Streptococcus iniae in aquaculture: a review of pathogenesis, virulence, and antibiotic resistance

References

• FAO. FAO leads global efforts to strengthen aquaculture for food and sustainable development. (s. f.). Newsroom. 2023. [cited 2024 Feb 5, de]. Available from: https://www.fao.org/newsroom/detail/fao-leads-global-efforts-to-strengthen-aquaculture-for-food-and-sustainable-development/en
   Google Scholar
• FAO. Fao fisheries and aquaculture division. 2022. ISBN 978-9o2-5-135757-6.
   Google Scholar
• Cain K. The many challenges of disease management in aquaculture. J World Aquacult Soc. 2022;53(6):1080–1083. doi: 10.1111/jwas.12936
   Web of Science ®Google Scholar
• Rattanachaikunsopon P, Phumkhachorn P. Potential of cinnamon (cinnamomum verum) oil to control streptococcus iniae infection in tilapia (Oreochromis niloticus). Fish Sci. 2010;76(2):287–293. doi: 10.1007/s12562-010-0218-6
   Web of Science ®Google Scholar
• Huang HY, Chen YC, Wang PC, et al. Efficacy of a formalin-inactivated vaccine against streptococcus iniae infection in the farmed grouper Epinephelus coioides by intraperitoneal immunization. Vaccine. 2014;32(51):7014–7020. doi: 10.1016/j.vaccine.2014.08.039
   PubMed Web of Science ®Google Scholar
• Dönmez AE, Cengizler I. Pathomorphology of experimental streptococcus iniae infection in tilapia (Oreochromis niloticus). Indian J Anim Res. 2020;54(2):234–238.
   Google Scholar
• Kirmaier A, Blackshear L, Lee MSL, et al. Cellulitis and bacteremia caused by the fish pathogen, streptococcus iniae, in an immunocompromised patient: case report and mini-review of zoonotic disease, lab identification, and antimicrobial susceptibility. Diagn Microbiol Infect Dis. 2024;108(4):116189. doi: 10.1016/j.diagmicrobio.2024.116189
   PubMed Web of Science ®Google Scholar
• Baiano JCF, Barnes AC. Towards control of streptococcus iniae. Emerg Infect Dis. 2009;15(12):1891–1896. doi: 10.3201/eid1512.090232
   PubMed Web of Science ®Google Scholar
• Pier GB, Madin SH. Streptococcus iniae sp. Nov. a beta-hemolytic streptococcus isolated from an amazon freshwater dolphin, Inia geoffrensis. Int J Bacteriol. 1976;26(4):545–553. doi: 10.1099/00207713-26-4-545
   Google Scholar
• Diaz JH. Skin and soft tissue infections following marine injuries and exposures in travelers. J Travel Med. 2014;21(3):207–213. doi: 10.1111/jtm.12115
   PubMed Web of Science ®Google Scholar
• Hussain A, Nazir F, Faizan M, et al. Significance of gene knockout for the detection of MurI gene in S. Iniae for evaluation of biochemical properties associated with pathogenicity at molecular level. Saudi J Life Sci. 2020;7:133–137.
   Google Scholar
• CDC. Invasive infection with streptococcus iniae—Ontario, 1995-1996. (S.F.). 1996 [cited 2024 Feb 6, de] Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/00043200.htm
   Google Scholar
• Awate S, Mubarka S, Huber RG. Whole genomic characterization of streptococcus iniae isolates from barramundi (lates calcarifer) and preliminary evidence of cross-protective immunization. Vaccines. 2023;11(9):1443. doi: 10.3390/vaccines11091443
   Web of Science ®Google Scholar
• Helmi AM, Mukti AT, Soegianto A, et al. A review of bacterial zoonoses and antimicrobial resistant (AMR) on grouper fish (Epinepholus sp.). Sys Rev Pharm. 2020;11(9):79–88.
   Google Scholar
• Dodson SV, Maurer JJ, Shotts EB. Biochemical and molecular typing of streptococcus iniae isolated from fish and human cases. J Fish Disease. 1999;22(5):331–336. doi: 10.1046/j.1365-2761.1999.00170.x
   Web of Science ®Google Scholar
• Daneshamouz S, Haghi F, Zeighami H. Detection and identification of bacterial pathogens in rainbow trout (Oncorhynchus mykiss) samples from fish farms in iran. Thalassas: Int J Mar Sci. 2020;36(1):133–141. doi: 10.1007/s41208-019-00169-9
   Google Scholar
• Legario FS, Choresca CH, Turnbull JF, et al. Isolation and molecular characterization of streptococcal species recovered from clinical infections in farmed Nile tilapia (Oreochromis niloticus) in the Philippines. J Fish Dis. 2020;43(11):1431–1442. doi: 10.1111/jfd.13247
   PubMed Web of Science ®Google Scholar
• Piamsomboon P, Thanasaksiri K, Murakami A, et al. Streptococcosis in freshwater farmed seabass lates calcarifer and its virulence in Nile tilapia Oreochromis niloticus. Aquaculture. 2020;523:735189. doi: 10.1016/j.aquaculture.2020.735189
   Web of Science ®Google Scholar
• Pierezan F, Shahin K, Heckman TI, et al. Outbreaks of severe myositis in cultured white sturgeon (Acipenser transmontanus l.) associated with streptococcus iniae. J Fish Dis. 2020;43(4):485–490. doi: 10.1111/jfd.13145
   PubMed Web of Science ®Google Scholar
• Ortega C, García I, Irgang R, et al. First identification and characterization of streptococcus iniae obtained from tilapia (Oreochromis aureus) farmed in Mexico. J Fish Dis. 2018;41(5):773–782. doi: 10.1111/jfd.12775
   PubMed Web of Science ®Google Scholar
• Rudenko O, Engelstädter J, Barnes AC. Evolutionary epidemiology of streptococcus iniae: linking mutation rate dynamics with adaptation to novel immunological landscapes. Infect Genet Evol. 2020;85:104435. doi: 10.1016/j.meegid.2020.104435
