Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 7, 2020 - Issue 5
Submit an article Journal homepage
438
Views
3
CrossRef citations to date
0
Altmetric
Commentary

A bidirectional crosstalk between autophagy and TP53 determines the pace of aging

Valentina Sicaa Centre De Recherche Des Cordeliers, Equipe Labellisée Par La Ligue Contre Le Cancer, Université De Paris, Sorbonne Université, Inserm, Paris, France;b Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France;c Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), Barcelona, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2770-5847
ORCID Icon &
Guido Kroemera Centre De Recherche Des Cordeliers, Equipe Labellisée Par La Ligue Contre Le Cancer, Université De Paris, Sorbonne Université, Inserm, Paris, France;b Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France;d Pôle De Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;e Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China;f Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9334-4405
ORCID Icon
Article: 1769434 | Received 30 Apr 2020, Accepted 11 May 2020, Published online: 18 Jun 2020

References

  • Labuschagne CF, Zani F, Vousden KH. Control of metabolism by p53 - Cancer and beyond. Biochim Biophys Acta Rev Cancer. 2018;1870(1):1–3. doi:10.1016/j.bbcan.2018.06.001.
  • García-Prat L, Martínez-Vicente M, Perdiguero E, Ortet L, Rodríguez-Ubreva J, Rebollo E, Ruiz-Bonilla V, Gutarra S, Ballestar E, Serrano AL, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529(7584):37–42. doi:10.1038/nature16187.
  • Tavernarakis N, Pasparaki A, Tasdemir E, Maiuri MC, Kroemer G. The effects of p53 on whole organism longevity are mediated by autophagy. Autophagy. 2008;4(7):870–873. doi:10.4161/auto.6730.
  • Yang Y, Karsli-Uzunbas G, Poillet-Perez L, Sawant A, Hu ZS, Zhao Y, Moore D, Hu W, White E. Autophagy promotes mammalian survival by suppressing oxidative stress and p53. Genes Dev. 2020;34(9–10):688–700. doi:10.1101/gad.335570.119.
  • Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov. 2014;4(8):914–927. doi:10.1158/2159-8290.CD-14-0363.
  • Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D’Amelio M, Criollo A, Morselli E, Zhu C, Harper F. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol. 2008;10(6):676–687. doi:10.1038/ncb1730.
  • Cassidy LD, Young ARJ, Young CNJ, Soilleux EJ, Fielder E, Weigand BM, Lagnado A, Brais R, Ktistakis NT, Wiggins KA. Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk. Nat Commun. 2020;11(1):307. doi:10.1038/s41467-019-14187-x.
  • Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020;11(1):189. doi:10.1038/s41467-019-13832-9.
  • Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017;169(1):132–147.e16. doi:10.1016/j.cell.2017.02.031.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.