970
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Toxic metals in cement induced hematological and DNA damage as well as carcinogenesis in occupationally-Exposed block-factory workers in Lagos, Nigeria

ORCID Icon, , , , , , & show all
Pages 499-509 | Received 03 Apr 2022, Accepted 22 Jul 2022, Published online: 11 Aug 2022

References

  • Allied Market Research (2022). Concrete block and brick manufacturing market by type (Block and Brick), application (Structural and Non-structural), and end users (Residential and Non-residential Sectors): global opportunity analysis and industry forecast, 2021-2030. Available at https://www.alliedmarketresearch.com/concrete-block-and-brick-manufacturing-market-A08300 (Accessed 2022 Mar 7).
  • NABMON (National Association of Block Moulders) (2016). SON to check production of substandard blocks. Available at https://guardian.ng/business-services/son-to-check-production-of-substandard-blocks/ (Accessed 2022 Mar 7).
  • Papesch R, Klus L, and Svoboda JR, et al. (2017). Research of cement mixtures with additions of industrial byproducts. IOP Conference Series: Earth and Environmental Science. Ostrava, Czech Republic, 92:012050
  • Yahaya T, Okpuzor J. Variation in exposure to cement dust in relation to distance from cement company. Res J Environ Toxicol. 2011;5:203–212.
  • Yahaya T, Okpuzor J, and Ajay T. The Protective Efficacy of Selected Phytonutrients on Liver Enzymes of Albino Rats Exposed To Cement Dust. IOSR Journal of Pharmacy and Biological Science (IOSR-JPBS). 2013;8(3):38–44.
  • Dunuweera SP, Rajapakse RMG. Cement types, composition, uses and advantages of nanocement, environmental impact on cement production, and possible solutions. Adv Mater Sci Eng. 2018; 4158682. DOI: 10.1155/2018/4158682
  • Akinola MO, Okwok NA, Yahaya T. The effects of cement dust on albino rats (Rattus norvegicus) around West African Portland cement factory in Sagamu, Ogun state, Nigeria. Res J Environ Toxicol. 2008;2(1):1–8.
  • Briffa J, Sinagra E, Blundell R. Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon. 2020;6(9):e04691.
  • Yan A, Wang Y, Tan SN, et al. Phytoremediation: a promising approach for revegetation of heavy metal-polluted land. Front Plant Sci. 2020;11:359.
  • Uddin MM, Zakeel MCM, Zavahir JS, et al. Heavy metal accumulation in rice and aquatic plants used as human food: a general review. Toxics. 2021;9(12):360.
  • Jaishankar M, Tseten T, Anbalagan N, et al. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol. 2014;7(2):60–72.
  • Jan AT, Azam M, Siddiqui K, et al. Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants. Int J Mol Sci. 2015;16(12):29592–29630.
  • Yahaya T, Muhammad A, Onyeziri J, et al. Health risks of ecosystem services in Ologe Lagoon, Lagos, Southwest Nigeria. Pollution. 2022;8(2):681–692.
  • Yahaya T, Oladele E, Chibs B, et al. Level and health risk evaluation of heavy metals and microorganisms in urban soils of Lagos, Southwest Nigeria. Algerian J Biosci. 2020;1(2):051–060.
  • Ladeira C, Smajdova L. The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies. AIMS genet. 2017;4(3):166–191.
  • Alrobaian M, Arida H. Assessment of heavy and toxic metals in the blood and hair of Saudi Arabia smokers using modern analytical techniques. Int J Anal Chem. 2019;2019:1–8. Article ID 7125210.
  • Onikanni AS, Lawal B, Olusola AO, et al. Leaf extract ameliorates STZ-Induced diabetes, oxidative stress, inflammation and neuronal Impairment. J Inflamm Res. 2021;14:6749–6764.
  • Luqman S, Kaushik S, Srivastava S, et al. Protective effect of medicinal plant extracts on biomarkers of oxidative stress in erythrocytes. Pharm Biol. 2009;47(6):483–490.
  • Healthline (2022). Treating and preventing cement (Concrete) chemical burns. Available from https://www.healthline.com/health/concrete-burns (Accessed 2022 Mar 11).
  • Lambers H, Piessens S, Bloem A, et al. Natural skin surface pH is on average below 5, which is beneficial for its resident flora. Int J Cosmet Sci. 2006;28(5):359–370.
  • ELCOSF (Electronic Library of Construction Occupational Safety and Health) (2022). Cement hazards and controls health risks and precautions in using Portland cement. Available from https://elcosh.org/document/1563/d000513/cement-hazards-and-controls-health-risks (Accessed 2022 Mar 11).
  • Cable J (2005). Study looks at possible link between skin exposure to silica and autoimmune disorders. Available at https://www.ehstoday.com/archive/article/21913539/study-looks-atpossible-link-between-skin-exposure-to-silica-and-autoimmune-disorders (Accessed 2022 Mar 11).
