Cyperus esculentus extract mitigates sertraline-induced behavioral and histopathological changes in the brain of rats

References

• Qiao Y, Li C, Zhang M, et al. Effects of Tibetan medicine metacinnabar (β-HgS) combined with imipramine or sertraline on depression-like symptoms in mice. Front Pharmacol. 2022;13:971243.
   PubMed Web of Science ®Google Scholar
• Onaolapo AY, Sulaiman H, Olofinnade AT, et al. Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: highlighting effects on behaviour, oxidative stress, and neuroinflammation. World J Pharm. 2022;11(3):27–47. doi: 10.5497/wjp.v11.i3.27
   Google Scholar
• Kafetzopoulos V, Kokras N, Sousa N, et al. Nucleus reuniens lesion and antidepressant treatment prevent hippocampal neurostructural alterations induced by chronic mild stress in male rats. Neuroscience. 2021;454:85–93. doi: 10.1016/j.neuroscience.2020.08.017
   PubMed Web of Science ®Google Scholar
• Istifli ES, Çelik R, Hüsunet MT, et al. In vitro cytogenotoxic evaluation of sertraline. Interdiscip Toxicol. 2018;11(3):181–188. doi: 10.2478/intox-2018-0015
   PubMedGoogle Scholar
• Ľupták M, Fišar Z, Hroudová J. Different effects of SSRIs, Bupropion, and Trazodone on Mitochondrial Functions and Monoamine oxidase isoform activity. Antioxidants. 2023;12(6):1208. doi: 10.3390/antiox12061208
   Web of Science ®Google Scholar
• Sayed DA. The protective effect of Nigella sativa oil against reproductive toxicity, hormonal alterations, and oxidative damage induced by Sertraline in male rats. Egypt J Exp Biol (Zoo). 2019;15(1):1–77. doi: 10.5455/egysebz.20190325113108
   Google Scholar
• Louei Monfared A, Yousefizadeh S. Curcumin Ameliorates Sertraline-mediated testicular toxicity in rats via inhibition of oxidative stress. Iran J Toxicol. 2023;17(1):25–34. doi: 10.32598/IJT.17.1.977.1
   Google Scholar
• Elkelany MM, Kashef SM. Role of spirulina extract in ameliorating histological and immunohistochemical changes induced by sertraline in the testis of adult albino rat. Egypt J Histol. 2021. doi: 10.21608/ejh.2021.91359.1545
   Google Scholar
• Prajapati NB, Gupta SD, Sood SV, et al. Antidepressants and seizure threshold: a case report on sertraline-induced seizure. Apollo Medicine. 2023;20(Suppl 2):S70–S72. doi: 10.4103/am.am_79_23
   Google Scholar
• Abdel-Salam OM, Youness ER, Khadrawy YA, et al. Brain and liver oxidative stress after sertraline and haloperidol treatment in mice. J Basic Clin Physiol Pharmacol. 2013;24(2):115–123. doi: 10.1515/jbcpp-2012-0022
   PubMedGoogle Scholar
• Yang H, Gu X, Chen H, et al. Transcriptome profiling reveals toxicity mechanisms following sertraline exposure in the brain of juvenile zebrafish (danio rerio). Ecotoxicol Environ Saf. 2022;242:113936. doi: 10.1016/j.ecoenv.2022.113936
   PubMed Web of Science ®Google Scholar
• Chen H, Liang X, Gu X, et al. Environmentally relevant concentrations of sertraline disrupts behavior and the brain and liver transcriptome of juvenile yellow catfish (tachysurus fulvidraco): implications for the feeding and growth axis. J Hazard Mater. 2021;409:124974. doi: 10.1016/j.jhazmat.2020.124974
   PubMed Web of Science ®Google Scholar
• Lozano AFQ, Moura MS, Tavares BM, et al. Exposure of pregnant rats to stress and/or sertraline: side effects on maternal health and neurobehavioral development of male offspring. Life Sci. 2021;285:119960. doi: 10.1016/j.lfs.2021.119960
   PubMed Web of Science ®Google Scholar
• Jing S-Q, Wang S-S, Zhong R-M, et al. Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury. Neural Regen Res. 2020;15(3):548. doi: 10.4103/1673-5374.266063
   PubMed Web of Science ®Google Scholar
• Arogundade T, Yawson E, Gbadamosi I, et al. Behavioural cellular and neurochemical alterations in rat prefrontal cortex and hippocampus exposed to tigernut (Cyperus esculentus) treatment. J Environ Toxicol Public Health. 2018;3:38–46.
