Engineering elastic properties into an anti-TNFα monoclonal antibody

References

• Baker, K., Qiao, S.-W., Kuo, T. T., Aveson, V. G., Platzer, B., Andersen, J.-T., … Blumberg, R. S. (2011). Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proceedings of the National Academy of Sciences of the United States of America, 108, 9927–19. doi:10.1073/pnas.1019037108
   PubMed Web of Science ®Google Scholar
• Betre, H., Liu, W., Zalutsky, M. R., Chilkoti, A., Kraus, V. B., & Setton, L. A. (2006). A thermally responsive biopolymer for intra-articular drug delivery. Journal of Controlled Release: Official Journal of the Controlled Release Society, 115, 175–182. doi:10.1016/j.jconrel.2006.07.022
   PubMed Web of Science ®Google Scholar
• Blanco, R., Martínez-Taboada, V. M., Villa, I., González-Vela, M. C., Fernández-Llaca, H., Agudo, M., & González-López, M. A. (2009). Long-term successful adalimumab therapy in severe hidradenitis suppurativa. Arch Dermatol, 145, 580–584. doi:10.1001/archdermatol.2009.49
   PubMed Web of Science ®Google Scholar
• Brehm, M. A., Daniels, K. A., & Welsh, R. M. (2005). Rapid production of TNF-following TCR engagement of naive CD8 T-cells. The Journal of Immunology, 175, 5043–5049. doi:10.4049/jimmunol.175.8.5043
   PubMed Web of Science ®Google Scholar
• Cawthorn, W. P., & Sethi, J. K. (2008). TNF-α and adipocyte biology. FEBS Letters, 582, 117–131. doi:10.1016/j.febslet.2007.11.051
   PubMed Web of Science ®Google Scholar
• Conrad, U., Plagmann, I., Malchow, S., Sack, M., Floss, D. M., Kruglov, A. A., … Scheller, J. (2011). ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock. Plant Biotechnology Journal, 9, 22–31. doi:10.1111/pbi.2010.9.issue-1
   PubMed Web of Science ®Google Scholar
• Correia, I., Sung, J., Burton, R., Jakob, C. G., Carragher, B., Ghayur, T., & Radziejewski, C. (2013). The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen. mAbs, 5, 364–372. doi:10.4161/mabs.24258
   PubMed Web of Science ®Google Scholar
• de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991). Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. The Journal of Experimental Medicine, 174, 1209–1220. doi:10.1084/jem.174.5.1209
   PubMed Web of Science ®Google Scholar
• Evans, C. H., Kraus, V. B., & Setton, L. A. (2014). Progress in intra-articular therapy. Nature reviews. Rheumatology, 10, 11–22.
   PubMed Web of Science ®Google Scholar
• Fiocco, U., Sfriso, P., Oliviero, F., Roux-Lombard, P., Scagliori, E., Cozzi, L., … Punzi, L. (2010). Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint. Arthritis Research & Therapy, 12, R148. doi:10.1186/ar3090
   PubMed Web of Science ®Google Scholar
• Fioravanti, A., Fabbroni, M., Cerase, A., & Galeazzi, M. (2009). Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: A pilot study. Rheumatology International, 29, 961–965. doi:10.1007/s00296-009-0872-0
   PubMed Web of Science ®Google Scholar
• Fisher, B. A., & Keat, A. (2006). Should we be using intraarticular tumor necrosis factor blockade in inflammatory monoarthritis? The Journal of Rheumatology, 33, 1934–1935.
   PubMed Web of Science ®Google Scholar
• Havell, E. A., & Rogerson, B. J. (1993). Endotoxin-induced tumor necrosis factor alpha synthesis in murine embryo fibroblasts. Infection and Immunity, 61, 1630–1635.
