Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China

References

• Wang X, Liu Y, Qi X, et al. Molecular epidemiology of colistin-resistant Enterobacteriaceae in inpatient and avian isolates from China: high prevalence of mcr-negative Klebsiella pneumoniae. Int J Antimicrob Agents. 2017 Oct;50(4):536–541.
   PubMed Web of Science ®Google Scholar
• Cai Y, Lee W, Kwa AL. Polymyxin B versus colistin: an update. Expert Rev Anti Infect Ther. 2015;13(12):1481–1497.
   PubMed Web of Science ®Google Scholar
• Mobasseri G, Teh CSJ, Ooi PT, et al. The emergence of colistin-resistant Klebsiella pneumoniae strains from swine in Malaysia. J Glob Antimicrob Resist. 2019 Jun;17:227–232.
   PubMed Web of Science ®Google Scholar
• Olaitan AO, Diene SM, Kempf M, et al. Worldwide emergence of colistin resistance in Klebsiella pneumoniae from healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB: an epidemiological and molecular study. Int J Antimicrob Agents. 2014 Dec;44(6):500–507.
   PubMed Web of Science ®Google Scholar
• Trimble MJ, Mlynarcik P, Kolar M, et al. Polymyxin: alternative mechanisms of action and resistance. Cold Spring Harb Perspect Med. 2016 Oct 3;6(10).
   PubMed Web of Science ®Google Scholar
• Moffatt JH, Harper M, Boyce JD. Mechanisms of polymyxin resistance. Adv Exp Med Biol. 2019;1145:55–71.
   PubMed Web of Science ®Google Scholar
• Liu Y-Y, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161–168.
   PubMed Web of Science ®Google Scholar
• Yang Q, Pogue JM, Li Z, et al. Agents of last resort: An update on polymyxin resistance. Infect Dis Clin North Am. 2020 Dec;34(4):723–750.
   PubMed Web of Science ®Google Scholar
• Bialek-Davenet S, Criscuolo A, Ailloud F, et al. Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg Infect Dis. 2014 Nov;20(11):1812–1820.
   PubMed Web of Science ®Google Scholar
• Zou H, Jia X, He X, et al. Emerging threat of multidrug resistant pathogens from neonatal sepsis. Front Cell Infect Microbiol. 2021;11:694093.
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18(1):37–46.
   PubMed Web of Science ®Google Scholar
• Guducuoglu H, Gursoy NC, Yakupogullari Y, et al. Hospital outbreak of a colistin-resistant, NDM-1- and OXA-48-producing Klebsiella pneumoniae: high mortality from pandrug resistance. Microb Drug Resist. 2018 Sep;24(7):966–972.
   PubMed Web of Science ®Google Scholar
• Huang YH, Chou SH, Liang SW, et al. Emergence of an XDR and carbapenemase-producing hypervirulent Klebsiella pneumoniae strain in Taiwan. J Antimicrob Chemother. 2018 Aug 1;73(8):2039–2046.
   PubMed Web of Science ®Google Scholar
• Zhang H, Johnson A, Zhang G, et al. Susceptibilities of gram-negative bacilli from hospital- and community-acquired intra-abdominal and urinary tract infections: a 2016-2017 update of the Chinese SMART study. Infect Drug Resist. 2019;12:905–914.
   PubMed Web of Science ®Google Scholar
• CLSI. CLSI document M100-ED30 Performance standards for antimicrobial susceptibility testing; thrityth informational supplement.
   Google Scholar
• EUCAST. European Committee on Antimicrobial Susceptibility Testing Breakpoint tables for interpretation of MICs and zone diameters Version 10.0.
   Google Scholar
• Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014 Aug 1;30(15):2114–2120.
   PubMed Web of Science ®Google Scholar
• Jolley K, Bray J, Maiden M. Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications. Wellcome open research. 2018. 3:124.
   Google Scholar
• Joensen KG, Tetzschner AM, Iguchi A, et al. Rapid and easy In silico serotyping of Escherichia coli isolates by Use of whole-genome sequencing data. J Clin Microbiol. 2015 Aug;53(8):2410–2426.
   PubMed Web of Science ®Google Scholar
• Wyres KL, Lam MMC, Holt KE. Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol. 2020 Jun;18(6):344–359.
   PubMed Web of Science ®Google Scholar
• Kurtz S, Phillippy A, Delcher A, et al. Versatile and open software for comparing large genomes. Genome Biol. 2004;5(2):R12.
   PubMed Web of Science ®Google Scholar
• Nguyen LT, Schmidt HA, von Haeseler A, et al. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol Biol Evol. 2015 Jan;32(1):268–274.
   PubMed Web of Science ®Google Scholar
• Zankari E, Allesoe R, Joensen KG, et al. Pointfinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens. J Antimicrob Chemother. 2017 Oct 1;72(10):2764–2768.
