2,138
Views
11
CrossRef citations to date
0
Altmetric
Review Article

A review of various efforts to increase artemisinin and other antimalarial compounds in Artemisia Annua L plant

ORCID Icon, , & | (Reviewing editor)
Article: 1513312 | Received 06 Apr 2018, Accepted 15 Aug 2018, Published online: 13 Sep 2018

References

  • Aftab, T., Khan., M. M., Idrees, M., Naeem, M., Moinuddin, & Hashmi, N. (2011). Methyl jasmonate counteracts boron toxicity by preventing oxidative stress and regulating antioxidant enzyme activities and artemisinin biosynthesis in Artemisia annua L. Protoplasma, 248(3), 601–612. doi:10.1007/s00709-010-0218-5
  • Aftab, T., Khan, M. M. A., Idrees, M., Naeem, M., & Ram, M. (2010). Boron induced oxidative stress, antioxidant defence response and changes in artemisinin content in artemisia Annua L. Journal of Agronomy and Crop Science, 196(6), 423–430. doi:10.1111/j.1439-037X.2010.00427.X
  • Aftab, T., KhanM, A. M., Naeem, M., Drees, M., Siddiqia, T., Moinuddin, & Varshne, L. (2014). Effect of irradiated sodium alginate and phosphorus on biomass and artemisinin production in Artemisia annua. Carbohydrate Polymers, 110, 396–404. doi:10.1016/j.carbpol.2014.04.045
  • Arora, M., Saxena, P., Choudhary, D. K., Abdin, M. Z., & Varma, A. (2016). Dual symbiosis between Piriformospora indica and Azotobacter chroococcum enhances the artemisinin content in Artemisia annua L. World Journal of Microbiology and Biotechnology, 32, 19. doi:10.1007/s11274-015-1972-5
  • Awasthi, A., Bharti, N., Nair, P., Singh, R., Ashutosh, K. S., Gupta, M. M., … Kalra, A. (2011). Synergistic effect of Glomus mosseae and nitrogen fixing Bacillus subtilis strain Daz26 on artemisinin content in Artemisia annua L. Applied Soil Ecology, 49, 125–130. doi:10.1016/j.apsoil.2011.06.005
  • Ayanoglu, F., Mert, A., & Kirici, S. (2002). The effects of different nitrogen doses on Artemisia annua L. Journal of Herbs, Spices & Medicinal Plants, 9, 399–404. doi:10.1300/J044v09n04
  • Azcón-Aguilar, C., & Barea, J. M. (1997, March). Applying mycorrhiza biotechnology to horticulture: Significance and potentials. Scientia Horticulturae Volume 68, Issues 1–4, 3 March 1997, Pages 1-24, 68(1–4), 1–24.
  • Bagchi, G. D., Haider, F., Dwivedi, P. D., Singh, A., & Naqvi, A. A. (2003). Essential oil constituents of Artemisia annua during different growth periods at monsoon conditions of subtropical North Indian plains essential oil constituents of artemisia annua during different growth periods at monsoon conditions of Subtropical North. Journal of Essential Oil Research, 15, 248–250. doi:10.1080/10412905.2003.9712131
  • Banyai, W., Mii, M., & Kanyaratt, S. (2011). Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment. Plant Growth Regulation, 63(1), 45–54. doi:10.1007/s10725-010-9510-9
  • Bilia, A. R., De Malgalhaes, P. M., Bergonzi, M. C., & Vincieri, F. F. (2006). Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar. Phytomedicine, 13, 487–493. doi:10.1016/j.phymed.2006.01.008
  • Charles, D. J., Simon, J. E., Shock, C. C., Feibert, E. B. G., & Smith, R. M. (1993). Effect of water stress and post-harvest handling on artemisinin content in the leaves of Artemisia. In J. Janick & J. E. Simon (Eds.), New crops (pp. 628–631). New York, NY: Wiley.
