Lovastatin: A Journey from Ascomycetes to Basidiomycetes Fungi

References

• Biggerstaff, K.D. and Wooten, J.S. (2004). Understanding lipoproteins as transporters of cholesterol and other lipids. Adv. Physiol. Edu. 28: 105–106.
   PubMed Web of Science ®Google Scholar
• Kaur, J., Singh, P., Sowers, J.R. (2002). Diabetes and cardiovascular diseases. Am. J. Ther. 9: 510–515.
   PubMedGoogle Scholar
• Tourlouki, E., Matalas, A.L., Panagiotakos, D.B. (2009). Dietary habits and cardiovascular disease risk in middle-aged and elderly populations: a review of evidence. Clin. Interv. Aging. 4: 319–330.
   PubMed Web of Science ®Google Scholar
• Mahdy, A.K., Wonnerth, A., Huber, K., Wojta, J. (2012). Cardiovascular disease risk reduction by raising HDL cholesterol-current therapies and future opportunities. Brit. J. Pharmacol. 167(6): 1177–1194.
   PubMed Web of Science ®Google Scholar
• Eckel, R.H., Kahn, R., Robertson, R.M., Rizza, R.A. (2006). Preventing cardiovascular disease and diabetes: a call to action from the American diabetes association and the American heart association. Diabetes. Care. 29(7): 1697–1699.
   PubMed Web of Science ®Google Scholar
• Ali, M.K., Bullard, K.M., Imperatore, G., Barker, L., Gregg, E.W. (2012). Characteristics associated with poor glycemic control among adults with self-reported diagnosed diabetes-National health and nutrition examination survey, United States, 2007–2010.MMWRMorbMortal Wkly Rep. 61(2): 32-37.
   Google Scholar
• Celermajer, D.S., Chow, C.K., Marijon, E., Anstey, N.M., Woo, K.S. (2012). Cardiovascular disease in the developing world: prevalences, patterns, and the potential of early disease detection. J. Amer. Coll. Cardiol. 60(14): 1207–1216.
   PubMedGoogle Scholar
• Hanukoglu, I., Steroidogenic., 1992. Enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. J. Steroid. Biochem. Mol. Biol. 43: 779-804.
   PubMed Web of Science ®Google Scholar
• Robert, K.M., Daryl, K.G., Peter, A.M., Victor, W.R. (2003). Cholesterol synthesis, transport and excretion. Peter A.Mayes, Kathleen M.Botham. 26th ed. Mc Graw Hill, 219-241.
   Google Scholar
• Report of the National Cholesterol Education Program Expert Panel on Detection, Evalua- tion, and Treatment of High Blood Cholesterol in Adults. (1998). The Expert Panel. Arch. Intern. Med. 148: 36–69.
   Google Scholar
• Brunzell, J.D., Davidson, M., Furberg, C.D., Goldberg, R.B., Howard, B.V., Stein, J.H., Witztum, J.L., (2008). Lipoprotein management in patients with cardio metabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care. 31: 811–822.
   PubMed Web of Science ®Google Scholar
• Cardiovascular Diseases, WHO. Link: https://www.afro.who.int/health-topics/cardiovascular- diseases
   Google Scholar
• WHO Report, (2012). World Health statistics. World Health Organization. Retrieved on 16 September 2018. http://www.who.int/gho/publications/world-health-statistics/EN-WHS2012-Full.pdf
   Google Scholar
• Kirby, T.J. (1967). Cataracts produced by triparanol. (MER-29). Trans. Amer. Ophthalmol. Soc. 65: 494–543.
   PubMedGoogle Scholar
• Endo, A., Kuroda, M., Tsujita, Y. (1976). ML-236A, ML-236B and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. 29: 1346–1348.
   PubMed Web of Science ®Google Scholar
• Vagelos, P.R. (1991). Are prescribing drug prices high? Sci. 252: 1080-1084.