  • Shah KR, Tiwari RR. Occupational skin problems in construction workers. Indian J Dermatol. 2010;55(4):348–351.
  • Esmail RY, Sakwari GH. Occupational skin diseases among building construction workers in dar es Salaam, Tanzania. Ann Glob Health. 2021;87(1):92.
  • Jumbo-Uzosike TC, Douglas KE. Caustic cement burn in a Nigerian male: a surrogate for the state of occupational safety in Nigeria. Niger J Health. 2014;14(1):37–43.
  • Chen Y, Forgetta V, Richards JB, et al. Health effects of calcium: evidence from Mendelian randomization studies. JBMR Plus. 2021;5(11):e10542.
  • Boqué N, Valls RM, Pedret A. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep. 2021;11:16479.
  • Klotz K, Weistenhöfer W, Neff F, et al. The health effects of aluminum exposure. Dtsch Arztebl Int. 2017;114(39):653–659.
  • McDowell LA, Kudaravalli P, Sticco KL (2022). Iron overload. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526131/.
  • Barber RG, Grenier ZA, Burkhead JL. Copper toxicity is not just oxidative damage: zinc systems and insight from Wilson disease. Biomedicines. 2021;9:316.
  • Owonikoko MW, Emikpe BO, Olaleye SB. Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats. Toxicol Rep. 2021;8:1169–1178.
  • Omigie M, Agoreyo F, Agbontaen L, et al. Evaluation of serum Cd, Zn, and Cr in male cement loaders in Benin City. Nigeria. J Appl Sci Environ Manag. 2020;24(1):19–21.
  • Nwafor PC, Odukanmi OA, Salami AT, et al. Evaluation of a cement dust generation and exposure chamber for rodents: blood heavy metal status, haematological variables and gastrointestinal motility in rats. Afr J Biomed Res. 2019;22:79–87.
  • OSHA (Occupational Safety and Health Administration) (2022). Permissible exposure limits – annotated tables. Available from https://www.osha.gov/annotated-pels/table-z-1 (Accessed 2022 Mar 10).
  • Ray RR. Adverse hematological effects of hexavalent chromium: an overview. Interdiscip Toxicol. 2016;9(2):55–65.
  • Johnson LE (2021). MSD manuals: excess Cu. Available from https://www.msdmanuals.com/home/disorders-of-nutrition/minerals/copper-excess# (Accessed 2022 Mar 12).
  • Mahieu S, Carmen D, Contini M, et al. Aluminum toxicity. Hematological effects. Toxicol Lett. 2000;111(3):235–242.
  • Yahaya T, Okpuzor J, Adedayo TF. Investigation of general effects of cement dust to clear the controversy surrounding its toxicity. Asian J Sci Res. 2011;4:315–325.
  • Neboh EE, Ufelle SA, Achukwu PU, et al. Cement dust exposure affects haematological parameters in cement loaders in Enugu Metropolis, South-East Nigeria. J Exp Res. 2015;3(1):1–4.
  • Emmanuel TF, Alabi OJ. Effects of cement dust on the hematological parameters in Obajana cement factory workers. Eur Sci J. 2015;11:1857–7881.
  • MFMER (Mayo Foundation for Medical Education and Research) (2022). Complete blood count (CBC). Available from https://www.mayoclinic.org/tests-procedures/complete-blood-count/about/pac-20384919 (Accessed 2022 Mar 10).
  • Spanidis Y, Priftis A, Stagos D, et al. Oxidation of human serum albumin exhibits inter-individual variability after an ultra-marathon mountain race. Exp Ther Med. 2017;13(5):2382–2390.
  • Schomaker S, Potter D, Warner R, et al. Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments. PloS One. 2020;15(5):e0229753.
  • Nora A, Khreba M, Abdelsalam AM, et al. Kidney injury molecule 1 (KIM-1) as an early predictor for acute kidney injury in post-cardiopulmonary bypass (CPB) in open heart surgery patients. Int J Nephrol. 2019;2019:6265307.
  • Balali-Mood M, Naseri K, Tahergorabi Z, et al. Toxic mechanisms of five heavy metals: mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol. 2021;12:643972.
  • Richard EE, Nsonwu-Anyanwu A, Chinyere O, et al. Cement dust exposure and perturbations in some elements and lung and liver functions of cement factory workers. J Toxicol. 2016;2016:6104719.
  • Mandal A, Paul S. Liver enzyme status and cardiovascular parameters of construction workers from West Bengal, India. J human ergol. 2016;45(2):33–47.
  • Ogunbileje JO, Akinosun OM, Anetor JI, et al. Effects of different cement factory sections products on immunoglobulin levels and some biochemical parameters in Nigeria cement factory workers. New York Sci J. 2010;3(12):102–106.
  • UCSF (University of California San Francisco) (2022). Albumin blood (serum) test. Available from https://www.ucsfhealth.org/medical-tests/albumin-blood-(serum)-test# (Accessed 2022 Mar 10).
