Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 3, 2016 - Issue 4
Submit an article Journal homepage
606
Views
0
CrossRef citations to date
0
Altmetric
Commentary

Tumor responsiveness to statins requires overexpression of the ARF6 pathway

Hisataka SabeDepartment of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, JapanCorrespondence[email protected]
,
Ari HashimotoDepartment of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
,
Shigeru HashimotoDepartment of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
&
Tsukasa OikawaDepartment of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Article: e1185564 | Received 28 Apr 2016, Accepted 28 Apr 2016, Published online: 30 Jun 2016

References

  • Endo A, Kuroda M, Tsujita Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. J Antibiot 1976; 29:1346-1348; PMID:1010803; http://dx.doi.org/10.7164/antibiotics.29.1346
  • Goldstein JL, Brown MS. 1990. Regulation of the mevalonate pathway. Nature 1990; 343:425-430; PMID:1967820; http://dx.doi.org/10.1038/343425a0
  • Nielsen SF, Nordestgaard BG, Bojesen SE. Statin use and reduced cancer-related mortality. N Engl J Med 2012; 367:1792-1802; PMID:23134381; http://dx.doi.org/10.1056/NEJMoa1201735
  • Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, et al. P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. J Cell Biol 2016; 213:81-95; PMID:27044891; http://dx.doi.org/10.1083/jcb.201510002
  • Sabe H. Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion. J Biochem 2003; 134:485-489; PMID:14607973; http://dx.doi.org/10.1093/jb/mvg181
  • Sabe H, Hashimoto S, Morishige M, Ogawa E, Hashimoto A, Nam JM, Miura K, Yano H, Onodera Y. The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis. Traffic 2009; 10: 982-993; PMID:19416474; http://dx.doi.org/10.1111/j.1600-0854.2009.00917.x
  • Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, Furukawa S, Handa H, Oikawa T, Okada Y, et al. Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Nat Commun 2016; 7:10656; PMID:26854204; http://dx.doi.org/10.1038/ncomms10656
  • Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, et al. GEP100 links EGFR signaling to Arf6 activation to induce breast cancer invasion. Nat Cell Biol. 2008; 10:85-92; PMID:18084281; http://dx.doi.org/10.1038/ncb1672
  • Kinoshita R, Nam JM, Ito YM, Hatanaka KC, Hashimoto A, Handa H, Otsuka Y, Hashimoto S, Onodera Y, Hosoda M, et al. Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy. PLoS ONE 2013; 8:e76791; PMID:24116160; http://dx.doi.org/10.1371/journal.pone.0076791
  • Ahern TP, Lash TL, Damkier P, Christiansen PM, Cronin-Fenton DP. Statins and breast cancer prognosis: evidence and opportunities. Lancet Oncol 2014; 15:e461-8; PMID:25186049; http://dx.doi.org/10.1016/S1470-2045(14)70119-6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.