Unlocking the impact of translocated promoter region (TPR) on autophagy and cancer progression

References

• Wong RW, New activities of the nuclear pore complexes.Cells, 2021. 10(8). doi: 10.3390/cells10082123
   Web of Science ®Google Scholar
• Hase ME, Cordes VC, Direct interaction with nup153 mediates binding of tpr to the periphery of the nuclear pore complex. Mol Biol Cell, 2003. 14(5):1923–1940. doi: 10.1091/mbc.e02-09-0620
   PubMed Web of Science ®Google Scholar
• Fontoura BM, Dales S, Blobel G, et al. The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR. Proc Natl Acad Sci U S A. 2001;98(6):3208–3213. doi: 10.1073/pnas.061014698
   PubMed Web of Science ®Google Scholar
• Dewi FRP, Domoto T, Hazawa M, et al., Colorectal cancer cells require glycogen synthase kinase-3beta for sustaining mitosis via translocated promoter region (TPR)-dynein interaction. Oncotarget, 2018. 9(17):13337–13352. doi: 10.18632/oncotarget.24344
   PubMedGoogle Scholar
• Nakano H, Funasaka T, Hashizume C, et al. Nucleoporin translocated promoter region (tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis. J Biol Chem. 2010;285(14):10841–10849. doi: 10.1074/jbc.M110.105890
   PubMed Web of Science ®Google Scholar
• Rajanala K, Sarkar A, Jhingan GD et al., Correction: phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function. J Cell Sci, 2022. 135(6). doi: 10.1242/jcs.260004
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature. 2008;451(7182):1069–1075. doi: 10.1038/nature06639
   PubMed Web of Science ®Google Scholar
• Kraft C, Martens S. Mechanisms and regulation of autophagosome formation. Curr Opin Cell Biol. 2012;24(4):496–501. doi: 10.1016/j.ceb.2012.05.001
   PubMed Web of Science ®Google Scholar
• Maiuri MC, Tasdemir E, Criollo A, et al. Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ. 2009;16(1):87–93. doi: 10.1038/cdd.2008.131
   PubMed Web of Science ®Google Scholar
• Mah LY, O’Prey J, Baudot AD, et al. DRAM-1 encodes multiple isoforms that regulate autophagy. Autophagy. 2012;8(1):18–28. doi: 10.4161/auto.8.1.18077
   PubMed Web of Science ®Google Scholar
• Yun CW, Lee SH, The roles of autophagy in cancer. Int J Mol Sci, 2018. 19(11). 19 11. doi: 10.3390/ijms19113466
   Web of Science ®Google Scholar
• Rosenfeldt MT, Ryan KM. The multiple roles of autophagy in cancer. Carcinogenesis. 2011;32(7):955–963. doi: 10.1093/carcin/bgr031
   PubMed Web of Science ®Google Scholar
• Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Cancer Res. 2014;74(3):647–651. doi: 10.1158/0008-5472.CAN-13-2966
   PubMed Web of Science ®Google Scholar
• Comel A, Sorrentino G, Capaci V, et al., The cytoplasmic side of p53‘s oncosuppressive activities.FEBS Lett, 2014. 588(16):2600–2609. doi: 10.1016/j.febslet.2014.04.015
   PubMed Web of Science ®Google Scholar
• Choi AM, Ryter SW, Levine B, Autophagy in human health and disease. N Engl J Med, 2013. 368(7):651–662. doi: 10.1056/NEJMra1205406
   PubMed Web of Science ®Google Scholar
• Wang T, Hu J, Luo H, et al., Photosensitizer and autophagy promoter coloaded ROS-Responsive dendrimer-assembled carrier for synergistic enhancement of tumor growth suppression. Small, 2018. 14(38):e1802337. doi: 10.1002/smll.201802337
   PubMed Web of Science ®Google Scholar
• Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112(12):1809–1820. doi: 10.1172/JCI20039
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Livesey KM, et al. Endogenous HMGB1 regulates autophagy. J Cell Bio. 2010;190(5):881–892. doi: 10.1083/jcb.200911078
   PubMed Web of Science ®Google Scholar
• Shen Y, Li D-D, Wang L-L, et al. Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy. 2008;4(8):1067–1068. doi: 10.4161/auto.6827
   PubMed Web of Science ®Google Scholar
• Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004;432(7020):1032–1036. doi: 10.1038/nature03029
   PubMed Web of Science ®Google Scholar
• Komatsu M, Waguri S, Ueno T, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Bio. 2005;169(3):425–434. doi: 10.1083/jcb.200412022
   PubMed Web of Science ®Google Scholar
• Sou YS, Waguri S, Iwata J-I, et al. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell. 2008;19(11):4762–4775. doi: 10.1091/mbc.e08-03-0309
   PubMed Web of Science ®Google Scholar
• Moloney JN, Cotter TG, ROS signalling in the biology of cancer. Semin Cell Dev Biol, 2018. 80:50–64. doi: 10.1016/j.semcdb.2017.05.023
   PubMed Web of Science ®Google Scholar
• Avalos Y, Canales J, Bravo-Sagua R, et al., Tumor suppression and promotion by autophagy. Biomed Res Int, 2014. 2014:1–15. doi: 10.1155/2014/603980