   PubMed Web of Science ®Google Scholar
• Vagelos, P.R., Galambos, L. (2004). Medicine, Science and Merck. Cambridge University Press, Cambridge, United Kingdom. pp. 1-301.
   Google Scholar
• Subazini, T.K., Kumar, G.R. (2011). Characterization of Lovastatin biosynthetic cluster proteins in Aspergillus terreus strain ATCC 20542. Bioinformat. 6: 250–254.
   PubMedGoogle Scholar
• Manzoni, M., Rollini, M. (2002). Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl. Microbiol. Biotechnol. 58: 555–564.
   PubMed Web of Science ®Google Scholar
• MEVACOR™ Daily Tablets. (2018). (Nonprescription lovastatin 20 mg). Available online: http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4331b1-02-Merck.pdf (accessed on 16 September 2018).
   Google Scholar
• Crain’s New York Business via Associated Press. (2018). Lipitor becomes world’s top-selling drug. 28 December 2011. Retrieved 16 September 2018.
   Google Scholar
• Van ven Berg, M.A., Hans, M. (2011). Improved statin production. US 20110223640 A1, 2011.
   Google Scholar
• Hutchinson, C.R., Kennedy, J., Park, C. (2005). Transforming the organism (lovastatin pro- ducing 1362 organism) with the D4B segment of Aspergillus terreus, wherein the segment is transcribed and translated, and wherein an increase in lovastatin production occurs. US 1364 6943017 B2, 2005.
   Google Scholar
• Hajjaj, H., VanDen, B.P., Niederberger, P., Fay, L.B., Mace, C., Neeser, J.R. (2003). Koji molds for preparing cholesterol lowering products. US20030133920 A1, 2003.
   Google Scholar
• Hong, S.T., Kim, H.J., Lee, D.K., Yang, W.Y. (2003). Adding a microbial culture of a fermentation medial containing an anticholesterol agent to animal feed. US20030194394 A1, 2003.
   Google Scholar
• Vanven, B.M.A., Hans, M., Streekstra, H. (2009). Method for the production of simvastatin. US 20090197311 A1, 2009.
   Google Scholar
• Dimov, D.I., Grozdanov, G.A., Petkov, N.G., Todorova, D.T., Dimitrova, A.S. (1997). Method of production of lovastatin. WO1997020834, 1997.
   Google Scholar
• Hajko, P., Vesel, T., Radez, I., Pokorny, M. (1994). Process for the isolation of lovastatin. WO 199429292, 1994.
   Google Scholar
• Kumar, P.M., Mitra, A., Malviya, H.K. (2006). Process for the purification of lovastatin. WO 2006035295 A1, 2006.
   Google Scholar
• Jakubcova, M., Bosansky, M., Lucina, B., Borosova, G. (2000). Process for the isolation of lovastatin from fermentation broth. WO2000063411, 2000.
   Google Scholar
• Keri, V., Deak, L., Forgacs, I., Szabo, C., Nagyne, E.A. (2001). Process for recovering statin compounds from a fermentation broth. WO2001039768 A1, 2001.
   Google Scholar
• Huang, C.F. (2007). Effect of Monascus purpureus went rice on lowering lipid ratios in hyper- cholesterolemic patients. Eurp. J. Cardiovasc. Prev. Rehabil. 14(3): 438–440.
   PubMed Web of Science ®Google Scholar
• Becker, D.J., Gordon, R.Y., Halbert, S.C., French, B., Morris, P.B., Rader, D.J. (2009). Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized trial. Ann. Int. Med. 150: 830-839.
   PubMed Web of Science ®Google Scholar
• Stossel, T.P. (2008). The discovery of statins. Cell. 134: 903–905.
   PubMed Web of Science ®Google Scholar
• Tobert, J.A. (2003). Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug. Discov. 2(7): 517–26.
   PubMed Web of Science ®Google Scholar
• Endo, A., Monacolin, K. (1979). A new hypocholesterolemic agent produced by a monascus species. J. Antibiot. 32: 853–854.