   Google Scholar
• Saeed MM, Fernández-Ochoa Á, Saber FR, et al. The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches. Molecules. 2022;27(20):7118. doi: 10.3390/molecules27207118
   PubMed Web of Science ®Google Scholar
• Udefa AL, Amama EA, Archibong EA, et al. Antioxidant, anti-inflammatory and anti-apoptotic effects of hydro-ethanolic extract of Cyperus esculentus L.(tigernut) on lead acetate-induced testicular dysfunction in Wistar rats. Biomed Pharmacother. 2020;129(129):110491. doi: 10.1016/j.biopha.2020.110491
   PubMedGoogle Scholar
• Umukoro S, Okoh L, Igweze SC, et al. Protective effect of Cyperus esculentus (tiger nut) extract against scopolamine-induced memory loss and oxidative stress in mouse brain. Drug Metabol Personal Ther. 2020;35(3):20200112. doi: 10.1515/dmpt-2020-0112
   Google Scholar
• Ntukidem V, Ukwo P, Udoh I, Umoinyang E. Influence of different pretreatments on the nutritional and organoleptic properties of vegetable milk produced locally from tiger-nut (Cyperus esculentus) tubers. IOSR-JESTFT. 2019;13(6): 55–61. doi: 10.9790/2402-1306025561
   Google Scholar
• Adebayo-Oyetoro AO, Ogundipe OO, Adeyeye SAO, et al. Production and evaluation of tiger nut (Cyperus esculentus) milk flavoured with Moringa oleifera leaf extract. Curr Res Nutr Food Sci. 2019;7(1):265–271. doi: 10.12944/CRNFSJ.7.1.26
   Web of Science ®Google Scholar
• Willis S, Jackson C, Verghese M. Effects of processing on antioxidant capacity and metabolizing enzyme inhibition of tiger nut tubers. Food Nutr Sci. 2019;10(9):1132. doi: 10.4236/fns.2019.109082
   Google Scholar
• Imam T, Aliyu F, Umar H. Preliminary phytochemical screening, elemental and proximate composition of two varieties of Cyperus esculentus (tiger nut). Nig J Bas App Sci. 2013;21(4):247–251. doi: 10.4314/njbas.v21i4.1
   Google Scholar
• Selma-Royo M, García-Mantrana I, Collado MC, et al. Intake of natural, unprocessed tiger nuts (Cyperus esculentus L.) drink significantly favors intestinal beneficial bacteria in a short period of time. Nutrients. 2022;14(9):1709. doi: 10.3390/nu14091709
   PubMed Web of Science ®Google Scholar
• Nwosu LC, Edo GI, E Ö. The phytochemical, proximate, pharmacological, GC-MS analysis of Cyperus esculentus (tiger nut): a fully validated approach in health, food and nutrition. Food Biosci. 2022;46:101551. doi: 10.1016/j.fbio.2022.101551
   Web of Science ®Google Scholar
• Adebisi I, Mahmud M, Ibrahim Y, et al. Exacerbation of symptoms of renal toxicity by aqueous extract of Cyperus esculentus in a gentamicin nephrotoxicity Model. Nig J Bas App Sci. 2022;30(2):139–146. doi: 10.4314/njbas.v30i2.19
   Google Scholar
• Bezerra MS, Martins ABM, Trajano FMG, et al. Fluoxetine and sertraline effects on rat distal cauda epididymis contraction, sperm count and sperm transit time trough epididymis. Eur J Pharmacol. 2019;865(865):172774. doi: 10.1016/j.ejphar.2019.172774
   PubMedGoogle Scholar
• Misik J, Kassa J. A comparison of cholinesterase inhibitors in the treatment of quinuclidinyl benzilate-induced behavioural deficit in rats performing the multiple T-maze. J Appl Biomed. 2014;12(4):211–217. doi: 10.1016/j.jab.2014.01.006
   Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–358. doi: 10.1016/0003-2697(79)90738-3
   PubMed Web of Science ®Google Scholar
• Sandouka S, Shekh-Ahmad T. Induction of the Nrf2 pathway by sulforaphane is neuroprotective in a rat temporal lobe epilepsy model. Antioxidants. 2021;10(11):1702. doi: 10.3390/antiox10111702
   Web of Science ®Google Scholar
• Aebi H. [13] Catalase in vitro. Methods Enzymol. 1984;105:121–126. Elsevier.