   PubMed Web of Science ®Google Scholar
• Heckman T, Griffin M, Camus A, et al. Multilocus sequence analysis of diverse streptococcus iniae isolates indicates an underlying genetic basis for phenotypic heterogeneity. Dis Aquat Org. 2020;141:53–69. doi: 10.3354/dao03521
   PubMed Web of Science ®Google Scholar
• Feng Y, Bai M, Geng Y, et al. The potential risk of antibiotic resistance of streptococcus iniae in sturgeon cultivation in Sichuan, China. Enviro Sci Pollut Res. 2021;28(48):69171–69180. doi: 10.1007/s11356-021-15501-1
   PubMed Web of Science ®Google Scholar
• Alcántara-Jauregui FM, Valladares-Carranza B, Ortega C. Enfermedades bacterianas y sus agentes etiológicos identificados en peces de méxico - Una Revisión: enfermedades bacterianas en peces de méxico. Rev MVZ Córdoba. 2022;27(2):e2387–e2387. doi: 10.21897/rmvz.2387
   Google Scholar
• Pretto Giordano LG, Scarpassa JA. Streptococcus iniae: an unusual important pathogen fish in Brazil. J Aquac Res Dev. 2015;6(09). doi: 10.4172/2155-9546.1000363
   PubMedGoogle Scholar
• Souter R, Chaber AL, Lee K, et al. Streptococcus iniae infection in a juvenile free-ranging short-beaked common dolphin (Delphinus delphis). Animals. 2021;11(11):3123. doi: 10.3390/ani11113123
   Web of Science ®Google Scholar
• Genin A, Levy L, Sharon G, et al. Rapid onsets of warming events trigger mass mortality of coral reef fish. Proc Natl Acad Sci, USA. 2020;117(41):25378–25385. doi: 10.1073/pnas.2009748117
   PubMed Web of Science ®Google Scholar
• Panek FM. Epizootics and disease of coral reef fish in the tropical western Atlantic and Gulf of Mexico. Rev Fish Sci. 2005;13(1):1–21. doi: 10.1080/10641260590885852
   Web of Science ®Google Scholar
• Gnanagobal H, Santander J. Host–pathogen interactions of marine gram-positive bacteria. Biology. 2022;11(9):1316. doi: 10.3390/biology11091316
   PubMedGoogle Scholar
• Bowker JD, Ostland VE, Carty D, et al. Effectiveness of aquaflor (50% florfenicol) to control mortality associated with streptococcus iniae in freshwater‐reared subadult sunshine bass. J Aqua Anim Hlth. 2010;22(4):254–265. doi: 10.1577/H09-010.1
   PubMed Web of Science ®Google Scholar
• Tavares GC, De Queiroz GA, Assis GBN, et al. Disease outbreaks in farmed Amazon catfish (leiarius marmoratus x pseudoplatystoma corruscans) caused by streptococcus agalactiae, S. iniae, and S. dysgalactiae. Aquaculture. 2018;495:384–392. doi: 10.1016/j.aquaculture.2018.06.027
   Web of Science ®Google Scholar
• Watts J, Schreier H, Lanska L, et al. The rising tide of antimicrobial resistance in aquaculture: sources, sinks and solutions. Mar Drugs. 2017;15(6):158. doi: 10.3390/md15060158
   PubMed Web of Science ®Google Scholar
• Anumudu CK, Omoregbe O, Hart A, et al. Applications of bacteriocins of lactic acid bacteria in biotechnology and food preservation: a bibliometric review. Open Microbiol J. 2022;16(1):e187428582206300. doi: 10.2174/18742858-v16-e2206300
   Google Scholar
• Van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523–538. doi: 10.1007/s11192-009-0146-3
   PubMed Web of Science ®Google Scholar
• Dadar M, Dhama K, Vakharia VN, et al. Advances in aquaculture vaccines against fish pathogens: global status and current trends. Rev Fish Sci Aquacult. 2017;25(3):184–217. doi: 10.1080/23308249.2016.1261277
   Web of Science ®Google Scholar
• Barnes AC, Rudenko O, Landos M, et al. Autogenous vaccination in aquaculture: a locally enabled solution towards reduction of the global antimicrobial resistance problem. Rev Aquacult. 2022;14(2):907–918. doi: 10.1111/raq.12633
   Web of Science ®Google Scholar
• Huang H-Y, Chen Y-C, Wang P-C, et al. Efficacy of a formalin-inactivated vaccine against streptococcus iniae infection in the farmed grouper Epinephelus coioides by intraperitoneal immunization. Vaccine. 2014;32(51):7014–7020. doi: 10.1016/j.vaccine.2014.08.039
   PubMed Web of Science ®Google Scholar
• Whyte SK. The innate immune response of finfish – a review of current knowledge. Fish Shellfish Immunol. 2007;23(6):1127–1151. doi: 10.1016/j.fsi.2007.06.005
   PubMed Web of Science ®Google Scholar
• Sakai M, Hikima J, Kono T. Fish cytokines: Current research and applications. Fish Sci. 2021;87(1):1–9. doi: 10.1007/s12562-020-01476-4
   Web of Science ®Google Scholar
• Mahlapuu M, Håkansson J, Ringstad L, et al. Antimicrobial peptides: an emerging category of therapeutic agents. Front Cell Infect Microbiol. 2016;6:6. doi: 10.3389/fcimb.2016.00194
   PubMed Web of Science ®Google Scholar
• Zharkova MS, Orlov DS, Golubeva O, et al. Application of antimicrobial peptides of the innate immune system in combination with conventional antibiotics—A novel way to combat antibiotic resistance? Front Cell Infect Microbiol. 2019;9:128. doi: 10.3389/fcimb.2019.00128
   PubMed Web of Science ®Google Scholar
• Lei J, Sun L, Huang S, et al. The antimicrobial peptides and their potential clinical applications. Am J Transl Res. 2019;11(7):3919–3931.
