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Emerging Microbes & Infections Volume 11, 2022 - Issue 1
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Coronaviruses

Reduced neutralization of SARS-CoV-2 Omicron variant by BNT162b2 vaccinees’ sera: a preliminary evaluation

D. Miletoa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9414-0287
ORCID Icon,
V. Michelia Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
C. Feniziab Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy;c Department of Pathophysiology and Transplantation, University of Milan, Milan, ItalyORCID Iconhttps://orcid.org/0000-0003-0735-8331
ORCID Icon,
M. Cutreraa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
G. Gagliardia Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
A. Mancona Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, ItalyORCID Iconhttps://orcid.org/0000-0002-1490-636X
ORCID Icon,
F. Bracchittaa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
A. De Silvestrid Clinical Epidemiology and Biometeric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
,
G. Rizzardinie Division of Infectious Diseases, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, ItalyORCID Iconhttps://orcid.org/0000-0002-5183-7818
ORCID Icon,
A. Lombardia Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
,
M. Biasinb Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy
&
M. R. Gismondoa Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, L. Sacco University Hospital, Milan, Italy
 show all
Pages 790-792 | Received 13 Jan 2022, Accepted 19 Feb 2022, Published online: 10 Mar 2022

References

  • CDC. 2020. Coronavirus Disease 2019 (COVID-19).
  • Rella SA, Kulikova YA, Dermitzakis ET, et al. Rates of SARS-CoV-2 transmission and vaccination impact the fate of vaccine-resistant strains. Sci Rep. 2021;11:15729. doi:10.1038/s41598-021-95025-3.
  • Mileto D, Fenizia C, Cutrera M, et al. SARS-CoV-2 mRNA vaccine BNT162b2 triggers a consistent cross-variant humoral and cellular response. Emerg Microb Infect. 2021;10:2235–2243.
  • Micheli V, Bracchitta F, Rizzo A, et al. First identification of the new SARS-CoV-2 Omicron variant (B.1.1.529) in Italy. Clin Infect Dis. 2022 Jan 21: ciab1044. doi:10.1093/cid/ciab1044. Epub ahead of print. PMID: 35061887; PMCID: PMC8807288.
  • Kohmer N, Westhaus S, Rühl C, et al. Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays. J Clin Vir. 2020;129:104480.
  • Cele S, Jackson L, Khan K, et al. (2021). SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection. MedRxiv 2021.12.08.21267417.
  • Lu L, Mok BW-Y, Chen L-L, et al. Neutralization of SARS-CoV-2 Omicron variant by sera from BNT162b2 or Coronavac vaccine recipients. Clin Infect Dis. 2021: ciab1041.
  • Wilhelm A, Widera M, Grikscheit K, et al. (2021). Reduced neutralization of SARS-CoV-2 Omicron variant by vaccine sera and monoclonal antibodies. medRxiv 2021.12.07.21267432; doi: https://doi.org/10.1101/2021.12.07.21267432
  • Basile K, Rockett RJ, McPhie K, et al. (2021). Improved neutralization of the SARS-CoV-2 Omicron variant after Pfizer-BioNTech BNT162b2 COVID-19 vaccine boosting. bioRxiv 2021.12.12.472252; doi: https://doi.org/10.1101/2021.12.12.472252
  • Redd AD, Nardin A, Kared H, et al. (2021). Minimal cross-over between mutations associated with Omicron variant of SARS-CoV-2 and CD8+ T cell epitopes identified in COVID-19 convalescent individuals. BioRxiv 2021.12.06.471446.

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