   Web of Science ®Google Scholar
• Sayyad, S.A., Panda, B.P., Javed, S., Ali, M. (2007). Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology. Appl. Microbiol. Biotechnol. 73(5): 1054–8.
   PubMed Web of Science ®Google Scholar
• Wang, J.J., Lee, C.L., Pan, T.M. (2003). Improvement of monacolin K, -aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601. J. Ind. Microbiol. Biotechnol. 30: 669–676.
   PubMed Web of Science ®Google Scholar
• Porcel, E.R., Lopéz, J.L., Ferron, M.A., Perez, J.A., Sanchez, J.L., Chisti, Y. (2006). Effects of the sporulation conditions on the lovastatin production by Aspergillus terreus. Bioproc. Biosyst. Eng. 29(1): 1–5.
   PubMed Web of Science ®Google Scholar
• Hajjaj, H., Niederberger, P., Duboc, P. (2001). Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium. Appl. Environ. Microbiol. 67(6): 2596-2602.
   PubMed Web of Science ®Google Scholar
• Valera, H.R., Gomesa, J., Lakshmib, S., Gururajab, R., Suryanarayanb, S., Kumar, D. (2005). Lovastatin production by solid state fermentation using Aspergillus flavipes. Enz. Microb. Technol. 37(5): 521-526.
   Web of Science ®Google Scholar
• Samiee, S.M., Moazami, N., Haghighi, S., Mohseni, F.A., Mirdamadi, S., Bakhtiari, M.R. (2003). Screening of lovastatin production by filamentous fungi. Iran. Biomed. J. 7(1): 29–33.
   Google Scholar
• Sreenivasan, A., Shubahgar, S., Arvindan, R., Viruthagiri, T. (2008). Microbial production and biomedical applications of lovastatin. Ind. J. Pharm. Sci. 70(6): 701–709.
   PubMed Web of Science ®Google Scholar
• Barrios-González, J., Miranda, R.U. (2009). Biotechnological production and applications of statins. Appl. Microbiol. Biotechnol. 85: 869–883.
   PubMed Web of Science ®Google Scholar
• Istvan, E. (2003). Statin inhibition of HMG-CoA reductase: A 3-dimensional view. Atheroscler. Suppl. 4: 3–8.
   PubMed Web of Science ®Google Scholar
• Bizukojc, M.; Pecyna, M. (2011). Lovastatin and (+)-geodin formation by Aspergillus terreus ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources. Eng. Lif. Sci. 11: 272–282.
   Web of Science ®Google Scholar
• Lai, L.S., Hung, C.S., Lo, C.C. (2007). Effects of lactose and glucose on production of itaconic acid and lovastatin by Aspergillus terreus ATCC 20542. J. Biosci. Bioeng. 104(1): 9-13
   PubMed Web of Science ®Google Scholar
• Lopéz, J.L.C., Pérez, J.A.S., Sevilla, J.M.F., Fernández, F.G.A., Grima, E.M., Chisti, Y. (2003). Production of lovastatin by Aspergillus terreus: effects of the C: N ratio and the principal nutrients on growth and metabolite production. Enz. Microb. Technol. 33(2-3): 270–307.
   Web of Science ®Google Scholar
• Lopéz, J.L.C., Perez, J.A.S., Sevilla, J.M.F., Fernandez, F.G.A., Grima, E.M., Chisti, Y. (2003). Production of lovastatin by Aspergillus terreus: effects of the C: N ratio and the principal nutrients on growth and metabolite production. Enz. Microb. Technol. 33: 270–307.
   Web of Science ®Google Scholar
• Lai, L.S.T., Tsai, T.R., Wang, T.C., Cheng, T.Y. (2005). The influence of culturing environments on lovastatin production by Aspergillus terreus in submerged cultures. Enz. Microb. Technol. 36: 737–748.
