Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell lines

References

• Schweitzer A, Horn J, Mikolajczyk RT, et al. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet. 2015;386:1546–1555.
   PubMed Web of Science ®Google Scholar
• Liang TJ. Hepatitis B: the virus and disease. Hepatology. 2009;49:S13–S21.
   PubMed Web of Science ®Google Scholar
• Lebosse F, Testoni B, Fresquet J, et al. Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B. J Hepatol. 2017;66:897–909.
   PubMed Web of Science ®Google Scholar
• Liu H, Li F, Zhang X, et al. Differentially expressed intrahepatic genes contribute to control of hepatitis B virus replication in the inactive carrier phase. J Infect Dis. 2018;217:1044–1054.
   PubMed Web of Science ®Google Scholar
• Alpini G, Phillips JO, Vroman B, et al. Recent advances in the isolation of liver cells. Hepatology. 1994;20:494–514.
   PubMed Web of Science ®Google Scholar
• Levrero M, Zucman-Rossi J. Mechanisms of HBV-induced hepatocellular carcinoma. J Hepatol. 2016;64:S84–S101.
   PubMed Web of Science ®Google Scholar
• Ambros V. The functions of animal microRNAs. Nature. 2004;431:350–355.
   PubMed Web of Science ®Google Scholar
• Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007;129:1401–1414.
   PubMed Web of Science ®Google Scholar
• Ludwig N, Leidinger P, Becker K, et al. Distribution of miRNA expression across human tissues. Nucleic Acids Res. 2016;44:3865–3877.
   PubMed Web of Science ®Google Scholar
• Oda S, Takeuchi M, Akai S, et al. miRNA in rat liver sinusoidal endothelial cells and hepatocytes and application to circulating biomarkers that discern pathogenesis of liver injuries. Am J Pathol. 2018;188:916–928.
   PubMed Web of Science ®Google Scholar
• Klingenberg M, Matsuda A, Diederichs S, et al. Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets. J Hepatol. 2017;67:603–618.
   PubMed Web of Science ®Google Scholar
• Roderburg C, Luedde M, Cardenas DV, et al. miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis. J Hepatol. 2013;58:736–742.
   PubMed Web of Science ®Google Scholar
• Roderburg C, Urban GW, Bettermann K, et al. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology. 2011;53:209–218.
   PubMed Web of Science ®Google Scholar
• Zhang GL, Li YX, Zheng SQ, et al. Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antiviral Res. 2010;88:169–175.
   PubMed Web of Science ®Google Scholar
• Hu J, Xu YX, Li CF, et al. A cross-talk between Hepatitis B virus and host mRNAs confers viral adaptation to liver. Sci Rep. 2015;5:10572.
   PubMed Web of Science ®Google Scholar
• Lin Y, Deng W, Pang J, et al. The microRNA-99 family modulates hepatitis B virus replication by promoting IGF-1R/PI3 K/Akt/mTOR/ULK1 signaling-induced autophagy. Cell Microbiol. 2017;19:e12709.
   Web of Science ®Google Scholar
• Deng W, Zhang X, Ma Z, et al. MicroRNA-125b-5p mediates post-transcriptional regulation of hepatitis B virus replication via the LIN28B/let-7 axis. RNA Biol. 2017;14:1389–1398.
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhang E, Ma Z, et al. Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1. Hepatology. 2011;53:1476–1485.
   PubMed Web of Science ®Google Scholar
• Werner M, Driftmann S, Kleinehr K, et al. All-in-one: advanced preparation of human parenchymal and non-parenchymal liver cells. PLoS One. 2015;10:e0138655.
   PubMed Web of Science ®Google Scholar
• Li F, Zhou P, Deng W, et al. Serum microRNA-125b correlates with hepatitis B viral replication and liver necroinflammation. Clin Microbiol Infect. 2016;22:384 e381–384 e310.
   Web of Science ®Google Scholar
• Wei S, Wang L, Zhang L, et al. ZNF143 enhances metastasis of gastric cancer by promoting the process of EMT through PI3 K/AKT signaling pathway. Tumour Biol. 2016;37:12813–12821.
   PubMedGoogle Scholar
• Teng CF, Wu HC, Tsai HW, et al. Novel feedback inhibition of surface antigen synthesis by mammalian target of rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and therapy. Hepatology. 2011;54:1199–1207.
   PubMed Web of Science ®Google Scholar
• de Rie D, Abugessaisa I, Alam T, et al. An integrated expression atlas of miRNAs and their promoters in human and mouse. Nat Biotechnol. 2017;35:872–878.
   PubMed Web of Science ®Google Scholar
• Wang G, Dong F, Xu Z, et al. MicroRNA profile in HBV-induced infection and hepatocellular carcinoma. BMC Cancer. 2017;17:805.