   PubMed Web of Science ®Google Scholar
• Dehsorkhi A, Castelletto V, Hamley IW. Self‐assembling amphiphilic peptides. J Pept Sci. 2014;20(7):453–467. doi: 10.1002/psc.2633
   PubMed Web of Science ®Google Scholar
• Ting CH, Chen YC, Chen JY. Nile tilapia fry fed on antimicrobial peptide epinecidin-1-expressing artemia cyst exhibit enhanced immunity against acute bacterial infection. Fish Shellfish Immunol. 2018;81:37–48. doi: 10.1016/j.fsi.2018.07.008
   PubMed Web of Science ®Google Scholar
• Zahran E, Risha E, Elbahnaswy S, et al. Tilapia piscidin 4 (Tp4) enhances immune response, antioxidant activity, intestinal health and protection against streptococcus iniae infection in Nile tilapia. Aquaculture. 2019;513:734451. doi: 10.1016/j.aquaculture.2019.734451
   Web of Science ®Google Scholar
• Varga JFA, Brunner SR, Cheng G, et al. Identification and characterization of a novel peptide from rainbow trout (Oncorhynchus mykiss) with antimicrobial activity against streptococcus iniae. Dev Comp Immunol. 2022;137:104518. doi: 10.1016/j.dci.2022.104518
   PubMed Web of Science ®Google Scholar
• Van Baarlen P, Van Belkum A, Summerbell RC, et al. Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps? FEMS Microbiol Rev. 2007;31(3):239–277. doi: 10.1111/j.1574-6976.2007.00065.x
   PubMed Web of Science ®Google Scholar
• Casadevall A, Pirofski L, Fischetti VA. Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity. Fischetti VA, ed. Infect Immun. 1999;67(8):3703–3713. doi: 10.1128/IAI.67.8.3703-3713.1999
   PubMed Web of Science ®Google Scholar
• Esperanza-Cortés M, Consuegra-Bonilla J, Dario-Sinisterra R. Biofilm formation, control and novel strategies for eradication. Sci Against Microbial Pathog Commun Curr Res Technol Adv Adv. 2011;2:896–905.
   Google Scholar
• Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT, Ahmed N. Streptococcus iniae m-like protein contributes to virulence in fish and is a target for live attenuated vaccine development. Ahmed N, ed. PLoS One. 2008;3(7):e2824. doi: 10.1371/journal.pone.0002824
   PubMed Web of Science ®Google Scholar
• Eyngor M, Chilmonczyk S, Zlotkin A, et al. Transcytosis of Streptococcus iniae through skin epithelial barriers: an in vitro study. FEMS Microbiol Lett. 2007;277(2):238–248. doi: 10.1111/j.1574-6968.2007.00973.x
   PubMed Web of Science ®Google Scholar
• Zlotkin A, Chilmonczyk S, Eyngor M, et al. Trojan horse effect: phagocyte-mediated streptococcus iniae infection of fish. Infect Immun. 2003;71(5):2318–2325. doi: 10.1128/IAI.71.5.2318-2325.2003
   PubMed Web of Science ®Google Scholar
• Arasu A, Kumaresan V, Sathyamoorthi A, et al. Coagulation profile, gene expression and bioinformatics characterization of coagulation factor X of striped Murrel Channa striatus. Fish Shellfish Immunol. 2016;55:149–158. doi: 10.1016/j.fsi.2016.05.030
   PubMed Web of Science ®Google Scholar
• Xie H. Biogenesis and function of porphyromonas gingivalis outer membrane vesicles. Future Microbiol. 2015;10(9):1517–1527. doi: 10.2217/fmb.15.63
   PubMed Web of Science ®Google Scholar
• Cegelski L, Smith CL, Hultgren SJ. Microbial adhesion. Encyclopedia of Microbiology. Elsevier; 2019. pp. 93–102. doi: 10.1016/B978-0-12-801238-3.02317-5
   Google Scholar
• Sarkar P, Issac PK, Raju SV, et al. Pathogenic bacterial toxins and virulence influences in cultivable fish. Aquacult Res. 2021;52(6):2361–2376. doi: 10.1111/are.15089
   Web of Science ®Google Scholar
• Bolotin S, Fuller JD, Bast DJ, et al. The two-component system sivS/R regulates virulence in streptococcus iniae: a TCS regulates virulence in streptococcus iniae. FEMS Immunol Med Microbiol. 2007;51(3):547–554. doi: 10.1111/j.1574-695X.2007.00334.x
   PubMedGoogle Scholar
• Heckman TI, Soto E. Streptococcus iniae biofilm formation enhances environmental persistence and resistance to antimicrobials and disinfectants. Aquaculture. 2021;540:736739. doi: 10.1016/j.aquaculture.2021.736739
   Web of Science ®Google Scholar
• Muhammad M, Zhang T, Gong S, et al. Streptococcus iniae: a growing threat and causative agent of disease outbreak in farmed Chinese sturgeon (Acipenser sinensis). Pak J Zool. 2020;52(5). doi: 10.17582/journal.pjz/20190209200236
   Web of Science ®Google Scholar
• Yoon S, Kim YH, Jeun M, et al. Studies on a toxin/antitoxin system in streptococcus iniae. J Life Sci. 2019;29(1):97–104.
