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Emerging Microbes & Infections Volume 12, 2023 - Issue 2
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Drug Resistance and Novel Antimicrobial Agents

Convergent Klebsiella pneumoniae strains belonging to a sequence type 307 outbreak clone combine cefiderocol and carbapenem resistance with hypervirulence

Katharina Schauflera Institute of Infection Medicine, Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany;b Institute of Pharmacy, Pharmaceutical Microbiology, University of Greifswald, Greifswald, Germany;c Department of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research HZI, Greifswald, Germany;d University Medicine Greifswald, Greifswald, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2669-8799View further author information
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Thaddäus Echelmeyerb Institute of Pharmacy, Pharmaceutical Microbiology, University of Greifswald, Greifswald, GermanyView further author information
,
Michael Schwabeb Institute of Pharmacy, Pharmaceutical Microbiology, University of Greifswald, Greifswald, GermanyView further author information
,
Sebastian Guenthere Institute of Pharmacy, Pharmaceutical Biology, University of Greifswald, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0003-0173-7314View further author information
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Jürgen A. Bohnertf Friedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, GermanyView further author information
,
Karsten Beckerf Friedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0002-6391-1341View further author information
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Helmut Fickenschera Institute of Infection Medicine, Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein, Kiel, GermanyView further author information
,
Aike Buetera Institute of Infection Medicine, Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein, Kiel, GermanyView further author information
,
Gregor Maschkowitza Institute of Infection Medicine, Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein, Kiel, GermanyView further author information
,
Andi Krumbholza Institute of Infection Medicine, Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany;g Labor Dr. Krause und Kollegen MVZ GmbH, Kiel, GermanyView further author information
,
Dennis Nurjadih Department of Infectious Diseases and Microbiology, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, GermanyORCID Iconhttps://orcid.org/0000-0002-1278-5939View further author information
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Stefan E. Heidenc Department of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research HZI, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0001-9562-5529View further author information
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Elias Egera Institute of Infection Medicine, Christian-Albrecht University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany;c Department of Epidemiology and Ecology of Antimicrobial Resistance, Helmholtz Institute for One Health, Helmholtz Centre for Infection Research HZI, Greifswald, GermanyORCID Iconhttps://orcid.org/0000-0002-5514-8083View further author information
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Article: 2271096 | Received 05 Jul 2023, Accepted 11 Oct 2023, Published online: 31 Oct 2023

References

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  • McElheny CL, Fowler EL, Iovleva A, et al. In vitro evolution of cefiderocol resistance in an NDM-producing Klebsiella pneumoniae due to functional loss of CirA. Microbiol Spectr. 2021;9(3):e01779–21. doi:10.1128/Spectrum.01779-21
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