   Web of Science ®Google Scholar
• Filomeni G, De Zio D, Cecconi F. Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ. 2015;22(3):377–388. doi: 10.1038/cdd.2014.150
   PubMed Web of Science ®Google Scholar
• Gatto F, Milletti G, Carai A, et al. Recent advances in understanding the role of autophagy in paediatric brain tumours. Diagn (Basel). 2021;11(3):481. doi: 10.3390/diagnostics11030481
   PubMedGoogle Scholar
• Luo T, Fu J, Xu A, et al. PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy. 2016;12(8):1355–1371. doi: 10.1080/15548627.2015.1034405
   PubMed Web of Science ®Google Scholar
• Liu EY, Ryan KM. Autophagy and cancer–issues we need to digest. J Cell Sci. 2012;125(Pt 10):2349–2358. doi: 10.1242/jcs.093708
   PubMed Web of Science ®Google Scholar
• Rabinowitz JD, White E, Autophagy and metabolism. Science, 2010. 330(6009):1344–1348. doi: 10.1126/science.1193497
   PubMed Web of Science ®Google Scholar
• Wei H, Wei S, Gan B, et al. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev. 2011;25(14):1510–1527. doi: 10.1101/gad.2051011
   PubMed Web of Science ®Google Scholar
• Guo JY, Karsli-Uzunbas G, Mathew R, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013;27(13):1447–1461. doi: 10.1101/gad.219642.113
   PubMed Web of Science ®Google Scholar
• Guo JY, White E, Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors. Autophagy, 2013. 9(10):1636–1638. doi: 10.4161/auto.26123
   PubMed Web of Science ®Google Scholar
• Funasaka T, Tsuka E, Wong RW, Regulation of autophagy by nucleoporin Tpr. Sci Rep, 2012. 2:878. doi: 10.1038/srep00878
   PubMed Web of Science ®Google Scholar
• Crighton D, Wilkinson S, O’ Prey J, et al., DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell, 2006. 126(1):121–134. doi: 10.1016/j.cell.2006.05.034
   PubMed Web of Science ®Google Scholar
• Eby KG, Rosenbluth JM, Mays DJ, et al., ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy. Mol Cancer, 2010. 9:95. 1. doi: 10.1186/1476-4598-9-95
   PubMedGoogle Scholar
• Kenzelmann Broz D, Spano Mello S, Bieging KT, et al. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev. 2013;27(9):1016–1031. doi: 10.1101/gad.212282.112
   PubMed Web of Science ®Google Scholar
• Morimoto RI. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 1998;12(24):3788–3796. doi: 10.1101/gad.12.24.3788
   PubMed Web of Science ®Google Scholar
• Zhang B, Fan Y, Cao P, et al. Multifaceted roles of HSF1 in cell death: a state-of-the-art review. Biochim Biophys Acta Rev Cancer. 2021;1876(2):188591. doi: 10.1016/j.bbcan.2021.188591
   PubMed Web of Science ®Google Scholar
• Watanabe Y, Tsujimura A, Taguchi K, et al. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy. 2017;13(1):133–148. doi: 10.1080/15548627.2016.1248018
   PubMed Web of Science ®Google Scholar
• Dewi FRP, Jiapaer S, Kobayashi A, et al., Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma. Autophagy, 2021. 17(4):1001–1012. doi: 10.1080/15548627.2020.1741318
   PubMed Web of Science ®Google Scholar
• Silva BJA, Bittencourt TL, Leal-Calvo T, et al., Autophagy-Associated IL-15 Production Is Involved in the pathogenesis of leprosy type 1 reaction. Cells, 2021. 10(9). 2215 doi: 10.3390/cells10092215
   PubMed Web of Science ®Google Scholar
• de Mattos Barbosa MG, de Andrade Silva BJ, Assis TQ et al., Autophagy impairment is associated with increased inflammasome activation and reversal reaction development in multibacillary leprosy. Front Immunol, 2018. 9:1223. doi: 10.3389/fimmu.2018.01223
   PubMed Web of Science ®Google Scholar
• Schoenherr C, Byron A, Sandilands E, et al., Ambra1 spatially regulates src activity and Src/FAK-mediated cancer cell invasion via trafficking networks. Elife, 2017. 6. 6. doi: 10.7554/eLife.23172
   Web of Science ®Google Scholar
• Schoenherr C, Byron A, Griffith B, et al. The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes. J Biol Chem. 2020;295(34):12045–12057. doi: 10.1074/jbc.RA120.012565
   PubMed Web of Science ®Google Scholar
• Sun WL. Ambra1 in autophagy and apoptosis: implications for cell survival and chemotherapy resistance. Oncol Lett. 2016;12(1):367–374. doi: 10.3892/ol.2016.4644
   PubMed Web of Science ®Google Scholar
• Du C, Zhang J-L, Wang Y, et al., The long non-coding RNA LINC01705 regulates the development of breast cancer by sponging miR-186-5p to mediate TPR expression as a competitive endogenous RNA. Front Genet, 2020. 11:779. doi: 10.3389/fgene.2020.00779
   PubMed Web of Science ®Google Scholar
• Snow CJ, Paschal BM, Roles of the nucleoporin tpr in cancer and aging. Adv Exp Med Biol, 2014. 773:309–322.
