Toxicological Evaluation of Bioactive Sulfated Polysaccharides from the Edible Marine Algae Padina tetrastromatica and Ulva fasciata in Sprague-Dawley Rats

References

• Wells, M.L., Potin, P., Craigie, J.S., Raven, J.A., Merchant, S.S., Helliwell, K.E. and Brawley, S.H. (2017). Algae as nutritional and functional food sources: revisiting our understanding. Journal of Applied Phycology. 29(2): 949-982.
   PubMed Web of Science ®Google Scholar
• Thomas, N. and Kim, S.K. (2013). Beneficial effects of marine algal compounds in cosmeceuticals. Marine Drugs. 11(1): 146-164.
   PubMed Web of Science ®Google Scholar
• Gideon, T. P. and Rengasamy, R. (2008). Toxicological evaluation of fucoidan from Cladosiphon okamuranus. Journal of Medicinal Food. 11(4): 638-642.
   PubMed Web of Science ®Google Scholar
• Li, N., Zhang, Q. and Song, J. (2005). Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats. Food and Chemical Toxicology. 43(3): 421-426.
   PubMed Web of Science ®Google Scholar
• Patel, S. (2012). Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings. Biotech. 2(3):171-185.
   Google Scholar
• Fitton, J.H. (2011). Therapies from fucoidan; multifunctional marine polymers. Marine drugs. 9(10): 1731-1760.
   PubMed Web of Science ®Google Scholar
• Anis, M., Yasmeen, A., Baig, S.G., Ahmed, S., Rasheed, M. and Hasan, M.M. (2018). Phycochemical and pharmacological studies on Ulva fasciata Delile. Pakistan Journal of Pharmaceutical Sciences. 31(3): 875-883.
   PubMed Web of Science ®Google Scholar
• Geraldino, P.J.L., Liao, L.M. and Boo, S.M. (2005). Morphological study of the marine algal genus Padina (Dictyotales, Phaeophyceae) from southern Philippines: 3 species new to Philippines. Algae. 20: 99-112.
   Google Scholar
• Alamsjah, M.A., Hirao, S., Ishibashi, F. and Fujita, Y. (2005). Isolation and structure determination of algicidal compounds from Ulva fasciata. Bioscience, Biotechnology, and Biochemistry. 69(11): 2186-2192.
   PubMed Web of Science ®Google Scholar
• Suresh, V., Senthilkumar, N., Thangam, R., Rajkumar, M., Anbazhagan, C., Rengasamy, R. and Palani, P. (2013). Separation, purification and preliminary characterization of sulfated polysaccharides from Sargassum plagiophyllum and its in vitro anticancer and antioxidant activity. Process Biochemistry. 48(2): 364-373.
   Web of Science ®Google Scholar
• Athukorala, Y., Jung, W.K., Vasanthan, T. and Jeon, Y.J. (2006). An anticoagulative polysaccharide from an enzymatic hydrolysate of Ecklonia cava. Carbohydrate Polymers. 66(2): 184-191.
   Web of Science ®Google Scholar
• Dubois, M., Gilles, K.A., Hamilton, J.K., Rebers, P.T. and Smith, F. (1956). Colorimetric method for determination of sugars and related substances. Analytical Chemistry. 28(3): 350-356.
   Web of Science ®Google Scholar
• Dodgson, K.S. and Price, R.G. (1962). A note on the determination of the ester sulphate content of sulphated polysaccharides. Biochemical Journal. 84(1): 106.
   PubMed Web of Science ®Google Scholar
• Bitter, T. (1962). A modified uronic acid carbazole reaction. Analytical Biochemistry. 4: 330–334.
   PubMed Web of Science ®Google Scholar
• Dische, Z. and Shettles, L.B. (1948). A specific color reaction of methylpentoses and a spectrophotometric micromethod for their determination. Journal of Biological Chemistry. 175(2): 595–603.
   PubMed Web of Science ®Google Scholar
• Sawke, N.G. and Sawke, G.K. (2010). Serum fucose level in malignant diseases. Indian Journal of Cancer. 47(4): 452.
