An Update on Bioactive Potential of a Monoterpene Aldehyde Citral

References

• Mahmoud , S.S. and Croteau , R.B. 2002 . Strategies for transgenic manipulation of monoterpene biosynthesis in plants . 7 : 366 – 373 .
   Google Scholar
• Ganjewala , D. , Ambika , K. and Khan , K.H. 2009 . “ Ontogenic and developmental changes in essential oil content and compositions in Cymbopogon flexuosus cultivars ” . In Recent Advance in Biotechnology , Edited by: Prasad , B.N. and Lazar , M. 82 – 92 . New Delhi : Excel India Publishers .
   Google Scholar
• Ganjewala , D. 2009 . Cymbopogon Essential oils: Compositions and Bioactivities . The Int. J. Eessent. Oil Therapt , 3 ( 2–3 ) : 1 – 10 .
   Google Scholar
• Stotz , S.C. , Vriens , J. , Martyn , D. , Clardy , J. and Clapham , D.E. 2008 . Citral sensing by Transient Receptor Potential Channels in dorsal root ganglion neurons . PLoS ONE , 3 : e2082 – 2086 .
   Google Scholar
• Lin , C.T. , Chgen , C.J. , Lin , T.Y. , Tung , J.C. and Wang , S.Y. 2008 . Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Havata . Biores. Technol , 99 : 8783 – 8787 .
   Google Scholar
• Quintans-Júnior , L.J. , Guimaraes , A.G. , Araújo , B.E.S. , Oliveira , C.F. , Santana , M.T. , Moreiral , F.V. , Santos , M.R.V. , Cavalcanti , S.C.H. , Júnior , W.L.D. , Botelho , M.A. , Ribeiro , L.A.A. , Nóbrega , F.F.F. and Almeida , R.N. 2010 . Carvacrol, (-)-borneol and citral reduce convulsant activity in rodents . African J. Biotech , 9 : 6566 – 6572 .
   Google Scholar
• Sangwan , N.S. , Sangwan , R.S. , Luthra , R. and Thakur , R.S. 1993 . Geraniol dehydrogenase: A determinant of essential oil quality in lemongrass . Plant. Med , 59 : 168 – 170 .
   Google Scholar
• Saddiq , A.A. and Khayyat , S.A. 2010 . Chemical and antimicrobial studies of monoterpene: Citral . Pesticide Biochem. Physiol , 98 : 89 – 93 .
   Google Scholar
• Ganjewala , D. and Luthra , R. 2009 . Geranyl acetate esterase controls and regulates the level of geraniol in lemongrass (Cymbopogon flexuosus Nees ex Steud) Mutant cv. GRL-1 leaves . Z. Naturforsch , 64c : 251 – 259 .
   Google Scholar
• Luthra , R. , Shrivastava , A. and Ganjewala , D. 2007 . Histochemical localization of citral accumulating site in lemongrass (Cymbopogon flexuosus Nees ex Steud) Wats cultivar OD-19 . Asian J. Plant Sci , 6 : 419 – 422 .
   Google Scholar
• Silva Cde , B. , Guterres , S.S. , Weisheimer , V. and Schapoval , E.E. 2008 . Antifungal activity of the lemongrass oil and citral against Candida spp . Braz. J. Infect. Dis , 12 : 63 – 66 .
   Google Scholar
• Singh , A.A. , Potdar , Y.A. , Pawar , R.S. and Bhat , S.V. 2011 . Antibacterial potential of citral derivatives . Nat. Prod. Commun , 6 : 1221 – 1224 .
   Google Scholar
• Aiemsaard , J. , Aiumlamai , S. , Aromdee , C. , Taweechaisupapong , S. and Khunkitti , W. 2011 . The effect of lemongrass oil and its major components on clinical isolate mastitis pathogens and their mechanisms of action on Staphylococcus aureus DMST 4745 . Res. Vetern. Sci , 91 : e31 – e37 .
   Google Scholar
• Astani , A. , Reichling , J. and Schnitzler , P. 2010 . Comparative study on the antiviral activity of selected monoterpenes derived from essential oils . Phytother. Res , 24 : 673 – 679 .
