3,332
Views
6
CrossRef citations to date
0
Altmetric
Coronaviruses

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

, , , , , , , , & ORCID Icon show all
Pages 730-740 | Received 01 Dec 2021, Accepted 14 Feb 2022, Published online: 01 Mar 2022

References

  • Li Q, Guan X, Wu P, et al. Early transmission dynamics in wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382:1199.
  • Pal M, Berhanu G, Desalegn C, et al. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): An update. Cureus. 2020;12:e7423.
  • Sakamoto A, Kawakami R, Kawai K, et al. Ace2 (angiotensin-converting enzyme 2) and TMPRSS2 (transmembrane serine protease 2) expression and localization of SARS-CoV-2 infection in the human heart. Arterioscler Thromb Vasc Biol. 2021;41(1):542–544. https://doi.org/10.1161/ATVBAHA.120.315229
  • Huang WC, Zhou S, He X, et al. Sars-CoV-2 RBD neutralizing antibody induction is enhanced by particulate vaccination. Adv Mater. 2020;32:2005637.
  • Kreye J, Reincke SM, Kornau HC, et al. A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model. bioRxiv (2020).
  • Oran DP, Topol EJ. Prevalence of asymptomatic SARS-CoV-2 infection. Ann Intern Med 2020;173:362.
  • Hassert M, Harris MG, Brien JD, et al. Identification of protective CD8 T cell responses in a mouse model of Zika virus infection. Front Immunol. 2019;10:1678.
  • Larena M, Regner M, Lee E, et al. Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis. J Virol 2011;85:5446.
  • Wen J, Elong Ngono A, Regla-Nava JA, et al. Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge. Nat Commun. 2017;8:1459.
  • Bollard CM, Heslop HE. T cells for viral infections after allogeneic hematopoietic stem cell transplant. Blood. 2016;127:3331.
  • Zheng Y, Zhang Y, Ma Y, et al. Enhancement of immunotherapeutic effects of HPV16E7 on cervical cancer by fusion with CTLA4 extracellular region. J. Microbiol. 2008;46:728.
  • Croft NP, Smith SA, Pickering J, et al. Most viral peptides displayed by class I MHC on infected cells are immunogenic. Proc Natl Acad Sci USA. 2019;116:3112.
  • Zhang Y, Zhang H, Ma W, et al. Evaluation of Zika virus-specific T-cell responses in immunoprivileged organs of infected Ifnar1-/- mice. J Vis Exp. 2018. https://doi.org/10.3791/58110
  • Wu S, Zhong G, Zhang J, et al. A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge. Nat Commun. 2020;11(1):4081. https://doi.org/10.1038/s41467-020-17972-1
  • Smith TRF, Patel A, Ramos S, et al. Immunogenicity of a DNA vaccine candidate for COVID-19. Nat Commun. 2020;11:2601.
  • Lu J, Lu G, Tan S. A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice. Cell Res 2020;30:936.
  • Muraoka D, Situo D, Sawada S-i, et al. Identification of a dominant CD8+ CTL epitope in the SARS-associated coronavirus 2 spike protein. Vaccine. 2020;38:7697.
  • Reynisson B, Alvarez B, Paul S, et al. NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data. Nucleic Acids Res 2020;48:W449.
  • Clemente T, Dominguez MR, Vieira NJ, et al. In vivo assessment of specific cytotoxic T lymphocyte killing. Methods. 2013;61:105.
  • Balendiran GK, Solheim JC, Young ACM. The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide. Proc Natl Acad Sci USA. 1997;94:6880.
  • Speir JA, Garcia KC, Brunmark A, et al. Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes. Immun (Cambridge, Mass.). 1998;8:553.
  • Suri A, Walters JJ, Levisetti MG, et al. Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells. Eur J Immunol 2006;36:544.
  • Corr M, Boyd LF, Padlan EA, et al. H-2Dd exploits a four residue peptide binding motif. J Exp Med. 1993;178:1877.
  • Alter G, Yu J, Liu J, et al. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Nature (London) (2021).
  • DiPiazza AT, Graham BS, Ruckwardt TJ. T cell immunity to SARS-CoV-2 following natural infection and vaccination. Biochem Biophys Res Commun 2021;538:211.
  • Zhang G, Zhang J, Wang B. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in wuhan, China: a retrospective analysis. Respir Res 2020;21:74.
  • Bonifacius A, Tischer-Zimmermann S, Dragon AC. COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses. Immun. 2021;54:340.
  • Wang F, Nie J, Wang H, et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis 2020;221:1762.
  • Agerer B, Koblischke M, Gudipati V, et al. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses. Sci Immunol. 2021;6:g6461.