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Molecular & Cellular Oncology Volume 3, 2016 - Issue 4
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Commentary

Functional versus non-functional intratumor heterogeneity in cancer

Marc J. WilliamsEvolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK;Department of Cell and Developmental Biology, University College London, London, UK.;Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College, London, UKCorrespondence[email protected] [email protected]
,
Benjamin WernerCentre for Evolution and Cancer, The Institute of Cancer Research, London, UKCorrespondence[email protected] [email protected]
,
Trevor A. GrahamEvolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, London, UK
&
Andrea SottorivaCentre for Evolution and Cancer, The Institute of Cancer Research, London, UK
Article: e1162897 | Received 02 Mar 2016, Accepted 02 Mar 2016, Published online: 16 May 2016

References

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  • Ling S. et al. Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution. Proc Natl Acad Sci USA 2015; 112:E6496-505; PMID:26561581; http://dx.doi.org/10.1073/pnas.1519556112
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