Prevalence, risk factors and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in patients from Zhejiang, China, 2008–2018

References

• Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11:589–603. doi: 10.1128/CMR.11.4.589
   PubMed Web of Science ®Google Scholar
• Bradford PA, et al. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein. Antimicrob Agents Chemother. 1997;41:563–569. doi: 10.1128/AAC.41.3.563
   PubMed Web of Science ®Google Scholar
• MacKenzie FM, Forbes KJ, Dorai-John T, et al. Emergence of a carbapenem-resistant Klebsiella pneumoniae. Lancet. 1997;350:783, doi:10.1016/s0140-6736(05)62567-6.
   PubMed Web of Science ®Google Scholar
• Deshpande LM, Jones RN, Fritsche TR, et al. Occurrence and characterization of carbapenemase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program (2000-2004). Microb Drug Resist. 2006;12:223–230. doi:10.1089/mdr.2006.12.223.
   PubMed Web of Science ®Google Scholar
• Tacconelli E, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18:318–327. doi:10.1016/S1473-3099(17)30753-3.
   PubMed Web of Science ®Google Scholar
• Xu L, Sun X, Ma X. Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae. Ann Clin Microbiol Antimicrob. 2017;16:18, doi:10.1186/s12941-017-0191-3.
   PubMed Web of Science ®Google Scholar
• Tian L, et al. Epidemiology of Klebsiella pneumoniae bloodstream infections in a teaching hospital: factors related to the carbapenem resistance and patient mortality. Antimicrob Resist Infect Control. 2016;5:48, doi:10.1186/s13756-016-0145-0.
   PubMed Web of Science ®Google Scholar
• Zhang R, et al. Nationwide surveillance of clinical carbapenem-resistant Enterobacteriaceae (CRE) strains in China. EBioMedicine. 2017;19:98–106. doi:10.1016/j.ebiom.2017.04.032.
   PubMed Web of Science ®Google Scholar
• Wei ZQ, et al. Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. Antimicrob Agents Chemother. 2007;51:763–765. doi:AAC.01053-06 [pii]10.1128/AAC.01053-06.
   PubMed Web of Science ®Google Scholar
• Cai JC, Zhou HW, Zhang R, et al. Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. Antimicrob Agents Chemother. 2008;52:2014–2018. doi:10.1128/AAC.01539-07.
   PubMed Web of Science ®Google Scholar
• Shen P, et al. Novel genetic environment of the carbapenem-hydrolyzing beta-lactamase KPC-2 among Enterobacteriaceae in China. Antimicrob Agents Chemother. 2009;53:4333–4338. doi:AAC.00260-09 [pii]10.1128/AAC.00260-09.
   PubMed Web of Science ®Google Scholar
• Wyres KL, Holt KE. Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria. Curr Opin Microbiol. 2018;45:131–139. doi:10.1016/j.mib.2018.04.004.
   PubMed Web of Science ®Google Scholar
• Liu P, et al. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection: a meta-analysis. Microb Drug Resist. 2018;24:190–198. doi:10.1089/mdr.2017.0061.
   PubMed Web of Science ®Google Scholar
• Yan Z, et al. Prospective investigation of carbapenem-resistant Klebsiella pneumonia transmission among the staff, environment and patients in five major intensive care units, Beijing. J Hosp Infect. 2019;101:150–157. doi:10.1016/j.jhin.2018.11.019.
   PubMed Web of Science ®Google Scholar
• Jiao Y, et al. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection/colonization and predictors of mortality: a retrospective study. Pathog Glob Health. 2015;109:68–74. doi:10.1179/2047773215Y.0000000004.
   PubMed Web of Science ®Google Scholar
• Zhu J, et al. Antibiotic resistance profile of gram- negative bacteria isolated from children in hospitals across China:results of CHINET Antimicrobial Resistance Surveillance Program from 2005 to 2014. Chinese Journal of Infection and Chemotherapy. 2016;16:437–448. doi:10.16718/j.1009-7708.2016.04.011.
   Google Scholar
• Li G, et al. A 7-year surveillance of the drug resistance in Klebsiella pneumoniae from a primary health care center. Ann Clin Microbiol Antimicrob. 2019;18:34, doi:10.1186/s12941-019-0335-8.
   PubMed Web of Science ®Google Scholar
• Richet H. Seasonality in Gram-negative and healthcare-associated infections. Clin Microbiol Infect. 2012;18:934–940. doi:10.1111/j.1469-0691.2012.03954.x.
   PubMed Web of Science ®Google Scholar
• Kaier K, Frank U, Conrad A, et al. Seasonal and ascending trends in the incidence of carriage of extended-spectrum ss-lactamase-producing Escherichia coli and Klebsiella species in 2 German hospitals. Infect Control Hosp Epidemiol. 2010;31:1154–1159. doi:10.1086/656748.
   PubMed Web of Science ®Google Scholar
• Perez F, Bonomo RA. Evidence to improve the treatment of infections caused by carbapenem-resistant Gram-negative bacteria. Lancet Infect Dis. 2018;18:358–360. doi:10.1016/S1473-3099(18)30112-9.
   PubMed Web of Science ®Google Scholar
• Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018;7:142, doi:10.1186/s13756-018-0435-9.
   PubMed Web of Science ®Google Scholar
• Shields RK, et al. Emergence of ceftazidime-avibactam resistance due to plasmid-borne blaKPC-3 mutations during treatment of carbapenem-resistant Klebsiella pneumoniae infections. Antimicrob Agents Chemother. 2017;61; doi:10.1128/AAC.02097-16.
   Web of Science ®Google Scholar
• Raisanen K, et al. Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018. Euro Surveill. 2019;24; doi:10.2807/1560-7917.ES.2019.24.19.1900256.
   Google Scholar
• Shu L, et al. Emergence of OXA-232 carbapenemase-producing Klebsiella pneumoniae that carries a pLVPK-like virulence plasmid among elderly patients in China. Antimicrob Agents Chemother. 2019;63; doi:10.1128/AAC.02246-18.
   Web of Science ®Google Scholar
• Gu D, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18:37–46. doi:10.1016/S1473-3099(17)30489-9.
   PubMed Web of Science ®Google Scholar
• Bankevich A, et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comp Biol: J Comput Mol Cell Biol. 2012;19:455–477. doi:10.1089/cmb.2012.0021.
   PubMed Web of Science ®Google Scholar
• Zankari E, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012;67:2640–2644. doi:10.1093/jac/dks261.
   PubMed Web of Science ®Google Scholar
• Pichler C, et al. First report of invasive liver abscess syndrome with endophthalmitis caused by a K2 serotype ST2398 hypervirulent Klebsiella pneumoniae in Germany, 2016. New Microbes New Infect. 2017;17:77–80. doi:10.1016/j.nmni.2017.02.006.
   PubMedGoogle Scholar