Heterogeniteit Van De Leverparenchymcellen

References

• Rappaport AM, Borowy ZJ, Lougheed WM, Lotto WN. Subdivision of hexagonal liver lobules into a structural and functional unit. Role in hepatic physiology and pathology. Anal Rec. 1954; 119: 11–34.
   Google Scholar
• Rappaport AM. The microcirculatory acinar concept of normal and pathological hepatic structure. Beitr Path lid. 1976: 157: 215 43.
   Google Scholar
• Jones AJ and Schmucker DL. Current concepts of liver structure as related to function. Gastroenterology. 1977; 73: 833–51.
   Google Scholar
• Jones AL, Schmucker DL, Mooney JS, Ock ner RK, Adler RD. Alterations in hepatic peri canalicular cytoplasm during enhanced bile se cretory activity. Lab Invest. 1979; 40: 512–7.
   Google Scholar
• Jones AL, Schmucker DL, Mooney JS, Adler RD, Ockner RK. A quantitative analysis of hepatic ultrastructure in rats during enhanced bile secretion. Anal Rec. 1978; 192: 277 88.
   Google Scholar
• Layden TJ. Boyer JL. Influence of bile acids on bile canalicular membrane morphology and the lobular gradient in canalicular size. Lab Invest. 1978; 39: 110–9.
   Google Scholar
• Jones AL, Schmucker DL, Mooney JS, Adler RD, Ockner RK. Morphometric analysis of rat hepatocytes after total biliary obstruction. Gastroenterology. 1976; 71: 1050–60.
   Google Scholar
• Schmucker DL, Mooney JS, Jones JL. Stereological analysis of hepatic fine structure in the Fisher 344 rat. Influence of sublobular location and animal age. J Cell Biol. 1978; 78: 319 37.
   Google Scholar
• Gumucio JJ, Katz ME, Miller DL, Balabaud DP, Greenfield JM. Wagner RM. Bile salt transport after selective drainage to acinar zone 3 hepatocytes by bromobenzene in the rat. Toxicol Appl Pharmacol. 1979; 50: 77–85.
   Google Scholar
• Gumucio JJ, Miller D. Functional implications of liver cell heterogeneity. Gastroenterology. 1981; 80: 393–403.
   Google Scholar
• Jones AL, Hradck GT, Renston RH, Wong KY, Karlagans G, Paumgartner G. Autoradiographic evidence for hepatic lobular concentra tion gradient of bile acid derivative. Am J Phvsiol. 1980; 238: G233–7.
   Google Scholar
• Groothuis GMM. Weitering JG. Keulemans KPT, Hardonk MJ, Mulder D, Meyer DKF. Heterogeneity of rat hepatocytes in bile acid and DBSP transport studied after induction of selective acinar damage by N hydroxy-2 ace tylaminofluorene and carbon tetrachloride. Naunvn Schmiedeberg’s Arch Pharmacol. 1983; 322: 310–8.
   Google Scholar
• Gumucio JJ, Balabaud C. Miller DL, et al. Bile secretion and liver cell heterogeneity in the rat. J. Lab Clin Med. 1978; 91: 350–62.
   Google Scholar
• Groothuis GMM. Hardonk MJ, Keulemans KPT, Nieuwenhuis P, Meyer DKF. Autoradiographic and kinetic demonstration of acinar he terogeneity of taurocholate transport. Am J Physiol. 1982; 243: G455–62
   Google Scholar
• Gumucio JJ. Functional and anatomic hetero geneity in the liver acinus: impact on transport. Am J Physiol 1983; 244: G5 78–82.
   Google Scholar
• Miller DL. Zanolli CS, Gumucio JJ. Quantita tive morphology of the sinusoids of the hepatic acinus. Quantimet analysis of rat liver. Gastroenterology. 1979; 76: 965–9.
   Google Scholar
• Loud AV. A quantitative stereological descrip tion of the ultrastructure of normal rat liver parenchymal cells. J Cell Biol. 1968; 37: 27–46.