   PubMed Web of Science ®Google Scholar
• Nishikimi M, Rao NA, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 1972;46(2):849–854. doi: 10.1016/S0006-291X(72)80218-3
   PubMed Web of Science ®Google Scholar
• Jiang H, Li F, Liu S, et al. Acute pancreatitis affects the metabolism of catecholamine neurotransmitters in rats. Neuroscience. 2014;268:112–117. doi: 10.1016/j.neuroscience.2014.03.022
   PubMed Web of Science ®Google Scholar
• Bancroft JD, Layton C. 10 - the hematoxylins and eosin. In: Suvarna S, Layton C, and Bancroft J, editors Bancroft’s theory and practice of histological techniques. 8th ed. China: Elsevier; 2019. pp. 126–138.
   Google Scholar
• Varghese F, Bukhari AB, Malhotra R, et al. IHC profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PLoS One. 2014;9(5):e96801. doi: 10.1371/journal.pone.0096801
   PubMed Web of Science ®Google Scholar
• Ogunsuyi OB, Omage FB, Ijomone OM, et al. Effect of chlorogenic acid plus donepezil on critical neurocortical enzyme activities, inflammatory markers, and synaptophysin immunoreactivity in scopolamine‐assaulted rats, supported by multiple ligand simultaneous docking. J Food Biochem. 2022;46(11):e14312. doi: 10.1111/jfbc.14312
   PubMed Web of Science ®Google Scholar
• Sharma N, Jamwal S, Kumar P. Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats. Pathophysiology. 2016;23(2):123–134. doi: 10.1016/j.pathophys.2016.03.002
   PubMedGoogle Scholar
• Ilgin S, Kilic V, Baysal M, et al. Evidence for cardiotoxicity associated with sertraline in rats. Toxicol Res. 2018;7(5):817–825. doi: 10.1039/C8TX00072G
   Web of Science ®Google Scholar
• Almansour MI, Jarrar YB, Jarrar BM. In vivo investigation on the chronic hepatotoxicity induced by sertraline. Environ Toxicol Pharmacol. 2018;61(61):107–115. doi: 10.1016/j.etap.2018.05.021
   PubMedGoogle Scholar
• Matt S, Nolan R, Channer B, et al. Antidepressants and dopamine levels induced by substance misuse regulate inflammation and HIV in Myeloid Cells. JPET. 2023;385:271.
