Correlation of Moraxella catarrhalis macrolide susceptibility with the ability to adhere and invade human respiratory epithelial cells

References

• Ventura F, Barranco R, Buffelli F, et al. Unexpected and sudden death Due to undiagnosed moraxella catarrhalis meningoencephalitis in a 40-day-old infant. Am J Forensic Med Pathol. 2020;41:333–337.
   PubMed Web of Science ®Google Scholar
• Hirai J, Kinjo T, Koga T, et al. Clinical characteristics of community-acquired pneumonia due to moraxella catarrhalis in adults: a retrospective single-centre study. BMC Infect Dis. 2020;20:821.
   PubMed Web of Science ®Google Scholar
• National Health and Family Planning Commission Expert Committee on Rational Use of Medicines for Children Pharmaceutical Group. Investigation on the rational use of antibacterial agents by Chinese pediatricians in 2016. Zhonghua Er Ke Za Zhi. 2018;56:897–906.
   PubMedGoogle Scholar
• Liu Y, Zhao C, Zhang F, et al. High prevalence and molecular analysis of macrolide-nonsusceptiblemoraxella catarrhalisisolated from nasopharynx of healthy children in China. Microb Drug Resist. 2012;18:417–426.
   PubMed Web of Science ®Google Scholar
• Liu Y, Xu H, Xu Z, et al. High-Level macrolide-resistant moraxella catarrhalis and development of an allele-specific PCR assay for detection of 23S rRNA gene A2330T mutation: A three-year study at a Chinese tertiary hospital. Microb Drug Resist. 2015;21:507–511.
   PubMed Web of Science ®Google Scholar
• Richard MP, Aguado AG, Mattina R, et al. Sensitivity to sparfloxacin and other antibiotics, of streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis strains isolated from adult patients with community-acquired lower respiratory tract infections: a European multicentre study. SPAR study group. surveillance programme of antibiotic resistance. J Antimicrob Chemother. 1998;41:207–214.
   PubMed Web of Science ®Google Scholar
• Andersson DI, Hughes D. Antibiotic resistance and its cost: is it possible to reverse resistance? and its cost: is it possible to reverse resistance? Nat Rev Microbiol. 2010;8(4):260–271.
   PubMed Web of Science ®Google Scholar
• Cohen T, Sommers B, Murray M. The effect of drug resistance on the fitness of mycobacterium tuberculosis. Lancet Infect Dis. 2003;3:13–21.
   PubMed Web of Science ®Google Scholar
• Liu YL, Xiao M, Cheng JW, et al. Macrolide-Resistant isolates Are highly concentrated in Two MLST clonal complexes -CCN10 and CC363. Front Microbiol. 2017;8:201.
   PubMed Web of Science ®Google Scholar
• Du Y, Zhou H, Wang F, et al. Multilocus sequence typing-based analysis of moraxella catarrhalis population structure reveals clonal spreading of drug-resistant strains isolated from childhood pneumonia. Infect Genet Evol. 2017;56:117–124.
   PubMed Web of Science ®Google Scholar
• Holm MM, Vanlerberg SL, Sledjeski DD, et al. The Hag protein of moraxella catarrhalisstrain O35E Is associated with adherence to human lung and middle Ear cells. Infect Immun. 2003;71:4977–4984.
   PubMed Web of Science ®Google Scholar
• Lafontaine ER, Cope LD, Aebi C, et al. The UspA1 protein and a second type of UspA2 protein mediate adherence of moraxella catarrhalis to human epithelial cells In vitro. J Bacteriol. 2000;182:1364–1373.
   PubMed Web of Science ®Google Scholar
• Pearson MM, Lafontaine ER, Wagner NJ, et al. A hag mutant of moraxella catarrhalis strain O35E Is deficient in hemagglutination, autoagglutination, and immunoglobulin D-binding activities. Infect Immun. 2002;70:4523–4533.