   Google Scholar
• Bhavsar AP, Guttman JA, Finlay BB. Manipulation of host-cell pathways by bacterial pathogens. Nature. 2007;449(7164):827–834. doi: 10.1038/nature06247
   PubMed Web of Science ®Google Scholar
• Agnew W, Barnes A. Streptococcus iniae: an aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination. Vet Microbiol. 2007;122(1–2):1–15. doi: 10.1016/j.vetmic.2007.03.002
   PubMed Web of Science ®Google Scholar
• Bromage E, Thomas A, Owens L. Streptococcus iniae, a bacterial infection in barramundi lates calcarifer. Dis Aquat Org. 1999;36:177–181. doi: 10.3354/dao036177
   PubMed Web of Science ®Google Scholar
• Stanimirovic D, Kemmerich K, Haqqani AS, et al. Engineering and pharmacology of blood–brain barrier-permeable bispecific antibodies. Adv Pharmacol. Vol. 71. Elsevier; 2014. pp. 301–335. doi:10.1016/bs.apha.2014.06.005
   Google Scholar
• Bromage E, Owens L. Infection of barramundi lates calcarifer with streptococcus iniae: effects of different routes of exposure. Dis Aquat Org. 2002;52:199–205. doi: 10.3354/dao052199
   PubMed Web of Science ®Google Scholar
• Weinstein MR, Litt M, Kertesz DA, et al. Invasive infections due to a fish pathogen, streptococcus iniae. N Engl J Med. 1997;337(9):589–594. doi: 10.1056/NEJM199708283370902
   PubMed Web of Science ®Google Scholar
• Salvador R, Muller EE, Freitas JCD, et al. Isolation and characterization of streptococcus spp. group B in Nile tilapias (Oreochromis niloticus) reared in hapas nets and earth nurseries in the northern region of Parana State, Brazil. Cienc Rural. 2005;35(6):1374–1378. doi: 10.1590/S0103-84782005000600023
   Google Scholar
• Liu C, Hu X, Cao Z, et al. Construction and characterization of a DNA vaccine encoding the SagH against streptococcus iniae. Fish Shellfish Immunol. 2019;89:71–75. doi: 10.1016/j.fsi.2019.03.045
   PubMed Web of Science ®Google Scholar
• LaRock CN, Nizet V. Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. Biochim Biophys Acta - Biomembr. 2015;1848(11):3047–3054. doi: 10.1016/j.bbamem.2015.02.010
   Web of Science ®Google Scholar
• Jiang J, Miyata M, Chan C, Ngoh SY, Liew WC, Saju JM, Sing Ng K, Wong FS, Lee YS, Chang SF, Orbán L. Differential transcriptomic response in the spleen and head kidney following vaccination and infection of asian seabass with streptococcus iniae. In: Thune R, editor. PLoS one. Vol. 9. 2014. p. p. e99128(7.
   Google Scholar
• Abdelsalam M, Elgendy MY, Elfadadny MR, et al. A review of molecular diagnoses of bacterial fish diseases. Aquacult Int. 2023;31(1):417–434. doi: 10.1007/s10499-022-00983-8
   Web of Science ®Google Scholar
• Colussi S, Pastorino P, Mugetti D, et al. Isolation and genetic characterization of Streptococcus iniae virulence factors in Adriatic sturgeon (Acipenser naccarii). Microorganisms. 2022;10(5):883. doi: 10.3390/microorganisms10050883
   PubMed Web of Science ®Google Scholar
• Liu Y, Weng T, Pan X, et al. Construction of an alanine dehydrogenase gene deletion strain for vaccine development against nocardia seriolae in hybrid snakehead (Channa maculata ♀ × Channa argus ♂). Fish Shellfish Immunol. 2023;138:108827. doi: 10.1016/j.fsi.2023.108827
   PubMed Web of Science ®Google Scholar
• Soh KY, Loh JMS, Hall C, et al. Functional analysis of two novel streptococcus iniae virulence factors using a zebrafish infection model. Microorganisms. 2020;8(9):1361. doi: 10.3390/microorganisms8091361
   PubMed Web of Science ®Google Scholar
• Baiano JC, Tumbol RA, Umapathy A, et al. Identification and molecular characterisation of a fibrinogen binding protein from streptococcus iniae. BMC Microbiol. 2008;8(1):67. doi: 10.1186/1471-2180-8-67
   PubMedGoogle Scholar
• Zinkernagel AS, Timmer AM, Pence MA, et al. The il-8 protease spycep/scpc of group a streptococcus promotes resistance to neutrophil killing. Cell Host Microbe. 2008;4(2):170–178. doi: 10.1016/j.chom.2008.07.002
   PubMed Web of Science ®Google Scholar
• Fuller JD, Camus AC, Duncan CL, et al. Identification of a streptolysin s-associated gene cluster and its role in the pathogenesis of streptococcus iniae disease. Infect Immun. 2002;70(10):5730–5739. doi: 10.1128/IAI.70.10.5730-5739.2002
   PubMed Web of Science ®Google Scholar