   Google Scholar
• Katsukawa , M. , Nakata , R. , Takizawa , Y. , Hori , K. , Takahashi , S. and Inoue , H. 2010 . Citral, a component of lemongrass oil, activates PPARá and ã and suppresses COX-2 expression . Biochem. Biophy. Acta , 1801 : 1214 – 1220 .
   Google Scholar
• Ortiz , M.I. , González-García , M.P. , Ponce-Monter , H.A. , Castañeda-Hernández , G. and Aguilar-Robles , P. 2010 . Synergistic effect of the interaction between naproxen and citral on inflammation in rats . Phytomed , 18 : 74 – 79 .
   Google Scholar
• Ortiz , M.I. , Ramírez-Montiel , M.L. , González-García , M.P. , Ponce-Monter , H.A. , Castañeda-Hernández , G. and Cariño-Cortés , R. 2010 . The combination of naproxen and citral reduces nociception and gastric damage in rats . Arch Pharm. Res , 33 : 1691 – 1697 .
   Google Scholar
• Lee , H.J. , Jeong , H.S. , Kim , D.J. , Noh , Y.H. , Yuk , D.Y. and Hong , J.T. 2008 . Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-kappa B activation in RAW264.7 cells . Arch. Pharm. Res , 31 : 342 – 349 .
   Google Scholar
• Machado , M. , Pires , P. , Dinis , A.M. , Santos-Rosa , M. , Alves , V. , Salgueiro , L. , Cavaleiro , C. and Sousa , M.C. 2012 . Monoterpenic aldehydes as potential anti-Leishmania agents: Activity of Cymbopogon citratus and citral on L. infantum, L. tropica and L. major . Exp. Parasitol , In Press
   Google Scholar
• Santin , M.R. , dos Santos , A.O. , Nakamura , C.V. , Dias Filho , B.P. , Ferreira , I.C. and Ueda-Nakamura , T. 2009 . In vitro activity of the essential oil of Cymbopogon citratus and its major component (citral) on Leishmania amazonensis . Parasitol. Res. , 105 : 1489 – 1496 .
   Google Scholar
• Bachiega , T.F. and Sforcin , J.M. 2011 . Lemongrass and citral effect on cytokines production by murine macrophages . J. Ethnopharmacol , 137 : 909 – 913 .
   Google Scholar
• Chaouki , W , Leger , D.Y. , Liagre , B. , Beneytout , J.L. and Hmamouchi , M. 2009 . Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells . Fundam Clin. Pharmacol. , 23 : 549 – 556 .
   Google Scholar
• Chaimovitsh , D. , Stelmakh , R.O. , Altshuler , O. , Belausov , E. , Abu-Abied , M. , Rubin , B. , Sadot , E. and Dudai , N. 2012 . The relative effect of citral on mitotic microtubules in wheat roots and BY2 cells . Plant Biol (Stuttg) , 14 : 354 – 364 .
   Google Scholar
• Pingle , V. , Saraswati , K.J.T. , Sanakal , R. and Kaliwal , B.B. 2011 . Inhibition of Aldose Activity by Essential Phytochemicals of Cymbopogon Citratus (DC.) Stapf . Int. J. Biomet. Bioinform , 5 : 257 – 267 .
   Google Scholar
• Devi , R.C. , Sim , S.M. and Ismail , R. 2011 . Spasmolytic effect of citral and extracts of Cymbopogon citratus on isolated rabbit ileum . J. Smooth Muscle Res , 47 : 143 – 156 .
   Google Scholar
• Modak , T. and Mukhopadhaya , A. 2011 . Effects of citral, a naturally occurring antiadipogenic molecule, on an energy-intense diet model of obesity . Indian J. Pharmacol , 43 : 300 – 305 .
   Google Scholar
• Donald , A. , Sylvia , U. and Umoetok , B.A. 2011 . Repellent effects of five monoterpenoid odours against Tribolium castaneum (Herbst) and Rhyzopertha dominica (F.) in Calabar, Nigeria . Crop Protec , 30 : 1351 – 1355 .
   Google Scholar
• Cardoso , J. and Soares , M.J. 2010 . In vitro effects of citral on Trypanosoma cruzi metacyclogenesis . Mem Inst Oswaldo Cruz , 105 : 1026 – 1032 .
