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Research Letter

Identification of the VP37 pocket of monkeypox virus as a promising target for pan-orthopoxvirus inhibitors through virtual screening and antiviral assays

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Article: 2373309 | Received 27 Dec 2023, Accepted 22 Jun 2024, Published online: 15 Jul 2024

References

  • Shchelkunova GA, Shchelkunov SN. Smallpox, monkeypox and other human orthopoxvirus infections. Viruses. 2023;15(1):103. doi:10.3390/v15010103
  • Shchelkunov SN. Emergence and reemergence of smallpox: the need for development of a new generation smallpox vaccine. Vaccine. 2011;29:D49–D53. doi:https://doi.org/10.1016/j.vaccine.2011.05.037.
  • Lum FM, Torres-Ruesta A, Tay MZ, et al. Monkeypox: disease epidemiology, host immunity and clinical interventions. Nat Rev Immunol. 2022;22(10):597–613. doi:10.1038/s41577-022-00775-4
  • https://worldhealthorg.shinyapps.io/mpx global/.
  • Saied AA, Dhawan M, Metwally AA, et al. Disease history, pathogenesis, diagnostics, and therapeutics for human monkeypox disease: A comprehensive review. Vaccines (Basel). 2022;10(12):2091. doi:10.3390/vaccines10122091
  • Hoy SM. Tecovirimat: first global approval. Drugs. 2018;78(13):1377–1382. doi:10.1007/s40265-018-0967-6
  • Delaune D, Iseni F. Drug development against smallpox: present and future. Antimicrob Agents Chemother. 2020;64(4):10–1128. doi:10.1128/AAC.01683-19
  • Lederman ER, Davidson W, Groff HL, et al. Progressive vaccinia: case description and laboratory-guided therapy with vaccinia immune globulin, ST-246, and CMX001. J Infect Dis. 2012;206(9):1372–1385. doi:10.1093/infdis/jis510
  • Hung YP, Lee CC, Lee JC, et al. A brief on new waves of monkeypox and vaccines and antiviral drugs for monkeypox. J Microbiol Immunol Infect. 2022;55(5):795–802. doi:10.1016/j.jmii.2022.08.016
  • Adler H, Gould S, Hine P, et al. Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis. 2022;22(8):1153–1162. doi:10.1016/S1473-3099(22)00228-6
  • Vaughan A, Aarons E, Astbury J, et al. Two cases of monkeypox imported to the United Kingdom, September 2018. Euro Surveill Bull Eur sur les Mal Transm = Eur Commun Dis Bull. 2018;23(38):1800509. doi:10.2807/1560-7917.ES.2018.23.38.1800509
  • Rizk JG, Lippi G, Henry BM, et al. Prevention and treatment of monkeypox. Drugs. 2022;82(9):957–963. doi:10.1007/s40265-022-01742-y
  • Höer A, Schöneberg T, Harteneck C, et al. Enhancement of phospholipase D activity following baculovirus and adenovirus infection in Sf9 and COS-7 cells. Biochim Biophys Acta. 1998;1393(2-3):325–335. doi:10.1016/S0005-2760(98)00087-3
  • Li H, Zhang H, Ding K, et al. The evolving epidemiology of monkeypox virus. Cytokine Growth Factor Rev. 2022;68:1–12. doi:10.1016/j.cytogfr.2022.10.002