   Web of Science ®Google Scholar
• Kumar, M.S., Jana, S.K., Senthil, V., Shashanka, V., Kumar, S.V., Sadhukhan, A.K. (2000b). Repeated fed-batch process for improving lovastatin production. Proc. Biochem. 36: 363–368.
   Web of Science ®Google Scholar
• Gupta, K., Mishra, P.K., Srivastava, P. (2007). A correlative evaluation of morphology and rheology of Aspergillus terreus during lovastatin fermentation. Biotechnol. Bioproc. Eng. 12: 140–146.
   Web of Science ®Google Scholar
• Lopéz, J.L.C., Perez, J.A.S., Sevilla, J.M.F., Porcel, E.M.R., Chisti, Y. (2005). Pelletmorpho- logy, culture rheology and lovastatin production in cultures of Aspergillus terreus. J. Biotechnol. 116(1): 61–77.
   PubMed Web of Science ®Google Scholar
• Pansuriya, R.C., Singhal, R.S. (2010). Response surface methodology for optimization of pro- duction of lovastatin by solid-state fermentation. Braz. J. Microbiol. 41: 164–72.
   PubMed Web of Science ®Google Scholar
• Kavitha, V., Janani, B., Angayarkanni, J. (2012). Optimization of process parameters for lovastatin production from red gram bran by solid-state fermentation. Int. J. Sci. Res. 3: 1413- 1418.
   Google Scholar
• Osman, M.E., Khattab, O.H., Zaghlol, G.M., El-Hameed, R.M.M. (2011a). Optimization of some physical and chemical factors for lovastatin productivity by local strain of Aspergillus terreus. Aust. J. Basic. Appl. Sci. 5(6): 718–732.
   Google Scholar
• Pawlak, M., Bizukojc, M. (2013). Feeding profile is not the sole factor influencing lovastatin production by Aspergillus terreus ATCC20542 in a continuous fed-batch stirred tank bioreactor. Biochem. Eng. J. 81: 80–89.
   Web of Science ®Google Scholar
• Bizukojc, M., Pawlak, M., Boruta, T., Gonciarz, J. (2012). Effect of pH on biosynthesis of lovastatin and other secondary metabolites by Aspergillus terreus ATCC 20542. J. Biotechnol. 162(2-3): 253–261.
   PubMed Web of Science ®Google Scholar
• Li, S.W., Li, M., Song, H.P., Feng, J.L., Tai, X.S. (2011). Induction of a high-yield lovastatin mutant of Aspergillus terreus by 12c6+ heavy-ion beam irradiation and the influence of culture conditions on lovastatin production under submerged fermentation. Appl. Biochem. Biotechnol. 165: 913–925.
   PubMed Web of Science ®Google Scholar
• Panda, B.P., Javed, S., Ali, M. (2010). Optimization of fermentation parameters for higher lovastatin production in red mold rice through co-culture of Monascus purpureus and Monascus ruber. Food. Bioproc. Technol. 3(3): 373.
   Web of Science ®Google Scholar
• Syed, M.B., Rajasimman, M. (2015). Fermentative production and optimization of mevastatin in submerged fermentation using Aspergillus terreus. Biotechnol. Rep. 6: 124–128.
   Google Scholar
• Jahromi, M.F., Liang, J.B., Ho, Y.W., Mohamad, R., Goh, Y.M., Shokryazdan, P. (2012). Lovastatin production by Aspergillus terreus using agro-biomass as substrate in solid state fermen- tation. J. Biomed. Biotechnol. 2012: 1–11.
   PubMedGoogle Scholar
• Gulyamova, T., Ruzieva, D., Masmetova, S., Sattarova, R., Lobanova, K., Abdulmyanova, L., Rasulova, G. (2013). Lovastatin production by Aspergillus terreus in solid state and submerged fermentations. Int. J. Eng. Sci. Technol. 2013, 5, 19-24.
   Google Scholar
• Wei, P., Xu, Z., Cen, P. (2007). Lovastatin production by Aspergillus terreus in solid-state fermentation. J. Zhejiang. Uni. Sci. A.8: 1521-1526.