   Google Scholar
• Jungermann K, Katz N. Functional hepatocellular heterogeneity. Hepatology. 1982; 2: 38595.
   Google Scholar
• Tavassoli M. Ozols J, Sugimoto G, Cox KH, Muller-Eberhard U. Localization of cytochrome b5 in rat organs and tissues by immunohistochemistry. Biochem Biophys Res Commun. 1976; 72; 281–6.
   Google Scholar
• Baron J, Redick JA, Greenspan P. Taira Y. Immunohistochemical localization of NADPH-cytochrome C reductase in rat liver. Life Sci. 1978; 22: 1097 102.
   Google Scholar
• Gooding PE, Chayen J, Sawyer B. Slater TF. Cytochrome P450 distribution in rat liver and the effect of sodium phenobarbitone administration. Chem Biol Interactions. 1978; 20: 299–310.
   Google Scholar
• Baron J. Redick JA, Guengerich FP. Immunohistochemical localization of cytochromes P-450 in rat liver. Life Sci. 1978; 23: 2627–632.
   Google Scholar
• Teutsch HF, Rieder H. NADP-dependent dehydrogenases in rat liver parenchyma II. Comparison of qualitative and quantitative G6PDH distribution patterns with particular reference to sex differences. Histochemistry. 1979; 60: 43–52.
   Google Scholar
• Rieder H. NADP-dependent dehydrogenases in rat liver parenchyma. Histochemistry. 1981; 72: 579–615.
   Google Scholar
• Thurman RG, Kauffmann FC. Sublobular Compartmentation of Pharmacologic Events (SCOPE): metabolic fluxes in periportal and pericentral regions of the liver lobule. Hepatology. 1985; 5: 144–51.
   Google Scholar
• Vessey DA. Hepatic metabolism of drugs and toxins. In: Zakim D and Boyer TD, Eds. He patology. A Textbook of Liver Disease. W.B. Saunders Compagny. 1982: 197–230.
   Google Scholar
• Mitchell JR. Jollows DJ. Metabolic activation of drugs to toxic substances. Gastroenterology. 1975; 68: 392–410.
   Google Scholar
• Mitchell JR, Nelson SD, Thorgeirsson SS, McMurtry RJ, Dybing E. Metabolic activation: biochemical basis for many drug-induced liver injuries. Progr Liver Dis. 1976; 5: 259–79.
   Google Scholar
• Smith MT, Loveridge N, Wills ED, Chayen J. The distribution of glutathione in the rat liver lobule. Biochem J. 1979; 182: 103–8.
   Google Scholar
• Pang KS, Terrell JA. Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats. J Pharmacol Exp Ther. 1981; 216: 339–46.
   Google Scholar
• Conway JG, Kauffman FC, Thurman RG. Rates of sulfation and glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule. Molec Pharmacol. 1982; 22: 509–16.
   Google Scholar
• Conway JG, Kauffman FC, Tsukada T; Thurman RG. Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the liver lobule. Molec Pharmacol. 1983; 25: 487–93.
   Google Scholar
• James R, Desmond P, Kiipfer A, Schenker S, Branch RA. The differential localisation of various drug metabolizing systems within the rat liver lobule as determined by the hepatotoxins allyl alcohol, carbon tetrachloride and bromobenzene. J Pharmacol Exp Ther. 1981; 217: 127–32.
   Google Scholar
• Desmond PV, James R, Schenker S, Gerkens JF, Branch RA. Preservation of glucuronidation in carbon tetrachloride-induced acute liver injury in the rat. Biochem Pharmacol. 1981; 30: 993–9.
   Google Scholar
• Jungermann K. Metabolische Zonierung des Leberparcnchyms. Naturwissenschajten. 1985; 72: 76–84.
   Google Scholar
• Wimmer M, Pettc D. Microphotometric studies on intraacinar enzyme distribution in rat liver. Histochemistry. 1979; 64: 23–33.