   PubMed Web of Science ®Google Scholar
• Ho, L.-J., Wang, -J.-J., Shaio, M.-F., Kao, C.-L., Chang, D.-M., Han, S.-W., & Lai, J.-H. (2001). Infection of human dendritic cells by dengue virus causes cell maturation and cytokine production. The Journal of Immunology, 166, 1499–1506. doi:10.4049/jimmunol.166.3.1499
   PubMed Web of Science ®Google Scholar
• Hollander, J. L., Brown, E. M., Jr., Jessar, R. A., & Brown, C. Y. (1951). Hydrocortisone and cortisone injected into arthritic joints; comparative effects of and use of hydrocortisone as a local antiarthritic agent. Journal of the American Medical Association, 147, 1629–1635. doi:10.1001/jama.1951.03670340019005
   PubMed Web of Science ®Google Scholar
• Imaizumi, T., Itaya, H., Fujita, K., Kudoh, D., Kudoh, S., Mori, K., … Satoh, K. (2000). Expression of tumor necrosis factor-alpha in cultured human endothelial cells stimulated with lipopolysaccharide or interleukin-1alpha. Arteriosclerosis, Thrombosis, and Vascular Biology, 20, 410–415. doi:10.1161/01.ATV.20.2.410
   PubMed Web of Science ®Google Scholar
• Ionescu, R. M., Vlasak, J., Price, C., & Kirchmeier, M. (2008). Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies. Journal of Pharmaceutical Sciences, 97, 1414–1426. doi:10.1002/jps.21104
   PubMed Web of Science ®Google Scholar
• Kowalczyk, T., Hnatuszko-Konka, K., Gerszberg, A., & Kononowicz, A. K. (2014). Elastin-like polypeptides as a promising family of genetically-engineered protein based polymers. World Journal of Microbiology & Biotechnology, 30, 2141–2152. doi:10.1007/s11274-014-1649-5
   PubMed Web of Science ®Google Scholar
• Kriegler, M., Perez, C., DeFay, K., Albert, I., & Lu, S. D. (1988). A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF. Cell, 53, 45–53. doi:10.1016/0092-8674(88)90486-2
   PubMed Web of Science ®Google Scholar
• Lander, G. C., Stagg, S. M., Voss, N. R., Cheng, A., Fellmann, D., Pulokas, J., … Carragher, B. (2009). Appion: An integrated, database-driven pipeline to facilitate EM image processing. Journal of Structural Biology, 166, 95–102. doi:10.1016/j.jsb.2009.01.002
   PubMed Web of Science ®Google Scholar
• Langer, R., & Tirrell, D. A. (2004). Designing materials for biology and medicine. Nature, 428, 487–492. doi:10.1038/nature02388
   PubMed Web of Science ®Google Scholar
• Luginbuhl, K. M., Schaal, J. L., Umstead, B., Schaal, J. L., Umstead, B., Mastria, E. M., … Chilkoti, A. (2017). One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer. Nature Biomedical Engineering, 1, 78. doi:10.1038/s41551-017-0078
   Web of Science ®Google Scholar
• MacEwan, S. R., & Chilkoti, A. (2010). Elastin-like polypeptides: Biomedical applications of tunable biopolymers. Biopolymers, 94, 60–77. doi:10.1002/bip.21327
   PubMed Web of Science ®Google Scholar
• Mallick, S. P., Carragher, B., Potter, C. S., & Kriegman, D. J. (2005). ACE: Automated CTF estimation. Ultramicroscopy, 104, 8–29. doi:10.1016/j.ultramic.2005.02.004
   PubMed Web of Science ®Google Scholar
• Marshall, K. W. (2000). Intra-articular hyaluronan therapy. Current Opinion in Rheumatology, 12, 468–474. doi:10.1097/00002281-200009000-00022
   PubMed Web of Science ®Google Scholar
• McMillan, R. A., Caran, K. L., Apkarian, R. P., & Conticello, V. P. (1999). High resolution topographic imaging of environmentally responsive elastin-mimetic hydrogels. Macromolecules, 32, 9067–9070. doi:10.1021/ma991119z
   Web of Science ®Google Scholar
• McMillan, R. A., & Conticello, V. P. (2000). Synthesis and characterization of elastin-mimetic protein gels derived from a well defined polypeptide precursor. Macromolecules, 33, 4809–4821. doi:10.1021/ma9921091
   Web of Science ®Google Scholar
• Mindell, J. A., & Grigorieff, N. (2003). Accurate determination of local defocus and specimen tilt in electron microscopy. Journal of Structural Biology, 142, 334–347. doi:10.1016/S1047-8477(03)00069-8
   PubMed Web of Science ®Google Scholar
• Nagapudi, K., Brinkman, W., Leisen, J. E., Huang, L., McMillan, R. A., Apkarian, R. P., … Chaikof, E. L. (2002). Photomediated solid-state cross-linking of an elastin−mimetic recombinant protein polymer. Macromolecules, 35, 1730–1737. doi:10.1021/ma011429t
   Web of Science ®Google Scholar
• Nakao, A., Fukushima, H., Kajiya, H., Ozeki, S., & Okabe, K. (2007). RANKL-stimulated TNFα production in osteoclast precursor cells promotes osteoclastogenesis by modulating RANK signaling pathways. Biochemical and Biophysical Research Communications, 357, 945–950. doi:10.1016/j.bbrc.2007.04.058
   PubMed Web of Science ®Google Scholar
• Peppas, N. A., & Langer, R. (1994). New challenges in biomaterials. Science, 263, 1715–1720. doi:10.1126/science.8134835
   PubMed Web of Science ®Google Scholar
• Perez, C., Albert, I., DeFay, K., Zachariades, N., Gooding, L., & Kriegler, M. (1990). A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact. Cell, 63, 251–258. doi:10.1016/0092-8674(90)90158-B
   PubMed Web of Science ®Google Scholar
• Rath, T., Baker, K., Pyzik, M., & Blumberg, R. S. (2014). Regulation of immune responses by the neonatal fc receptor and its therapeutic implications. Frontiers in Immunology, 5, 664.
