Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells

References

• Karlsson Hedestam GB, Fouchier RA, Phogat S, et al. The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus. Nat Rev Microbiol. 2008;6(2):143–145.
   PubMed Web of Science ®Google Scholar
• Taubenberger JK, Kash JC, Morens DM. The 1918 influenza pandemic: 100 years of questions answered and unanswered. Sci Transl Med. 2019;24(11):502.
   Google Scholar
• Shi SJ, Li H, Liu M, et al. Mortality prediction to hospitalized patients with influenza pneumonia: PO2 /FiO2 combined lymphocyte count is the answer. Clin Respir J. 2017;11(3):352–360.
   PubMed Web of Science ®Google Scholar
• Guo L, Wei D, Zhang X, et al. Clinical features predicting mortality risk in patients with viral pneumonia: The MuLBSTA score. Front Microbiol. 2019;10:2752.
   PubMed Web of Science ®Google Scholar
• Jameson SC, Masopust D. Understanding subset diversity in T cell memory. Immunity. 2018;48(2):214–226.
   PubMed Web of Science ®Google Scholar
• Hoeve MA, Nash AA, Jackson D, et al. Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation. PLoS One. 2012;7(1):e29443.
   PubMed Web of Science ®Google Scholar
• Perrone LA, Plowden JK, Garcia-Sastre A, et al. H5n1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog. 2008;4(8):e1000115.
   PubMed Web of Science ®Google Scholar
• Herter S, Osterloh P, Hilf N, et al. Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells. J Immunol. 2005;175(2):891–888.
   PubMed Web of Science ®Google Scholar
• Marcet CW, St Laurent CD, Moon TC, et al. Limited replication of influenza A virus in human mast cells. Immunol Res. 2013;56(1):32–43.
   PubMed Web of Science ®Google Scholar
• Ivan FX, Tan KS, Phoon MC, et al. Neutrophils infected with highly virulent influenza H3N2 virus exhibit augmented early cell death and rapid induction of type I interferon signaling pathways. Genomics. 2013;101(2):101–112.
   PubMed Web of Science ®Google Scholar
• van Erp EA, van Kampen MR, van Kasteren PB, et al. Viral infection of human natural killer cells. Viruses. 2019;11(3).
   Web of Science ®Google Scholar
• Zhang Z, Huang T, Yu F, et al. Infectious progeny of 2009 A (H1N1) influenza virus replicated in and released from human neutrophils. Sci Rep. 2015;5:17809.
   PubMed Web of Science ®Google Scholar
• Granelli-Piperno A, Vassalli JD, Reich E. RNA and protein synthesis in human peripheral blood polymorphonuclear leukocytes. J Exp Med. 1979;149(1):284–289.
   PubMed Web of Science ®Google Scholar
• Dougan SK, Ashour J, Karssemeijer RA, et al. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 2013;503(7476):406–409.
   PubMed Web of Science ®Google Scholar
• Gu J, Xie Z, Gao Z, et al. H5n1 infection of the respiratory tract and beyond: a molecular pathology study. The Lancet. 2007;370(9593):1137–1145.
   PubMed Web of Science ®Google Scholar
• Fan K, Jia Y, Wang S, et al. Role of Itk signalling in the interaction between influenza A virus and T-cells. J Gen Virol. 2012;93(Pt 5):987–997.
   PubMed Web of Science ®Google Scholar
• Steuerman Y, Cohen M, Peshes-Yaloz N, et al. Dissection of influenza infection In vivo by single-cell RNA sequencing. Cell Syst. 2018;6(6):679–691. e4.
   PubMed Web of Science ®Google Scholar
• Huang X, Zheng M, Wang P, et al. An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells. Nat Commun. 2017;8:14751.
   PubMed Web of Science ®Google Scholar
• Li YG, Thawatsupha P, Chittaganpitch M, et al. Higher in vitro susceptibility of human T cells to H5N1 than H1N1 influenza viruses. Biochem Biophys Res Commun. 2008;371(3):484–489.
   PubMed Web of Science ®Google Scholar
• Blaum BS, Stehle T. Sialic acids in nonenveloped virus infections. Adv Carbohydr Chem Biochem. 2019;76:65–111.
   PubMed Web of Science ®Google Scholar
• Raman R, Tharakaraman K, Shriver Z, et al. Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus. Trends Microbiol. 2014;22(11):632–641.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Ito T, Suzuki T, et al. Sialic acid species as a determinant of the host range of influenza A viruses. J Virol. 2000;74(24):11825–11831.
   PubMed Web of Science ®Google Scholar
• Shinya K, Ebina M, Yamada S, et al. Avian flu: influenza virus receptors in the human airway. Nature. 2006;440(7083):435–436.
   PubMed Web of Science ®Google Scholar
• Meischel T, Villalon-Letelier F, Saunders PM, et al. Influenza A virus interactions with macrophages: lessons from epithelial cells. Cell Microbiol. 2020;22(5):e13170.