   Google Scholar
• Guder WG, Schmidt U. Liver cell heterogeneity. The distribution of pyruvate kinase and phosphoenolpyruvate carboxykinase (GPT) in the liver lobule of fed and starved rats. HoppeSeyler’s Z Physiol Chcm. 1976; 357: 1793800.
   Google Scholar
• Teutsch HF. Quantitative determination of G6Pase activity in histochemically defined zones of the liver acinus. Histochemistry. 1978; 58: 281–8.
   Google Scholar
• Katz N, Teutsch HF, Sasse D, Jungermann K. Heterogeneous distribution of glucose-6 phosphatase in microdissected periportal and perivenous rat liver tissue. FEBS Letters. 197776: 226–30.
   Google Scholar
• Richards WL, Potter VR. Scanning microden sitometry of glycogen zonation in the livers of rats adapted to a controlled feeding schedule and to 30, 60 or 90 % casein diets. Am J Anal 1980; 157: 71–85.
   Google Scholar
• Katz N, Teutsch HF, Jungermann K, Sasse D. Perinatal development of the metabolic zona tion of hamster liver parenchyma. FEBS Letters. 1976; 69: 23 6.
   Google Scholar
• Sasse D, Katz N, Jungermann K. Functional heterogeneity of rat liver parenchyma and of isolated hepatocytes. FEBS Letters. 1978; 57 • 83–8.
   Google Scholar
• Haussinger D. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur j Biochem. 1983; 133: 269–75.
   Google Scholar
• Haussinger D, Sies H, Gerok W. Functional hepatocyte heterogeneity in ammonia metabolism. J Hepatology. 1984; 1: 3–14.
   Google Scholar
• Goresky CA, Bach GG, Nadeau BE. On the uptake of materials by the intact liver. The transport and net removal of galactose. J Clin Invest. 1973; 52: 991–1009.
   Google Scholar
• Gumucio JJ, Miller DL, Krauss MD, Zanollj CC. Transport of fluorescent compounds into hepatocytes and the resultant zonal labeling of the hepatic acinus in the rat. Gastroenterology 1981; 80: 639–46.
   Google Scholar
• Gonzalez J, Esteller A. Heterogeneity of rabbit hepatocytes for bile secretion after acinar zone 3 damage induced by bromobenzene. Biochem Pharmacol. 1985; 34: 507–14.
   Google Scholar
• Hardonk MJ and Scholtens HB. A histochemical study about the zonal distribution of the galactose-binding protein in rat liver. Histochemistry. 1980; 69: 289–97.
   Google Scholar
• Nauck M. Wolfie D, Katz N, Jungermann K. Modulation of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by arterial and venous oxygen concentrations in hepatocyte cultures. Eur J Biochem. 1981; 119: 657–61.
   Google Scholar
• Katz N, Nauck M, Wilson P. Induction of glucokinase by insulin under the permissive action of dexamethasone in primary rat hepatocyte cultures. Biochem Biophys Res Commun. 1979; 88: 23–9.
   Google Scholar
• Wolfie D, Hartmann H; Jungermann K. In duction of phosphoenolpyruvate carboxyki nase by sympathetic agents in primary cultures of adult rat hepatocytes. Biochem Biophys Res Commun. 1981; 98: 1084–90.
   Google Scholar
• Jungermann K, Heilbronn R; Katz N, Sasse D. The glucose/glucose-6-phophate cycle in the periportal and perivenous zone of rat liver. Eur J Biochem. 1982; 123: 429–36.
   Google Scholar
• Reid WD. Mechanism of allyl alcohol induced hepatic necrosis. Experienta. 1972; 28: 105861.
   Google Scholar
• Meerman JHN, Mulder GJ. Prevention of the hepatotoxic action of N-hydroxy-2-acetylaminofluorcne in the rat by inhibition of N O-sulfation by pentachlorophenol. Life Sci. 1981; 28: 2361 5.
   Google Scholar