Taurine and N-acetylcysteine reverse reproductive and neuroendocrine dysfunctions in levetiracetam-treated epileptic male rats

References

• Beghi E, Giussani G, Sander JW. The natural history and prognosis of epilepsy. Epileptic Disord. 2015;17(3):243–253. doi: 10.1684/epd.2015.0751
   PubMed Web of Science ®Google Scholar
• Thijs RD, Surges R, O’Brien TJ, et al. Epilepsy in adults. Lancet. 2019;393(10172):689–701. doi: 10.1016/S0140-6736(18)32596-0 (London, England).
   PubMed Web of Science ®Google Scholar
• Wang A, Si Z, Li X, et al. FK506 attenuated pilocarpine-induced epilepsy by reducing inflammation in rats. Front Neurol. 2019;10:971. doi: 10.3389/fneur.2019.00971
   PubMed Web of Science ®Google Scholar
• Ahmed JI, Che HA. The evolution of the pilocarpine animal model of status epilepticus. Heliyon. 2020;6(7):e04557. doi: 10.1016/j.heliyon.2020.e04557
   PubMed Web of Science ®Google Scholar
• Svalheim S, Sveberg L, Mochol M, et al. Interactions between antiepileptic drugs and hormones. Seizure [ pmid:25797888]. 2015;28:12–17. doi: 10.1016/j.seizure.2015.02.022
   PubMed Web of Science ®Google Scholar
• Montouris G, Morris GL. Reproductive and sexual dysfunction in men with epilepsy. Epilepsy Behav. 2005;7(2):S7–14. doi: 10.1016/j.yebeh.2005.08.026
   PubMedGoogle Scholar
• Morris GL, Vanderkolk C. Human sexuality, sex hormones, and epilepsy. Epilepsy Behav. 2005;7(2):S22–S28. doi: 10.1016/j.yebeh.2005.08.028 E&B.
   PubMedGoogle Scholar
• Calabrò RS, Marino S, Bramanti P. Sexual and reproductive dysfunction associated with antiepileptic drug use in men with epilepsy. Expert Rev Neurother. 2011;11(6):887–895. doi: 10.1586/ern.11.58 pmid:21651335.
   PubMed Web of Science ®Google Scholar
• Herzog AG, Coleman AE, Jacobs AR, et al. Interictal EEG discharges, reproductive hormones, and menstrual disorders in epilepsy. Ann Neurol. 2003 Nov;54(5):625–637. doi: 10.1002/ana.10732
   PubMed Web of Science ®Google Scholar
• Baysal M, Ilgin S, Kilic G, et al. Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress. PLoS One. 2017;12(4):e0175990. doi: 10.1371/journal.pone.0175990
   PubMed Web of Science ®Google Scholar
• Roste LS, Taubol E. Women and epilepsy: review and practical recommendations. Expert RevNeurother. 2007;7(3):289–300. doi: 10.1586/14737175.7.3.289
   PubMedGoogle Scholar
• Roste LS, Tauboll E, Haugen TB, et al. Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. Eur J Neurol. 2003;10(5):501–506. doi: 10.1046/j.1468-1331.2003.00615.x
   PubMed Web of Science ®Google Scholar
• Harden CL. Sexuality in men and women withepilepsy. CNSSpectr. 2006;11(8, suppl 9):13–18. doi: 10.1017/S1092852900026717
   Google Scholar
• Lyseng-Williamson KA. Levetiracetam: a review of its use in epilepsy. Drugs. 2011;71(4):489–514. doi: 10.2165/11204490-000000000-00000 pmid:21395360.
   PubMed Web of Science ®Google Scholar
• Kwong KL, Tsui KW, Wu SP, et al. Utilization of antiepileptic drugs in Hong Kong children. Pediatr Neurol. 2012;46(5):281–286. pmid:22520348. doi: 10.1016/j.pediatrneurol.2012.02.019
   PubMed Web of Science ®Google Scholar
• Spencer D. Levetiracetam in men with epilepsy: Testosterone is left alone but sperm count is paramount. Epilepsy Curr. 2017;17(2):99–100. doi: 10.5698/1535-7511.17.2.99
   PubMed Web of Science ®Google Scholar
• Li Y, Peng Q, Shang J, et al. The role of taurine in male reproduction: Physiology, pathology and toxicology. Front Endocrinol (Lausanne). 2023 Jan 18;14:1017886. doi: 10.3389/fendo.2023.1017886
   PubMed Web of Science ®Google Scholar
• Elsayed A, Elkomy A, Alkafafy M, et al. Testicular toxicity of cisplatin in rats: ameliorative effect of lycopene and N-acetylcysteine. Environ Sci Pollut Res. 2022 Apr;1:1–8.
   Google Scholar
• Emojevwe V, Nwangwa EK, Naiho AO, et al. Toxicological outcome of phthalate exposure on male fertility: ameliorative impacts of the co-administration of N-acetylcysteine and zinc sulfate in rats. Middle East Fertil Soc J. 2022;27(1). doi: 10.1186/s43043-022-00096-5
   Web of Science ®Google Scholar
• Oyovwi MO, Oghenetega OB, Victor E, et al. Quercetin protects against levetiracetam induced gonadotoxicity in rats. Toxicology. 2023 Jun 1;491:153518. doi: 10.1016/j.tox.2023.153518
   PubMed Web of Science ®Google Scholar
• Oyovwi MO, Nwangwa EK, Ben-Azu B, et al. Prevention and reversal of chlorpromazine induced testicular dysfunction in rats by synergistic testicle-active flavonoids, taurine and coenzyme-10. Reprod Toxicol. 2021 Apr 1;101:50–62. doi: 10.1016/j.reprotox.2021.01.013
   PubMed Web of Science ®Google Scholar
• Toishi Y, Tsunoda N, Nagata SI, et al. Evaluation of the chemiluminescent enzyme immunoassay system for the measurement of testosterone in the serum and whole blood of stallions. J Reprod Dev. 2018;64(1):41–47. doi: 10.1262/jrd.2017-099
   PubMed Web of Science ®Google Scholar
• Omirinde JO, Olukole SG, Oke BO. Age-related changes in the testicular and epididymal sperm parameters in the African greater cane rat (Thryonomys Swinderianus, Temminck, 1827). Anim Res Int. 2019;16:3255–3264.