   Web of Science ®Google Scholar
• Cai L, Wang C, Huo X-K, et al. Effect of alkaloids isolated from phyllodium pulchellum on monoamine levels and monoamine oxidase activity in rat brain. Evid Based Complement Alternat Med. 2016;2016:1–6. doi: 10.1155/2016/6826175
   Web of Science ®Google Scholar
• Arihan O, Yabanoglu SC, Ucar G, et al. Effects of two selected SSRIs on hemorheological parameters in rats. Clin Hemorheol Microcirc. 2019;71(1):27–38. doi: 10.3233/CH-170353
   PubMed Web of Science ®Google Scholar
• Azimzadeh K, Jafarpour H, Adldoost S. Sertraline alters level of adenosine deaminase activity, oxidative stress markers and cardiac biomarkers (homocysteine cardiac troponin I) in rats. Pharma Biomed Res. 2017;3(3):17–22. doi: 10.29252/pbr.3.3.17
   Google Scholar
• Liaquat L, Sadir S, Batool Z, et al. Acute aluminum chloride toxicity revisited: study on DNA damage and histopathological, biochemical and neurochemical alterations in rat brain. Life Sci. 2019;217:202–211. doi: 10.1016/j.lfs.2018.12.009
   PubMed Web of Science ®Google Scholar
• Ugbaja RN, Akinhanmi TF, Onunkwor BO, et al. Flavonoid-rich fractions of C. volubile and V. amygdalina alleviates arsenic-induced neurotoxicity by improving neurosignaling and antioxidant capacity in rats’ brain. Brain Disord. 2022;1–11. doi: 10.1016/j.dscb.2022.100050
   Google Scholar
• Owoeye O, Salami O. Monosodium glutamate toxicity: Sida acuta leaf extract ameliorated brain histological alterations, biochemical and haematological changes in wistar rats. Afr J Biomed Res. 2017;20(2):173–182.
   Google Scholar
• Bauchi Z, Kizito D, Alhassan A, et al. Effect of aqueous seed extract of Nigella sativa on lead-induced cerebral cortex toxicity in long evans rats. Bayero J Pure App Sci. 2016;9(1):48–52. doi: 10.4314/bajopas.v9i1.8
   Google Scholar
• Abou-Zeid SM, Tahoun EA, AbuBakr HO. Ameliorative effects of jojoba oil on fipronil-induced hepatorenal-and neuro-toxicity: the antioxidant status and apoptotic markers expression in rats. Environ Sci Pollut Res. 2021;28(20):25959–25971. doi: 10.1007/s11356-020-12083-2
   PubMed Web of Science ®Google Scholar
• Mandour DA, Bendary M, Alsemeh AE. Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid “hesperidin”. J Mol Histol. 2021;52(5):1043–1065. doi: 10.1007/s10735-021-09998-6
   PubMed Web of Science ®Google Scholar
• Niu H-M, Ma D-L, Wang M-Y, et al. Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model. Brain Res Bull. 2020;162:132–140. doi: 10.1016/j.brainresbull.2020.06.012
   PubMed Web of Science ®Google Scholar
• Shalaby AM, Sharaf Eldin HE, Abdelsameea AA, et al. Betahistine attenuates seizures, neurodegeneration, apoptosis, and Gliosis in the Cerebral Cortex and hippocampus in a mouse Model of epilepsy: a histological, immunohistochemical, and biochemical study. Microsc Microanal. 2022;28(5):1734–1748. doi: 10.1017/S1431927622012107
   Web of Science ®Google Scholar
• Abd Elmaaboud MA, Awad MM, El-Shaer RA, et al. The immunomodulatory effects of ethosuximide and sodium butyrate on experimentally induced fibromyalgia: the interaction between IL-4, synaptophysin, and TGF-β1/NF-κB signaling. Int Immunopharmacol. 2023;118(118):110061. doi: 10.1016/j.intimp.2023.110061
   PubMedGoogle Scholar
