Advanced search
Publication Cover
Emerging Microbes & Infections Volume 11, 2022 - Issue 1
Submit an article Journal homepage
38,173
Views
250
CrossRef citations to date
0
Altmetric
Coronaviruses

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

Li Zhanga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Qianqian Lia Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of China;b Jiangsu Recbio Technology Co., Ltd., Taizhou, People’s Republic of ChinaView further author information
,
Ziteng Lianga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of China;c Graduate School of Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Tao Lia Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Shuo Liua Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Qianqian Cuia Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Jianhui Niea Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaView further author information
,
Qian Wud Translational Medicine Institute, The First People’s Hospital of Chenzhou, University of South China, Chenzhou, People’s Republic of ChinaView further author information
,
Xiaowang Qud Translational Medicine Institute, The First People’s Hospital of Chenzhou, University of South China, Chenzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Weijin Huanga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Youchun Wanga Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9769-5141View further author information
ORCID Icon show all
Pages 1-5 | Received 07 Dec 2021, Accepted 08 Dec 2021, Published online: 21 Dec 2021

References

  • Callaway E. Heavily mutated Omicron variant puts scientists on alert. Nature. 2021;600:21. doi:10.1038/d41586-021-03552-w.
  • WHO. Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern. 2021. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern.
  • GISAID. 2021. https://www.gisaid.org/hcov19-variants/.
  • Li Q, Nie J, Wu J, et al. SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape. Cell. 2021;184:2362–2371.e9. doi:10.1016/j.cell.2021.02.042.
  • Garcia-Beltran WF, Lam EC, St.Dennis K, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell. 2021;184:2523. doi:10.1016/j.cell.2021.04.006.
  • Zhang L, Cui Z, Li Q, et al. Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization. Commun Biol. 2021;4:1196. doi:10.1038/s42003-021-02728-4.
  • Wang M, Zhang L, Li Q, et al. Reduced sensitivity of the SARS-CoV-2 Lambda variant to monoclonal antibodies and neutralizing antibodies induced by infection and vaccination. Emerg Microbes Infect. 2021: 1–30. doi:10.1080/22221751.2021.2008775.
  • Pulliam JRC, van Schalkwyk C, Govender N, et al. Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa. J medRxiv (2021). 2021.2011.2011.21266068. doi:10.1101/2021.11.11.21266068.
  • Shi R, Shan C, Duan X, et al. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature. 2020;584:120–124. doi:10.1038/s41586-020-2381-y.
  • Khoury DS, Cromer D, Reynaldi A, et al. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nat Med. 2021;27:1205–1211. doi:10.1038/s41591-021-01377-8.
  • Nie J, Li Q, Wu J, et al. Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2. Emerg Microbes Infect. 2020;9:680–686. doi:10.1080/22221751.2020.1743767.
  • ] Nie J, Li Q, Wu J, et al. Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay. Nat Protoc. 2020;15:3699–3715. doi:10.1038/s41596-020-0394-5.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.