   PubMed Web of Science ®Google Scholar
• Chen Z, Diaz G, Pollicino T, et al. Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure. Proc Natl Acad Sci USA. 2018;115:E11369–E11378.
   PubMed Web of Science ®Google Scholar
• Winther TN, Bang-Berthelsen CH, Heiberg IL, et al. Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B. PLoS One. 2013;8:e58236.
   PubMed Web of Science ®Google Scholar
• van der Ree MH, Jansen L, Kruize Z, et al. Plasma microRNA levels are associated with hepatitis B e antigen status and treatment response in chronic hepatitis B patients. J Infect Dis. 2017;215:1421–1429.
   PubMed Web of Science ®Google Scholar
• Liu J, Wen Y, Liu Z, et al. VPS33B modulates c-Myc/p53/miR-192-3p to target CCNB1 suppressing the growth of non-small cell lung cancer. Mol Ther Nucleic Acids. 2021;23:324–335.
   PubMedGoogle Scholar
• Wang Z, Miu KK, Zhang X, et al. Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor. JHEP Rep. 2020;2:100179.
   PubMedGoogle Scholar
• Wang J, Chen J, Liu Y, et al. Hepatitis B virus induces autophagy to promote its replication by the axis of miR-192-3p-XIAP through NF kappa B signaling. Hepatology. 2019;69:974–992.
   PubMed Web of Science ®Google Scholar
• Winther TN, Heiberg IL, Bang-Berthelsen CH, et al. Hepatitis B surface antigen quantity positively correlates with plasma levels of microRNAs differentially expressed in immunological phases of chronic hepatitis B in children. PLoS One. 2013;8:e80384.
   PubMed Web of Science ®Google Scholar
• Brunetto MR, Cavallone D, Oliveri F, et al. A serum microRNA signature is associated with the immune control of chronic hepatitis B virus infection. PLoS One. 2014;9:e110782.
   PubMed Web of Science ®Google Scholar
• Li D, Liu Y, Li H, et al. MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5). FEBS Lett. 2015;589:68–76.
   PubMed Web of Science ®Google Scholar
• Guo H, Zhou T, Jiang D, et al. Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway. J Virol. 2007;81:10072–10080.
   PubMed Web of Science ®Google Scholar
• Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926–1945.
   PubMed Web of Science ®Google Scholar
• Kim YC, Guan KL. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015;125:25–32.
   PubMed Web of Science ®Google Scholar
• Huning L, Kunkel GR. The ubiquitous transcriptional protein ZNF143 activates a diversity of genes while assisting to organize chromatin structure. Gene. 2021;769:145205.
   PubMed Web of Science ®Google Scholar
• Schuster C, Krol A, Carbon P. Two distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA promoters. Mol Cell Biol. 1998;18:2650–2658.
   PubMed Web of Science ®Google Scholar
• Ye B, Yang G, Li Y, et al. ZNF143 in chromatin looping and gene regulation. Front Genet. 2020;11:338.
   PubMed Web of Science ®Google Scholar
• Paek AR, You HJ. GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cells. Mol Cells. 2011;32:415–419.
   PubMed Web of Science ®Google Scholar
• Zhang L, Huo Q, Ge C, et al. ZNF143-mediated h3k9 trimethylation upregulates CDC6 by activating MDIG in hepatocellular carcinoma. Cancer Res. 2020;80:2599–2611.
   PubMed Web of Science ®Google Scholar
• Kai K, Dittmar RL, Sen S. Secretory microRNAs as biomarkers of cancer. Semin Cell Dev Biol. 2018;78:22–36.
   PubMed Web of Science ®Google Scholar
• Zhang XN, Chen CC, Wu M, et al. Plasma microRNA profile as a predictor of early virological response to interferon treatment in chronic hepatitis B patients. Antivir Ther. 2012;17:1243–1253.
   PubMed Web of Science ®Google Scholar
• Akamatsu S, Hayes CN, Tsuge M, et al. Differences in serum microRNA profiles in hepatitis B and C virus infection. J Infect. 2015;70:273–287.
   PubMed Web of Science ®Google Scholar
• Enomoto Y, Takagi R, Naito Y, et al. Identification of the novel 3′ UTR sequences of human IL-21 mRNA as potential targets of miRNAs. Sci Rep. 2017;7:7780.
   PubMed Web of Science ®Google Scholar
• Novellino L, Rossi RL, Bonino F, et al. Circulating hepatitis B surface antigen particles carry hepatocellular microRNAs. PLoS One. 2012;7:e31952.
   PubMed Web of Science ®Google Scholar
• Chen R, Wu JC, Liu T, et al. MicroRNA profile analysis in the liver fibrotic tissues of chronic hepatitis B patients. J Dig Dis. 2017;18:115–124.
   PubMed Web of Science ®Google Scholar