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Acta Clinica Belgica
International Journal of Clinical and Laboratory Medicine
Volume 51, 1996 - Issue 6
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Editorial

Lessons From the Discovery of Leptin: is Obesity an Endocrine Disease?

Pages 371-376 | Published online: 16 May 2016

References

  • Stunkard AJ. Current views on obesity Am J Med 1996; 100:230–6.
  • Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci. 1953; 140: 578–92.
  • Hcrvey GR, Duggan JP. The concept of feedback control of body fat content and the evidence for it. Int Monograph on Nutr Me tab and Obesity. 1990; 1:1–18.
  • Weigle DS. Appetite and the regulation of body composition. FASEB (Fed Am Soc Ex Biol) J. 1994; 8: 302–10.
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372: 425–32.
  • McGarry JD. Does leptin lighten the problem of obesity? Cur Biol. 1995; 5: 1342–44.
  • Cusin I, Sainsbury A, Doyle P. Rohner-Jeanrenaud F. Jeanrenaud B. The ob gene and insulin. A relationship leading to clues to the understanding of obesity. Diabetes. 1995; 44: 1467–70.
  • Lindpainter K. Finding an obesity gene: a tale of mice and man. N Engl J Med. 1995; 332: 679–80.
  • Rohner-Jeanrenaud F, Jeanrenaud B. Obesity, leptin, and the brain. N Engl J Med. 1996; 334:324–5.
  • Berry F.M, Schneider BS. The ob gene product. A long term satiety signal? Nutr Metab Cardiovasc Dis. 1996; 6: 3–5.
  • Ltinnqvist F. The obese (ob) gene and its product leptin-a new route toward obesity treatment in man? Q J Med. 1996; 89: 327–32.
  • Wurtman RJ. What is leptin for, and docs it act on the brain? Nature Med. 1996; 2: 492–3.
  • Bray GA. Leptin and leptinomania. Lancet. 1996; 348: 140–1.
  • Keesey RE, Powley TL. The regulation of body weight. Annu Rev Psychol. 1986; 37: 109–33.
  • Bouchard C, PtSrusse L. Genetics of obesity. Ann Rev Nutr. 1993; 13: 337–54.
  • Ingalls AM, Dickie MM, Snell GD. Obese, new mutation in house mouse. J Hered. 1950; 41: 3178.
  • Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 1978; 14: 141–8.
  • Friedman JM, Lcibel RD, Siegel DS, Walsh J, Bahary N. Molecular mapping of the mouse ob mutation. Genomics. 1991; 11: 1054–62.
  • Halaas JL, Gajiwala KS, Maffei M, et al. Weight reducing effects of the plasma protein encoded by the obese gene. Science. 1995; 269: 543–6.
  • Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995; 269: 5403.
  • Campfield LA, Smith FJ, Guise/. Y, Devos R, Burn P. Recombinant mouse leptin: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995; 269: 546–9.
  • Weigle DS, Bukowski TR, Foster DC, et al. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest. 1995; 96: 2065–70.
  • Levin N, Nelson C, Gurney A, Vandlen R, de Sauvage F. Decreased food intake docs not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA. 1996; 93: 1726–30.
  • Stephens TW, Basinski M, Brislow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 1995; 377: 530–2.
  • Bray GA. The nutrient balance hypothesis: peptides, sympathetic activity, and food intake. Ann NY Acad Sci. 1993; 676: 223–41.
  • Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 1996; 12: 318–20.
  • Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995; 83: 1263–71.
  • Devos R. Richards JG, Campfield LA et al. OB protein binds specifically to the choroid plexus in mice and rats. Proc Natl Acad Sci USA. 1996; 93: 5668–73.
  • Banks WA, Kastin AJ, Huang WT, Jaspan JD, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides. 1996; 17: 305–11.
  • Lee G-H, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 1996; 379: 632–5.
  • Chua SC Jr. Chung WK, Wu-Peng S et al, Phcnotypes of mouse diabetes and rat falty due to mutations in the OB (leptin) receptor. Science. 1996; 271: 994–6.
  • Frcderich RC, Lollmann B, Hamann A, et al. Expression of ob mRNA and its encoded protein in rodents: impact of nutrition and obesity. J Clin Invest. 1995; 96: 1658–63.
  • Maffei M, Halaas J. Ravussin E, et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.Mature Med. 1995; 1: 1155–61.
  • Saladin R, De Vos P, Guerre-Millo M, et al. Transient increase in obese gene expression after food intake or insulin administration. Nature. 1995; 377: 527–9.
  • De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem. 1995; 270: 15958–61.
  • Zimmet P, Alberti KGMM. Leptin: is it important in diabetes? Diabetic Med. 1996; 13:501–3.
  • Maffei M, Stoffel M, Barone M, et al. Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes. 1996; 45: 679–82.
  • Niki T, Mori H, Tamori Y et al. Human obese gene. Molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. Diabetes. 1996; 45: 675–8.
  • Clement K, Garner C, Hager J, et al. Indication for linkage of the human OB gene region with extreme obesity. Diabetes. 1996; 45: 687–90.
  • Reed DR, Ding Y, Xu W, Calher C, Green ED, Price RA. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes. 1996; 45:691–4.
  • Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292–5.
  • Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med. 1995; 1:950–3.
  • Hamilton BS, Paglia D, Kwan AYM, Deitel M Increased obese mRNA expression in omental fa cells from massively obese humans. Nature Med. 1995; 1:953–6.
  • Considine RV, Considine EL, Williams CJ, et al. Evidence against either a premature stop codon oi the absence of obese gene mRNA in human obesity. J Clin Invest. 1995; 95: 2986–88.
  • Masuzaki H, Ogawa Y, Isse N et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes. 1995; 44: 855–8.
  • Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes. 1996; 19: 992–6.
  • Schwartz M W, Peskind E, Raskind M, Boyko EJ, Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Med. 1996; 2: 587–93.
  • Caro JF, Kolaczynski J W, Nyce MR, et al. Decreased cerebrospinal-fiuid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 1996; 348: 159–61.
  • Scheen AJ, Paquot N, Letiexhe M, Paolisso G, Castillo MJ, LeRibvre PJ. Glucose metabolism in obese subjects: lessons from OGTT, IVGTT, and clamp studies, hit J Obesity. 1995; 19, Suppl. 3: S14–S20.
  • Scheen AJ, Leffcbvre PJ. Pathophysiology of Type 2 diabetes. In: Handbook of Experimental Pharmacology, Oral Antidiabetics (J. Kuhlmann and W. Puis, Eds), Springer, Berlin, 1995, pp. 7–42.
  • Scheen AJ, Desaive C, Leffcbvre PJ. Therapy for obesity-today and tomorrow. Bailliere’s Clin Endocrinol Metab. 1994; 8: 705–27.

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