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Research Article

Hepatoprotective potentials of methanolic extracts of Roselle and beetroots against carbon tetrachloride and Escherichia coli induced stress in Wistar rats

ORCID Icon, , & ORCID Icon
Pages 423-440 | Received 22 Mar 2022, Accepted 03 Jul 2022, Published online: 11 Aug 2022

References

  • Gondokesumo ME, Kusuma HS, Widowati W. α‐/β‐glucosidase and α‐amylase inhibitory activities of roselle (Hibiscus sabdariffa L.) ethanol extract. Mol Cell Biomed Sci. 2017;1:34. DOI:10.21705/mcbs.v1i1.3
  • Peredo Pozos GI, Ruiz-López MA, Zamora Nátera JF, et al. Antioxidant capacity and antigenotoxic effect of Hibiscus sabdariffa L. Extracts obtained with ultrasound-assisted extraction process. Appl Sci. 2020;10(2):560.
  • Banwo K, Sanni A, Sarkar D, et al. Phenolics-Linked antioxidant and anti-hyperglycemic properties of edible Roselle (Hibiscus sabdariffa Linn.) Calyces targeting type 2 diabetes nutraceutical benefits in vitro. Front Sustain Food Syst. 2022;6:660831.
  • Riaz G, Chopra RA. Review on phytochemistry and therapeutic uses of Hibiscus sabdariffa L. Biomed Pharm. 2018;102:575–586.
  • Izquierdo-Vega J, Arteaga-Badillo D, Sánchez-Gutiérrez M, et al. Organic acids from Roselle (Hibiscus sabdariffa L.)—A brief review of its pharmacological effects. Biomedicines. 2020;8(5):100.
  • Wruss J, Waldenberger G, Huemer G, et al. Compositional characteristics of commercial beetroot products and beetroot juice prepared from seven beetroot varieties grown in Upper Austria. J Food Compos Anal. 2015;42:46–55.
  • Iahtisham‐Ul‐Haq Butt MS, Randhawa MA, Shahid M. Hepatoprotective effects of red beetroot‐based beverages against CCl4 ‐induced hepatic stress in Sprague Dawley rats. J Food Biochem. 2019;e13057:1–11.
  • Zhang A, Sun H, Wang X. Recent advances in natural products from plants for treatment of liver diseases. Eur J Med Chem. 2013;63:570–577.
  • Kazimierczak R, Hallmann E, Lipowski J, et al. Beetroot (Beta vulgaris L.) and naturally fermented beetroot juices from organic and conventional production: metabolomics, antioxidant levels and anti-cancer activity. J Sci Food Agric. 2014;94(13):2618–2629.
  • Clifford T, Howatson G, West DJ, et al. The potential benefits of red beetroot supplementation in health and disease. Nutrients. 2015;7:2801–2822.
  • Kouakou TH, Konkon NG, Obouayeba AP, et al. Anthocyanin production in the calyx and callus of Roselle (Hibiscus sabdariffa L.) and its impact on antioxidant activity. J Pharmacog Phytochem. 2015;4(3):09–15.
  • Abdelhafez OH, Fawzy MA, Fahim JR, et al. Hepatoprotective potential of Malvaviscus arboreus against carbon tetrachloride-induced liver injury in rats. PLoS ONE. 2018;13(8):e0202362.
  • Nguyen Y, Sperandio V. Enterohemorrhagic Escherichia coli (EHEC) pathogenesis. Front Cell Inf Microbiol. 2012;2:1–7.
  • Baronetti JL, Villegas NA, Aiassa V, et al. Hemolysin from Escherichia coli induces oxidative stress in blood. Toxicon. 2013;70:15–20.
  • Sharma KD, Vinod KG, Surendra K, et al. Evaluation of antidiarrheal activity of ethanolic extract of Holarrhena antidysenterica seeds in rats. Vet World. 2015;812:1392–1395.
