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Review Article

Melatonin vs. phytomelatonin: Therapeutic uses with special reference to polycystic ovarian syndrome (PCOS)

& | (Reviewing Editor)
Article: 1136257 | Received 28 Oct 2015, Accepted 22 Dec 2015, Published online: 09 Feb 2016

References

  • Attarchi, M., Darkhi, H., Khodarahmian, M., Dolati, M., Kashanian, M., Ghaffari, M., … Mohammadi, S. (2013). Characteristics of menstrual cycle in shift workers. Global Journal of Health Science, 5, 163–172.
  • Badria, F. A. (2002). Melatonin, serotonin, and tryptamine in some Egyptian food and medicinal plants. Journal of Medicinal Food, 5, 153–157.10.1089/10966200260398189
  • Balen, A. (Ed.). (2010). Current management of polycystic ovary syndrome. London: RCOG Press.
  • Boczek-Leszczyk, E., & Juszczak, M. (2007). The influence of melatonin on human reproduction. Polski Merkuriusz Lekarski, 23, 128–130.
  • Brannstrom, M., & Norman, R. J. (1993). Involvement of leukocytes and cytokines in the ovulatory process and corpus luteum function. Human Reproduction, 8, 1762–1775.
  • Brzezinski, A., Seibel, M., Lynch, H., Deng, M., & Wurtman, R. (1987). Melatonin in human preovulatory follicular fluid. The Journal of Clinical Endocrinology & Metabolism, 64, 865–867.10.1210/jcem-64-4-865
  • Bukulmez, O., & Arici, A. (2000). Leukocytes in ovarian function. Human Reproduction Update, 6, 1–15.10.1093/humupd/6.1.1
  • Burkhardt, S., Tan, D. X., Manchester, L. C., Hardeland, R., & Reiter, R. J. (2001). Detection and quantification of the antioxidant melatonin in montmorency and balaton tart cherries (Prunus cerasus). Journal of Agricultural and Food Chemistry, 49, 4898–4902.10.1021/jf010321+
  • Carlomagno, G., Nordio, M., Chiu, T. T., & Unfer, V. (2011). Contribution of myo-inositol and melatonin to human reproduction. European Journal of Obstetrics & Gynecology and Reproductive Biology, 159, 267–272.10.1016/j.ejogrb.2011.07.038
  • Chaouat, G., Dubanchet, S., & Ledée, N. (2007). Cytokines: Important for implantation? Journal of Assisted Reproduction and Genetics, 24, 491–505.10.1007/s10815-007-9142-9
  • Clark, A. M., Thornley, B., Tomlinson, L., Galletley, C., & Norman, R. J. (1998). Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Human Reproduction, 13, 1502–1505.10.1093/humrep/13.6.1502
  • Cuzzocrea, S., Zingarelli, B., Gilad, E., Hake, P., Salzman, A. L., & Szabó, C. (1997). Protective effect of melatonin in carrageenan-induced models of local inflammation: Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. Journal of Pineal Research, 23, 106–116.10.1111/jpi.1997.23.issue-2
  • de la Puerta, C., Carrascosa-Salmoral, M. P., García-Luna, P. P., Lardone, P. J., Herrera, J. L., Fernández-Montesinos, R., … Pozo, D. (2007). Melatonin is a phytochemical in olive oil. Food Chemistry, 104, 609–612.10.1016/j.foodchem.2006.12.010
  • Decio, A., Mee, J. M., Cristina, F., Guglielmo, B., Carla, S., Paola, S., & Mario, P. (2004). Licorice reduces serum testosterone in healthy women. Steroids, 69, 763–766.
  • Diamanti-Kandarakis, E., Kandarakis, H., & Legro, R. S. (2006). The role of genes and environment in the etiology of PCOS. Endocrine, 30, 19–26.10.1385/ENDO:30:1
  • Dubbels, R., Reiter, R. J., Klenke, E., Goebel, A., Schnakenberg, E., Ehlers, C., … Schloot, W. (1995). Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. Journal of Pineal Research, 18, 28–31.10.1111/jpi.1995.18.issue-1
  • Fauser, B. C. J. M., Pache, T. D., Lamberts, S. W., Hop, W. C., De Jong, F. H., & Dahl, K. D. (1991). Serum bioactive and immunoreactive luteinizing hormone and follicle-stimulating hormone levels in women with cycle abnormalities, with or without polycystic ovarian disease. Journal of Clinical Endocrinology & Metabolism, 73, 811–817.
