Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection

References

• Korn K, et al. Fatal encephalitis associated with Borna disease virus 1. N Engl J Med. 2018;379(14):1375–1377. doi:10.1056/NEJMc1800724
   PubMed Web of Science ®Google Scholar
• Schlottau K, et al. Fatal encephalitic Borna disease virus 1 in solid-organ transplant recipients. N Engl J Med. 2018;379(14):1377–1379. doi:10.1056/NEJMc1803115
   PubMed Web of Science ®Google Scholar
• Liesche F, et al. The neuropathology of fatal encephalomyelitis in human Borna virus infection. Acta Neuropathol. 2019;138(4):653–665.
   PubMed Web of Science ®Google Scholar
• Niller HH, et al. Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999–2019: an epidemiological investigation. Lancet Infect Dis. 2020;20(4):467–477.
   Web of Science ®Google Scholar
• Bauswein M, et al. Human infections with Borna disease virus 1 (BoDV-1) primarily lead to severe encephalitis: further evidence from the seroepidemiological BoSOT study in an endemic region in southern Germany. Viruses. 2023;15(1):188. doi:10.3390/v15010188
   PubMed Web of Science ®Google Scholar
• Bourg M, et al. Bicolored white-toothed shrews as reservoir for borna disease virus, Bavaria, Germany. Emerg Infect Dis. 2013;19(12):2064–2066.
   PubMed Web of Science ®Google Scholar
• Durrwald R, et al. The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus. PLoS One. 2014;9(4):e93659. doi:10.1371/journal.pone.0093659
   PubMed Web of Science ®Google Scholar
• Hilbe M, et al. Shrews as reservoir hosts of Borna disease virus. Emerg Infect Dis. 2006;12(4):675–677. doi:10.3201/eid1204.051418
   PubMed Web of Science ®Google Scholar
• Nobach D, et al. Shedding of infectious borna disease virus-1 in living bicolored white-toothed shrews. PLoS One. 2015;10(8):e0137018.
   PubMed Web of Science ®Google Scholar
• Gosztonyi G. Natural and experimental Borna disease virus infections–neuropathology and pathogenetic considerations. APMIS Suppl. 2008;116(124):53–57.
   Google Scholar
• Kupke A, et al. Intranasal borna disease virus (BoDV-1) infection: insights into initial steps and potential contagiosity. Int J Mol Sci. 2019;20:6.
   Web of Science ®Google Scholar
• Pörtner K, et al. Risk factors for Borna disease virus 1 encephalitis in Germany – a case-control study. Emerg Microbes Infect. 2023;12(1):e2174778. doi:10.1080/22221751.2023.2174778
   PubMed Web of Science ®Google Scholar
• Grosse L, et al. First detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications. Infection. 2023;51(5):1383–1398.
   PubMed Web of Science ®Google Scholar
• Allartz P, et al. Detection of bornavirus-reactive antibodies and BoDV-1 RNA only in encephalitis patients from virus endemic areas: a comparative serological and molecular sensitivity, specificity, predictive value, and disease duration correlation study. Infection. 2024;52(1): 59–71.
   PubMed Web of Science ®Google Scholar
• Lee BJ, et al. Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils. Antiviral Res. 2008;80(3):380–384. doi:10.1016/j.antiviral.2008.08.001
   PubMed Web of Science ®Google Scholar
• Tokunaga T, et al. Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses. Antiviral Res. 2017;143:237–245. doi:10.1016/j.antiviral.2017.04.018
   PubMed Web of Science ®Google Scholar
• Hallensleben W, et al. Borna disease virus-induced neurological disorder in mice: infection of neonates results in immunopathology. J Virol. 1998;72(5):4379–4386. doi:10.1128/JVI.72.5.4379-4386.1998
   PubMed Web of Science ®Google Scholar
• Noske K, et al. Virus-specific CD4+ T cells eliminate borna disease virus from the brain via induction of cytotoxic CD8+ T cells. J Virol. 1998;72(5):4387–4395. doi:10.1128/JVI.72.5.4387-4395.1998
   PubMed Web of Science ®Google Scholar
• Stitz L, Bilzer T, Planz O. The immunopathogenesis of Borna disease virus infection. Front Biosci. 2002;7:541–555. doi:10.2741/A793
   Web of Science ®Google Scholar
• Stitz L, Sobbe M, Bilzer T. Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats. J Virol. 1992;66(6):3316–3323. doi:10.1128/jvi.66.6.3316-3323.1992
   PubMed Web of Science ®Google Scholar
• Rauch J, et al. Human Borna disease virus 1 encephalitis shows marked pro-inflammatory biomarker and tissue immunoactivation during the course of disease. Emerg Microbes Infect. 2022;11(1):1843–1856. doi:10.1080/22221751.2022.2098831
   PubMed Web of Science ®Google Scholar
• Finck T, et al. Bornavirus encephalitis shows a characteristic magnetic resonance phenotype in humans. Ann Neurol. 2020;88(4):723–735.
