Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 3, 2016 - Issue 4
Submit an article Journal homepage
770
Views
3
CrossRef citations to date
0
Altmetric
Author's Views

Asymmetric division: An antitumor player?

Lihua WangDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA
,
Pengcheng BuDepartment of Biomedical Engineering, Cornell University, Ithaca, NY, USA;Departments of Biomedical Engineering, Duke University, Durham, NC, USA
&
Xiling ShenDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA;Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA;Departments of Biomedical Engineering, Duke University, Durham, NC, USACorrespondence[email protected]
Article: e1164279 | Received 02 Mar 2016, Accepted 05 Mar 2016, Published online: 31 May 2016

References

  • Clevers H. Stem cells, asymmetric division and cancer. Nat Genet 2005; 37:1027-8; PMID:16195718; http://dx.doi.org/10.1038/ng1005-1027
  • Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 2010; 143:134-44; PMID:20887898; http://dx.doi.org/10.1016/j.cell.2010.09.016
  • Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009; 457:608-11; PMID:19092804; http://dx.doi.org/10.1038/nature07602
  • Bu P, Wang L, Chen KY, Srinivasan T, Murthy PK, Tung KL, Varanko AK, Chen HJ, Ai Y, King S, et al. A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. Cell Stem Cell 2016; 18:189-202; PMID:26849305; http://dx.doi.org/10.1016/j.stem.2016.01.006
  • Hermeking H. p53 enters the microRNA world. Cancer Cell 2007; 12:414-8; PMID:17996645; http://dx.doi.org/10.1016/j.ccr.2007.10.028
  • Choi YJ, Lin CP, Ho JJ, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, et al. miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol 2011; 13:1353-60; PMID:22020437; http://dx.doi.org/10.1038/ncb2366
  • Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011; 17:211-5; PMID:21240262; http://dx.doi.org/10.1038/nm.2284
  • Bu P, Chen KY, Chen JH, Wang L, Walters J, Shin YJ, Goerger JP, Sun J, Witherspoon M, Rakhilin N, et al. A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell 2013; 12:602-15; PMID:23642368; http://dx.doi.org/10.1016/j.stem.2013.03.002
  • van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005; 435:959-63; PMID:15959515; http://dx.doi.org/10.1038/nature03659
  • Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW, et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol 2014; 16:268-80; PMID:24561623; http://dx.doi.org/10.1038/ncb2910

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.