• Nizet V, Beall B, Bast DJ, Datta V, Kilburn L, Low DE, De Azavedo JC, Tuomanen EI. Genetic locus for streptolysin s production by group a streptococcus. Tuomanen EI, ed. Infect Immun. 2000;68(7):4245–4254. doi: 10.1128/IAI.68.7.4245-4254.2000
   PubMed Web of Science ®Google Scholar
• Shutou K, Kanai K, Yoshikoshi K. Virulence attenuation of capsular polysaccharide-deleted mutants of streptococcus iniae in Japanese flounder Paralichthys olivaceus. Fish Pathol. 2007;42(1):41–48. doi: 10.3147/jsfp.42.41
   Web of Science ®Google Scholar
• Milani CJE, Aziz RK, Locke JB, et al. The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen streptococcus iniae. Microbiology. 2010;156(2):543–554. doi: 10.1099/mic.0.028365-0
   PubMedGoogle Scholar
• Hansen GR, Woodall J, Brown C, Jaax N, McNamara T, Ruiz A. Emerging zoonotic diseases. Panel summary from the International Conference on Emerging Infectious Diseases Conference, Atlanta, Georgia, 2000. Emerg Infect Dis. 2001;7(7):537. doi: 10.3201/eid0707.017716
   PubMedGoogle Scholar
• Al-Harbi AH. Molecular characterization of streptococcus iniae isolated from hybrid tilapia (Oreochromis niloticus×Oreochromis aureus). Aquaculture. 2011;312(1–4):15–18. doi: 10.1016/j.aquaculture.2010.12.014
   Web of Science ®Google Scholar
• Zlotkin A, Hershko H, Eldar A. Possible transmission of streptococcus iniae from wild fish to cultured marine fish. Appl Environ Microbiol. 1998;64(10):4065–4067. doi: 10.1128/AEM.64.10.4065-4067.1998
   PubMed Web of Science ®Google Scholar
• Lau SKP, Woo PCY, Tse H, et al. Invasive streptococcus iniae infections outside North America. J Clin Microbiol. 2003;41(3):1004–1009. doi: 10.1128/JCM.41.3.1004-1009.2003
   PubMed Web of Science ®Google Scholar
• Sun JR, Yan JC, Yeh CY, et al. Invasive infection with streptococcus iniae in Taiwan. J Med Microbiol. 2007;56(9):1246–1249. doi: 10.1099/jmm.0.47180-0
   PubMed Web of Science ®Google Scholar
• Facklam R, Elliott J, Shewmaker L, et al. Identification and characterization of sporadic isolates of streptococcus iniae isolated from humans. J Clin Microbiol. 2005;43(2):933–937. doi: 10.1128/JCM.43.2.933-937.2005
   PubMed Web of Science ®Google Scholar
• Koh TH, Kurup A, Chen J. Streptococcus iniae discitis in Singapore. Emerg Infect Dis. 2004;10(9):1694–1696. doi: 10.3201/eid1009.040029
   PubMed Web of Science ®Google Scholar
• Dodson SV, Maurer JJ, Shotts EB. Biochemical and molecular typing of streptococcus iniae isolated from fish and human cases. J Fish Dis. 1999;22(5):331–336. doi: 10.1046/j.1365-2761.1999.00170.x
   Web of Science ®Google Scholar
• Zhou SM, Fan Y, Zhu XQ, et al. Rapid identification of streptococcus iniae by specific PCR assay utilizing genetic markers in ITS rDNA. J Fish Dis. 2011;34(4):265–271. doi: 10.1111/j.1365-2761.2010.01233.x
   PubMed Web of Science ®Google Scholar
• Farzadnia A, Naeemipour M. Molecular techniques for the detection of bacterial zoonotic pathogens in fish and humans. Aquacult Int. 2020;28(1):309–320. doi: 10.1007/s10499-019-00462-7
   Web of Science ®Google Scholar
• Torres‐Corral Y, Santos Y. Development of a real‐time PCR assay for detection and quantification of streptococcus iniae using the lactate permease gene. J Fish Dis. 2021;44(1):53–61. doi: 10.1111/jfd.13267
   PubMed Web of Science ®Google Scholar
• Charo F, Mbuthia P, Bebora L, et al. Influence of aquaculture management practices and water quality on bacterial occurrence in fish culture units in Kenya. Int J Fish Aquat Stud. 2023;11(2):01–07. doi: 10.22271/fish.2023.v11.i2a.2782
   Google Scholar
• Thompson KD, Rodkhum C, Bunnoy A, et al. Addressing nanovaccine strategies for tilapia. Vaccines. 2023;11(8):1356. doi: 10.3390/vaccines11081356
   Web of Science ®Google Scholar
• Limbu SM. The current status of antibiotic-resistant bacteria and resistance genes in african aquaculture. In: Abia ALK, Essack SY, editors. Antimicrobial Research and One Health in Africa. Springer International Publishing. 2023. pp. 81–106 doi: 10.1007/978-3-031-23796-6_6
   Google Scholar
• Ahmed J, Vasagam KPK, Ramalingam K. Nanoencapsulated aquafeeds and current uses in fisheries/shrimps: a review. Appl Biochem Biotechnol. [cited 2023 Mar 8];195(11):7110–7131. doi: 10.1007/s12010-023-04418-9
   PubMed Web of Science ®Google Scholar
• FAO. The State of World Fisheries and Aquaculture. 2020. ISBN 92-5-132692-3.
