Advanced search
Publication Cover
Emerging Microbes & Infections Volume 11, 2022 - Issue 1
Submit an article Journal homepage
3,714
Views
13
CrossRef citations to date
0
Altmetric
Coronaviruses

A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants

Joy-Yan Lama Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaView further author information
,
Yau-Yee Nga Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaView further author information
,
Chun-Kit Yuena Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China;b Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-2646-2054View further author information
ORCID Icon,
Wan-Man Wonga Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China;c State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People’s Republic of ChinaView further author information
,
Kwok-Yung Yuena Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China;c State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People’s Republic of China;b Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2083-1552View further author information
ORCID Icon &
Kin-Hang Koka Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China;c State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People’s Republic of China;b Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3426-332XView further author information
ORCID Icon
Pages 964-967 | Received 31 Jan 2022, Accepted 08 Mar 2022, Published online: 30 Mar 2022

References

  • Buchan SA, Chung H, Brown KA, et al. Effectiveness of COVID-19 vaccines against Omicron or Delta symptomatic infection and severe outcomes. medRxiv. 2022: 2021.12.30.21268565.
  • Bernal J L, Andrews N, Gower C, et al. Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) variant. N Engl J Med. 2021 Aug 12;385(7):585–594.
  • Callaway E. Heavily mutated Omicron variant puts scientists on alert. Nature. 2021 Dec;600(7887):21.
  • National Center for Immunization and Respiratory Diseases (NCIRD) DoVD. Science Brief: Omicron (B.1.1.529) Variant. Centers for Disease Control and Prevention2021. Available from: https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/scientific-brief-omicron-variant.html.
  • Dejnirattisai W, Huo J, Zhou D, et al. SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Cell. 2022 Feb 3;185(3):467-484 e15.
  • Flemming A. Omicron, the great escape artist. Nat Rev Immunol. 2022 Feb;22(2):75.
  • Israel A, Shenhar Y, Green I, et al. Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection. Vaccines (Basel). 2021 Dec 31;10(1):64.
  • Khoury J, Najjar-Debbiny R, Hanna A, et al. COVID-19 vaccine – long term immune decline and breakthrough infections. Vaccine. 2021 Nov 26;39(48):6984–6989.
  • Schmidt F, Muecksch F, Weisblum Y, et al. Plasma neutralization of the SARS-CoV-2 Omicron variant. N Engl J Med. 2021 Dec 30.
  • Muik A, Lui BG, Wallisch AK, et al. Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera. Science. 2022 Jan 18;375(6581):678-680.
  • An X, Martinez-Paniagua M, Rezvan A, et al. Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2. iScience. 2021 Sep 24;24(9):103037.
  • Du Y, Xu Y, Feng J, et al. Intranasal administration of a recombinant RBD vaccine induced protective immunity against SARS-CoV-2 in mouse. Vaccine. 2021 Apr 15;39(16):2280–2287.
  • Jangra S, Landers JJ, Rathnasinghe R, et al. A combination adjuvant for the induction of potent antiviral immune responses for a recombinant SARS-CoV-2 protein vaccine. Front Immunol. 2021;12:729189.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.