   Google Scholar
• Freitas , F.P. , Freitas , S.P. , Lemos , G.C. , Vieira , I.J. , Gravina , G.A. and Lemos , F.J. 2010 . Comparative larvicidal activity of essential oils from three medicinal plants against Aedes aegypti L . Chem. Biodivers , 7 : 2801 – 2807 .
   Google Scholar
• Yang , Z. , Xi , J. , Li , J. and Qu , W. 2009 . Biphasic effect of citral, a flavoring and scenting agent, on spatial learning and memory in rats . Pharmacol. Biochem. Behav , 93 : 391 – 396 .
   Google Scholar
• Belletti , N. , Kamdem , S.S. , Tabanelli , G. , Lanciotti , R. and Gardini , F. 2010 . Modeling of combined effects of citral, linalool and β-pinene used against Saccharomyces cerevisiae in citrus-based beverages subjected to a mild heat treatment . Int. J. Food Microbiol , 136 : 283 – 289 .
   Google Scholar
• Belleti , N. , Lanciotti , R. , Patrignani , R. and Ardini , F. 2008 . Antimicrobial efficacy of citron essential oil on spoilage and pathogenic microorganisms in fruit-based salads . J. Food Sci , 73 : M331 – M338 .
   Google Scholar
• Zore , G.B. , Thakre , A.D. , Jadhav , S. and Karuppayil , S.M. 2011 . Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle . Phytomed , 18 : 1181 – 1190 .
   Google Scholar
• Park , M.J. , Gwak , K.S. , Yang , I. , Kim , K.W. , Jeung , E.B. , Chang , J.W. and Choi , I.G. 2009 . Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes . Fitoterapia , 80 : 290 – 296 .
   Google Scholar
• Thota , N. , Koul , S. , Reddy , M.V. , Sangwan , P.L. , Khan , IA. , Kumar , A. , Raja , A.F. , Andotra , S.S. and Qazi , G.N. 2008 . Citral derived amides as potent bacterial NorA efflux pump inhibitors . Bioorg. Med. Chem , 16 : 6535 – 6543 .
   Google Scholar
• Somolinos , M. , Garcia , D. , Condon , S. , Markey , B. and Pagan , R. 2010 . Inactivation of Escherichia coli by citral . J. Appl. Micobiol , 6 : 1928 – 1939 .
   Google Scholar
• Espina , L. , Somolinos , M. , Pagán , R. and García-Gonzalo , D.J. 2010 . Effect of citral on the thermal inactivation of Escherichia coli O157:H7 in citrate phosphate buffer and apple juice . Food Protect , 73 : 2189 – 2196 .
   Google Scholar
• Coura , J.R. and de Castro , S.L. 2002 . A critical review on Chagas disease chemotherapy . Mem. Inst. Oswaldo. Cruz , 97 : 3 – 24 .
   Google Scholar
• Urbina , J.A. 2009 . New advances in the management of a long-neglected disease . Clin. Infect. Dis , 49 : 1685 – 1687 .
   Google Scholar
• Santoro , G.F. , Cardoso , M.G. , Guimaraes , L.G. , Freire , J.M. and Soares , M.J. 2007a . Anti-proliferative effect of the essential oil of Cymbopogon citratus (DC) Stapf (lemongrass) on intracellular amastigotes, bloodstream trypomastigotes and culture epimastigotes of Trypanosoma cruzi (Protozoa: Kinetoplastida) . Parasitol , 134 : 1649 – 1656 .
   Google Scholar
• Santoro , G.F. , Cardoso , M.G. , Guimaraes , L.G. , Mendonça , L.Z. and Soares , M.J. 2007b . Trypanosoma cruzi: activity of essential oils from Achillea millefolium L., Syzygium aromaticum L. and Ocimum basilicum L. on epimastigotes and trypomastigotes . Exp. Parasitol , 116 : 283 – 290 .
   Google Scholar
• Santoro , G.F. , das Gracas Cardoso , M. , Guimaraes , L.G. , Salgado , A.P. , Menna-Barreto , R.F. and Soares , M.J. 2007c . Effect of oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) essential oils on Trypanosoma cruzi (Protozoa: Kinetoplastida) growth and ultra-structure . Parasitol. Res , 100 : 783 – 790 .