   Google Scholar
• Tuan LC, Khanh NV, HTNB T, Phuong PT, Hieu DV, Thanh LTH, Loc NH. The occurrence of antibiotic resistance vibrio isolates from brackish water shrimp ponds in the coastal area in Thua Thien Hue, Vietnam. J App Biol Biotech. 2022. doi: 10.7324/JABB.2023.110211
   Google Scholar
• Prabina D, Swaminathan TR, Mohandas SP, et al. Investigation of antibiotic-resistant vibrios associated with shrimp (Penaeus vannamei) farms. Arch Microbiol. 2023;205(1):41. doi: 10.1007/s00203-022-03376-w
   Web of Science ®Google Scholar
• He S, Wang Q, Li S, et al. Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis. Sci China Life Sci. 2017;60(11):1260–1270. doi: 10.1007/s11427-016-9072-6
   PubMed Web of Science ®Google Scholar
• Qian M, Wang J, Ji X, et al. Sub-chronic exposure to antibiotics doxycycline, oxytetracycline or florfenicol impacts gut barrier and induces gut microbiota dysbiosis in adult zebrafish (Daino rerio). Ecotoxicol Environ Saf. 2021;221:112464. doi: 10.1016/j.ecoenv.2021.112464
   PubMed Web of Science ®Google Scholar
• Araújo C, Muñoz-Atienza E, Nahuelquín Y, et al. Inhibition of fish pathogens by the microbiota from rainbow trout (Oncorhynchus mykiss, Walbaum) and rearing environment. Anaerobe. 2015;32:7–14. doi: 10.1016/j.anaerobe.2014.11.001
   PubMed Web of Science ®Google Scholar
• Liao X, Deng R, Warriner K, et al. Antibiotic resistance mechanism and diagnosis of common foodborne pathogens based on genotypic and phenotypic biomarkers. Comp Rev Food Sci Food Safe. 2023;22(4):3212–3253. doi: 10.1111/1541-4337.13181
   PubMed Web of Science ®Google Scholar
• Kusunur AB, Mogilipuri SS, Moturu D, et al. Tetracycline resistance potential of heterotrophic bacteria isolated from freshwater fin-fish aquaculture system. J Appl Microbiol. 2023;134(4):lxad060. doi: 10.1093/jambio/lxad060
   PubMed Web of Science ®Google Scholar
• Chetri S. The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: urgent need for an improved new generation of EPIs. Front Microbiol. 2023;14:1149418. doi: 10.3389/fmicb.2023.1149418
   PubMed Web of Science ®Google Scholar
• Varela MF, Stephen J, Bharti D, et al. Inhibition of multidrug efflux pumps belonging to the major facilitator superfamily in bacterial pathogens. Biomedicines. 2023;11(5):1448. doi: 10.3390/biomedicines11051448
   PubMed Web of Science ®Google Scholar
• Munita JM, Arias CA. Mechanisms of antibiotic resistance. Microbiol Spectr; 2016. pp. 481–511. doi: 10.1128/microbiolspec.VMBF-0016-2015
   Google Scholar
• Manage PM. Heavy use of antibiotics in aquaculture: emerging human and animal health problems – a review. Sri Lanka J Aquat. 2018;23(1):13–27. doi: 10.4038/sljas.v23i1.7543
   Google Scholar
• Lulijwa R, Rupia EJ, Alfaro AC. Antibiotic use in aquaculture, policies and regulation, health and environmental risks: a review of the top 15 major producers. Rev Aquacult. 2020;12(2):640–663. doi: 10.1111/raq.12344
   Web of Science ®Google Scholar
• Grudlewska-Buda K, Bauza-Kaszewska J, Wiktorczyk-Kapischke N, et al. Antibiotic resistance in selected emerging bacterial foodborne pathogens—an issue of concern? Antibiotics. 2023;12(5):880. doi: 10.3390/antibiotics12050880
   Google Scholar
• Zuidmeer-Jongejan L, Huber H, Swoboda I, et al. Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy. Int Arch Allergy Immunol. 2015;166(1):41–51. doi: 10.1159/000371657
   PubMed Web of Science ®Google Scholar
• Cabello FC. Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment. Environ Microbiol. 2006;8(7):1137–1144. doi: 10.1111/j.1462-2920.2006.01054.x
   PubMed Web of Science ®Google Scholar
• Vazirzadeh A, Jalali S, Farhadi A. Antibacterial activity of Oliveria decumbens against streptococcus iniae in Nile tilapia (Oreochromis niloticus) and its effects on serum and mucosal immunity and antioxidant status. Fish Shellfish Immunol. 2019;94:407–416. doi: 10.1016/j.fsi.2019.09.025
   PubMed Web of Science ®Google Scholar
• Abdelkhalek NK, Risha E, MA E-A, et al. Antibacterial and antioxidant activity of clove oil against streptococcus iniae infection in Nile tilapia (Oreochromis niloticus) and its effect on hepatic hepcidin expression. Fish Shellfish Immunol. 2020;104:478–488. doi: 10.1016/j.fsi.2020.05.064
   PubMed Web of Science ®Google Scholar
• Stoffregen DA, Backman SC, Perham RE, et al. Initial disease report of streptococcus iniae infection in hybrid striped (sunshine) bass and successful therapeutic intervention with the fluoroquinolone antibacterial enrofloxacin. J World Aquacult Soc. 1996;27(4):420–434. doi: 10.1111/j.1749-7345.1996.tb00626.x
   Web of Science ®Google Scholar
• Naylor RL, Hardy RW, Buschmann AH, et al. A 20-year retrospective review of global aquaculture. Nature. 2021;591(7851):551–563. doi: 10.1038/s41586-021-03308-6
   PubMed Web of Science ®Google Scholar
• Shoemaker CA, Lozano CA, LaFrentz BR, et al. Additive genetic variation in resistance of Nile tilapia (Oreochromis niloticus) to streptococcus iniae and S. agalactiae capsular type ib: is genetic resistance correlated? Aquaculture. 2017;468:193–198. doi: 10.1016/j.aquaculture.2016.10.022
   Web of Science ®Google Scholar
• Sánchez Roncancio CO, Fonseca De Freitas RT. Supervivencia observada en tres familias de tilapia del nilo (Oreochromis niloticus) infectadas con streptococcus agalactiae. Rev Med Vet Zoot. 2022;69(3). doi: 10.15446/rfmvz.v69n3.103804
   Google Scholar
• Sitjà-Bobadilla A, Oidtmann B. Integrated pathogen management strategies in fish farming. In: Galina J, editor. Fish diseases. Academic Press: Elsevier; 2017. pp. 119–144. doi: 10.1016/B978-0-12-804564-0.00005-3
   Google Scholar
• Panigrahi A, Naveenkumar R, Das RR. Immunoprophylactic measures in aquaculture. In: Pandey PK, Parhi J, editors. Advances in fisheries biotechnology. Springer Nature Singapore; 2021. pp. 263–288. doi: 10.1007/978-981-16-3215-0_18
   Google Scholar
• O’Neill J. Antimicrobials in agriculture and the environment: reducing unnecessary use and waste, the review on antimicrobial resistance, AMR-review.Org. 2015.