   PubMed Web of Science ®Google Scholar
• Tako, M., Tamanaha, M., Tamashiro, Y. and Uechi, S. (2015). Structure of ulvan isolated from the edible green seaweed, Ulva pertusa. Advances in Bioscience and Biotechnology. 6(10): 645.
   Google Scholar
• Shimada, K., Fujikawa, K., Yahara, K. and Nakamura, T. (1992). Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. Journal of Agricultural and Food Chemistry. 40(6): 945-948.
   Web of Science ®Google Scholar
• Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M. and Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine. 26(9–10): 1231-1237
   PubMed Web of Science ®Google Scholar
• Liu, F., Ooi, V.E.C. and Chang, S.T. (1997). Free radical scavenging activities of mushroom polysaccharide extracts. Life Sciences. 60(10): 763-771.
   PubMed Web of Science ®Google Scholar
• Mosmanm, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods. 65(1-2): 55-63.
   PubMed Web of Science ®Google Scholar
• Chikku, A.M. and Rajamohan, T. (2012). Coconut haustorium maintains cardiac integrity and alleviates oxidative stress in rats subjected to isoproterenol-induced myocardial infarction. Indian Journal of Pharmaceutical Sciences. 74(5): 397.
   PubMed Web of Science ®Google Scholar
• Agerguard, N. and Jense, P.T. (1982). Procedure for blood glutathione peroxidase determination in cattle and swine. Acta Veterinaria Scandinavica. 23: 515-527.
   PubMed Web of Science ®Google Scholar
• David, M. and Richard, J.S. (1983). Glutathione reductase. Methods of Enzymatic Analysis. Bermeyer, Hans, Ulrich, Jr. (Eds.). 258-265.
   Google Scholar
• Kakkar, P., Das, B. and Viswanathan, P.N. (1984). A modified spectrophotometric assay of SOD. Indian Journal Biochemistry and Biophysics. 2: 130-132.
   Google Scholar
• Maehly, A.C. and Chance, B. (1954). The assay of CAT and peroxides. Methods of Biochemical Analysis. 1: 357-424.
   PubMedGoogle Scholar
• Patterson, J.W. and Lazarow, A. (1955). Determination of glutathione. Methods of Biochemical Analysis. 2: 259-278.
   PubMedGoogle Scholar
• Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. The Journal of Biological Chemistry. 193: 265-275.
   PubMed Web of Science ®Google Scholar
• Alves, A., Sousa, R.A. and Reis, R.L. (2013). In vitro cytotoxicity assessment of ulvan, a polysaccharide extracted from green algae. Phytotherapy Research. 27(8): 1143-1148.
   PubMed Web of Science ®Google Scholar
• Cassolato, J.E., Noseda, M.D., Pujol, C.A., Pellizzari, F.M., Damonte, E.B. and Duarte, M.E. (2008). Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma. Carbohydrate Research. 343(18): 3085-3095.
   PubMed Web of Science ®Google Scholar
• Costa, L.S., Fidelis, G.P., Cordeiro, S.L., Oliveira, R.M., Sabry, D.A., Câmara, R.B.G., Nobre, L.T.D.B. (2010). Biological activities of sulfated polysaccharides from tropical seaweeds. Biomedicine and Pharmacotherapy. 64(1): 21-28.
   PubMed Web of Science ®Google Scholar
• Karmakar, P., Ghosh, T., Sinha, S., Saha, S., Mandal, P., Ghosal, P.K. and Ray, B. (2009). Polysaccharides from the brown seaweed Padina tetrastromatica: Characterization of a sulfated fucan. Carbohydrate Polymers. 78(3): 416-421.
   Web of Science ®Google Scholar
• Wijesinghe, W.A.J.P. and Jeon, Y.J. (2012). Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review. Carbohydrate Polymers. 88(1): 13-20.
