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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

Li Zhanga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
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Qianqian Lia Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of China;b Jiangsu Recbio Technology Co., Ltd., Taizhou, People’s Republic of ChinaView further author information
,
Ziteng Lianga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of China;c Graduate School of Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Tao Lia Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Shuo Liua Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Qianqian Cuia Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Jianhui Niea Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Qian Wud Translational Medicine Institute, The First People’s Hospital of Chenzhou, University of South China, Chenzhou, People’s Republic of ChinaView further author information
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Xiaowang Qud Translational Medicine Institute, The First People’s Hospital of Chenzhou, University of South China, Chenzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Weijin Huanga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Youchun Wanga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9769-5141View further author information
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Pages 1-5 | Received 07 Dec 2021, Accepted 08 Dec 2021, Published online: 21 Dec 2021

References

  • Callaway E. Heavily mutated Omicron variant puts scientists on alert. Nature. 2021;600:21. doi:10.1038/d41586-021-03552-w.
  • WHO. Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern. 2021. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern.
  • GISAID. 2021. https://www.gisaid.org/hcov19-variants/.
  • Li Q, Nie J, Wu J, et al. SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape. Cell. 2021;184:2362–2371.e9. doi:10.1016/j.cell.2021.02.042.
  • Garcia-Beltran WF, Lam EC, St.Dennis K, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell. 2021;184:2523. doi:10.1016/j.cell.2021.04.006.
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  • Pulliam JRC, van Schalkwyk C, Govender N, et al. Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa. J medRxiv (2021). 2021.2011.2011.21266068. doi:10.1101/2021.11.11.21266068.
  • Shi R, Shan C, Duan X, et al. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature. 2020;584:120–124. doi:10.1038/s41586-020-2381-y.
  • Khoury DS, Cromer D, Reynaldi A, et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med. 2021;27:1205–1211. doi:10.1038/s41591-021-01377-8.
  • Nie J, Li Q, Wu J, et al. Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2. Emerg Microbes Infect. 2020;9:680–686. doi:10.1080/22221751.2020.1743767.
  • ] Nie J, Li Q, Wu J, et al. Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay. Nat Protoc. 2020;15:3699–3715. doi:10.1038/s41596-020-0394-5.

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