   Google Scholar
• Patil, R.H., Krishnan, P., Maheshwari, V.L. (2011). Production of lovastatin by wild strains of Aspergillus terreus. Natl. Prod. Commun. 6: 183-186
   PubMed Web of Science ®Google Scholar
• Kaur, H., Kaur, A., Saini, H., Chadha, B. (2009). Screening and selection of lovastatin hyper- producing mutants of Aspergillus terreus using cyclic mutagenesis. Acta Microbiol. Immunol. Hung. 56: 169–180.
   PubMed Web of Science ®Google Scholar
• Lopéz, J.L.C., Pérez, J.A.S., Sevilla, J.M.F., Fernández, F.G.A., Grima, E.M., Chisti, Y. (2004a). Fermentation optimization for the production of lovastatin by Aspergillus terreus: use of response surface methodology. J. Chem. Technol. Biotechnol. 79(10): 1119–26.
   Web of Science ®Google Scholar
• Sorrentino, F., Roy, I., Keshavarz, T. (2010). Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. Appl. Microbiol. Biotechnol. 88(1): 65–73.
   PubMed Web of Science ®Google Scholar
• Jia, Z., Zhang, X., Zhao, Y., Cao, X. (2010). Enhancement of lovastatin production by supple- menting polyketide antibiotics to the submerged culture of Aspergillus terreus. Appl. Biochem. Biotechnol. 160(7): 2014-25.
   PubMed Web of Science ®Google Scholar
• Jia, Z., Zhang, X., Cao, X. (2009). Effects of carbon sources on fungal morphology and lovastatin biosynthesis by submerged cultivation of Aspergillus terreus. Asia-Pacific J. Chem. Eng. 4: 672-677.
   Web of Science ®Google Scholar
• Jia, Z., Zhang, X., Zhao, Y., Cao, X. (2009). Effects of divalent metal cations on lovastatin biosynthesis from Aspergillus terreus in chemically defined medium. World J. Microbiol. Biotechnol. 25: 1235–1241.
   Web of Science ®Google Scholar
• Porcel, E.M.R., López, J.L.C., Pérez, J.A.S., Chisti, Y. (2008). Lovastatin production by Aspergillus terreus in a two-staged feeding operation. J. Chem. Technol. Biotechnol. 83: 1236-1243.
   Web of Science ®Google Scholar
• Nasmetova, S., Ruzieva, D., Rasulova, G., Sattarova, R., Gulyamova, T. (2015). Effect of the principal nutrients on simvastatin production by wild strain Aspergillus terreus 20 in submerged fermentation. Int. J. Curr. Microbiol. App. Sci. 4: 894–898.
   Google Scholar
• Abd-Rahim, M.H., Hasan, H., Montoya, A., Abbas, A. (2015). Lovastatin and (+)-geodin production by Aspergillus terreus from crude glycerol. Eng. Life. Sci. 15: 220–228.
   Web of Science ®Google Scholar
• Raina, S., De Vizio, D., Palonen, E.K., Odell, M., Brandt, A.M., Soini, J.T., Keshavarz, T. (2012). Is quorum sensing involved in lovastatin production in the filamentous fungus Aspergillus terreus? Proc. Biochem. 47: 843–852.
   Web of Science ®Google Scholar
• Vinci, V.A., Hoerner, T.D., Coffman, A.D., Schimmel, T.G., Dabora, R.L., Kirpekar, A.C., Ruby, C.L., Stieber, R.W. (1991). Mutants of a lovastatin-hyperproducing Aspergillus terreus deficient in the production of sulochrin. J. Ind. Microbiol. 8: 113–119.
   Google Scholar
• Ferrón, M.A.V., Lopéz, J.L.C., Perez, J.A.S., Sevilla, J.M.F., Chisti, Y. (2005). Rapid screening of Aspergillus terreus mutants for overproduction of lovastatin. World. J. Microbiol. Biotechnol. 21(2): 123–12.