   Web of Science ®Google Scholar
• Lahaye, M., Cimadevilla, E.A.C., Kuhlenkamp, R., Quemener, B., Lognoné, V. and Dion, P. (1999). Chemical composition and 13C NMR spectroscopic characterisation of ulvans from Ulva (Ulvales, Chlorophyta). Journal of Applied Phycology. 11(1): 1.
   Web of Science ®Google Scholar
• Lekshmi, V.S. and Kurup, G.M. (2019). Sulfated polysaccharides from the edible marine algae Padina tetrastromatica protects heart by ameliorating hyperlipidemia, endothelial dysfunction and inflammation in isoproterenol induced experimental myocardial infarction. Journal of Functional Foods. 54: 22-31.
   Web of Science ®Google Scholar
• Li, B., Lu, F., Wei, X. and Zhao, R. (2008). Fucoidan: structure and bioactivity. Molecules. 13 (8): 1671-1695.
   PubMed Web of Science ®Google Scholar
• Patankar, M.S., Oehninger, S., Barnett, T., Williams, R.L. and Clark, G.F. (1993). A revised structure for fucoidan may explain some of its biological activities. Journal of Biological Chemistry. 268(29): 21770-21776.
   PubMed Web of Science ®Google Scholar
• Prathapan, A., Vineetha, V.P., Abhilash, P.A. and Raghu, K.G. (2013). Boerhaaviadiffusa L. attenuates angiotensin II-induced hypertrophy in H9c2 cardiac myoblast cells via modulating oxidative stress and down-regulating NF-κβ and transforming growth factor β1. British Journal of Nutrition. 110(7): 1201-1210.
   PubMed Web of Science ®Google Scholar
• Ozer, J., Ratner, M., Shaw, M., Bailey, W. and Schomaker, S. (2008). The current state of serum biomarkers of hepatotoxicity. Toxicology. 245(3): 194-205.
   PubMed Web of Science ®Google Scholar
• Tonomura, Y., Mori, Y., Torii, M. and Uehara, T. (2009). Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats. Toxicology. 266(1-3): 48-54.
   PubMed Web of Science ®Google Scholar
• Gowda, S., Desai, P.B., Kulkarni, S.S., Hull, V.V., Math, A.A. and Vernekar, S.N. (2010). Markers of renal function tests. North American Journal of Medical Sciences. 2(4): 170.
   PubMedGoogle Scholar
• Baroletti, S.A, Piovella, C, Fanikos, J., Labreche, M., Lin, J. and Goldhaber, S.Z. (2008). Heparin induced thrombocytopenia: clinical and economic outcomes. Thrombosis and Haemostasis. 100(12): 1130-1135.
   PubMedGoogle Scholar
• Spinler, S.A., Wittkowsky, A.K., Nutescu, E.A. and Smythe, M.A. (2005). Anticoagulation monitoring part 2: unfractionated heparin and low-molecular-weight heparin. Annals of Pharmacotherapy. 39(7-8): 1275-1285.
   PubMed Web of Science ®Google Scholar
• Lekshmi, V.S. and Kurup, G.M. (2019). Anticoagulant activities of sulfated polysaccharides from the edible marine algae Padina tetrastromatica and Ulva fasciata: A combined in vitro and in vivo approach. Journal of Pharmacognosy and Phytochemistry. 8(1): 693-698
   Google Scholar
• Lekshmi, V.S. and Kurup, G.M. (2018). In silico, in vitro and in vivo evaluation of the Cardioprotective effect of Heparinoid active Sulfated polysaccharides from the edible marine algae Ulva fasciata. Literary Findings. 3: 49-52
   Google Scholar
• Kumar, S.V., Saritha, G. and Fareedullah, M.D. (2010). Role of antioxidants and oxidative stress in cardiovascular diseases. Annals of Biological Research. 1(3): 158-173.
   Google Scholar
• Kim, K.J., Lee, O.H., Lee, H.H. and Lee, B.Y. (2010). A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley rats. Toxicology. 267(1-3): 154-158.
   PubMed Web of Science ®Google Scholar