   PubMed Web of Science ®Google Scholar
• Karlas A, Machuy N, Shin Y, et al. Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature. 2010;463(7282):818–822.
   PubMed Web of Science ®Google Scholar
• Thompson MG, Munoz-Moreno R, Bhat P, et al. Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing. Nat Commun. 2018;9(1):2407.
   PubMed Web of Science ®Google Scholar
• Kumar R, Ichihashi Y, Kimura S, et al. A high-throughput method for illumina RNA-seq library preparation. Front Plant Sci. 2012;3(202). https://doi.org/10.3389/fpls.2012.00202
   Google Scholar
• Thome JJ, Yudanin N, Ohmura Y, et al. Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell. 2014;159(4):814–828.
   PubMed Web of Science ®Google Scholar
• Sridhar S, Begom S, Bermingham A, et al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med. 2013;19(10):1305–13112.
   PubMed Web of Science ®Google Scholar
• Berdal JE, Mollnes TE, Waehre T, et al. Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza. J Infect. 2011;63(4):308–316.
   PubMed Web of Science ®Google Scholar
• Wu XX, Zhao LZ, Tang SJ, et al. Novel pathogenic characteristics of highly pathogenic avian influenza virus H7N9: viraemia and extrapulmonary infection. Emerg Microbes Infect. 2020;9(1):962–975.
   PubMed Web of Science ®Google Scholar
• He Z, Zhao C, Dong Q, et al. Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets. Int J Infect Dis. 2005;9(6):323–330.
   PubMed Web of Science ®Google Scholar
• Chu H, Zhou J, Wong BH, et al. Middle East respiratory syndrome Coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. J Infect Dis. 2016;213(6):904–914.
   PubMed Web of Science ®Google Scholar
• Fathi N, Rezaei N. Lymphopenia in COVID-19: therapeutic opportunities. Cell Biol Int. 2020;44(9):1792–1797.
   PubMed Web of Science ®Google Scholar
• Sheu TT, Chiang BL. Lymphopenia, lymphopenia-induced proliferation, and autoimmunity. Int J Mol Sci. 2021;22(8):4152–4177.
   PubMed Web of Science ®Google Scholar
• He J, Sun E, Bujny MV, et al. Dual function of CD81 in influenza virus uncoating and budding. PLoS Pathog. 2013;9(10):e1003701.
   PubMed Web of Science ®Google Scholar
• Ma N, Li X, Jiang H, et al. Influenza virus neuraminidase engages CD83 and promotes pulmonary injury. J Virol. 2021 Jan 13;95(3):e01753–20.
   PubMed Web of Science ®Google Scholar
• Rahman SK, Ansari MA, Gaur P, et al. The immunomodulatory CEA cell adhesion molecule 6 (CEACAM6/CD66c) Is a protein receptor for the influenza a virus. Viruses. 2021;13(5):726–748.
   PubMed Web of Science ®Google Scholar
• V'Kovski P, Kratzel A, Steiner S, et al. Coronavirus biology and replication: implications for SARS-CoV-2. Nat Rev Microbiol. 2021;19(3):155–170.
   PubMed Web of Science ®Google Scholar
• Yun SI, Lee YM. Zika virus: An emerging flavivirus. J Microbiol. 2017;55(3):204–219.
   PubMed Web of Science ®Google Scholar
• Rehwinkel J, Reis e Sousa C. RIGorous detection: exposing virus through RNA sensing. Science. 2010;327(5963):284–286.
   PubMed Web of Science ®Google Scholar
• Sun J, Vera JC, Drnevich J, et al. Single cell heterogeneity in influenza A virus gene expression shapes the innate antiviral response to infection. PLoS Pathog. 2020;16(7):e1008671.
   PubMed Web of Science ®Google Scholar
• Heink S, Ludwig D, Kloetzel PM, et al. IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response. Proc Natl Acad Sci U S A. 2005;102(26):9241–9246.
   PubMed Web of Science ®Google Scholar
• Gizzi AS, Grove TL, Arnold JJ, et al. A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature. 2018;558(7711):610–614.
   PubMed Web of Science ®Google Scholar
• Wang X, Hinson ER, Cresswell P. The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe. 2007;2(2):96–105.
   PubMed Web of Science ®Google Scholar
• Liu Y, Pan Y, Hu Z, et al. Thymosin alpha 1 reduces the mortality of severe Coronavirus disease 2019 by restoration of lymphocytopenia and reversion of exhausted T cells. Clin Infect Dis. 2020;71(16):2150–2157.
   PubMed Web of Science ®Google Scholar
• Zhang JL, Li YH, Wang LL, et al. Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduct Target Ther. 2021;6(1):414.
   PubMed Web of Science ®Google Scholar
• Winthrop KL, Skolnick AW, Rafiq AM, et al. Opaganib in COVID-19 pneumonia: Results of a randomized, placebo-controlled Phase 2a trial. medRxiv. 2021:2021.08.23.21262464.
   Google Scholar