   PubMed Web of Science ®Google Scholar
• Rath, T., Kuo, T. T., Baker, K., Qiao, S.-W., Kobayashi, K., Yoshida, M., … Blumberg, R. S. (2013). The immunologic functions of the neonatal Fc receptor for IgG. Journal of Clinical Immunology, 33(Suppl 1), S9–S17. doi:10.1007/s10875-012-9768-y
   PubMed Web of Science ®Google Scholar
• Sakellariou, G. T., Kakavouli, G., & Chatzigiannis, I. (2006). Intraarticular injection of infliximab. The Journal of Rheumatology, 33, 1912–1913. author reply 1913.
   PubMed Web of Science ®Google Scholar
• Shamji, M. F., Betre, H., Kraus, V. B., Chen, J., Chilkoti, A., Pichika, R., … Setton, L. A. (2007). Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: Sustained release of a local antiinflammatory therapeutic. Arthritis & Rheumatism, 56, 3650–3661. doi:10.1002/(ISSN)1529-0131
   PubMed Web of Science ®Google Scholar
• Shamji, M. F., Chen, J., Friedman, A. H., Richardson, W. J., Chilkoti, A., & Setton, L. A. (2008). Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist. Journal of Controlled Release: Official Journal of the Controlled Release Society, 129, 179–186. doi:10.1016/j.jconrel.2008.04.021
   PubMed Web of Science ®Google Scholar
• Shields, R. L., Namenuk, A. K., Hong, K., Meng, Y. G., Rae, J., Briggs, J., … Presta, L. G. (2001). High resolution mapping of the binding site on human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and design of IgG1 variants with improved binding to the FcγR. The Journal of Biological Chemistry, 276, 6591–6604. doi:10.1074/jbc.M009483200
   PubMed Web of Science ®Google Scholar
• Simkin, P. A. (1995). Synovial perfusion and synovial fluid solutes. Annals of the Rheumatic Diseases, 54, 424–428. doi:10.1136/ard.54.5.424
   PubMed Web of Science ®Google Scholar
• Simkin, P. A., Bassett, J. E., & Koh, E. M. (1995). Synovial perfusion in the human knee: A methodologic analysis. Seminars in arthritis and rheumatism, 25, 56–66.
   PubMed Web of Science ®Google Scholar
• Sorzano, C. O., Marabini, R., Velázquez-Muriel, J., Bilbao-Castro, J. R., Scheres, S. H. W., Carazo, J. M., & Pascual-Montano, A. (2004). XMIPP: A new generation of an open-source image processing package for electron microscopy. Journal of Structural Biology, 148, 194–204. doi:10.1016/j.jsb.2004.06.006
   PubMed Web of Science ®Google Scholar
• Suloway, C., Pulokas, J., Fellmann, D., Cheng, A., Guerra, F., Quispe, J., … Carragher, B. (2005). Automated molecular microscopy: The new Leginon system. Journal of Structural Biology, 151, 41–60. doi:10.1016/j.jsb.2005.03.010
   PubMed Web of Science ®Google Scholar
• Tatham, A. S., & Shewry, P. R. (2000). Elastomeric proteins: Biological roles, structures and mechanisms. Trends in Biochemical Sciences, 25, 567–571. doi:10.1016/S0968-0004(00)01670-4
   PubMed Web of Science ®Google Scholar
• Urry, D. W., Parker, T. M., Reid, M. C., & Gowda, D. C. (1991). Biocompatibility of the bioelastic materials, poly(GVGVP) and its γ-Irradiation cross-linked matrix: Summary of generic biological test results. Journal of Bioactive and Compatible Polymers, 6, 263–282. doi:10.1177/088391159100600306
   Web of Science ®Google Scholar
• van der Zee, H. H., Laman, J. D., de Ruiter, L., Dik, W. A., & Prens, E. P. (2012). Adalimumab (antitumour necrosis factor-α) treatment of hidradenitis suppurativa ameliorates skin inflammation: An in situ and ex vivo study. British Journal of Dermatology, 166, 298–305. doi:10.1111/j.1365-2133.2011.10698.x
   PubMed Web of Science ®Google Scholar
• Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003). Tumor necrosis factor signaling. Cell Death and Differentiation, 10, 45–65. doi:10.1038/sj.cdd.4401189
   PubMed Web of Science ®Google Scholar
• Williamson, B. D., Carswell, E. A., Rubin, B. Y., Prendergast, J. S., & Old, L. J. (1983). Human tumor necrosis factor produced by human B-cell lines: Synergistic cytotoxic interaction with human interferon. Proceedings of the National Academy of Sciences of the United States of America, 80, 5397–5401. doi:10.1073/pnas.80.17.5397
   PubMed Web of Science ®Google Scholar