Bioactivity Guided Isolation, Characterization and Quantification of an Anxiolytic Constituent - Kaempferol, from Melilotus officinalis Aerial Parts

References

• Dey, Y.N., Sarada, O., Srikanth, N. and Jamal, M. (2012). Phytopharmacological review on an important medicinal plant – Amorphophallus paeoniifolius. Ayu. 33: 27–32. doi: 10.4103/0974-8520.100303
   PubMedGoogle Scholar
• Zwanzger, P., Eser, D., Rupprecht, R. (2007). Anticonvulsant in the treatment of anxietyan alternative treatment option. Nervenarzt. 78: 1274–1282. doi: 10.1007/s00115-007-2361-6
   PubMed Web of Science ®Google Scholar
• Kim, J.H., Kim, S.Y., Lee, S.Y., Jang, C.G. (2007). Antidepressant like effects of Albizzia julibrassi in mice: involvement of 5-HT 1A receptors system. Pharmacology Biochemistry and Behavior. 87: 41–47. doi: 10.1016/j.pbb.2007.03.018
   PubMed Web of Science ®Google Scholar
• Michael, T., Zetushe, U. and Margraf, J. (2007). Epidemiology of anxiety disorders. Psychiatry. 6: 136.
   Google Scholar
• Cates, M., Wells, B.G. and Thatcher, G.W. (1996). Textbook of Therapeutics Drug and Disease Management. Williams and Wilkins, Baltimore. 1073–93p.
   Google Scholar
• Cha, H.Y., Seo, J.J., Park, J.H., Choi, K.J., Hong, J.T., Oh, K.W. (2004). Anxiolytic Effects of Total Saponin Fraction from Ginseng Radix Rubra on the Elevated Plus-Maze Model in Mice. Journal of Ginseng Research. 28: 132–135. doi: 10.5142/JGR.2004.28.3.132
   Google Scholar
• Zhang, Z.J. (2004). Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sciences. 75: 1659–1699. doi: 10.1016/j.lfs.2004.04.014
   PubMed Web of Science ®Google Scholar
• Anonymous (2003). The wealth of India: A dictionary of Indian raw material and industrial products, Vol VI (L-M), Publisher and information Directorate (CSIR), New Delhi. 331 p.
   Google Scholar
• Duke, J.A. (2002). Handbook of Medicinal Herbs, 2nd Edition, CRC Press, New York. 806–807 p.
   Google Scholar
• Foldi, M., Zoltan, O.T. (1970). Effect of coumarin from Melilotus officinalis on the convulsion threshold of the central nervous system of rats and guinea pigs. Arzneimittel-Forschung. 20: 1614–16.
   Google Scholar
• Nasser, N.M., Araji, M.A., Widad, M.K. (2014). Antifungal activity of Mellilotus officinalis of Iraq. Journal of Chemical and Pharmaceutical Research. 6: 611–617.
   Google Scholar
• Parejo, I., Viladomat, F., Bastida, J., Romero, A.R., Flerlage, J.S., Codina, C. (2002). Comparison between the radical scavenging activity and antioxidant activity of Six Distilled and Non distilled Mediterranean Herbs and aromatic plants. Journal of Agricultural and Food Chemistry. 50: 6882–6890. doi: 10.1021/jf020540a
   PubMed Web of Science ®Google Scholar
• Anwer, M.S., Shamim, S., Ahmed, S., Hasan, M.M., Azhar, I. (2015). Hypotensive Activity of Melilotus officinalis(L.) Pallas. European Journal of Medicine. Series B. 3: 80–85. doi: 10.13187/ejm.s.b.2015.3.80
   Google Scholar
• Pastorino, G., Marchetti, C., Borghesi, B., Cornara, L., Ribulla, S., Burlando, B. (2017). Biological activities of the legume crops Melilotus officinalis and Lespedeza capitata for skin care and pharmaceutical applications. Industrial Crops and Products. 96: 158–164. doi: 10.1016/j.indcrop.2016.11.047
   Web of Science ®Google Scholar
• Khodakov, G.V. (2010). Triterpene and steroidal glycosides from the genus Melilotus and their genins. - V. Melilotosides A1, B1, and C1 from Melilotus officinalis roots. Chemistry of Natural Compounds. 46: 572–575. doi: 10.1007/s10600-010-9678-2
   Web of Science ®Google Scholar
• Kang, S.S., Lee, Y.S., Lee, E.B. (1988). Saponin and Flavonoid Glycosides from Yellow Sweetclover. Arch Pharmaceutical Research. 11: 197–202. doi: 10.1007/BF02861309
   Google Scholar
• Cong, J.M., Chen, F.G., Ye, J.S., Ding, S.W., Wang, T., Wang, P., Sun, C. (2014). Extraction and antibacterial activity of coumarin from Melilotus officinalis. Natural Product Research and Development. 26: 588–593.