  • Chaudhary, V., Kapoor, R., & Bhatnagar, A. (2008). Effectiveness of two arbuscular mycorrhizal fungi on concentrations of essential oil and artemisinin in three accessions of Artemisia annua L. Applied Soil Ecology, 40(1), 174–181. doi:10.1016/j.apsoil.2008.04.003
  • Cockram, J., Hill, C., Burns, C., Arroo, R. R. J., Woolley, J. G., Flockart, I., … Bentley, S. (2012). Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin. Plant Genetic Resources: Characterisation and Utilisation, 10(2), 152–154. doi:10.1017/S1479262112000159
  • Damtew, Z, Tesfaye, B, & Bisrat, D. (2011). Leaf essential oil and artemisinin yield of artemisia (Artemisia annua L) as influenced by harvesting age and plant population density. World Journal of Agricultural Sciences, 7(4), 404-412.
  • Davies, M. J., Atkinson, C. J., Burns, C., Woolley, J. G., Hipps, N. A., Arroo, R. R. J., … Bentley, S. (2009). Enhancement of artemisinin concentration and yield in response to optimization of nitrogen and potassium supply to artemisia annua. Annals of Botany, 104(2), 315–323. doi:10.1093/aob/mcp126
  • De Jesus-Gonzalez, L., & Weathers, P. J. (2003). Tetraploid Artemisia annua hairy roots produce more artemisinin than diploids. Plant Cell Reports, 809–813. doi:10.1007/s00299-003-0587-8
  • Delabays, N., Simonnet, X., & Gaudin, M. (2001). The genetics of artemisinin content in artemisia annua L. and the breeding of high yielding cultivars. Current Medicinal Chemistry, 8, 1795–1801. doi:10.2174/0929867013371635
  • Engeu, P. O., Omujal, F., Agwaya, M., Kyakulaga, H., & Celestino, O. (2015). Variations in antimalarial components of Artemisia annua Linn from three regions of Uganda. African Health Sciences, 15(3), 828–834. doi:10.4314/ahs.v15i3.17
  • Ferreira, J. F. S. (2007). Nutrient deficiency in the production of Artemisinin, dihydroartemisinic acid, and Artemisinic acid in. Journal of Agricultural and Food Chemistry, 1–9.
  • Ferreira, J. F. S., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010). Flavonoids from artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules, 15, 3135–3170. doi:10.3390/molecules15053135
  • Guo, X., Yang, X., Yang, R., & Zeng, Q. (2010). Salicylic acid and methyl jasmonate but not Rose Bengal enhance artemisinin production through invoking burst of endogenous singlet oxygen. Plant Science, 178, 390–397. doi:10.1016/j.plantsci.2010.01.014
  • Han, X., Huang, L., Guo, L., Li, M., Liu, X., & Zhang, X. (2010). Accumulation and translocation of cadmium in soil and plant and its effects on growth of Artemisia annua and artemisinin content. China J Chin Materia Medica (Zhongguo Zhong Yao Za Zhi), 35(13), 1655–1659. in Chinese.
  • Hisamuddin, A., Akhtar, A., & Sharf, R. (2015). Vesicular Arbuscular Mycorrhizal (VAM) Fungi: A Tool for Sustainable Agriculture. American Journal of Plant Nutrition and Fertilization Technology, 5, 40–49. doi:10.3923/ajpnft.2015.40.49
  • Jansen, F. H. (2006). The herbal tea approach for artemisinin as a therapy for malaria? Transactions of the Royal Society of Tropical Medicine and Hygiene, 100(3), 285–286. doi:10.1016/j.trstmh.2005.12.006
  • Jha, P., Ram, M., Khan, M. A., Kiran, U., Mahmooduzzafara, & Abdin, M. Z. (2011). Impact of organic manure and chemical fertilizers on artemisinin content and yield in Artemisia annua L. Industrial Crops and Products, 33(2), 296–301. doi:10.1016/j.indcrop.2010.12.011
  • Kapoor, R., Chaudhary, V., & Bhatnagar, A. K. (2007). Effects of arbuscular mycorrhiza and phosphorus application on artemisinin concentration in Artemisia annua L. Mycorrhiza, 17, 581–587. doi:10.1007/s00572-007-0135-4
  • Keshavarzi, M. H. B., Mousavi-Nik, S. M., & Abdin, M. Z. (2012). The effect of biological and chemical fertilizers on chlorophyll and artemisinin content in Artemisia annua L. In The 1st international and the 4th national congress on recycling of organic waste in agriculture (pp. 1–8).