   PubMed Web of Science ®Google Scholar
• Liesche-Starnecker F, et al. Hemorrhagic lesion with detection of infected endothelial cells in human bornavirus encephalitis. Acta Neuropathol. 2022;144(2):377–379. doi:10.1007/s00401-022-02442-3
   PubMed Web of Science ®Google Scholar
• Haas B, Becht H, Rott R. Purification and properties of an intranuclear virus-specific antigen from tissue infected with Borna disease virus. J Gen Virol. 1986;67 (Pt 2):235–241.
   PubMed Web of Science ®Google Scholar
• Herden C, Schluesener HJ, Richt JA. Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus. Neuropathol Appl Neurobiol. 2005;31(5):512–521. doi:10.1111/j.1365-2990.2005.00668.x
   PubMed Web of Science ®Google Scholar
• Werner-Keiss N, et al. Restricted expression of Borna disease virus glycoprotein in brains of experimentally infected Lewis rats. Neuropathol Appl Neurobiol. 2008;34(6):590–602. doi:10.1111/j.1365-2990.2008.00940.x
   PubMed Web of Science ®Google Scholar
• Holzgreve A, et al. Psma expression in glioblastoma as a basis for theranostic approaches: a retrospective, correlational panel study including immunohistochemistry, clinical parameters and PET imaging. Front Oncol. 2021;11:646387. doi:10.3389/fonc.2021.646387
   PubMed Web of Science ®Google Scholar
• Liesche-Starnecker F, et al. Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging. EJNMMI Res. 2021;11(1):72. doi:10.1186/s13550-021-00817-3
   PubMed Web of Science ®Google Scholar
• Schon S, et al. Imaging glioma biology: spatial comparison of amino acid PET, amide proton transfer, and perfusion-weighted MRI in newly diagnosed gliomas. Eur J Nucl Med Mol Imaging. 2020;47(6):1468–1475. doi:10.1007/s00259-019-04677-x
   PubMed Web of Science ®Google Scholar
• Stitz L, et al. A functional role for neutralizing antibodies in Borna disease: influence on virus tropism outside the central nervous system. J Virol. 1998;72(11):8884–8892. doi:10.1128/JVI.72.11.8884-8892.1998
   PubMed Web of Science ®Google Scholar
• Ludwig H. The biology of bornavirus. APMIS Suppl. 2008;116(124):14–20.
   Google Scholar
• Furstenau J, et al. Borna disease virus 1 infection in alpacas: Comparison of pathological lesions and viral distribution to other dead-end hosts. Vet Pathol. 2024;61(1):62–73. doi:10.1177/03009858231185107
   PubMed Web of Science ®Google Scholar
• Kinnunen PM, et al. Epidemiology and host spectrum of Borna disease virus infections. J Gen Virol. 2013;94(Pt 2):247–262.
   Web of Science ®Google Scholar
• Chevalier G, et al. Neurons are MHC class I-dependent targets for CD8 T cells upon neurotropic viral infection. PLoS Pathog. 2011;7(11):e1002393. doi:10.1371/journal.ppat.1002393
   PubMed Web of Science ®Google Scholar
• Hausmann J, et al. T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein. Proc Natl Acad Sci U S A. 1999;96(17):9769–9774. doi:10.1073/pnas.96.17.9769
   PubMed Web of Science ®Google Scholar
• Stitz L, et al. Transforming growth factor-beta modulates T cell-mediated encephalitis caused by Borna disease virus. Pathogenic importance of CD8+ cells and suppression of antibody formation. J Immunol. 1991;147(10):3581–3586. doi:10.4049/jimmunol.147.10.3581
   PubMed Web of Science ®Google Scholar
• Dürrwald R, et al. Vaccination against borna disease: overview, vaccine virus characterization and investigation of live and inactivated vaccines. Viruses. 2022;14:12.
   Web of Science ®Google Scholar