Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 3, 2016 - Issue 4
Submit an article Journal homepage
782
Views
0
CrossRef citations to date
0
Altmetric
Author's Views

Drug targets evolve, and so should the methods

Christopher WilsonHoward Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, MA, USA.
,
Roman V. AgafonovHoward Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, MA, USA.
&
Dorothee KernHoward Hughes Medical Institute, Department of Biochemistry, Brandeis University, Waltham, MA, USA.Correspondence[email protected]
Article: e1046580 | Received 22 Apr 2015, Accepted 23 Apr 2015, Published online: 31 May 2016

References

  • Hunter T. Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol 2009; 21(2):140-6; PMID:19269802; http://dx.doi.org/10.1016/j.ceb.2009.01.028.
  • Rokas A. The molecular origins of multicellular transitions. Curr Opin Genet Dev 2008; 18(6):472-8; PMID:18926910; http://dx.doi.org/10.1016/j.gde.2008.09.004.
  • Cohen MH, Williams G, Johnson JR, Duan J, Gobburu J, Rahman A, Benson K, Leighton J, Kim SK, Wood R, et al. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res 2002; 8(5):935-42; PMID:12006504.
  • Agafonov RV, Wilson C, Otten R, Buosi V, Kern D. Energetic dissection of Gleevec's selectivity toward human tyrosine kinases. Nat Struct Mol Biol 2014; 21(10):848-53; PMID:25218445; http://dx.doi.org/10.1038/nsmb.2891.
  • DePristo M.A, Weinreich DM, Hartl DL. Missense meanderings in sequence space: a biophysical view of protein evolution. Nat Rev Genet 2005; 6(9):678-87; PMID:16074985; http://dx.doi.org/10.1038/nrg1672.
  • Vishveshwara S, Ghosh A, Hansia P. Intra and inter-molecular communications through protein structure network. Curr Protein Pept Sci 2009; 10(2):146-60; PMID:19355982; http://dx.doi.org/10.2174/138920309787847590.
  • Pauling L and Zuckerkandl E, Chemical Paleogenetics: Molecular ‘Restoration Studies’ of Extinct Forms of Life, Acta Chem. Scand. 1963; 17:S9–S16.
  • Harms MJ, Thornton JW. Evolutionary biochemistry: revealing the historical and physical causes of protein properties. Nat Rev Genet 2013; 14(8):559-71; PMID:23864121; http://dx.doi.org/10.1038/nrg3540.
  • Wilson C, Agafonov RV, Hoemberger M, Kutter S, Zorba A, Halpin J, Buosi V, Otten R, Waterman D, Theobald DL, et al. Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism. Science 2015; 347(6224):882-6; PMID:25700521; http://dx.doi.org/10.1126/science.aaa1823.
  • King N. The unicellular ancestry of animal development. Dev Cell 2004; 7(3):313-25; PMID:15363407; http://dx.doi.org/10.1016/j.devcel.2004.08.010.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.