   PubMed Web of Science ®Google Scholar
• Timpe JM, Holm MM, Vanlerberg SL, et al. Identification of amoraxella catarrhalisouter membrane protein exhibiting both adhesin and lipolytic activities. Infect Immun. 2003;71:4341–4350.
   PubMed Web of Science ®Google Scholar
• Su Y-C, Singh B, Riesbeck K. Moraxella catarrhalis: from interactions with the host immune system to vaccine development. Future Microbiol. 2012;7:1073–1100.
   PubMed Web of Science ®Google Scholar
• Bankevich A, Nurk S, Antipov D, et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol. 2012;19:455–477.
   PubMed Web of Science ®Google Scholar
• Seemann T. Prokka: rapid prokaryotic genome annotation. Bioinformatics. 2014;30:2068–2069.
   PubMed Web of Science ®Google Scholar
• Inouye M, Dashnow H, Raven L-A, et al. SRST2: rapid genomic surveillance for public health and hospital microbiology labs. Genome Med. 2014;6:90.
   PubMed Web of Science ®Google Scholar
• Page AJ, Cummins CA, Hunt M, et al. Roary: rapid large-scale prokaryote pan genome analysis. Bioinformatics. 2015;31:3691–3693.
   PubMed Web of Science ®Google Scholar
• Ye J, Zhang Y, Cui H, et al. WEGO 2.0: a web tool for analyzing and plotting GO annotations, 2018 update. Nucleic Acids Res. 2018;46:W71–W75.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang J, Chen J, et al. A literature review of gene function prediction by modeling gene ontology. Front Genet. 2020;11:400.
   PubMed Web of Science ®Google Scholar
• Slevogt H, Seybold J, Tiwari KN, et al. Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response. Cell Microbiol. 2007;9:694–707.
   PubMed Web of Science ®Google Scholar
• Inoue S, Nakamura H, Otake K, et al. Impaired pulmonary inflammatory responses are a prominent feature of streptococcal pneumonia in mice with experimental emphysema. Am J Respir Crit Care Med. 2003;167:764–770.
   PubMed Web of Science ®Google Scholar
• Jones MM, Johnson A, Koszelak-Rosenblum M, et al. Role of the oligopeptide permease ABC transporter of moraxella catarrhalis in nutrient acquisition and persistence in the respiratory tract. Infect Immun. 2014;82:4758–4766.
   PubMed Web of Science ®Google Scholar
• Murphy TF, Brauer AL, Johnson A, et al. ATP-Binding Cassette (ABC) transporters of the human respiratory tract pathogen, moraxella catarrhalis: role in virulence. PloS one. 2016;11:e0158689.
   PubMed Web of Science ®Google Scholar
• Singh B, Alvarado-Kristensson M, Johansson M, et al. The respiratory pathogen moraxella catarrhalis targets collagen for maximal adherence to host tissues. mBio. 2016;7:e00066.
   PubMed Web of Science ®Google Scholar
• Blakeway LV, Tan A, Peak IRA, et al. Virulence determinants of moraxella catarrhalis: distribution and considerations for vaccine development. Microbiology. 2017;163:1371–1384.
   PubMed Web of Science ®Google Scholar
• Riesbeck K. Complement evasion by the human respiratory tract pathogens haemophilus influenzae and moraxella catarrhalis. FEBS Lett 2020;594:2586–2597.
   PubMed Web of Science ®Google Scholar
• Tan TT, Nordström T, Forsgren A, et al. The respiratory pathogen moraxella catarrhalis adheres to epithelial cells by interacting with fibronectin through ubiquitous surface proteins A1 and A2. J Infect Dis. 2005;192:1029–1038.
   PubMed Web of Science ®Google Scholar
• Singh B, Al-Jubair T, Voraganti C, et al. Moraxella catarrhalis binds plasminogen To evade host innate immunity. Infect Immun. 2015;83:3458–3469.