  • Fiske, V. M., Bryant, G. K., & Putnam, J. (1960). Effects of light on the weight of pineal in the rat. Endocrinology, 66, 489–491.
  • Galletly, C., Clark, A., Tomlinson, L., & Blaney, F. (1996). A group program for obese, infertile women: Weight loss and improved psychological health. Journal of Psychosomatic Obstetrics & Gynecology, 17, 125–128.10.3109/01674829609025672
  • Goldman, B. D. (2001). Mammalian photoperiodic system: Formal properties and neuroendocrine mechanisms of photoperiodic time measurement. Journal of Biological Rhythms, 16, 283–301.10.1177/074873001129001980
  • Grajewski, B., Nguyen, M. M., Whelan, E. A., Cole, R. J., & Hein, M. J. (2003). Measuring and identifying large-study metrics for circadian rhythm disruption in female flight attendants. Scandinavian Journal of Work, Environment & Health, 29, 337–346.10.5271/sjweh.740
  • Grant, P. (2010). Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytotherapy Research, 24, 186–188.
  • Haldar, C., & Rai, S. (2006). In S. K. Maitra (Ed.), Hormone biotechnology: And melatonin and immunomodulation in seasonally breeding mammals. Hormone Biotechnology, 13, 189–211.
  • Haldar, C., Rai, S., & Singh, R. (2004). Melatonin blocks dexamethasone-induced immunosuppression in a seasonally breeding rodent Indian palm squirrel, Funambulus pennanti. Steroids, 69, 367–377.10.1016/j.steroids.2004.03.006
  • Haldar, C., Rai, S., & Tripathi, R. (2006). Melatonin mediated endocrine changes in immune function. Frontiers in Molecular Endocrinology of Invertebrates and Vertebrates, 2, 25–33.
  • Haldar, C., Singh, S. S., Rai, S., Skwarlo-Sonta, K., Pawlak, J., & Singaravel, M. (2008). Melatonin and immunomodulation: Involvement of the neuroendocrine network. Experimental Endocrinology and Reproductive Biology, 3, 297–314.
  • Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011). Melatonin—A pleiotropic, orchestrating regulator molecule. Progress in Neurobiology, 93, 350–384.10.1016/j.pneurobio.2010.12.004
  • Hattori, A., Migitaka, H., Iigo, M., Itoh, M., Yamamoto, K., Ohtani-Kaneko, R., … Reiter R. J. (1995). Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates. Biochemistry and Molecular Biology International, 35, 627–634.
  • Hattori, A., Suzuki, N., & Somei, M. (2006). Melatonin up to date-melatonin effects on bone. Anti-Aging Igaku, 2, 78–86 (in Japanese).
  • Hernández-Ruiz, J., Cano, A., & Arnao, M. B. (2004). Melatonin: A growth-stimulating compound present in lupin tissues. Planta, 220, 140–144.10.1007/s00425-004-1317-3
  • Hernández-Ruiz, J., Cano, A., & Arnao, M. B. (2005). Melatonin acts as a growth-stimulating compound in some monocot species. Journal of Pineal Research, 39, 137–142.10.1111/j.1600-079X.2005.00226.x
  • Hickey, M., Sloboda, D. M., Atkinson, H. C., Doherty, D. A., Franks, S., Norman, R. J., … Hart, R. (2009). The relationship between maternal and umbilical cord androgen levels and polycystic ovary syndrome in adolescence: A prospective cohort study. Journal of Clinical Endocrinology & Metabolism, 94, 3714–3720.
  • Hirano, T., Taga, T., Nakano, N., Yasukawa, K., Kashiwamura, S., Shimizu, K., … Kishimoto, T. (1985). Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proceedings of the National Academy of Sciences, 82, 5490–5494.10.1073/pnas.82.16.5490
  • Huber-Buchholz, M. M., Carey, D. G., & Norman, R. J. (1999). Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone. Journal of Clinical Endocrinology and Metabolism, 84, 1470–1474.
  • Ikegami, T., Azuma, K., Nakamura, M., Suzuki, N., Hattori, A., & Ando, H. (2009). Diurnal expressions of four subtypes of melatonin receptor genes in the optic tectum and retina of goldfish. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 152, 219–224.