   PubMed Web of Science ®Google Scholar
• Bortolaia V, Kaas RS, Ruppe E, et al. Resfinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother. 2020 Dec 1;75(12):3491–3500.
   PubMed Web of Science ®Google Scholar
• Rebelo AR, Bortolaia V, Kjeldgaard JS, et al. Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes. Euro Surveill. 2018 Feb;23(6).
   PubMedGoogle Scholar
• Borowiak M, Baumann B, Fischer J, et al. Development of a novel mcr-6 to mcr-9 Multiplex PCR and Assessment of mcr-1 to mcr-9 occurrence in colistin-resistant Salmonella enterica isolates from environment, feed, animals and food (2011-2018) in Germany. Front Microbiol. 2020;11:80.
   PubMed Web of Science ®Google Scholar
• Wang C, Feng Y, Liu L, et al. Identification of novel mobile colistin resistance gene mcr-10. Emerg Microbes Infect. 2020;9(1):508–516.
   PubMed Web of Science ®Google Scholar
• Feldgarden M, Brover V, Gonzalez-Escalona N, et al. AMRFinderPlus and the reference gene catalog facilitate examination of the genomic links among antimicrobial resistance, stress response, and virulence. Sci Rep. 2021 Jun 16;11(1):12728.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang S, Chen W, et al. CRISPR-Cas9 and CRISPR-assisted cytidine deaminase enable precise and efficient genome editing in Klebsiella pneumoniae. Appl Environ Microbiol. 2018;84(23).
   Web of Science ®Google Scholar
• Liu B, Zheng D, Jin Q, et al. VFDB 2019: a comparative pathogenomic platform with an interactive web interface. Nucleic Acids Res. 2019 Jan 8;47(D1):D687–D692.
   PubMed Web of Science ®Google Scholar
• Tian D, Wang W, Li M, et al. Acquisition of the conjugative virulence plasmid from a CG23 hypervirulent Klebsiella pneumoniae strain enhances bacterial virulence. Front Cell Infect Microbiol. 2021;11:752011.
   PubMed Web of Science ®Google Scholar
• Russo TA, MacDonald U, Hassan S, et al. An assessment of siderophore production. Mucoviscosity, and mouse infection models for defining the virulence spectrum of hypervirulent Klebsiella Pneumoniae. MSphere. 2021 Mar 24;6(2).
   Web of Science ®Google Scholar
• Crofts AA, Giovanetti SM, Rubin EJ, et al. Enterotoxigenic E. coli virulence gene regulation in human infections. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8968–E8976.
   PubMed Web of Science ®Google Scholar
• Vuotto C, Longo F, Pascolini C, et al. Biofilm formation and antibiotic resistance in Klebsiella pneumoniae urinary strains. J Appl Microbiol. 2017 Oct;123(4):1003–1018.
   PubMed Web of Science ®Google Scholar
• Anders S, Pyl P, Huber W. HTSeq–a python framework to work with high-throughput sequencing data. Bioinformatics (Oxford. England). 2015;31(2):166–169.
   PubMed Web of Science ®Google Scholar
• Love M, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.
   PubMed Web of Science ®Google Scholar
• Yu G, Wang L, Han Y, et al. Clusterprofiler: an R package for comparing biological themes among gene clusters. Omics: A Journal of Integrative Biology. 2012;16(5):284–287.
   PubMed Web of Science ®Google Scholar
• Langstraat J, Bohse M, Clegg S. Type 3 fimbrial shaft (MrkA) of Klebsiella pneumoniae, but not the fimbrial adhesin (MrkD), facilitates biofilm formation. Infect Immun. 2001 Sep;69(9):5805–5812.
   PubMed Web of Science ®Google Scholar
• Allan RN, Skipp P, Jefferies J, et al. Pronounced metabolic changes in adaptation to biofilm growth by Streptococcus pneumoniae. PLoS One. 2014;9(9):e107015.
   PubMed Web of Science ®Google Scholar
• Yang X, Peng K, Zhang Y, et al. Characterization of a novel mcr-8.2-bearing plasmid in ST395 Klebsiella pneumoniae of chicken origin. Infect Drug Resist. 2020;13:1781–1784.
   PubMed Web of Science ®Google Scholar
• Yan W, Zhang Q, Zhu Y, et al. Molecular mechanism of polymyxin resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli isolates from henan province, China: A multicenter study. Infect Drug Resist. 2021;14:2657–2666.
   PubMed Web of Science ®Google Scholar
• Haeili M, Javani A, Moradi J, et al. Mgrb alterations mediate colistin resistance in Klebsiella pneumoniae isolates from Iran. Front Microbiol. 2017;8:2470.
