Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 3, 2016 - Issue 4
Submit an article Journal homepage
1,440
Views
8
CrossRef citations to date
0
Altmetric
Commentary

Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia

S. KasarDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
&
J. R. BrownDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA;Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
Article: e1157667 | Received 05 Feb 2016, Accepted 18 Feb 2016, Published online: 31 May 2016

References

  • Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS, Sougnez C, Stewart C, Sivachenko A, Wang L, et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013; 152, 714-26; PMID:23415222; http://dx.doi.org/10.1016/j.cell.2013.01.019
  • Quesada V, Conde L, Villamor N, Ordóñez GR, Jares P, Bassaganyas L, Ramsay AJ, Beà S, Pinyol M, Martínez-Trillos A, et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2012; 44, 47-52; PMID:22158541; http://dx.doi.org/10.1038/ng.1032
  • Landau DA, et al. Mutations driving CLL and their evolution in progression and relapse. Nature 2015; 526, 525-30; PMID:26466571; http://dx.doi.org/10.1038/nature15395
  • Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, et al. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature 2015; 526, 519-24; PMID:26200345; http://dx.doi.org/10.1038/nature14666
  • Klein U, Lia M, Crespo M, Siegel R, Shen Q, Mo T, Ambesi-Impiombato A, Califano A, Migliazza A, Bhagat G, et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010; 17, 28-40; PMID:20060366; http://dx.doi.org/10.1016/j.ccr.2009.11.019
  • Kasar S, Kim J, Improgo R, Tiao G, Polak P, Haradhvala N, Lawrence MS, Kiezun A, Fernandes SM, Bahl S, et al. Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution. Nat Commun 2015; 6, 8866; PMID:26638776; http://dx.doi.org/10.1038/ncomms9866
  • Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL, et al. Signatures of mutational processes in human cancer. Nature 2013; 500, 415-21; PMID:23945592; http://dx.doi.org/10.1038/nature12477
  • Oppezzo P, Vuillier F, Vasconcelos Y, Dumas G, Magnac C, Payelle-Brogard B, Pritsch O, Dighiero G. Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation. Blood 2003; 101, 4029-32; PMID:12521993; http://dx.doi.org/10.1182/blood-2002-10-3175
  • Heintel D, Kroemer E, Kienle D, Schwarzinger I, Gleiss A, Schwarzmeier J, Marculescu R, Le T, Mannhalter C, Gaiger A, et al. High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia. Leukemia 2004; 18, 756-62; PMID:14961036; http://dx.doi.org/10.1038/sj.leu.2403294
  • Abstracts from the XVI International Workshop on Chronic Lymphocytic Leukemia 2015 6 – 9 September 2015 Sydney, Australia. Leuk Lymphoma, 2015; 1-327; PMID:26332288; http://dx.doi.org/10.3109/10428194.2015.1080893

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.