  • Ishii, H., Tanaka, N., Kobayashi, M., Kato, M., & Sakuma, Y. (2009). Gene structures, biochemical characterization and distribution of rat melatonin receptors. The Journal of Physiological Sciences, 59, 37–47.10.1007/s12576-008-0003-9
  • Itoh, M., Ishizuka, B., Kuribayashi, Y., Amemiya, A., & Sumi, Y. (1999). Melatonin, its precursors, and synthesizing enzyme activities in the human ovary. Molecular Human Reproduction, 5, 402–408.10.1093/molehr/5.5.402
  • Kitay, J. I., & Altschule, M. D. (1954). The pineal gland. A review of the physiological literature. Cambridge, MA: Harvard University Press.
  • Kolar, J., Machackova, I., Eder, J., Prinsen, E., Van, D. W., Van, O. H., & Illnerova, H. (1997). Melatonin occurrence and daily rhythm in Chenopodium rubrum. Phytochemistry, 44, 1047–1413.
  • Kolar, J., Machackova, I., Illnerova, H., Prinsen, E., Van Dongen, W., & Van Onckelen, H. A. (1995). Melatonin in higher plants determined by radioimmunoassay and liquid chromatography–mass spectrometry. Biological Rhythm Research, 26, 406–409.
  • Lahiri, S., Rai, S., & Haldar, C. (2006). Trade-off relationship between melatonin and gonadal steroid on melatonin receptor (MEL 1A R) expression in lymphoid tissue. Journal of Endocrine Research, 1, 1–4.
  • Lawson, C. C., Whelan, E. A., Lividoti-Hibert, E. N., Spiegelman, D., Schernhammer, E. S., & Rich-Edwards, J. W. (2011). Rotating shift work and menstrual cycle characteristics. Epidemiology, 22, 305–312.10.1097/EDE.0b013e3182130016
  • Lee, H. Y., Byeon, Y., & Back, K. (2014). Melatonin as a signal molecule triggering defense responses against pathogen attack in Arabidopsis and tobacco. Journal of Pineal Research, 57, 262–268.10.1111/jpi.2014.57.issue-3
  • Legro, R. S., Bentley-Lewis, R., Driscoll, D., Wang, S. C., & Dunaif, A. (2002). Insulin resistance in the sisters of women with polycystic ovary syndrome: Association with hyperandrogenemia rather than menstrual irregularity. The Journal of Clinical Endocrinology & Metabolism, 87, 2128–2133.10.1210/jcem.87.5.8513
  • Lerner, A. B., Case, J. D., & Heinzelman, R. V. (1959). Structure of melatonin. Journal of the American Chemical Society, 81, 6084–6085.10.1021/ja01531a060
  • Lerner, A. B., Case, J. D., & Takahashi, Y. (1958). Isolation of melatonin, the pineal gland factor that lightens melanocytes. Journal of the American Chemical Society, 80, 2587–2587.10.1021/ja01543a060
  • Maharjan, R., & Nagar, P. S. (2010). Effect of Aloe barbadensis mill. formulation on Letrozole induced polycystic ovarian syndrome rat model. Journal of Ayurveda Integrated Medicine, 1, 273–279.
  • Malpaux, B., Migaud, M., Tricoire, H., & Chemineau, P. (2001). Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin. Journal of Biological Rhythms, 16, 336–347.10.1177/074873001129002051
  • Manchester, L. C., Tan, D. X., Reiter, R. J., Park, W., Monis, K., & Qi, W. (2000). High levels of melatonin in the seeds of edible plants. Life Sciences, 67, 3023–3029.10.1016/S0024-3205(00)00896-1
  • Mannerås, L., Fazliana, M., Wan-Nazaimoon, W. M., Lönn, M., Gu, H. F., Östenson, C. G., & Stener-Victorin, E. (2010). Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome. Journal of Ethnopharmacology, 127, 346–351.10.1016/j.jep.2009.10.032
  • Masana, M. I., & Dubocovich, M. L. (2001). Melatonin receptor signaling: Finding the path through the dark. Science STKE, 2, 39.
