The novel fosfomycin resistance gene fosY is present on a genomic island in CC1 methicillin-resistant Staphylococcus aureus

References

• Kahan FM, Kahan JS, Cassidy PJ, et al. The mechanism of action of fosfomycin (phosphonomycin). Ann N Y Acad Sci. 1974;235:364–386.
   PubMed Web of Science ®Google Scholar
• Pujol M, Miro JM, Shaw E, et al. Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant Staphylococcus aureus bacteremia and endocarditis. A randomized clinical trial. Clin Infect Dis. 2020;72:1517–1525.
   Web of Science ®Google Scholar
• Falagas ME, Vouloumanou EK, Samonis G, et al. Fosfomycin. Clin Microbiol Rev. 2016;29:321–347.
   PubMed Web of Science ®Google Scholar
• Silver LL. Fosfomycin: mechanism and resistance. Cold Spring Harbor Perspect Med. 2017;7:a025262.
   PubMed Web of Science ®Google Scholar
• Chandrangsu P, Loi VV, Antelmann H, et al. The role of bacillithiol in gram-positive firmicutes. Antioxid Redox Signaling. 2018;28:445–462.
   PubMed Web of Science ®Google Scholar
• Etienne J, Gerbaud G, Fleurette J, et al. Characterization of staphylococcal plasmids hybridizing with the fosfomycin resistance gene fosB. FEMS Microbiol Lett. 1991;68:119–122.
   PubMed Web of Science ®Google Scholar
• Nakaminami H, Noguchi N, Nishijima S, et al. Characterization of the pTZ2162 encoding multidrug efflux gene qacB from Staphylococcus aureus. Plasmid. 2008;60:108–117.
   PubMed Web of Science ®Google Scholar
• DeLeo FR, Otto M, Kreiswirth BN, et al. Community-associated meticillin-resistant Staphylococcus aureus. Lancet (London, England). 2010;375:1557–1568.
   PubMed Web of Science ®Google Scholar
• Manara S, Pasolli E, Dolce D, et al. Whole-genome epidemiology, characterisation, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital. Genome Med. 2018;10:82.
   PubMed Web of Science ®Google Scholar
• Yang X, Zhang J, Yu S, et al. Prevalence of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in retail ready-to-eat foods in China. Front Microbiol. 2016;7:816.
   PubMed Web of Science ®Google Scholar
• Wu D, Chen Y, Sun L, et al. Prevalence of fosfomycin resistance in methicillin-resistant Staphylococcus aureus isolated from patients in a university hospital in China from 2013 to 2015. Jpn J Infect Dis. 2018;71:312–314.
   PubMed Web of Science ®Google Scholar
• Chen Y, Sun L, Ba X, et al. Epidemiology, evolution and cryptic susceptibility of methicillin-resistant Staphylococcus aureus in China: a whole-genome-based survey. Clin Microbiol Infect. 2021;28:85–92.
   PubMed Web of Science ®Google Scholar
• EUCAST. The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 90. 2019. Available from: http://www.eucast.org
   Google Scholar
• CLSI. Performance standards for antimicrobial susceptibility testing. 29th ed. CLSI supplement M100. Wayne (PA): Clinical and Laboratory Standards Institute. 2019.
   Google Scholar
• Tonkin-Hill G, MacAlasdair N, Ruis C, et al. Producing polished prokaryotic pangenomes with the Panaroo pipeline. Genome Biol. 2020;21:180.
   PubMed Web of Science ®Google Scholar
• Kumar S, Stecher G, Li M, et al. MEGA x: molecular evolutionary genetics analysis across computing platforms. Mol Biol Evol. 2018;35:1547–1549.
   PubMed Web of Science ®Google Scholar
• Robert X, Gouet P. Deciphering key features in protein structures with the new ENDscript server. Nucleic Acids Res. 2014;42:W320–W324.
   PubMed Web of Science ®Google Scholar
• Minh BQ, Schmidt HA, Chernomor O, et al. IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era. Mol Biol Evol. 2020;37:1530–1534.
   PubMed Web of Science ®Google Scholar
• Wang R, Braughton KR, Kretschmer D, et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med. 2007;13:1510–1514.
   PubMed Web of Science ®Google Scholar
• del Río A, Gasch O, Moreno A, et al. Efficacy and safety of fosfomycin plus imipenem as rescue therapy for complicated bacteremia and endocarditis due to methicillin-resistant Staphylococcus aureus: a multicenter clinical trial. Clin Infect Dis. 2014;59:1105–1112.
   PubMed Web of Science ®Google Scholar
• del Río A, García-de-la-Mària C, Entenza JM, et al. Fosfomycin plus β-lactams as synergistic bactericidal combinations for experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2016;60:478–486.
