1,335
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Young and mature leaves of Azadirachta indica (neem) display different antidiabetic and antioxidative effects

, , , , , & ORCID Icon show all
Pages 316-328 | Received 19 Nov 2022, Accepted 09 Mar 2023, Published online: 10 Apr 2023

References

  • Guariguata L, Nola T, Beagley J, et al. IDF diabetes atlas. 6th ed. Brussels, Belgium: International Diabetes Federation; 2013.
  • Chikezie PC, Ojiako OA, Nwufo KC. Overview of anti-diabetic medicinal plants: the Nigerian research experience. J Diabetes Metab. 2015;6(6):546.
  • Sanni O, Ochuko L, Erukainure Chika I, et al. Azadirachta indica inhibits key enzyme linked to type 2 diabetes in vitro, abates oxidative hepatic injury and enhances muscle glucose uptake ex vivo. Biomed Pharmacother. 2019;109:734–743.
  • Janakiraman N, SahayaSathish S, Johnson M. UV-VIS and FTIR spectroscopic studies on Peristrophe bicalyculata (Retz.) Nees. Asian J Pharm Clin Res. 2011;4(4):125–129.
  • Wylie MR, Merrell DS. The antimicrobial potential of the neem tree Azadirachta indica. Front Pharmacol. 2022;13:891535.
  • Alzohairy MA. Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid Based Complement Alternat Med. 2016;2016:7382506.
  • Sarkar S, Singh RP, Bhattacharya G. Exploring the role of Azadirachta indica (neem) and its active compounds in the regulation of biological pathways: an update on molecular approach. 3 Biotech. 2021;11(4):178.
  • Raya KB, Ahmad SH, Farhana SF, et al. Changes in phytochemical contents in different parts of Clinacanthus nutans (Burm. f.) Lindau due to storage duration. Bragantia Campinas. 2015;74(4):445–452.
  • Baby AR, Freire TB, GdA M, et al. Azadirachta indica (Neem) as a potential natural active for dermocosmetic and topical products: a narrative review. Cosmetics. 2022;9(3):58.
  • Harjai K, Bala A, Gupta RK, et al. Leaf extract of Azadirachta indica (neem): a potential antibiofilm agent for pseudomonas aeruginosa. Pathog Dis. 2013;69:62–65.
  • Graham ML, Janecek JL, Kittredge JA, et al. The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources. Comp Med. 2011;61(4):356–360.
  • Beutler E, Gelbart T, Pegelow C. Erythrocyte glutathione synthetase deficiency leads not only to glutathione but also to glutathione-S-transferase deficiency. J Clin Invest. 1986;77(1):38–41.
  • Rizvi SI, Pandey KB. Activation of the erythrocyte plasma membrane redox system by resveratrol: a possible mechanism for antioxidant properties. Pharmacol Rep. 2010;62(4):726–732.
  • Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Meth Enzymol. 1990;186:407–421.
  • Saraswat K, Kumar R, Rizvi SI. Glycolytic inhibitor 2-deoxy-D-Glucose at chronic low dose mimics calorie restriction in rats through mitohormetic induction of reactive oxygen species. Rejuvenation Res. 2019 Oct;22(5):377–384.
  • Witko-Sarsat V, Gausson V, Descamps-Latscha B. Are advanced oxidation protein products potential uremic toxins? Kidney Int. 2003;63(84):S11–14.
  • Stadtman ER, Levine RL. Protein oxidation. Ann N Y Acad Sci. 2000;899(1):191–208.
  • Kumar R, Akhtar F, Rizvi SI. Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat. Clin Exp Pharmacol Physiol. 2020 Apr;47(4):571–582. DOI:10.1111/1440-1681.13221.
  • Sánchez-Gómez FJ, Espinosa-Díez C, Dubey M, et al. S-glutathionylation: relevance in diabetes and potential role as a biomarker. Biol Chem. 2013;394(10):1263–1280.
  • Mohan CG, Deepak M, Viswanatha GL, et al. Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica. Asian Pac J Trop Med. 2013;6(4):311–314.
  • Selmeci L, Seres L, Antal M, et al. Advanced oxidation protein products (AOPP) for monitoring oxidative stress in critically ill patients: a simple, fast and inexpensive automated technique. Clin. Chem Lab Med. 2005;43(3):294–297.
  • Nemzer BV, Rodriguez LC, Hammond L, et al. Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization. Nutr J. 2011;10(67):1–11.
  • Taylor EL, Armstrong KR, Perrett D, et al. Optimisation of an advanced oxidation protein products assay: its application to studies of oxidative stress in diabetes mellitus. Oxid Med Cell Longev. 2015;2015:496271.
  • Conti G, Caccamo D, Siligato R, et al. Association of Higher Advanced Oxidation Protein products (AOPPs) levels in patients with diabetic and hypertensive nephropathy. Med (Kaunas). 2019;55(10):675. DOI:10.3390/medicina55100675
  • Zhou LL, Cao W, Xie C, et al. The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis. Kidney Int. 2012;82(7):759–770. DOI:10.1038/ki.2012.184
  • Guo ZJ, Niu HX, Hou FF, et al. Advanced oxidation protein products activate vascular endothelial cells via a RAGE-Mediated signaling pathway. Antioxid Redox Signal. 2008;10(10):1699–1712. DOI:10.1089/ars.2007.1999
  • Podkowińska A, Formanowicz D. Chronic kidney disease as oxidative stress- and inflammatory-mediated cardiovascular disease. Antioxidants. 2020;9(8):752.
  • Sies H. Polyphenols and health: update and perspectives. Arch Biochem Biophys. 2010;501(1):2–5.
  • Fraga CG. Plant polyphenols: how to translate their in vitro antioxidant actions to in vivo conditions. IUBMB Life. 2007;59(4–5):308–315.
  • Greenberg ME, Li XM, Gugiu BG, et al. The lipid whisker model of the structure of oxidized cell membranes. J Biol Chem. 2008;283(4):2385–2396.
  • Pandey KB, Mehdi MM, Maurya PK, et al. Plasma protein oxidation and its correlation with antioxidant potential during human aging. Dis Markers. 2010;28(1):1–6.
  • Rizvi SI, Srivastava N. Erythrocyte plasma membrane redox system in first degree relatives of type 2 diabetic patients. Int J Diabetes Mellitus. 2010;2(2):119–121.
  • Cheng B, Xie R, Dong L, et al. Metabolic remodeling of cell-surface sialic acids: principles, applications, and recent advances. Chembiochem. 2016;17(1):11.
  • Tiwari BK, Kumar D, Abidi AB, et al. Efficacy of composite extract from leaves and fruits of medicinal plants used in traditional diabetic therapy against oxidative stress in alloxan-induced diabetic rats. ISRN Pharmacol. 2014;Volume:7. Article ID 608590. DOI:10.1155/2014/608590.
  • Liu Y, Hu H. Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab Dispos. 2002;30(4):370–377.
  • Dalle-Donne I, Rossi R, Giustarini D, et al. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta. 2003;329(1–2):23–38.
  • Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem. 1997;272(33):20313–20316.
  • Benzie IFF, Strain JJ. The ferric reducing ability of plasma(FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 1996; 239(1):70–76.
  • Martín JA, Solla A, Woodward S, Gil L. Fourier transform-infrared spectroscopy as a new method for evaluating host resistance in the Dutch elm disease complex. Tree Physiology 2005; 25, 1331–1338.
  • Chait A, den Hartigh LJ. Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease. Front Cardiovasc Med. 2020;7:22.