  • Miyauchi, F., Nanjo, K., & Otsuka, K. (1992). Effects of night shift on plasma concentrations of melatonin, LH, FSH and prolactin, and menstrual irregularity. Sangyo Igaku, 34, 545–550.10.1539/joh1959.34.545
  • Mizuno, M., & Terasawa, E. (2005). Search for neural substrates mediating inhibitory effects of oestrogen on pulsatile luteinising hormone-releasing hormone release in vivo in ovariectomized female rhesus monkeys (Macaca mulatta). Journal of Neuroendocrinology, 17, 238–245.10.1111/jne.2005.17.issue-4
  • Moffett, A., & Loke, Charlie (2006). Immunology of placentation in eutherian mammals. Nature Reviews Immunology, 6, 584–594.10.1038/nri1897
  • Moran, L. J., Pasquali, R., Teede, H. J., Hoeger, K. M., & Norman, R. J. (2009). Treatment of obesity in polycystic ovary syndrome: A position statement of the Androgen Excess and Polycystic Ovary Syndrome Society. Fertility and Sterility, 92, 1966–1982.10.1016/j.fertnstert.2008.09.018
  • Murch, S. J., KrishnaRaj, S., & Saxena, P. K. (2000). Tryptophan is a precursor for melatonin and serotonin biosynthesis in in vitro regenerated St. John’s wort (Hypericum perforatum L. cv. Anthos) plants. Plant Cell Reports, 19, 698–704.10.1007/s002990000206
  • Nakamura, Y., Tamura, H., Takayama, H., & Kato, H. (2003). Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertility and Sterility, 80, 1012–1016.10.1016/S0015-0282(03)01008-2
  • Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007). Polycystic ovary syndrome. The Lancet, 370, 685–697.10.1016/S0140-6736(07)61345-2
  • Norman, R. J., Masters, S. C., Hague, W., Beng, C., Pannall, P., & Wang, J. X. (1995). Metabolic approaches to the subclassification of polycystic ovary syndrome. Fertilization and Sterility, 63, 329–335.
  • Nowak, D. A., & Snyder, D. C. (2007). The effect of flaxseed supplementation on hormonal levels associated with polycystic ovarian syndrome: A case study. Current Topics in Nutraceutical Research, 5, 177–181.
  • Oba, S., Nakamura, K., Sahashi, Y., Hattori, A., & Nagata, C. (2008). Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration. Journal of Pineal Research, 45, 17–23.10.1111/jpi.2008.45.issue-1
  • Okatani, Y., Wakatsuki, A., & Kaneda, C. (2000). Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain. Journal of Pineal Research, 28, 89–96.10.1034/j.1600-079X.2001.280204.x
  • Pape, C., & Luning, K. (2006). Quantification of melatonin in phototrophic organisms. Journal of Pineal Research, 41, 157–165. doi:10.1111/j.1600-079X.2006.00348.x
  • Paredes, S. D., Korkmaz, A., Manchester, L. C., Tan, D. X., & Reiter, R. J. (2009). Phytomelatonin: A review. Journal of Experimental Botany, 60, 57–69.
  • Paria, B. C., Reese, J., Das, S. K., & Dey, S. K. (2002). Deciphering the cross-talk of implantation: Advances and challenges. Science, 296, 2185–2188.10.1126/science.1071601
  • Pieri, C., Marra, M., Moroni, F., Recchioni, R., & Marcheselli, F. (1994). Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sciences, 55, PL271–PL276.
  • Rai, S., Basheer, M., Ghosh, H., Acharya, D., & Hajam, Y. A. (2015). Melatonin attenuates free radical load and reverses histologic architect and hormone profile alteration in female rat: An in vivo study of pathogenesis of letrozole induced poly cystic ovary. Unpublished manuscript.
  • Rai, S., & Haldar, C. (2003). Pineal control of immune status and hematological changes in blood and bone marrow of male squirrels (Funumbulus pennanti) during their reproductively active phase. Comparative Biochemistry and Physiology Part C, 136, 319–328.
  • Rai, S., & Haldar, C. (2006). Adaptive significance of annual variation in immune parameters and endogenous hormones (Melatonin and thyroxine) of a tropical rodent Funumbulus pennanti. Journal of Endocrinology and Reproduction, 10, 111–116.
  • Rai, S., & Haldar, C. (2011). Melatonin ameliorates oxidative stress and induces cellular proliferation of lymphoid tissues of a tropical rodent, Funumbulus pennanti, during reproductively active phase. Protoplasma, 248. doi:10.1007/s00709-011-0367-1
  • Rai, S., Haldar, C., & Shankar Singh, S. S. (2005). Trade-off between L-thyroxine and melatonin in immune regulation of Indian palm squirrel, Funambulus pennanti during the reproductively inactive phase. Neuroendocrinology, 82, 103–110.10.1159/000091034
  • Rai, S., Haldar, C., & Singh, R. (2009). Modulation of immunity in young adult and aged squirrel, Funumbulus pennanti by melatonin and p-chlorophenylalanine. Immunity and Ageing, 6, 1011. doi: 86/1742-4933-6-5
  • Randolph, J. F. (2008). The endocrinology of the reproductive years. Journal of Sexual Medicine, 5, 2274–2281.