  • DDSG (DiasyDiagnostic Systems GmbH) (2022). Glutamate dehydrogenase (GLDH). Available from https://www.diasys-diagnostics.com/service-area/support/reference-ranges/analyte/glutamate-dehydrogenase-gldh/analyte.show (Accessed 2022 Mar 10).
  • AII (Advanced ImmunoChemical Incorporation) (2020). Kidney injury molecule-1 (KIM-1): early diagnostic urinary marker. Available at https://www.advimmuno.com/2017/06/kidney-injury-molecule-1-kim-1-early-diagnostic-urinary-marker/ (Accessed 2020 Mar 10).
  • Graille M, Wild P, Sauvain J, et al. Urinary 8-OHdG as a biomarker for oxidative stress: a systematic literature review and meta-analysis. Int J Mol Sci. 2020;21(11):3743.
  • Wong RH, Kuo CY, Hsu ML, et al. Increased levels of 8-hydroxy-2 -deoxyguanosine attributable to carcinogenic metal exposure among school children. Environ Health Perspect. 2005;113(10):1386–1390.
  • Su T, Chih-Hong P, Yuan-Ting H, et al. Effects of heavy metal exposure on shipyard welders: a cautionary note for 8-Hydroxy-2′-Deoxyguanosine. Int J Environ Res Public Health. 2019;16(23):4813.
  • Hall C, Clarke L, Pal A, et al. A review of the role of carcinoembryonic antigen in clinical practice. Ann Coloproctol. 2019;35(6):294–305.
  • Szymańska-Chabowska A, Antonowicz-Juchniewicz J, Andrzejak R. Plasma concentration of selected neoplastic markers in persons occupationally exposed to arsenic and heavy metals. Medycynapracy. 2004;55(4):313–320.
  • Abbas MB, Kredy HM, Hasan MS. Serum trace elements, heavy metals and carcinoembryonic antigen levels among postoperative colorectal cancer patients. Turk J Physiother Rehabil. 2021;32(3):19986–19993.
  • Nigar T, Goodman A, Pervin S. Total antioxidant capacity and lipid peroxidation in cervical cancer patients compared with women without cervical cancer in Bangladesh. Indian J Gynecol Oncol. 2021;19:60.
  • Stedile N, Canuto R, Col CD, et al. Dietary total antioxidant capacity is associated with plasmatic antioxidant capacity, nutrient intake and lipid and DNA damage in healthy women. Int J Food Sci Nutr. 2016;67(4):479–488.
  • Odewabi AO, Ekor M. Levels of heavy and essential trace metals and their correlation with antioxidant and health status in individuals occupationally exposed to municipal solid wastes. Toxicol Ind Health. 2017;33(5):431–442.
  • Singh Z, Karthigesu IP, Singh P, et al. Use of Malondialdehyde as a biomarker for assessing oxidative stress in different disease pathologies: a review. Iran J Public Health. 2014;43(3):7–16.
  • AL-Fartosy AJM, Awad NA, Shana SK. Biochemical correlation between some heavy metals, malondialdehyde and total antioxidant capacity in blood of gasoline station workers. Int Res J Environ Sci. 2014;3(9):1–5.
  • Sciskalska M, Zalewska M, Grzelak A, et al. The influence of the occupational exposure to heavy metals and tobacco smoke on the selected oxidative stress markers in smelters. Biol Trace Elem Res. 2014;159(1–3):59–68.
  • Orman A, Kahraman A, Cakar H, et al. Plasma malondialdehyde and erythrocyte glutathione levels in workers with cement dust- exposure [corrected]. Toxicology. 2005;207(1):15–20.
  • Afaghi A, Oryan S, Rahzani K, et al. Study on genotoxicity, oxidative stress biomarkers and clinical symptoms in workers of an asbestos-cement factory. EXCLI J. 2015;14:1067–1077.
  • Kondkar AA, Tahira S, Taif AA, et al. Increased plasma levels of 8-Hydroxy-2′-deoxyguanosine (8-OHdG) in patients with pseudoexfoliation glaucoma. J Ophthalmol. 2019;2019:8319563. Article ID.
  • CTCA (Cancer Treatment Center of America). (2022). CEA test. Available from https://www.cancercenter.com/diagnosing-cancer/lab-tests/cea-test# (Accessed 2022 Mar 10).
  • Konuganti K, Seshan H, Zope S, et al. A comparative evaluation of whole blood total antioxidant capacity using a novel nitrobluetetrazolium reduction test in patients with periodontitis and healthy subjects: a randomized, controlled trial. J Indian Soc Periodontol. 2012;16(4):620–622.
  • Angirekula S, Atti L, Atti S. Estimation of serum MDA (Malondialdehyde) in various morphological types and clinical stages of age related (senile cataract). Int J Adv Med. 2018;5:674–680.