  • Ojekunle O, Banwo K, Sanni AI. In vitro and In vivo evaluation of Weissella cibaria and Lactobacillus plantarum for their protective effect against cadmium and lead toxicities. Lett Appl Microbiol. 2017;64:379–385.
  • Banwo K, Alao MB, Sanni AI. Antioxidant and antidiarrhoeal activities of methanolic extracts of stem bark of Parkia biglobosa and leaves of Parquetina nigrescens. J Herbs Spices Med Plants. 2020;26(1):14–29.
  • Hossain MA, Al-Hdhrami SS, Weli AM, et al. Isolation, fractionation, and identification of chemical constituents from the leaves crude extracts of Mentha piperita L grown in Sultanate of Oman. Asian Pacific J Trop Biomed. 2014;4:S368–S372.
  • Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol. 1983;54:275–287.
  • Gulcin H, Hassan Y, Aboul E. Radical scavenging and antioxidant activity of tannic acid. Arabian J Chem. 2010;31:43–53.
  • Sun Y, Rukeya J, Tao W, et al. Bioactive compounds and antioxidant activity of wolfberry infusion. Sci Rep. 2017;7:40605.
  • Kwon YI, Vattem DA, Shetty K. Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pac J Clin Nutr. 2006;15:107–118.
  • Benzie IF, Strain JJ. The Ferric Reducing Ability of Plasma FRAP as a measure of “Antioxidant power”: the FRAP Assay. Anal Biochem. 1996;239:70–76.
  • Joseph JA, Ayyappan UPT, Sasidharan SR, et al. Ameliorative effect of phytocee™ cool against carbon tetrachloride‑induced oxidative stress. Pharmacog Res. 2014;6(4):320–325.
  • Zhai Q, Wang G, Zhao J, et al. Protective effects of Lactobacillus plantarum CCFM8610 against acute cadmium toxicity in mice. Appl Environ Microbiol. 2013;79:1508–1515.
  • Sedlak J, Lindsay RH. Estimation of total, protein-bound and non-protein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem. 1968;28:192–205.
  • Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47:469–474.
  • Aebi HC. Catalase In vitro. Meth Enzymol. 1983;105:121–126.
  • Varshney R, Kale RK. Effect of calmodulin antagonists on radiation induced lipid peroxidation in microsomes. Int J Rad Biol. 1990;58:733–743.
  • Canadanović-Brunet JM, Savatović SS, Ćetković GS, et al. Antioxidant and antimicrobial activities of beet root pomace extracts. Czech J Food Sc. 2011;29(6):575–585.
  • Mensah JK, Golomeke D. Antioxidant and antimicrobial activities of the extracts of the Calyx of Hibiscus sabdariffa Linn. Curr Sc Persp. 2015;1(2):69–76.
  • Obouayeba AP, Djyh NB, Diabate S, et al. Phytochemical and antioxidant activity of Roselle (Hibiscus sabdariffa L.) petal extracts. Res J Pharm Biol Chem Sc. 2014;5(2):1453–1464.
  • Onkar PR, Powar PV, Sharma PH, et al. Evaluation of phytochemical and pharmacological activity of beetroot extracts (Beta vulgaris). J Biochem Pharmacol. 2013;2(4):456–468.
  • Builders PF, Kabele-Toge B, Builders M, et al. Wound healing potential of formulated extract from Hibiscus sabdariffa Calyx. Indian J Pharm Sci. 2013;6:45–52.
  • Al-Hashimi AG. Antioxidant and antibacterial activities of Hibiscus sabdariffa L. extracts. Afr J Food Sci. 2012;6(21):506–511.
  • Liuqing Y, Ying G, Ting Z, et al. Antioxidant capacity of extracts from calyx fruits of Roselle (Hibiscus sabdariffa L.). Afr J Biotechnol. 2012;1(17):4063–4068.