• Farag EA, Filobbos SA, Afifi NM, et al. Thyroxine restores hippocampal neurogenesis and synaptogenesis in a male rat model of carbimazole-induced hypothyroidism: a histological study. Beni-Suef Univ J Basic Appl. 2023;12(1):1–17. doi: 10.1186/s43088-023-00395-4
   Google Scholar
• Josiah SS, Umar HI, Saliu IO, et al. Quercetin and catechin assuage redox imbalance and neurochemical dysfunction in rotenone-induced neurotoxicity: a comparative in vivo experiment supported by in silico study. Phytomed Plus. 2021;1(4):100077. doi: 10.1016/j.phyplu.2021.100077
   Google Scholar
• Zhu LJ, Zhang C, Chen C. Research progress on vesicle cycle and neurological disorders. J Pharm Pharm Sci. 2021;24:400–412. doi: 10.18433/jpps31458
   PubMed Web of Science ®Google Scholar
• Kumar B, Kumar V, Prashar V, et al. Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase. Eur J Med Chem. 2019;177(177):221–234. doi: 10.1016/j.ejmech.2019.05.039
   PubMedGoogle Scholar
• Rad I, Salari M, Dehghani A, et al. Effect of chronic exposure to sertraline on social and cognitive behavior of adult male and female rats under social isolation stress. Learn Motiv. 2022;78:101807. doi: 10.1016/j.lmot.2022.101807
   Web of Science ®Google Scholar
• Patil SS, Sunyer B, Höger H, et al. Evaluation of spatial memory of C57BL/6J and CD1 mice in the Barnes maze, the Multiple T-maze and in the Morris water maze. Behav Brain Res. 2009;198(1):58–68. doi: 10.1016/j.bbr.2008.10.029
   PubMed Web of Science ®Google Scholar
• Owoeye O, Akinbami R, Thomas M. Neuroprotective potential of Citrullus lanatus seed extract and vitamin E against mercury chloride intoxication in male rat brain. Afr J Biomed Res. 2018;21(1):43–49.
   Google Scholar
• Adefegha SA, Dada FA, Oyeleye SI, et al. Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats. J Basic Clin Physiol Pharmacol. 2021;33(4):389–397. doi: 10.1515/jbcpp-2020-0173
   PubMedGoogle Scholar
• Olajide OJ, Gbadamosi IT, Yawson EO, et al. Hippocampal degeneration and behavioral impairment during Alzheimer-like pathogenesis involves glutamate excitotoxicity. J Mol Neurosci. 2021;71(6):1205–1220. doi: 10.1007/s12031-020-01747-w
   PubMed Web of Science ®Google Scholar
• Badgujar SB, Bandivdekar AH. Evaluation of a lactogenic activity of an aqueous extract of Cyperus rotundus Linn. J Ethnopharmacol. 2015;163(163):39–42. doi: 10.1016/j.jep.2015.01.019
   PubMedGoogle Scholar
• Ekpenyong NE, Ogar OP, Ekpo, AE. Feeding Value of Tiger Nut (Cyperus Esculentus) Meal for Growing Rabbits. Sumerianz Journal of Agriculture and Veterinary. 2020;3(7):85–89.
   Google Scholar
• Enye LA, Edem EE, Onyeogaziri LI, et al. Tiger nut/coconut dietary intervention as antidotal nutritional remediation strategy against neurobehavioural deficits following organophosphate-induced gut-brain axis dysregulation in mice. Toxicol Rep. 2024;12:23–40. doi: 10.1016/j.toxrep.2023.12.003
   PubMedGoogle Scholar
• Dhiman P, Malik N, Sobarzo-Sánchez E, et al. Quercetin and related chromenone derivatives as monoamine oxidase inhibitors: targeting neurological and mental disorders. Molecules. 2019;24(3):418. doi: 10.3390/molecules24030418
   PubMed Web of Science ®Google Scholar
• Allouh MZ, Daradka HM, Ghaida JHA. Influence of Cyperus esculentus tubers (Tiger Nut) on male rat copulatory behavior. BMC Complement Altern Med. 2015;15(1):1–7. doi: 10.1186/s12906-015-0851-9
   PubMedGoogle Scholar