Outer membrane vesicles-transmitted virulence genes mediate the emergence of new antimicrobial-resistant hypervirulent Klebsiella pneumoniae

References

• Russo TA, Marr CM. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev. 2019;32(3):e00001-19.
   PubMed Web of Science ®Google Scholar
• Shon AS, Russo TA. Hypervirulent Klebsiella pneumoniae: the next superbug? Future Microbiol. 2012;7(6):669–671.
   PubMed Web of Science ®Google Scholar
• Ye M, Tu J, Jiang J, et al. Clinical and genomic analysis of liver abscess-causing Klebsiella pneumoniae identifies new liver abscess-associated virulence genes. Front Cell Infect Microbiol. 2016;6(165). Epub 2016/12/15.
   Google Scholar
• Wyres KL, Lam MMC, Holt KE. Population genomics of Klebsiella pneumoniae. Nat Rev Microbiol. 2020;18(6):344–359. Epub 2020/02/15.
   PubMed Web of Science ®Google Scholar
• Paczosa MK, Mecsas J. Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev. 2016;80(3):629–661. Epub 2016/06/17.
   PubMed Web of Science ®Google Scholar
• Xu Y, Zhang J, Wang M, et al. Mobilization of the nonconjugative virulence plasmid from hypervirulent Klebsiella pneumoniae. Genome Med. 2021;13(1):119, Epub 2021/07/24.
   PubMed Web of Science ®Google Scholar
• Wyres KL, Wick RR, Judd LM, et al. Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae. PLoS Genet. 2019;15(4):e1008114, Epub 2019/04/16.
   PubMed Web of Science ®Google Scholar
• Lam MMC, Wyres KL, Duchene S, et al. Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination. Nat Commun. 2018;9(1):2703, Epub 2018/07/15.
   PubMed Web of Science ®Google Scholar
• Li W, Sun G, Yu Y, et al. Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin Infect Dis. 2014;58(2):225–232. Epub 2013/10/09.
   PubMed Web of Science ®Google Scholar
• Toyofuku M, Nomura N, Eberl L. Types and origins of bacterial membrane vesicles. Nat Rev Microbiol. 2019;17(1):13–24. Epub 2018/11/07.
   PubMed Web of Science ®Google Scholar
• Kim JH, Lee J, Park J, et al. Gram-negative and gram-positive bacterial extracellular vesicles. Semin Cell Dev Biol. 2015;40:97–104. Epub 2015/02/24.
   PubMed Web of Science ®Google Scholar
• Kalra H, Drummen GP, Mathivanan S. Focus on extracellular vesicles: introducing the next small big thing. Int J Mol Sci. 2016;17(2):170, Epub 2016/02/11.
   PubMed Web of Science ®Google Scholar
• Schwechheimer C, Kuehn MJ. Outer-membrane vesicles from gram-negative bacteria: biogenesis and functions. Nat Rev Microbiol. 2015;13(10):605–619. Epub 2015/09/17.
   PubMed Web of Science ®Google Scholar
• Dell'Annunziata F, Dell'Aversana C, Doti N, et al. Outer membrane vesicles derived from Klebsiella pneumoniae are a driving force for horizontal gene transfer. Int J Mol Sci. 2021;22(16):8732.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhao J, Li J, et al. Outer membrane vesicles derived from hypervirulent Klebsiella pneumoniae stimulate the inflammatory response. Microb Pathog. 2021;154:104841, Epub 2021/03/11.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Jin L, Ouyang P, et al. Evolution of hypervirulence in carbapenem-resistant Klebsiella pneumoniae in China: a multicentre, molecular epidemiological analysis. J Antimicrob Chemother. 2020;75(2):327–336. Epub 2019/11/13.
   PubMed Web of Science ®Google Scholar
• Lee CR, Lee JH, Park KS, et al. Antimicrobial resistance of hypervirulent Klebsiella pneumoniae: epidemiology, hypervirulence-associated determinants, and resistance mechanisms. Front Cell Infect Microbiol. 2017;7:483, Epub 2017/12/07.
   PubMed Web of Science ®Google Scholar
• Yang X, Ye L, Chan EW-C, et al. Tracking recombination events that occur in conjugative virulence plasmid p15WZ-82_Vir during the transmission process. Msystems. 2020;5(4):e00140–20.
   PubMed Web of Science ®Google Scholar
• Kulp A, Kuehn MJ. Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol. 2010;64:163–184. Epub 2010/09/10.
   PubMed Web of Science ®Google Scholar
• Tsatsaronis JA, Franch-Arroyo S, Resch U, et al. Extracellular vesicle RNA: A universal mediator of microbial communication? Trends Microbiol. 2018;26(5):401–410. Epub 2018/03/20.
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Mondal A, Mitra S, et al. Acinetobacter baumannii transfers the blaNDM-1 gene via outer membrane vesicles. J Antimicrob Chemother. 2017;72(8):2201–2207. Epub 2017/05/16.
   PubMed Web of Science ®Google Scholar
• Bou G, Cervero G, Dominguez MA, et al. PCR-based DNA fingerprinting (REP-PCR, AP-PCR) and pulsed-field gel electrophoresis characterization of a nosocomial outbreak caused by imipenem- and meropenem-resistant Acinetobacter baumannii. Clin Microbiol Infect. 2000;6(12):635–643. Epub 2001/04/04.
   PubMed Web of Science ®Google Scholar
• Yaron S, Kolling GL, Simon L, et al. Vesicle-mediated transfer of virulence genes from Escherichia coli O157: H7 to other enteric bacteria. Appl Environ Microbiol. 2000;66(10):4414–4420.
   PubMed Web of Science ®Google Scholar
• Bielska E, Sisquella MA, Aldeieg M, et al. Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii. Nat Commun. 2018;9(1):1556, Epub 2018/04/21.
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, Fang C-T, et al. Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae. J Clin Microbiol. 2018;56(9):e00776–18.
   PubMed Web of Science ®Google Scholar
• Dell'Annunziata F, Ilisso CP, Dell'Aversana C, et al. Outer membrane vesicles derived from Klebsiella pneumoniae influence the miRNA expression profile in human bronchial epithelial BEAS-2B cells. Microorganisms. 2020;8(12):1985. Epub 2020/12/17.
   PubMed Web of Science ®Google Scholar
• Pan YJ, Lin TL, Hsu CR, et al. Use of a dictyostelium model for isolation of genetic loci associated with phagocytosis and virulence in Klebsiella pneumoniae. Infect Immun. 2011;79(3):997–1006. Epub 2010/12/22.
   PubMed Web of Science ®Google Scholar
• Cheng HY, Chen YS, Wu CY, et al. Rmpa regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43. J Bacteriol. 2010;192(12):3144–3158. Epub 2010/04/13.
   PubMed Web of Science ®Google Scholar
• Russo TA, MacDonald U, Hassan S, et al. An assessment of siderophore production, mucoviscosity, and mouse infection models for defining the virulence spectrum of hypervirulent klebsiella pneumoniae. mSphere. 2021;6(2):e00045-21. Epub 2021/03/26.
   PubMed Web of Science ®Google Scholar
• Pletzer D, Mansour SC, Wuerth K, et al. New mouse model for chronic infections by gram-negative bacteria enabling the study of anti-infective efficacy and host-Microbe interactions. mBio. 2017;8(1):e00140-7. Epub 2017/03/02.
   Web of Science ®Google Scholar
• Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically—Tenth Edition: M07. (2015).
   Google Scholar