  • Kumar, S., Gupta, S. K., Gupta, M. M., Verma, R. K., Jain, D. C., Shasany, A. K., … Khanuja, S. P. S. (2002). Method for maximization of artemisinin production by the plant artemisia annua (US 6,393,763 B1).
  • Kumar, V. (2014). Characterization, bio-formulation development and shelf-life studies of locally isolated bio-fertilizer strains. Octa Journal of Environmental Research, 2(1), 32–37.
  • Li, X., Zhao, M., Guo, L., & Huang, L. (2012). Effect of cadmium on photosynthetic pigments, lipid peroxidation, antioxidants, and artemisinin in hydroponically grown Artemisia annua. Journal of Environmental Sciences (China), 24(8), 1511–1518. doi:10.1016/S1001-0742(11)60920-0
  • Liersch, R., Soicke, H., Stehr, C., & Tüllner, H.-U. (1986). Formation of artemisinin in artemisia annua during one vegetation period. Planta medica, 52(5), 387–390. doi:10.1055/s-2007-969193
  • Lin, X., Zhou, Y., Zhang, J., Lu, X., Zhang, F., Shen, Q., … Tang, K. (2011). Enhancement of artemisinin content in tetraploid Artemisia annua plants by modulating the expression of genes in artemisinin biosynthetic pathway. Biotechnology and Applied Biochemistry, 58(1), 50–57. doi:10.1002/bab.28
  • Liu, K. C. C., Yang, S., Roberts, M. F., Elford, B. C., & Phillipson, J. D. (1992). Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plant Cell Reports, 11, 637–640. doi:10.1007/BF00236389
  • Lulie, B., Nigussie, A., & Chala, M. (2017). Response of Artemisia (Artemisia annua L .) to nitrogen and phosphorus fertilizers in wondo response of Artemisia (Artemisia annua L .) to nitrogen and phosphorus fertilizers in Wondo Genet and Koka, Ethiopia. Academic Research Journal of Agricultural Science and Research, 5(6), 407–413. doi:10.14662/ARJASR2017.051
  • Magalhaes, P. M. D., Raharinaivo, J., & Delabays, N. (1996). Influence de la dose et du type d’azote sur la production en artémisinine d’Artemisia annua L. (Influence of dose and nitrogen type on Artemisinin Production of Artemisia annua L). Revue suisse de viticulture arboriculture horticulture, 28(4), 349–352.
  • Malik, A., Ahmad, J., Mir, S. R., Ali, M., & Abdin, M. Z. (2009). Influence of chemical and biological treatments on volatile oil composition of Artemisia annua Linn. Industrial Crops and Products, 30(3), 380–383. doi:10.1016/j.indcrop.2009.07.006
  • Mandal, S., Shivangi, U., Wajid, S., Ram, M., Jain, D. C., Singh, V. P., … Kapoor, R. (2014). Arbuscular mycorrhiza increase artemisinin accumulation in Artemisia annua by higher expression of key biosynthesis genes via enhanced jasmonic acid levels. Mycorrhiza, 25(5), 345–357. doi:10.1007/s00572-014-0614-3
  • Marchese, J. A., Ferreira, J. F. S., Rehder, V. L. G., & Rodrigues, O. (2010). Water deficit effect on the accumulation of biomass and artemisinin in annual wormwood (Artemisia annua L., Asteraceae). Brazilian Journal of Plant Physiology, 22(1), 1–9. doi:10.1590/S1677-04202010000100001
  • Ogwang, P. E., Ogwal, J. O., Kasasa, S., Olila, D., Ejobi, F., Kabasa, D., & Obua, C. (2012). Artemisia Annua L. Infusion consumed once a week reduces risk of multiple episodes of Malaria : A Randomised trial in a ugandan community. Tropical Journal of Pharmaceutical Research, 11(3), 445–453.