   PubMed Web of Science ®Google Scholar
• Liu G, Ermert D, Johansson ME, et al. PRELP enhances host innate immunity against the respiratory tract pathogen moraxella catarrhalis. J Immunol. 2017;198:2330–2340.
   PubMed Web of Science ®Google Scholar
• Pearson MM, Hansen EJ. Identification of gene products involved in biofilm production by moraxella catarrhalis ETSU-9 In vitro. Infect Immun. 2007;75:4316–4325.
   PubMed Web of Science ®Google Scholar
• Verhaegh SJC, Streefland A, Dewnarain JK, et al. Age-related genotypic and phenotypic differences in moraxella catarrhalis isolates from children and adults presenting with respiratory disease in 2001-2002. Microbiology. 2008;154:1178–1184.
   PubMed Web of Science ®Google Scholar
• Karuppiah V, Collins RF, Thistlethwaite A, et al. Structure and assembly of an inner membrane platform for initiation of type IV pilus biogenesis. Proc Natl Acad Sci U S A. 2013;110:E4638–E4647.
   PubMed Web of Science ®Google Scholar
• Leighton TL, Mok MC, Junop MS, et al. Conserved, unstructured regions in pseudomonas aeruginosa PilO are important for type IVa pilus function. Sci Rep. 2018;8:2600.
   PubMed Web of Science ®Google Scholar
• Bonnah RA, Wong H, Loosmore SM, et al. Characterization ofmoraxella(branhamella)catarrhalis lbpB,lbpA, and lactoferrin receptor orf3 isogenic mutants. Infect. Infect Immun. 1999;67:1517–1520.
   PubMed Web of Science ®Google Scholar
• Ostan NKH, Yu RH, Ng D, et al. Lactoferrin binding protein B - a bi-functional bacterial receptor protein. PLoS Pathog. 2017;13:e1006244.
   PubMed Web of Science ®Google Scholar
• Ma D, Alberti M, Lynch C, et al. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of escherichia coli by global stress signals. Mol Microbiol. 1996;19:101–112.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Feng S, Zhang J, et al. Two glycosyltransferase genes of SC096 implicated in lipooligosaccharide biosynthesis, serum resistance, adherence, and invasion. Front Cell Infect Microbiol. 2016;6:100.
   PubMed Web of Science ®Google Scholar
• Seib KL, Peak IRA, Jennings MP. Phase variable restriction-modification systems in moraxella catarrhalis. FEMS Immunol Med Microbiol. 2002;32:159–165.
   PubMed Web of Science ®Google Scholar
• Blakeway LV, Power PM, Jen FEC, et al. Modm DNA methyltransferase methylome analysis reveals a potential role for moraxella catarrhalis phasevarions in otitis media. FASEB J. 2014;28:5197–5207.
   PubMed Web of Science ®Google Scholar
• Liu YL, Li DF, Xu HP, et al. Use of next generation sequence to investigate potential novel macrolide resistance mechanisms in a population of moraxella catarrhalis isolates. Sci Rep. 2016;6:35711.
   PubMed Web of Science ®Google Scholar
• Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity. 2010;32:593–604.
   PubMed Web of Science ®Google Scholar
• Laurent S, Monique S, Viviane B, et al. Lack of IL-10 synthesis by murine alveolar macrophages upon lipopolysaccharide exposure. comparison with peritoneal macrophages. J Leukoc Biol. 2000;67:545–552.
   PubMed Web of Science ®Google Scholar
• Thomas PG, Dash P, Aldridge JR, et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity. 2009;30:566–575.
   PubMed Web of Science ®Google Scholar
• Tisoncik JR, Korth MJ, Simmons CP, et al. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012;76:16–32.
   PubMed Web of Science ®Google Scholar
• Wang CH, Liu CY, Wan YL, et al. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Respir Res. 2005;6:42.
   PubMed Web of Science ®Google Scholar