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Research Paper

CORM-401, an orally active carbon monoxide-releasing molecule, increases body temperature by activating non-shivering thermogenesis in rats

, ORCID Icon, , ORCID Icon &
Pages 310-317 | Received 22 Feb 2022, Accepted 29 Mar 2022, Published online: 26 Apr 2022

References

  • Dawson TM, Snyder SH. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci Off J Soc Neurosci. 1994;14:5147–5159.
  • Motterlini R. Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities. Biochem Soc Trans. 2007;35:1142–1146.
  • Foresti R, Bani-Hani MG, Motterlini R. Use of carbon monoxide as a therapeutic agent: promises and challenges. Intensive Care Med. 2008;34:649–658.
  • Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov. 2010;9:728–743.
  • Verma A, Hirsch DJ, Glatt CE, et al. Carbon monoxide: a putative neural messenger. Science. 1993;259:381–384.
  • Morita T, Perrella MA, Lee ME, et al. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A. 1995;92:1475–1479.
  • Motterlini R, Foresti R. Biological signaling by carbon monoxide and carbon monoxide-releasing molecules. Am J Physiol Cell Physiol. 2017;312:C302–C313.
  • Steiner AA, Branco LG. Central CO-heme oxygenase pathway raises body temperature by a prostaglandin-independent way. J Appl Physiol Bethesda Md 1985. 2000;88:1607–1613.
  • Steiner AA, Branco LG. Carbon monoxide is the heme oxygenase product with a pyretic action: evidence for a cGMP signaling pathway. Am J Physiol Regul Integr Comp Physiol. 2001;280:R448–457.
  • Steiner AA, Colombari E, Branco LG. Carbon monoxide as a novel mediator of the febrile response in the central nervous system. Am J Physiol. 1999;277:R499–507.
  • Jang C-G, Lee S-J, Yang S-I, et al. Carbon monoxide as a novel central pyrogenic mediator. Arch Pharm Res. 2002;25:343–348.
  • Branco LGS, Soriano RN, Steiner AA. Gaseous mediators in temperature regulation. Compr Physiol. 2014;4:1301–1338.
  • Motterlini R, Mann BE, Foresti R. Therapeutic applications of carbon monoxide-releasing molecules. Expert Opin Investig Drugs. 2005;14:1305–1318.
  • Crook SH, Mann BE, Ajhm M, et al. [Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule. Dalton Trans Camb Engl 2003. 2011;40:4230–4235.
  • Fayad-Kobeissi S, Ratovonantenaina J, Dabiré H, et al. Vascular and angiogenic activities of CORM-401, an oxidant-sensitive CO-releasing molecule. Biochem Pharmacol. 2016;102:64–77.
  • Kaczara P, Motterlini R, Rosen GM, et al. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: a role for mitoBKCa channels. Biochim Biophys Acta. 2015;1847:1297–1309.
  • Braud L, Pini M, Muchova L, et al. Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice. JCI Insight. 2018;3:123485.
  • Brand MD. Uncoupling to survive? The role of mitochondrial inefficiency in ageing. Exp Gerontol. 2000;35:811–820.
  • Divakaruni AS, Brand MD. The regulation and physiology of mitochondrial proton leak. Physiol Bethesda Md. 2011;26:192–205.
  • Nikam A, Ollivier A, Rivard M, et al. Diverse Nrf2 activators coordinated to cobalt carbonyls induce heme oxygenase-1 and release carbon monoxide in Vitro and in Vivo. J Med Chem. 2016;59:756–762.
  • Rodkey FL, Hill TA, Pitts LL, et al. Spectrophotometric measurement of carboxyhemoglobin and methemoglobin in blood. Clin Chem. 1979;25:1388–1393.
  • Romanovsky AA, Ivanov AI, Shimansky YP. Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. J Appl Physiol Bethesda Md 1985. 2002;92:2667–2679.
  • Santos BM, Francescato HDC, Turcato FC, et al. Increased hypothalamic hydrogen sulphide contributes to endotoxin tolerance by down-modulating PGE2 production. Acta Physiol Oxf Eng. 2020;228:e13373.
  • Amorim MR, Moreira DA, Santos BM, et al. Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamicproduction and increased heat loss. J Physiol. 2020. DOI:10.1113/JP280321
  • Banet M, Hensel H, Liebermann H. The central control of shivering and non-shivering thermogenesis in the rat. J Physiol. 1978;283:569–584.
  • Azzu V, Brand MD. The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem Sci. 2010;35:298–307.
  • Edwards MM, Nguyen HK, Dodson AD, et al. Effects of combined oxytocin and Beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats. Front Physiol. 2021;12:725912.
  • Fiumana E, Parfenova H, Jaggar JH, et al. Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs. Am J Physiol Heart Circ Physiol. 2003;284:H1073–1079.
  • Collins MG, Hunter WS, Blatteis CM. Factors producing elevated core temperature in spontaneously hypertensive rats. J Appl Physiol Bethesda Md. 1987;1985(63):740–745.
  • Berkey DL, Meeuwsen KW, Barney CC. Measurements of core temperature in spontaneously hypertensive rats by radiotelemetry. Am J Physiol. 1990;258:R743–749.
  • Leffler CW, Parfenova H, Jaggar JH. Carbon monoxide as an endogenous vascular modulator. Am J Physiol - Heart Circ Physiol. 2011;301:H1–H11.
  • Motterlini R, Gonzales A, Foresti R, et al. Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo. Circ Res. 1998;83:568–577.
  • Stec DE, Drummond HA, Vera T. Role of carbon monoxide in blood pressure regulation. Hypertension. 2008;51:597–604.
  • Hosick PA, AlAmodi AA, Storm MV, et al. Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet. Int J Obes 2005. 2014;38:132–139.
  • Fredenburgh LE, Perrella MA, Barragan-Bradford D, et al. A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI Insight. 2018;3:124039.

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