  • Omer, E. A., Abou Hussein, E. A., Hendawy, S. F., Ezz El-Din, A. A., & Gendy, E.-G. A. (2014). Effect of nitrogen and potassium fertilizers on growth, yield, essential oil and artemisinin of Artemisia Annua L plant. International Research Journal of Horticulture, 2(2), 11–20. doi:10.12966/irjh.05.02.2013
  • Özgüven, M., Şener, B., Orhan, I., Şekeroğlu, N., Kirpik, M., Kartal, M., … Kaya, Z. (2008). Effects of varying nitrogen doses on yield, yield components and artemisinin content of Artemisia annua L. Industrial Crops and Products, 27(1), 60–64. doi:10.1016/j.indcrop.2007.07.012
  • Paniego, N. B., & Giulietti, A. M. (1996). Artemisinin production by Artemisia annua L. -transformed organ cultures. Enzyme and Microbial Technology, 18, 526–530. doi:10.1016/0141-0229(95)00216-2
  • Panwar, N. (2015). Bio-fertilizers: Demand of agriculture. Research and Reviews: Journal of Agriculture and Allied Science, 4(1), 1–3.
  • Ram, M., Gupta, M., Naqvi, A., & Kumar, S. (1997). Effect of planting time on the yield of essential oil and Artemisinin in Artemisia annua under Subtropical Conditions. Journal of Essential Oil Research, 9(2), 193–197. doi:10.1080/10412905.1997.9699458
  • Rapparini, F., Llusià, J., & Peñuelas, J. (2007). Effect of Arbuscular Mycorrhizal (AM) colonization on terpene emission and content of Artemisia annua L. Plant Biology, 9, e20–e32.
  • Sharma, G., & Agrawal, V. (2013). Marked enhancement in the artemisinin content and biomass productivity in Artemisia annua L. shoots co-cultivated with Piriformospora indica. World Journal of Microbiology and Biotechnology, 29(6), 1133–1138. doi:10.1007/s11274-013-1263-y
  • Singh, A., Vishwakarma, R. A., & Husain, A. (1988). Evalutation of Artemisia annua strains for higher artemisinin production*. Planta Medica, 475–476. doi:10.1055/s-2006-962515
  • Singh, M. (2000). Effect of nitrogen, phosphorus and potassium nutrition on herb, oil and artemisinin yield of Artemisia annua under semi-arid tropical condition. Journal of Medicinal and Aromatic Plant Sciences 2000 Vol.22 No.4a Pp.368-369 Ref.7, 22(4), 368–369.
  • Sivasakthivelan, P., & Saranraj, P. (2013). Azospirillum and its formulations : A Review. International Journal of Microbiological Research, 4(3), 275–287. doi:10.5829/idosi.ijmr.2013.4.3.825
  • Srivastava, N. K., & Sharma, S. (1990). Influence of micronutrient imbalance on growth and artemisinin content in Artemisia annua. Indian Journal of Pharmaceutical Science, 52(5), 225–227.
  • Wang, H., Ma, C., Li, Z., Ma, L., Wang, H., Ye, H., … Liu, B. (2010). Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L. Industrial Crops and Products, 31, 214–218. doi:10.1016/j.indcrop.2009.10.008
  • Wang, Y., Zhang, H., Zhao, B., & Yuan, X. (2001). Improved growth of Artemisia annua L hairy roots and artemisinin production under red light conditions. Biotechnology Letters, 23, 1971–1973. doi:10.1023/A:1013786332363
  • Weathers, P. J., & Towler, M. J. (2012). The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. Planta medica, 78, 1024–1026. doi:10.1055/s-00000058
  • WHO. (2006). WHO monograph on good agricultural and collection practices (GACP) for Artemisia annua L. World Health Organisation.
  • Woerdenbag, H. J., Lfiers, J. F. J., Van Uden, W., Pras, N., Malingr, T. M., & Alfermann, A. W. (1993). Production of the new antimalarial drug artemisinin in shoot cultures of. Plant Cell, Tissue and Organ Culture, 32, 247–257. doi:10.1007/BF00029850
  • Zhou, L., Yang, G., Sun, H., Tang, J., Yang, J., Wang, Y., … Guo, L. (2016). Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annua L. Frontiers of Medicine, 1–10. doi:10.1007/s11684-016-0486-3