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Molecular & Cellular Oncology Volume 3, 2016 - Issue 4
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HMGB1: The metabolic weapon in the arsenal of NK cells

Adelheid CerwenkaGerman Cancer Research Center, Research Group Innate Immunity, Heidelberg, Germany
,
Jürgen KopitzInstitute of Pathology, University of Heidelberg, Heidelberg, Germany
,
Peter SchirmacherInstitute of Pathology, University of Heidelberg, Heidelberg, Germany
,
Wilfried RothInstitute of Pathology, University Medical Center Mainz, Mainz, Germany
&
Georg GdyniaInstitute of Pathology, University of Heidelberg, Heidelberg, Germany;German Cancer Research Center, Clinical Cooperation Unit Molecular Tumor Pathology, Heidelberg, GermanyCorrespondence[email protected]
Article: e1175538 | Received 01 Apr 2016, Accepted 02 Apr 2016, Published online: 09 Jun 2016

References

  • Vanherberghen B, Olofsson PE, Forslund E, Sternberg-Simon M, Khorshidi MA, Pacouret S, Guldevall K, Enqvist M, Malmberg KJ, Mehr R, et al. Classification of human natural killer cells based on migration behavior and cytotoxic response. Blood 2013; 121:1326-34; PMID:23287857; http://dx.doi.org/10.1182/blood-2012-06-439851
  • van der Burg SH, Arens R, Ossendorp F, van Hall T, Melief CJ. Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nat Rev Cancer 2016; 16(4):219-33; PMID:26965076; http://dx.doi.org/10.1038/nrc.2016.16
  • Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, et al. The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun 2016; 7:10764; PMID:26948869; http://dx.doi.org/10.1038/ncomms10764
  • Saidi H, Melki MT, Gougeon ML. HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk. PloS One 2008; 3:e3601; PMID:18974890; http://dx.doi.org/10.1371/journal.pone.0003601
  • Calogero S, Grassi F, Aguzzi A, Voigtlander T, Ferrier P, Ferrari S, Bianchi ME. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet 1999; 22:276-80; PMID:10391216; http://dx.doi.org/10.1038/10338
  • Gdynia G, Keith M, Kopitz J, Bergmann M, Fassl A, Weber AN, George J, Kees T, Zentgraf HW, Wiestler OD, et al. Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria. Cancer Res 2010; 70:8558-68; PMID:20959471; http://dx.doi.org/10.1158/0008-5472.CAN-10-0204
  • Janssen HL, Haustermans KM, Balm AJ, Begg AC. Hypoxia in head and neck cancer: how much, how important? Head & Neck 2005; 27:622-38; PMID:15952198; http://dx.doi.org/10.1002/hed.20223
  • Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008; 452:181-6; PMID:18337815; http://dx.doi.org/10.1038/nature06667
  • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
  • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4:891-9; PMID:15516961; http://dx.doi.org/10.1038/nrc1478

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