   Google Scholar
• Sutiashvili, M.G., Alaniya, M.D. (1999). Flavonoids of Melilotus officinalis. Chemistry of Natural Compounds. 35: 584. doi: 10.1007/BF02323303
   Web of Science ®Google Scholar
• Bubenchikova, V.N., Drozdova, I.L. (2004). HPLC analysis of phenolic compounds in Yellow Sweet-Clover. Pharmaceutical Chemistry Journal. 38: 195–196. doi: 10.1023/B:PHAC.0000038418.92096.39
   Google Scholar
• Kaur, S., Sharma, A., Bedi, P.M.S. (2017). Evaluation of anxiolytic effects of Melilotus officinalis extracts in mice. Asian Journal of Pharmaceutical and Clinical Research, 10:396–399. doi: 10.22159/ajpcr.2017.v10i6.17183
   Google Scholar
• Vogel, H.G., Vogel, W.H. (1997). Drug discovery and evaluation. Pharmacological assays, Springer Verlag, New York. 204–245 p.
   Google Scholar
• Kulkarni, S.K. (2003). Handbook of Experimental Pharmacology, 3rd edn., Vallabh Prakashan, Pitampura: New Delhi. 135 p.
   Google Scholar
• Mabry, T., Markham, K., Thomas, M. (1970). The systematic identification of flavonoids. Springer - Verlag, New York. 24 p.
   Google Scholar
• ICH (1994). Harmonised Tripartite Guideline. Validation of analytical procedures: text and methodology Q2 (R1).
   Google Scholar
• Tsaknis, J., Lalas, S. (2005). Extraction and identification of natural antioxidant from Sideritis euboea (mountain tea). Journal of Agricultural and Food Chemistry. 53: 6375–6381. doi: 10.1021/jf0479261
   PubMed Web of Science ®Google Scholar
• Rodgers, R.J., Cao, B.J., Dalvi, A., Holmes, A. (1997). Animal models of anxiety: an ethological perspective. Brazilian journal of medical and biological research. 30: 289–304. doi: 10.1590/S0100-879X1997000300002
   PubMed Web of Science ®Google Scholar
• Toubas, P.L., Abla, K.A., Cao, W., Logan, L.G., Seau, T.W. (1990). Latency to enter mirrored chamber: A novel behavioral assay for anxiolytic agents. Pharmacology Biochemistry and Behaviour. 35: 121–126. doi: 10.1016/0091-3057(90)90215-4
   PubMed Web of Science ®Google Scholar
• Lopez-Sanchez, C., Martin-Romero, F.J., Sun, F., Luis, L., Samhan-Arias, A.K., Garcia-Martinez, V., Gutierrez-Merino, C. (2007). Blood micromolar concentrations of kaempferol afford protection against ischaemia/reperfusion-induced damage in rat brain. Brain Research. 1182: 123–37. doi: 10.1016/j.brainres.2007.08.087
   PubMed Web of Science ®Google Scholar
• Samhan-Arias, A.K., Martin-Romero, F.J., Gutierrez-Merino, C. (2004). Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis. Free Radical Biology and Medicine. 37: 48–61. doi: 10.1016/j.freeradbiomed.2004.04.002
   PubMed Web of Science ®Google Scholar
• Grundmann, O., Nakajima, J.I., Kamata, K., Seo, S., Butterweck, V. (2009). Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice. Phytomedicine. 16: 295–302. doi: 10.1016/j.phymed.2008.12.020
   PubMed Web of Science ®Google Scholar
• Vissiennon, C., Nieber, K., Kelber, O., Butterweck, V. (2012). Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin-are they prodrugs? Journal of Nutritional Biochemistry. 23: 733–40. doi: 10.1016/j.jnutbio.2011.03.017
   PubMed Web of Science ®Google Scholar