1,379
Views
5
CrossRef citations to date
0
Altmetric
Commentary

Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism

ORCID Icon, &
Article: 1735284 | Received 12 Feb 2020, Accepted 20 Feb 2020, Published online: 19 Mar 2020

References

  • Lukey MJ, Greene KS, Erickson JW, Wilson KF, Cerione RA. The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy. Nat Commun. 2016;7:1. doi:10.1038/ncomms11321.
  • Gao P, Tchernyshyov I, Chang T-C, Lee Y-S, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009;458:762–3. doi:10.1038/nature07823.
  • Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MCJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, et al. SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis. Proc Natl Acad Sci USA. 2019;116:26625–26632. doi:10.1073/pnas.1911954116.
  • Wagner GR, Bhatt DP, O'Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, et al. A class of reactive acyl-CoA species reveals the non-enzymatic origins of protein acylation. Cell Metab. 2017;25:823–837. doi:10.1016/j.cmet.2017.03.006.
  • Kumar S, Lombard DB. Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal. 2015;22:1060–1077. doi:10.1089/ars.2014.6213.
  • Park J, Chen Y, Tishkoff D, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner M, et al. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Molecular Cell. 2013;50:919–930. doi:10.1016/j.molcel.2013.06.001.
  • Weinert BT, Schölz C, Wagner S, Iesmantavicius V, Su D, Daniel J, Choudhary C. Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep. 2013;4:842–851. doi:10.1016/j.celrep.2013.07.024.
  • Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, et al. SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion. Cell Metab. 2017;25:838–855. doi:10.1016/j.cmet.2017.03.003.
  • Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB. Emerging roles for SIRT5 in metabolism and cancer. Antioxid Redox Signal. 2018;28:677–690. doi:10.1089/ars.2017.7264.
  • Zhu Y, Yan Y, Principe DR, Zou X, Vassilopoulos A, Gius D. SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab. 2014;2:15. doi:10.1186/2049-3002-2-15.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.