   Google Scholar
• Yu S, Rubin M, Geevarughese S, et al. Emerging technologies for home-based semen analysis. Andrology. 2018;6(1):10–19. doi: 10.1111/andr.12441
   PubMed Web of Science ®Google Scholar
• Oyovwi MO, Ben-Azu B, Edesiri TP, et al. Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: the implications for neuroendopathobiological changes during chemotherapy. Biomed Pharmacother. 2021;2021b(142):112022. doi: 10.1016/j.biopha.2021.112022
   Google Scholar
• Selvam MKP, Agarwal A. A systematic review on sperm DNA fragmentation in male factor infertility: laboratory asses. Arab J Urol. 2018;16(1):65–76. doi: 10.1016/j.aju.2017.12.001
   PubMed Web of Science ®Google Scholar
• Leite JP, Garcia-Cairasco N, Cavalheiro EA. New insights from the use of pilocarpine and kainate models. Epilepsy Res. 2002;50(1–2):93–103. doi: 10.1016/S0920-1211(02)00072-4
   PubMed Web of Science ®Google Scholar
• Kandratavicius L, Monteiro MR, Assirati JA, et al. Neurotrophins in mesial temporal lobe epilepsy with and without psychiatric comorbidities. J Neuropathol Exp Neurol. 2013;72(11):1029–1042. doi: 10.1097/NEN.0000000000000002
   PubMed Web of Science ®Google Scholar
• Kandratavicius L, Rosa-Neto P, Monteiro MR, et al. Distinct increased metabotropic glutamate receptor type 5 (mGlur5) in temporal lobe epilepsy with and without hippocampal sclerosis. Hippocampus. 2013;23(12):1212–1230. doi: 10.1002/hipo.22160
   PubMed Web of Science ®Google Scholar
• Wang L, Yuan LL. (Activation of M2 muscarinic receptors leads to sustained suppression of hippocampal transmission in the medial prefrontal cortex. Journal Of Physiology. 2009;587(Pt 21):5139–5147. doi: 10.1113/jphysiol.2009.174821
   PubMed Web of Science ®Google Scholar
• Deshpande LS, Delorenzo RJ. Mechanisms of levetiracetam in the control of status epilepticus and epilepsy. Front Neurol. 2004;5:11. doi: 10.3389/fneur.2014.00011
   Google Scholar
• Victor E, Osarugue I, Oyovwi Mega Obukohwo N, et al. Endocrine functions of the testes. (BOOK CHAPTER ON MALE REPRODUCTIVE ANATOMY). 2022c DOI. doi:10.5772/intechopen.101170
   Google Scholar
• Oyovwi Mega Obukohwo, Eze Kingsley N, Mega Obukohwo O, et al. Rotu arientare rume and emojevwe victor. the concept of male reproductive anatomy. In: Wu W, editor. (BOOK CHAPTER on male reproductive anatomy by. IntechOpen; 2022d. pp. 3–34. doi: 10.5772/intechopen.94696)
   Google Scholar
• Oyovwi MO, Ben-Azu B, Edesiri TP, et al. Lutein attenuates cyclosporin-induced testicular impairment in male rats through modulation of androgenic hormones and enzymes. Pharmacol Toxicol. 2022 Feb 12;2(1):12–24. doi: 10.52406/ptnm.v2i1.17
   Google Scholar
• Skorupskaite K, George JT, Anderson RA. The kisspeptin-GnRH pathway in human reproductive health and disease. Human Reproduction Update. 2014;20(4):485–500. doi: 10.1093/humupd/dmu009
   PubMed Web of Science ®Google Scholar
• Güveli BT, Rosti RÖ, Güzeltaş A, et al. Teratogenicity of antiepileptic drugs. Clin Psychopharmacol Neurosci. 2017;15(1):19–27. doi: 10.9758/cpn.2017.15.1.19
   PubMed Web of Science ®Google Scholar
• Suarez SS, Pacey AA. Sperm transport in the female reproductive tract. Human Reproduction Update. 2006 January/February;12(1):23–37. doi: 10.1093/humupd/dmi047
   PubMed Web of Science ®Google Scholar
• Agarwal A, Virk G, Ong C, et al. Effect of oxidative stress on male reproduction. World J Mens Health. 2014;32(1):1–17. doi: 10.5534/wjmh.2014.32.1.1
   PubMedGoogle Scholar
• Alahmar AT. Role of oxidative stress in male infertility: an updated review. J Hum Reprod Sci. 2019;12(1):4–18. doi: 10.4103/jhrs.JHRS_150_18
   PubMedGoogle Scholar
• Shukry M, Alotaibi SS, Albogami SM, et al. Garlic alleviates the injurious impact of cyclosporine-A in male rats through modulation of fibrogenic and steroidogenic genes. Animals. 2020;11(1):64. doi: 10.3390/ani11010064
   Web of Science ®Google Scholar
• Cheng CY, Mruk DD, Sibley DR. The blood-testis barrier and its implications for male contraception. Pharmacol Rev. 2012;64(1):16–64. doi: 10.1124/pr.110.002790
   PubMed Web of Science ®Google Scholar