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Molecular & Cellular Oncology Volume 7, 2020 - Issue 5
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Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Yue Liua Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA;b Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USAView further author information
,
Haojian Lia Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA;b Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USAORCID Iconhttps://orcid.org/0000-0002-2194-1227View further author information
ORCID Icon,
Susan E. Zimmermana Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA;b Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USAORCID Iconhttps://orcid.org/0000-0003-4344-9943View further author information
ORCID Icon &
Urbain Weyemia Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA;b Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2693-3234View further author information
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Article: 1771959 | Received 07 May 2020, Accepted 14 May 2020, Published online: 13 Jul 2020

References

  • McKinnon PJ. Maintaining genome stability in the nervous system. Nat Neurosci. 2013;16:1–3. doi:10.1038/nn.3537.
  • McKinnon PJ. DNA repair deficiency and neurological disease. Nat Rev Neurosci. 2009;10:100–112. doi:10.1038/nrn2559.
  • Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier Y. GammaH2AX and cancer. Nat Rev Cancer. 2008;8:957–967. doi:10.1038/nrc2523.
  • Weyemi U, Redon CE, Choudhuri R, Aziz T, Maeda D, Boufraqech M, Parekh PR, Sethi TK, Kasoji M, Abrams N, et al. The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition. Nat Commun. 2016;7:10711. doi:10.1038/ncomms10711.
  • Weyemi U, Redon CE, Bonner WM. H2AX and EMT: deciphering beyond DNA repair. Cell Cycle. 2016;15:1305–1306. doi:10.1080/15384101.2016.1160659.
  • Weyemi U, Redon CE, Sethi TK, Burrell AS, Jailwala P, Kasoji M, Abrams N, Merchant A, Bonner WM. Twist1 and Slug mediate H2AX-regulated epithelial-mesenchymal transition in breast cells. Cell Cycle. 2016;15:2398–2404. doi:10.1080/15384101.2016.1198864.
  • Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nat Commun. 2018;9:1526. doi:10.1038/s41467-018-03948-9.
  • Gruosso T, Mieulet V, Cardon M, Bourachot B, Kieffer Y, Devun F, Dubois T, Dutreix M, Vincent‐Salomon A, Miller KM, et al. Chronic oxidative stress promotes H2 AX protein degradation and enhances chemosensitivity in breast cancer patients. EMBO Mol Med. 2016;8:527–549. doi:10.15252/emmm.201505891.
  • Weyemi U, Paul BD, Bhattacharya D, Malla AP, Boufraqech M, Harraz MM, Bonner WM, Snyder SH. Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis. Proc Natl Acad Sci U S A. 2019;116:7471–7476. doi:10.1073/pnas.1820245116.
  • LeBleu VS, O’Connell JT, Herrera KNG, Wikman H, Pantel K, Haigis MC, De Carvalho FM, Damascena A, Chinen LTD, Rocha RM, et al. PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014;16(992–1003):1001–1015. doi:10.1038/ncb3039.

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