   PubMed Web of Science ®Google Scholar
• Long T, Wu W, Wang X, et al. TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma. Mol Clin Oncol. 2024;20(4):27. doi: 10.3892/mco.2024.2725
   PubMed Web of Science ®Google Scholar
• Choi YL, Lira ME, Hong M, et al. A novel fusion of TPR and ALK in lung adenocarcinoma. J Thorac Oncol. 2014;9(4):563–566. doi: 10.1097/JTO.0000000000000093
   PubMed Web of Science ®Google Scholar
• Chen M, Long Q, Borrie MS, et al. Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells. PloS Genet. 2021;17(11):e1009899. doi: 10.1371/journal.pgen.1009899
   PubMed Web of Science ®Google Scholar
• Peschard P, Park M. From tpr-met to met, tumorigenesis and tubes. Oncogene. 2007;26(9):1276–1285. doi: 10.1038/sj.onc.1210201
   PubMed Web of Science ®Google Scholar
• Kosar M, Giannattasio M, Piccini D, et al. The human nucleoporin Tpr protects cells from RNA-mediated replication stress. Nat Commun. 2021;12(1):3937. doi: 10.1038/s41467-021-24224-3
   PubMed Web of Science ®Google Scholar
• Lee SH, Sterling H, Burlingame A, et al., Tpr directly binds to Mad1 and Mad2 and is important for the Mad1–Mad2-mediated mitotic spindle checkpoint. Genes Dev, 2008. 22(21):2926–2931. doi: 10.1101/gad.1677208
   PubMed Web of Science ®Google Scholar
• Schweizer N, Ferrás C, Kern DM, et al. Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis. J Cell Bio. 2013;203(6):883–893. doi: 10.1083/jcb.201309076
   PubMed Web of Science ®Google Scholar
• Lopez-Soop G, Rønningen T, Rogala A, et al. AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint. Cell Cycle. 2017;16(10):947–956. doi: 10.1080/15384101.2017.1310350
   PubMed Web of Science ®Google Scholar
• Kobayashi A, Hashizume C, Dowaki T, et al. Therapeutic potential of mitotic interaction between the nucleoporin tpr and aurora kinase a. Cell Cycle. 2015;14(9):1447–1458. doi: 10.1080/15384101.2015.1021518
   PubMed Web of Science ®Google Scholar
• Hartono, H, Hazawa M, et al., Nucleoporin Nup58 localizes to centrosomes and mid-bodies during mitosis. Cell Div, 2019. 14:7. 1. doi: 10.1186/s13008-019-0050-z
   PubMed Web of Science ®Google Scholar
• Hashizume C, Kobayashi A, Wong RW. Down-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastrophe. Cell Death Dis. 2013;4(10):e854. doi: 10.1038/cddis.2013.370
   PubMedGoogle Scholar
• Hashizume C, Moyori A, Kobayashi A, et al., Nucleoporin Nup62 maintains centrosome homeostasis. Cell Cycle, 2013. 12(24):3804–3816. doi: 10.4161/cc.26671
   PubMed Web of Science ®Google Scholar
• Wong RW, Blobel G, Coutavas E. Rae1 interaction with NuMA is required for bipolar spindle formation. Proc Natl Acad Sci U S A. 2006;103(52):19783–19787. doi: 10.1073/pnas.0609582104
   PubMed Web of Science ®Google Scholar
• Kimura M, Yoshioka T, Saio M, et al. Mitotic catastrophe and cell death induced by depletion of centrosomal proteins. Cell Death Dis. 2013;4(4):e603. doi: 10.1038/cddis.2013.108
   PubMedGoogle Scholar
• Ha GH, Kim H-S, Lee CG, et al. Mitotic catastrophe is the predominant response to histone acetyltransferase depletion. Cell Death Differ. 2009;16(3):483–497. doi: 10.1038/cdd.2008.182
   PubMed Web of Science ®Google Scholar
• Holland AJ, Cleveland DW, Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep, 2012. 13(6):501–514. doi: 10.1038/embor.2012.55
   PubMed Web of Science ®Google Scholar
• Nam HJ, van Deursen JM. Cyclin B2 and p53 control proper timing of centrosome separation. Nat Cell Biol. 2014;16(6):538–549. doi: 10.1038/ncb2952
   PubMed Web of Science ®Google Scholar
• Zou Z, Yuan Z, Zhang Q, et al. Aurora kinase a inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy. 2012;8(12):1798–1810. doi: 10.4161/auto.22110
   PubMed Web of Science ®Google Scholar
• de Carcer G, Malumbres M. A centrosomal route for cancer genome instability. Nat Cell Biol. 2014;16(6):504–506. doi: 10.1038/ncb2978
   PubMed Web of Science ®Google Scholar