   Google Scholar
• Sforcin , J.M. , Amaral , J.T. , Fernandes , A. Jr. , Sousa , J.P.B. and Bastos , J.K. 2009 . LG effects on IL-1 and IL-6 production by macrophages . Natl. Prod. Res , 23 : 1151 – 1159 .
   Google Scholar
• Simmons , D.L. , Botting , R.M. and Hla , T. 2004 . Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition, Pharmacol . Rev , 56 : 387 – 437 .
   Google Scholar
• Michalik , L. , Auwerx , J. , Berger , J.P. , Chatteriee , V.K. , Glass , C.K. , Gonzalez , F.J. , Grimaldi , P.A. , Kadowaki , T. , Lazar , M.A. , O’Rahilly , S. , Palmer , C.N. , Plutzky , L. , Reddy , J.K. , Spiegelman , B.M. , Staels , B. and Wahli , W. 2006 . International Union of Pharmacology: LXI . Peroxisome proliferator-activated receptors, Pharmacol. Rev. , 58 : 726 – 741 . (2006)
   Google Scholar
• Sonoda , J. , Pei , L. and Evans , R.M. 2008 . Nuclear receptors: decoding metabolic disease . FEBS Lett , 582 : 2 – 9 .
   Google Scholar
• Ponce-Monter , H. , Fernández-Martínez , E. , Ortiz , M.I. , Ramírez-Montiel , M.L. , Cruz-Elizalde , D. , Pérez-Hernández , N. and Cariño-Cortés , R. 2009 . Spasmolytic and anti-inflammatory effects of Aloysia triphylla and citral, in vitro and in vivo studies . Int. J. Immunopathol. Pharmacol , 22 : 97 – 104 .
   Google Scholar
• De Martino , L. , D’Arena , G. , Minervini , M.M. , Deaglio , S. , Fusco , B.M. , Cascavilla , N. and De Feo , V. 2009 . Verbena officinalis essential oil and its component citral as apoptotic-inducing agent in chronic lymphocytic leukemia . Int. J. Immunopathol. Pharmacol , 22 : 1097 – 104 .
   Google Scholar
• Farah , I.O. , Holt-Gray , C. and Brown , R.J. 2010 . Impact of supra-physiologic retinoids on ovalbumin-sensitized f344 lung tissue and reversal of related pathology by citral - biomed 2011 . Naunyn Schmiedebergs Arch Pharmacol , 381 : 415 – 426 .
   Google Scholar
• Farah , I.O. , Trimble , Q. , Ndebele , K. and Mawson , A. 2010b . Retinoids and citral modulated cell viability, metabolic stability, cell cycle progression and distribution in the a549 lung carcinoma cell line - biomed 2010 . Biomed. Sci. Instrum , 46 : 410 – 4121 .
   Google Scholar
• Di Renzo , F. , Broccia , M.L. , Giavini , E. and Menegola , E. 2007 . Citral, an inhibitor of retinoic acid synthesis, attenuates the frequency and severity of branchial arch abnormalities induced by triazole-derivative fluconazole in rat embryos cultured in vitro . Reprod. Toxicol , 24 : 326 – 332 .
   Google Scholar
• Seo , K.A. , Kim , H. , Ku , H.Y. , Ahn , H.J. , Park , S.J. , Bae , S.K. , Shin , J.G. and Liu , K.H. 2008 . The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity . Chem. Biol. Interact , 174 : 141 – 146 .
   Google Scholar
• Lopez , M.A. , Stashenko , E.E. and Fuentes , J.L. 2011 . Chemical composition and antigenotoxic properties of Lippia alba essential oils . Genet. Mol. Biol , 34 : 479 – 488 .
   Google Scholar
• Chaimovitsh , D. , Abu-Abied , M. , Belausov , E. , Rubin , B. , Dudai , N. and Sadot , E. 2009 . Microtubules are an intracellular target of the plant terpene citral . Plant J , 61 : 399 – 408 .
   Google Scholar
• Ilayperuma , I. 2008 . Effects of intraperitoneal administration of citral on male reproductive organs in the rat . Galle Med. J , 13 : 29 – 32 .
   Google Scholar