Infect Microbiol. 2019;9:277. doi: 10.3389/fcimb.2019.00277