  • Reiter, R., Tan, D., Manchester, L., Simopoulos, A., Maldonado, M., Flores, L., & Terron, M. (2007). Melatonin in edible plants (phytomelatonin): Identification, concentrations, bioavailability and proposed functions. World Review of Nutrition and Dietetics, 97, 211–230.
  • Reiter, R. J. (1980). The pineal and its hormones in the control of reproduction in mammals. Endocrine Reviews, 1, 109–131.10.1210/edrv-1-2-109
  • Reiter, R. J. (1981). Pineal control of reproduction. In Vidrio, E. A. (Ed.), Eleventh international congress of anatomy: Advances in the morphology of cells and tissues (pp. 349–355). New York, NY: Alan R Liss.
  • Reiter, R. J., Calvo, J. R., Karbownik, M., Qi, W., & Tan, D. X. (2000). Melatonin and its relation to the immune system and inflammation. Annals of the New York Academy of Sciences, 917, 376–386.
  • Ronnberg, L., Kauppila, A., Leppaluoto, J., Martikainen, H., & Vakkuri, O. (1990). Circadian and seasonal variation in human preovulatory follicular fluid melatonin concentration. Journal of Clinical and Endocrinology Metabolism, 71, 492–496.
  • Saito, S. (2000). Cytokine network at the feto–maternal interface. Journal of Reproductive Immunology, 47, 87–103.10.1016/S0165-0378(00)00060-7
  • Salhab, M., Dhorne-Pollet, S., Auclair, S., Guyader-Joly, C., Brisard, D., Dalbies-Tran, R., … Ponsart, C. (2013). In-vitro maturation of oocytes alters gene expression and signaling pathways in bovine cumulus cells. Molecular Reproduction and Development, 80, 166–182.10.1002/mrd.v80.2
  • Schäfer-Somi, S. (2003). Cytokines during early pregnancy of mammals: A review. Animal Reproduction Science, 75, 73–94.10.1016/S0378-4320(02)00222-1
  • Singh, S. S., Haldar, C., & Rai, S. (2006). Melatonin and differential effect of l-thyroxine on immune system of Indian tropical bird Perdicula asiatica. General and Comparative Endocrinology, 145, 215–221.10.1016/j.ygcen.2005.09.007
  • Sok, P. C., Sung, L. C., Seung, N. Y., Jiae, L., Joseph, H. A., & Chun, B. S. (2005). Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries. Fertility and Sterility, 84, 1139–1143.
  • Sun, Q., Zhang, N., Wang, J., Zhang, H., Li, D., Shi, J., … Guo, Y. D. (2015). Melatonin promotes ripening and improves quality of tomato fruit during postharvest life. Journal of Experimental Botany, 66, 657–668.10.1093/jxb/eru332
  • Taher, M. A., Atia, Y. A., & Amin, M. K. (2010). Improving an ovulation rate in women with polycystic ovary syndrome by using silymarin. Iraqi Journal of Pharmaceutical Sciences, 19, 11–18.
  • Tamura, H., Nakamura, Y., Korkmaz, A., Manchester, L. C., Tan, D. X., Sugino, N., & Reiter, R. J. (2009). Melatonin and the ovary: Physiological and pathophysiological implications. Fertility and Sterility, 92, 328–343.10.1016/j.fertnstert.2008.05.016
  • Tan, D. X., Chen, L. D., Poeggeler, B., Manchester, L. C., & Reiter, R. J. (1993). Melatonin: A potent, endogenous hydroxyl radical scavenger. Endocrine Journal, 1, 57–60.
  • Tan, D. X., Hardeland, R., Manchester, L. C., Galano, A., & Reiter, R. J. (2014). Cyclic-3-hydroxymelatonin (C3HOM), A potent antioxidant, scavenges free radicals and suppresses oxidative reactions. Current Medicinal Chemistry, 21, 1557–1565.10.2174/0929867321666131129113146
  • Tan, D. X., Hardeland, R., Manchester, L. C., Korkmaz, A., Ma, S., Rosales-Corral, S., & Reiter, R. J. (2012). Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science. Journal of Experimental Botany, 63, 577–597.10.1093/jxb/err256
  • Tassel, D. V., & O’Neill, S. (1993). Melatonin: Identification of a potential dark signal in plants. Plant Physiology, 102, 659.