   Web of Science ®Google Scholar
• Mukhtar, H., Ijaz, S.S., Ikram-ul-Haq. (2014). Upstream and downstream processing of lovas- tatin by Aspergillus terreus. Cell Biochem. Biophys. 70: 309–320.
   PubMed Web of Science ®Google Scholar
• Sreedevi, K., Venkateswara, R.J., Lakshmi, N., Fareedullah, M.D. (2011). Strain improvement of Aspergillus terreus for the enhanced production of lovastatin, a HMG-COA reductase inhibitor. J. Microbiol. Biotech. 1: 96–100.
   Google Scholar
• Jia, Z., Zhang, X., Cao, X., Liu, J., Qin, B. (2011). Production of lovastatin by a self-resistant mutant of Aspergillus terreus. Ann. Microbiol. 61: 615–621.
   Web of Science ®Google Scholar
• Kumar, M.S., Kumar, P.M., Sarnaik, H.M., Sadhukhan, A.K. (2000a). A rapid technique for screening of lovastatin-producing strains of Aspergillus terreus by agar plug and Neurospora crassa bioassay. J. Microbiol. Methods. 40(1): 99–104.
   PubMed Web of Science ®Google Scholar
• Slot, J.C., Rokas, A. (2011). Horizontal transfer of a large and highly toxic secondary metabolic gene cluster between fungi. Curr. Biol. 21(2): 134–139.
   PubMed Web of Science ®Google Scholar
• Barrios-González, J., Baños, J.G., Covarrubias, A.A., Garay-Arroyo, A. (2008). Lovastatin biosynthetic genes of Aspergillus terreus are expressed differentially in solid-state and in liquid submerged fermentation. Appl. Microbiol. Biotechnol. 79(2): 179–86.
   PubMed Web of Science ®Google Scholar
• Chen, Y.P., Tseng, C.P., Liaw, L.L., Wang, C.L., Chen, I.C., Wu, W.J., Wu, M.D., Yuan, G.F. (2008). Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus. J. Agril. Food. Chem. 56: 5639–5646.
   PubMed Web of Science ®Google Scholar
• Kennedy, J., Auclair, K., Kendrew, S.G., Park, C., Vederas, J.C., Hutchinson, C.R. (1999). Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis Amer. Assoc. Adv. Sci. 284(5418): 1368–1372.
   Google Scholar
• Vanven, B.MA., Hans, M. (2011). Improved statin production. US 20110223640 A1, 2011.
   Google Scholar
• Vinci, V.A., Conder, M.J., McAda, P.C., Reeves, C.D., Rambosek, J., Davis, C.R., Hendrick- son, L.E. (1998). DNA encoding triol polyketide synthase. US 5744350 A, 1998.
   Google Scholar
• Xu, W., Chooi, Y.H., Choi, J.W., Li, S., Vederas, J.C., Da Silva, N.A. (2013). LovG: the thio- esterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angew. Chem. Int. Ed. Engl. 52(25): 6472–6505.
   PubMed Web of Science ®Google Scholar
• Burr, D.A., Chen, X.B., Vederas, J.C. (2007). Syntheses of conjugated pyrones for the enzymatic assay of lovastatin nonaketide synthase, an iterative polyketide synthase. Org. Lett. 9(1): 161-164.
   PubMed Web of Science ®Google Scholar
• Hendrickson, L., Davis, C.R., Roach, C., Nguyen, D.K., Aldrich, T., McAda, P.C. (1999). Lovastatin biosynthesis in Aspergillus terreus - characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. Chem. Biol. 6(7): 429–439.
   PubMedGoogle Scholar
• Mulder, K.C., Mulinari, F., Franco, O.L., Soares, M.S., Magalhaes, B.S., Parachin, N.S. (2015). Lovastatin Production: From Molecular Basis to Industrial Process Optimization. Bio- technol. Adv. 33: 648–665.
   Google Scholar
• Monaghan, L.R., Alfred, W.A., Carl, H.H., George, Albers, S. (1980). Antilipemic agents; US 4231938 A.