   PubMed Web of Science ®Google Scholar
• Xu Q, Xu T, Zhuang Y, et al. In vivo development of polymyxin B resistance in Klebsiella pneumoniae owing to a 42 bp deletion in the sequence of phoQ. Biomed Res Int. 2020;2020:5868479.
   PubMed Web of Science ®Google Scholar
• Giordano C, Barnini S, Tsioutis C, et al. Expansion of KPC-producing Klebsiella pneumoniae with various mgrB mutations giving rise to colistin resistance: the role of ISL3 on plasmids. Int J Antimicrob Agents. 2018 Feb;51(2):260–265.
   PubMed Web of Science ®Google Scholar
• Shamina OV, Kryzhanovskaya OA, Lazareva AV, et al. Emergence of a ST307 clone carrying a novel insertion element MITEKpn1 in the mgrB gene among carbapenem-resistant Klebsiella pneumoniae from Moscow, Russia. Int J Antimicrob Agents. 2020 Feb;55(2):105850.
   PubMed Web of Science ®Google Scholar
• Yang TY, Wang SF, Lin JE, et al. Contributions of insertion sequences conferring colistin resistance in Klebsiella pneumoniae. Int J Antimicrob Agents. 2020 Mar;55(3):105894.
   PubMed Web of Science ®Google Scholar
• Jayol A, Poirel L, Brink A, et al. Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin. Antimicrob Agents Chemother. 2014 Aug;58(8):4762–4766.
   PubMed Web of Science ®Google Scholar
• Jayol A, Nordmann P, Brink A, et al. Heteroresistance to colistin in Klebsiella pneumoniae associated with alterations in the PhoPQ regulatory system. Antimicrob Agents Chemother. 2015 May;59(5):2780–2784.
   PubMed Web of Science ®Google Scholar
• Cheng YH, Lin TL, Pan YJ, et al. Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan. Antimicrob Agents Chemother. 2015 May;59(5):2909–2913.
   PubMed Web of Science ®Google Scholar
• Gao R, Stock AM. Biological insights from structures of two-component proteins. Annu Rev Microbiol. 2009;63:133–154.
   PubMed Web of Science ®Google Scholar
• Cheng YH, Lin TL, Lin YT, et al. Amino acid substitutions of CrrB responsible for resistance to colistin through CrrC in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2016 Jun;60(6):3709–3716.
   PubMed Web of Science ®Google Scholar
• Rojas LJ, Salim M, Cober E, et al. Colistin resistance in carbapenem-resistant Klebsiella pneumoniae: Laboratory detection and impact on mortality. Clin Infect Dis. 2017 Mar 15;64(6):711–718.
   PubMed Web of Science ®Google Scholar
• Zhang B, Yu B, Zhou W, et al. Klebsiella pneumoniaemobile plasmid mediated transition from colistin-sensitive to resistant phenotype in. Front Microbiol. 2021;12:619369.
   PubMed Web of Science ®Google Scholar
• Kidd TJ, Mills G, Sa-Pessoa J, et al. A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence. EMBO Mol Med. 2017 Apr;9(4):430–447.
   PubMed Web of Science ®Google Scholar
• Lin Z, Cai X, Chen M, et al. Virulence and stress responses of Shigella flexneri regulated by PhoP/PhoQ. Front Microbiol. 2017;8:2689.
   PubMed Web of Science ®Google Scholar
• de Campos TA, Goncalves LF, Magalhaes KG, et al. A fatal bacteremia caused by hypermucousviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae in Brazil. Front Med (Lausanne. 2018;5:265.
   PubMed Web of Science ®Google Scholar
• Esposito EP, Cervoni M, Bernardo M, et al. Molecular epidemiology and virulence profiles of colistin-resistant Klebsiella pneumoniae blood isolates from the Hospital agency “Ospedale dei Colli,” Naples, Italy. Front Microbiol. 2018;9:1463.
   PubMed Web of Science ®Google Scholar
• Li L, Li R, Qi C, et al. Mechanisms of polymyxin resistance induced by Salmonella typhimurium in vitro. Vet Microbiol. 2021 Jun;257:109063.
   PubMed Web of Science ®Google Scholar
• Farshadzadeh Z, Taheri B, Rahimi S, et al. Growth rate and biofilm formation ability of clinical and laboratory-evolved colistin-resistant strains of Acinetobacter baumannii. Front Microbiol. 2018;9:153.
   PubMed Web of Science ®Google Scholar
• Wilton M, Charron-Mazenod L, Moore R, et al. Extracellular DNA acidifies biofilms and induces aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016 Jan;60(1):544–553.
   PubMed Web of Science ®Google Scholar
• Alcantar-Curiel MD, Blackburn D, Saldana Z, et al. Multi-functional analysis of Klebsiella pneumoniae fimbrial types in adherence and biofilm formation. Virulence. 2013 Feb 15;4(2):129–138.
   PubMed Web of Science ®Google Scholar