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Molecular & Cellular Oncology Volume 5, 2018 - Issue 5
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Dual mechanism of DICER downregulation facilitates cancer metastasis

Hui-Huang LaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C;Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.CORCID Iconhttp://orcid.org/0000-0003-3594-3271
ORCID Icon &
Pai-Sheng ChenInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C;Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.CCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-0513-1467
ORCID Icon
Article: e1472056 | Received 13 Apr 2018, Accepted 16 Apr 2018, Published online: 24 Aug 2018

References

  • Lin S, Gregory RI. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015; (15):321–333. PMID:25998712. doi:10.1038/nrc3932.
  • Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J, Kirsch DG, Golub TR, Jacks T. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009; (23):2700–2704. PMID:19903759. doi:10.1101/gad.1848209.
  • Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet. 2007; (39):673–677. PMID:17401365. doi:10.1038/ng2003.
  • Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, et al. A MicroRNA targeting dicer for metastasis control. Cell. 2010; (141):1195–1207. PMID:20603000. doi:10.1016/j.cell.2010.05.017.
  • Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, et al. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest. 2018; (128):625–643. PMID:29251629. doi:10.1172/JCI89212.
  • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003; (3):721–732. PMID:13130303. doi:10.1038/nrc1187.
  • Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, et al. Parkin targets HIF-1alpha for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun. 2017; (8):1823. PMID:29180628. doi:10.1038/s41467-017-01947-w.
  • Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, et al. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nat Commun. 2014; (5):5202. PMID:25351346. doi:10.1038/ncomms6202.
  • van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, et al. Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun. 2014; (5): 5203. PMID:25351418. doi:10.1038/ncomms6203.
  • Ho JJ, Metcalf JL, Yan MS, Turgeon PJ, Wang JJ, Chalsev M, Petruzziello-Pellegrini TN, Tsui AK, He JZ, Dhamko H, et al. Functional importance of Dicer protein in the adaptive cellular response to hypoxia. J Biol Chem. 2012; (287):29003–29020. PMID:22745131. doi:10.1074/jbc.M112.373365.

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