   Google Scholar
• Wasser, S.P., Reshetnikov, S.V. (2002). Process for producing, methods and compositions of cholesterol-lowering agents from higher basidiomycetes mushrooms. US Patent (6372462), 6: 327–462.
   Google Scholar
• Song, T.Y., Yen G.C. (2002). Antioxidant properties of Antrodia camphorata in submerged culture. J. Agric. Food. Chem. 50: 3322–3327.
   PubMed Web of Science ®Google Scholar
• Asatiani, M.D., Elisashvili, V., Wasser, S.P., Reznick, A.Z., Nevo, E. (2007). Antioxidant acti- vity of submerged cultured mycelium extracts of higher Basidiomycetes mushrooms. Int. J. Med. Mushrooms. 9: 151–58.
   Web of Science ®Google Scholar
• Burcu, A., Eskisehir O., Mustafa, Y. (2012). Screening of Medicinal Higher Basidiomycetes Mushrooms from Turkey for Lovastatin Production, International J. Med. Mushrooms. 14 (2): 149-159.
   PubMed Web of Science ®Google Scholar
• Macreadie, I.G., Johnson, G., Schlosser, T., Macreadie, P.I. (2006). Growth inhibition of Candida species and Aspergillus fumigatus by statins. FEMS. Microbiol. Lett. 262: 9–13.
   PubMed Web of Science ®Google Scholar
• Shin-Yu, C., Kung-Jui, H., Yun-Jung, H., Li-Ting, W., Jeng-Leun, M. (2012). Contents of lovastatin, -aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia. LWT. 47(2): 274–278.
   Web of Science ®Google Scholar
• Alarcon, J., Aguila, S., Arancibia-Avila, P., Fuentes, O., Zamorano-Ponce, E., Hernandez, M. (2003). Production and purification of statins from Pleurotus ostreatus (Basidiomycetes) strains. Z. Naturforsch. C. 58(1-2): 62–64.
   PubMedGoogle Scholar
• Lee, J.W., Lee, S.M., Gwak, K.S., Lee, J.Y., Choi, I.G. (2006). Screening of edible mushrooms for the production of Lovastatin and its HMG-CoA reductase inhibitory activity. Kor. J. Microbiol. 42: 83–88.
   Google Scholar
• Lindequist, U., Niedermeyer, T. H. J., Jülich, W.D. (2005). The pharmacological potential of mushrooms. Evid. Compl. Altern. Med. 2: 285–299.
   PubMed Web of Science ®Google Scholar
• Cohen, N., Cohen, J., Asatiani, M.D., Varshney, V.K., Yu, H.T., Yang, Y.C., Li, Y.H., Mau, J.L., Wasser, S.P. (2014). Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms. Int. J. Med. Mushrooms. 16: 273-291
   PubMed Web of Science ®Google Scholar
• Altmaier, E., Fobo, G., Heier, M., Thorand, B., Meisinger, C., Römisch-Margl, W., Walden- berger, M., Gieger, C., Illig, T., Adamski, J., Suhre, K., Kastenmüller, G. (2014). Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. Eur. J. Epidemiol. 29(5): 325-336
   PubMed Web of Science ®Google Scholar
• Subhan, M., Faryal, R., Macreadie, I. (2016). Exploitation of Aspergillus terreus for the production of natural statins, J. Fungi. 2(2): 13.
   Web of Science ®Google Scholar
• Bhargavi, S.D., Praveen, V.K. and Savitha, J., (2014). Bioinformatic comparative analysis of lovastatin gene cluster in endophytic fungi and a soil fungus, Aspergillus terreus, MOJ. Proteom. Bioinform. 1(4): 1–4.
   Google Scholar
• FAOSTAT. (2014). Available online: http://faostat.fao.org/site/567/DesktopDefault.aspx?PageID=567#ancor (Retrieved on 1-11-2018).
   Google Scholar