  • Tassel, D. V., Roberts, N., & O’Neill, S. (1995). Melatonin from higher plants: Isolation and identification of N-acetyl-5-methoxytryptamine. Plant Physiology, 108, 101.
  • Terranova, P. F., & Rice, V. M. (1997). Review: Cytokine involvement in ovarian processes. American Journal of Reproductive Immunology, 37, 50–63.10.1111/aji.1997.37.issue-1
  • Turkowska, E., Majewski, P. M., Rai, S., & Skwarlo Sonta, K. (2013). Pineal oscillator in the functioning in the chicken-effect of photoperiod and Melatonin. Chronobiology International. doi:10.3109/07420528.213.832279
  • van Santbrink, E. J., Hop, W. C., & Fauser, B. C. (1997). Classification of normogonadotropic infertility: Polycystic ovaries diagnosed by ultrasound versus endocrine characteristics of polycystic ovary syndrome. Fertility and Sterility, 67, 452–458.10.1016/S0015-0282(97)80068-4
  • Vink, J. M., Sadrzadeh, S., Lambalk, C. B., & Boomsma, D. I. (2006). Heritability of polycystic ovary syndrome in a dutch twin-family study. The Journal of Clinical Endocrinology & Metabolism, 91, 2100–2104.10.1210/jc.2005-1494
  • Voordouw, B., Euser, R., Verdonk, R., Alberda, B., de Jong, F., Drogendijk, A., … Cohen, M. (1992). Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. Journal of Clinical Endocrinology & Metabolism, 74, 108–117.
  • Wang, J. G., & Anderson, R. A. (2007). The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: A pilot study. Fertility and Sterility, 88, 240–243.10.1016/j.fertnstert.2006.11.082
  • Westphal, L. M., Polan, M. L., & Trant, A. S. (2006). Double-blind, placebocontrolled study of FertilityBlend®: A nutritional supplement for improving fertility in women. Clinical and Experimental Obstetrics & Gynecology, 33, 205–208.
  • Wurtman, R., Axelrod, J., & Potter, L. (1964). The uptake of h3-melatonin in endocrine and nervous tissues and the effects of constant light exposure. Journal of Pharmacology and Experimental Therapeutics, 143, 314–318.
  • Wurtman, R. J., & Waldhauser, F. (1986). Melatonin in humans. Journal of Neural Transmission. Vienna: Springer-Verlag.
  • Yeoman, R. R., Wegner, F. H., Gibson, S. V., Williams, L. E., Abbott, D. H., & Abee, C. R. (2000). Midcycle and luteal elevations of follicle stimulating hormone in squirrel monkeys (Saimiri boliviensis) during the estrous cycle. American Journal of Primatology, 52, 207–211.10.1002/(ISSN)1098-2345
  • Yonei, Y., Takahashi, Y., Shionoiri, A., & Inada, S. (2007). Evaluation of the effect of α gel embedded mattresses as bedding on the mind and body. Anti-Aging Medicine, 4, 11–18.10.3793/jaam.4.11
  • Zafari, Z. F., Minaee, B., Amirzargar, A., & Ahangarpour, A. (2010). Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome. Journal of Reproduction & Infertility, 11, 169–174.
  • Zeleznik, A. J., & Pohl, C. R. (2006). In J. D. Neill (Ed.), Knobil and Neill’s physiology of reproduction (Third Edition). Vol. 2: Control of follicular development, corpus luteum function, the maternal recognition of pregnancy, and the neuroendocrine regulation of the menstrual cycle in higher primates (pp. 2449–2510). St. Louis, MO: Elsevier.
  • Zhang, L., Wei, W., Xu, J., Min, F., Wang, L., Wang, X., … Reiter, R. J. (2006). Inhibitory effect of melatonin on diquat-induced lipid peroxidation in vivo as assessed by the measurement of F 2-isoprostanes. Journal of Pineal Research, 40, 326–331.10.1111/jpi.2006.40.issue-4
  • Zhang, N., Sun, Q., Zhang, H., Cao, Y., Weeda, S., Ren, S., & Guo, Y. (2015). Roles of melatonin in abiotic stress resistance in plants. Journal of Experimental Botany, 66, 647–656.10.1093/jxb/eru336