   Google Scholar
• Chen C-P, Chuang S-C, Su K-L, et al. Application of proteomics in identifying crucial virulence factors shared by different streptococcus iniae isolates for developing an effective subunit vaccine against S. iniae in tilapia. Aquaculture. 2024;581:740477. doi: 10.1016/j.aquaculture.2023.740477
   Web of Science ®Google Scholar
• Adams A. Progress, challenges and opportunities in fish vaccine development. Fish Shellfish Immunol. 2019;90:210–214. doi: 10.1016/j.fsi.2019.04.066
   PubMed Web of Science ®Google Scholar
• Vinh NT, Dong HT, Lan NGT, et al. Immunological response of 35 and 42 days old Asian seabass (lates calcarifer, Bloch 1790) fry following immersion immunization with streptococcus iniae heat-killed vaccine. Fish Shellfish Immunol. 2023;138:108802. doi: 10.1016/j.fsi.2023.108802
   PubMed Web of Science ®Google Scholar
• Komar C, Ariav R, Thompson KD, et al. To vaccinate or not to vaccinate? Tilapia health: quo vadis? 1–3 December 2021. [cited 2023 Aug 28]. Available from: http://infofish.org/tilapia/media/attachments/2021/12/06/18_komar_to-vaccinate-or-not.pdf
   Google Scholar
• Embregts CWE, Forlenza M. Oral vaccination of fish: lessons from humans and veterinary species. Dev Comp Immunol. 2016;64:118–137. doi: 10.1016/j.dci.2016.03.024
   PubMed Web of Science ®Google Scholar
• Monir MS, Yusoff MSM, Zamri-Saad M, et al. Effect of an oral bivalent vaccine on immune response and immune gene profiling in vaccinated red tilapia (Oreochromis spp.) during infections with streptococcus iniae and Aeromonas hydrophila. Biology. 2022;11(9):1268. doi: 10.3390/biology11091268
   PubMedGoogle Scholar
• Halimi M, Alishahi M, Abbaspour MR, et al. Valuable method for production of oral vaccine by using alginate and chitosan against Lactococcus garvieae/Streptococcus iniae in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2019;90:431–439. doi: 10.1016/j.fsi.2019.05.020
   PubMed Web of Science ®Google Scholar
• Meachasompop P, Bunnoy A, Keaswejjareansuk W, et al. Development of immersion and oral bivalent nanovaccines for streptococcosis and columnaris disease prevention in fry and fingerling asian seabass (lates calcarifer) nursery farms. Vaccines. 2023;12(1):17. doi: 10.3390/vaccines12010017
   Web of Science ®Google Scholar
• Wang B, Thompson KD, Wangkahart E, et al. Strategies to enhance tilapia immunity to improve their health in aquaculture. Rev Aquacult. 2023;15(S1):41–56. doi: 10.1111/raq.12731
   Google Scholar
• Mishra S, Seshagiri B, Rathod R, et al. Recent advances in fish disease diagnosis, therapeutics, and vaccine development. Front Aquacult Biotechnol Elsevier. 2023:115–145. doi: 10.1016/B978-0-323-91240-2.00011-7
   Google Scholar
• Kate GU, Krishnani KK, Kumar N, et al. Abiotic and biotic stress alleviating effects of the medicinal and aromatic plant-derived product on striped catfish pangasianodon hypophthalmus. Fish Shellfish Immunol. 2023;135:108625. doi: 10.1016/j.fsi.2023.108625
   PubMed Web of Science ®Google Scholar
• Aly SM, ElBanna NI, Fathi M. Chlorella in aquaculture: challenges, opportunities, and disease prevention for sustainable development. Aquacult Int. [cited 2023 Aug 14];32(2):1559–1586. doi: 10.1007/s10499-023-01229-x
   Google Scholar
• Heckman TI, Shahin K, Henderson EE, et al. Development and efficacy of Streptococcus iniae live-attenuated vaccines in Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunol. 2022;121:152–162. doi: 10.1016/j.fsi.2021.12.043
   PubMed Web of Science ®Google Scholar
• Jose Priya TA, Kappalli S. Chemicals and their interaction in the aquaculture system. In: Mohanan PV, Kappalli S, editors. Biomedical applications and toxicity of nanomaterials. Springer Nature Singapore; 2023. pp. 277–297. doi: 10.1007/978-981-19-7834-0_11
   Google Scholar
• Zhu J, Gan X, Ao Q, et al. Basal polarization of the immune responses to Streptococcus agalactiae susceptible and resistant tilapia (Oreochromis niloticus). Fish Shellfish Immunol. 2018;75:336–345. doi: 10.1016/j.fsi.2018.01.022
   PubMed Web of Science ®Google Scholar
• Wang J, Zou LL, Li AX. Construction of a streptococcus iniae sortase a mutant and evaluation of its potential as an attenuated modified live vaccine in Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol. 2014;40(2):392–398. doi: 10.1016/j.fsi.2014.07.028
   PubMed Web of Science ®Google Scholar
• Pérez-Sánchez T, Mora-Sánchez B, Balcázar JL. Biological approaches for disease control in aquaculture: advantages, limitations and challenges. Trends Microbiol. 2018;26(11):896–903. doi: 10.1016/j.tim.2018.05.002