  • Tsai PJ, Mcintosh J, Pearce P, et al. Anthocyanin and antioxidant capacity in roselle (Hibiscus sabdariffa L.) extract. Food Res Int. 2002;35:351–356.
  • Falade OS, Otemuyiwa IO, Oladipo A, et al. The chemical composition and membrane stability activity of some herbs used in local therapy for anemia. J Ethnopharmacol. 2005;102:15–22.
  • Gulcin I, Oktay M, Kırecci E, et al. Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chem. 2003;83:371–382.
  • Wootton-Beard PC, Ryan L. A beetroot juice shot is a significant and convenient source of bioaccessible antioxidants. J Funct Foods. 2011;3(4):329–334.
  • El -Gamal AA, MS A, Raish M, et al. Beetroot (Beta vulgaris L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model. Mediators Inflam. 2014;3:1–12.
  • Barhe TA, Tchouya GRF. Comparative study of the antioxidant activity of the total polyphenols extracted from Hibiscus sabdariffa L., Glycine max L. Merr., yellow tea and red wine through reaction with DPPH free radicals. Arabian J Chem. 2016;9:1–8.
  • Garcia-Alonso J, Ros G, Vidal-Guevara L, et al. Acute intake of phenolic-rich juice improves antioxidant status in healthy subjects. J Nutr Res. 2006;26:330–339.
  • Wang Y, Changyun T, Zhang H. Hepatoprotective effects of kaempferol 3-O-rutinoside and kaempferol 3-O-glucoside from Carthamus tinctorius L. on CCl4-induced oxidative liver injury in mice. Food Drug J Analy. 2015;23(2):310–317.
  • World Health Organization (WHO). General guidelines for methodologies on research and evaluation of traditional medicine. Geneva: World Health Organization; 2000.
  • Mahmoodzadeh Y, Mazani M, Rezagholizadeh L. Hepatoprotective effect of methanolic Tanacetum parthenium extract on CCl4 - induced liver damage in rats. Toxicol Rep. 2017;4:455–462.
  • Wu T, Li J, Li Y, et al. Antioxidant and hepatoprotective effect of Swertiamarin on carbon tetrachloride-induced hepatotoxicity via the Nrf2/HO-1 pathway. Cell Physiol Biochem. 2017;41:2242–2254.
  • Srivastava A, Shivanandappa T. Hepatoprotective effect of the root extract of Decalepis hamiltonii against carbon tetrachloride-induced oxidative stress in rats. Food Chem. 2010;118:411–417.
  • Vitcheva V, Simeonova R, Krasteva I, et al. Protective effects of a purified Saponin mixture from Astragalus corniculatus bieb, in vivo hepatotoxicity models. Phyt Res. 2012;27(5):731–736.
  • Vulić JJ, Ćebović TN, Čanadanović‐Brunet JM, et al. In vivo and in vitro antioxidant effects of beetroot pomace extracts. J Func Foods. 2014;6:168–175.
  • Indo HP, Yen H‐C, Nakanishi I, et al. A mitochondrial superoxide theory for oxidative stress diseases and aging. J Clin Biochem Nutr. 2015;56(1):1–7.
  • Roleira FM, Tavares‐Da‐Silva EJ, Varela CL, et al. Plant derived and dietary phenolic antioxidants: anticancer properties. Food Chem. 2015;183:235–258.
  • Al-Harbi NO, Imam F, Nadeem A, et al. Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin. Intl Immunopharmacol. 2014;21(2):383–388.
  • Onoja SO, Madubuike GK, Ezeja MI. Hepatoprotective and antioxidant activity of hydromethanolic extract of Daniella oliveri leaves in carbon tetrachloride-induced hepatotoxicity in rats. J Bas Clin Physiol Pharmacol. 2015;26(5):465–470.
  • Da-Costa-Rocha I, Bonnlaender B, Sievers H, et al. Hibiscus sabdariffa L. – a phytochemical and pharmacological review. Food Chem. 2014;165:424–443.