   PubMed Web of Science ®Google Scholar
• Fu Z, Ma Y, Chen C, et al. Prevalence of fosfomycin resistance and mutations in murA, glpT, and uhpT in methicillin-resistant Staphylococcus aureus strains isolated from blood and cerebrospinal fluid samples. Front Microbiol. 2015;6:1544.
   PubMed Web of Science ®Google Scholar
• Xu W, Chen T, Wang H, et al. Molecular mechanisms and epidemiology of fosfomycin resistance in Staphylococcus aureus isolated from patients at a teaching hospital in China. Front Microbiol. 2020;11:1290.
   PubMed Web of Science ®Google Scholar
• Fu Z, Liu Y, Chen C, et al. Characterization of fosfomycin resistance gene, fosB, in methicillin-resistant Staphylococcus aureus isolates. PLoS One. 2016;11, e0154829.
   PubMed Web of Science ®Google Scholar
• Xu X, Chen C, Lin D, et al. The fosfomycin resistance gene fosB3 is located on a transferable, extrachromosomal circular intermediate in clinical Enterococcus faecium isolates. PLoS One. 2013;8, e78106.
   PubMed Web of Science ®Google Scholar
• Thompson MK, Keithly ME, Harp J, et al. Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus. Biochemistry. 2013;52:7350–7362.
   PubMed Web of Science ®Google Scholar
• Perera VR, Newton GL, Pogliano K. Bacillithiol: a key protective thiol in Staphylococcus aureus. Expert Rev Anti-Infect Ther. 2015;13:1089–1107.
   PubMed Web of Science ®Google Scholar
• Partridge SR, Kwong SM, Firth N, et al. Mobile genetic elements associated with antimicrobial resistance. Clin Microbiol Rev. 2018;31:e00088–17.
   PubMed Web of Science ®Google Scholar
• Kadlec K, Schwarz S. Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain. Antimicrob Agents Chemother. 2010;54:3475–3477.
   PubMed Web of Science ®Google Scholar
• Schauer B, Szostak MP, Ehricht R, et al. Diversity of methicillin-resistant coagulase-negative Staphylococcus spp. and methicillin-resistant Mammaliicoccus spp. isolated from ruminants and new world camelids. Vet Microbiol. 2021;254: Article 109005.
   PubMed Web of Science ®Google Scholar
• Karki AB, Neyaz L, Fakhr MK. Comparative genomics of plasmid-bearing Staphylococcus aureus strains isolated from various retail meats. Front Microbiol. 2020;11: Article 574923.
   Google Scholar
• Liu BH, Lei CW, Zhang AY, et al. Colocation of the multiresistance gene cfr and the fosfomycin resistance gene fosD on a novel plasmid in Staphylococcus arlettae from a chicken farm. Antimicrob Agents Chemother. 2017;61:e01388–17.
   PubMed Web of Science ®Google Scholar
• Garbinski LD, Rosen BP, Chen J. Pathways of arsenic uptake and efflux. Environ Int. 2019;126:585–597.
   PubMed Web of Science ®Google Scholar
• Yang HC, Rosen BP. New mechanisms of bacterial arsenic resistance. Biomed J. 2016;39:5–13.
   PubMed Web of Science ®Google Scholar
• Ji X, Shen Q, Liu F, et al. Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai, China. J Hazard Mater. 2012;235-236:178–185.
   PubMed Web of Science ®Google Scholar
• Witte W. Community-acquired methicillin-resistant Staphylococcus aureus: what do we need to know? Clin Microbiol Infect. 2009;15(Suppl 7):17–25.
   PubMed Web of Science ®Google Scholar
• Taniguchi Y, Koide S, Maeyama Y, et al. Predominance of methicillin-resistant Staphylococcus aureus SCCmec type II-CC5 and SCCmec type IV-CC1/CC8 among companion animal clinical isolates in Japan: findings from phylogenetic comparison with human clinical isolates. J Glob Antimicrob Resist. 2020;20:253–259.
   PubMed Web of Science ®Google Scholar
• Rodríguez-López P, Filipello V, Di Ciccio PA, et al. Assessment of the antibiotic resistance profile, genetic heterogeneity and biofilm production of methicillin-resistant Staphylococcus aureus (MRSA) isolated from the Italian swine production chain. Foods (Basel, Switzerland). 2020;9:1141.
   PubMed Web of Science ®Google Scholar
• Zhang P, Liu X, Zhang J, et al. Prevalence and characterization of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus isolated from retail yak butter in Tibet, China. J Dairy Sci. 2021;104:9596–9606.
   PubMed Web of Science ®Google Scholar
• Dan M, Yehui W, Qingling M, et al. Antimicrobial resistance, virulence gene profile and molecular typing of Staphylococcus aureus isolates from dairy cows in Xinjiang Province, northwest China. J Glob Antimicrob Resist. 2019;16:98–104.
   PubMed Web of Science ®Google Scholar