   PubMed Web of Science ®Google Scholar
• Guimarães MC, Cerezo IM, Fernandez-Alarcon MF, et al. Oral administration of probiotics (Bacillus subtilis and lactobacillus plantarum) in Nile tilapia (Oreochromis niloticus) vaccinated and challenged with streptococcus agalactiae. Fishes. 2022;7(4):211. doi: 10.3390/fishes7040211
   Google Scholar
• Balcázar JL, Vendrell D, De Blas I, et al. Effect of Lactococcus lactis CLFP 100 and Leuconostoc mesenteroides CLFP 196 on Aeromonas salmonicida infection in brown trout (salmo trutta). Microbial Physiol. 2009;17(3):153–157. doi: 10.1159/000226588
   Google Scholar
• Hoseinifar SH, Yousefi S, Van Doan H, et al. Oxidative stress and antioxidant defense in fish: the implications of probiotic, prebiotic, and synbiotics. Rev Fish Sci Aquacult. 2021;29(2):198–217. doi: 10.1080/23308249.2020.1795616
   Web of Science ®Google Scholar
• Kuebutornye FKA, Abarike ED, Lu Y. A review on the application of Bacillus as probiotics in aquaculture. Fish Shellfish Immunol. 2019;87:820–828. doi: 10.1016/j.fsi.2019.02.010
   PubMed Web of Science ®Google Scholar
• Etyemez M, Balcazar JL. Isolation and characterization of bacteria with antibacterial properties from Nile tilapia (Oreochromis niloticus). Res Vet Sci. 2016;105:62–64. doi: 10.1016/j.rvsc.2016.01.019
   PubMed Web of Science ®Google Scholar
• Gutowska MA, Drazen JC, Robison BH. Digestive chitinolytic activity in marine fishes of Monterey Bay, California. Comp Biochem Physiol Part A: Mol Integr Physiol. 2004;139(3):351–358. doi: 10.1016/j.cbpb.2004.09.020
   PubMed Web of Science ®Google Scholar
• Wu ZX, Feng X, Xie LL, et al. Effect of probiotic Bacillus subtilis Ch9 for grass carp, Ctenopharyngodon idella (Valenciennes, 1844), on growth performance, digestive enzyme activities and intestinal microflora: probiotic Bacillus subtilis Ch9 effect on grass carp. J Appl Ichthyol. 2012;28(5):721–727. doi: 10.1111/j.1439-0426.2012.01968.x
   Web of Science ®Google Scholar
• Purwandari AR. Profiling of intestinal microbial diversity by PCR-DGGE genes coding for 16S rDNA and immunity status of the Orange Spotted Grouper (Epinephelus coioides) following probiotic Bacillus subtilis adminis [ Ph. D. thesis]. Universitas Brawijaya; 2012.
   Google Scholar
• Nayak S, Limsuwan C, Chuchird N, et al. A study on the effect of bacillus spp. to control the pathogenic bacteria in aquaculture. J Fish Environ. 2012;36(2):1–13.
   PubMedGoogle Scholar
• James G, Das BC, Jose S, et al. Bacillus as an aquaculture friendly microbe. Aquacult Int. 2021;29(1):323–353. doi: 10.1007/s10499-020-00630-0
   Web of Science ®Google Scholar
• Etyemez Büyükdeveci M, Cengizler İ, Balcázar JL, et al. Effects of two host-associated probiotics Bacillus mojavensis B191 and Bacillus subtilis MRS11 on growth performance, intestinal morphology, expression of immune-related genes and disease resistance of Nile tilapia (Oreochromis niloticus) against streptococcus iniae. Dev Comp Immunol. 2023;138:104553.
   PubMed Web of Science ®Google Scholar
• Al-Deriny SH, Dawood MAO, Zaid AAA, et al. The synergistic effects of spirulina platensis and Bacillus amyloliquefaciens on the growth performance, intestinal histomorphology, and immune response of Nile tilapia (Oreochromis niloticus). Aquacult Rep. 2020;17:100390. doi: 10.1016/j.aqrep.2020.100390
   Web of Science ®Google Scholar
• Verburg‐Van Kemenade BML, Stolte EH, Metz JR, et al. Chapter 7 neuroendocrine–immune interactions in teleost fish. In: Fish physiology. Vol. 28. Elsevier; 2009. pp. 313–364. doi: 10.1016/S1546-5098(09)28007-1
   Google Scholar
• Chen SW, Liu CH, Hu SY. Dietary administration of probiotic Paenibacillus ehimensis NPUST1 with bacteriocin-like activity improves growth performance and immunity against Aeromonas hydrophila and streptococcus iniae in Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol. 2019;84:695–703. doi: 10.1016/j.fsi.2018.10.059
   PubMed Web of Science ®Google Scholar
• Abid S, Farid A, Abid R, et al. Identification, biochemical characterization, and safety attributes of locally isolated lactobacillus fermentum from Bubalus bubalis (Buffalo) milk as a probiotic. Microorganisms. 2022;10(5):954. doi: 10.3390/microorganisms10050954
   PubMed Web of Science ®Google Scholar
• Akmal U, Ghori I, Elasbali AM, et al. Probiotic and antioxidant potential of the lactobacillus spp. isolated from artisanal fermented pickles. Fermentation. 2022;8(7):328. doi: 10.3390/fermentation8070328
   Google Scholar