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Molecular & Cellular Oncology Volume 7, 2020 - Issue 5
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Commentary

EIF2α phosphorylation: a hallmark of both autophagy and immunogenic cell death

Juliette Humeaua Equipe Labellisée Par La Ligue Contre Le Cancer, Université De Paris, Sorbonne Université, INSERM UMR1138, Centre De Recherche Des Cordeliers, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France
,
Lucillia Bezua Equipe Labellisée Par La Ligue Contre Le Cancer, Université De Paris, Sorbonne Université, INSERM UMR1138, Centre De Recherche Des Cordeliers, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France;c Département D’anesthésie-réanimation, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceORCID Iconhttps://orcid.org/0000-0002-3569-6066
ORCID Icon,
Oliver Keppa Equipe Labellisée Par La Ligue Contre Le Cancer, Université De Paris, Sorbonne Université, INSERM UMR1138, Centre De Recherche Des Cordeliers, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6081-9558
ORCID Icon &
Guido Kroemera Equipe Labellisée Par La Ligue Contre Le Cancer, Université De Paris, Sorbonne Université, INSERM UMR1138, Centre De Recherche Des Cordeliers, Paris, France;b Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France;d Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China;e Pôle De Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;f Karolinska Institutet, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9334-4405
ORCID Icon
Article: 1776570 | Received 21 May 2020, Accepted 27 May 2020, Published online: 19 Jun 2020

References

  • Hetz C, Papa FR. The unfolded protein response and cell fate control. Mol Cell. 2018;69(2):1–3. doi:10.1016/j.molcel.2017.06.017.
  • Bezu L, Sauvat A, Humeau J, Gomes-da-Silva LC, Iribarren K, Forveille S, Garcia P, Zhao L, Liu P, Zitvogel L, et al. eIF2alpha phosphorylation is pathognomonic for immunogenic cell death. Cell Death Differ. 2018;25(8):1375–1393. doi:10.1038/s41418-017-0044-9.
  • Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, et al. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020;8(1):e000337. doi:10.1136/jitc-2019-000337.
  • Humeau J, Sauvat A, Cerrato G, Xie W, Loos F, Iannantuoni F, Bezu L, Lévesque S, Paillet J, Pol J, et al. Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress. EMBO Mol Med. 2020;12(5):e11622. doi:10.15252/emmm.201911622.
  • Humeau J, Leduc M, Cerrato G, Loos F, Kepp O, Kroemer G, et al. Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy. Cell Death Dis. 2020. doi:10.1038/s41419-020-2642-6.
  • Garg AD, Elsen S, Krysko DV, Vandenabeele P, de Witte P, Agostinis P. Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. Oncotarget. 2015;6(29):26841–26860. doi:10.18632/oncotarget.4754.
  • Aurelius J, Möllgård L, Kiffin R, Ewald Sander F, Nilsson S, Thorén FB, Hellstrand K, Martner A. Anthracycline-based consolidation may determine outcome of post-consolidation immunotherapy in AML. Leuk Lymphoma. 2019;60(11):2771–2778. doi:10.1080/10428194.2019.1599110.
  • Fucikova J, Becht E, Iribarren K, Goc J, Remark R, Damotte D, Alifano M, Devi P, Biton J, Germain C. Calreticulin expression in human non-small cell lung cancers correlates with increased accumulation of antitumor immune cells and favorable prognosis. Cancer Res. 2016;76(7):1746–1756. doi:10.1158/0008-5472.CAN-15-1142.
  • Kasikova L, Hensler M, Truxova I, Skapa P, Laco J, Belicova L, Praznovec I, Vosahlikova S, Halaska MJ, Brtnicky T, et al. Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients. J Immunother Cancer. 2019;7(1):312. doi:10.1186/s40425-019-0781-z.
  • Darini C, Ghaddar N, Chabot C, Assaker G, Sabri S, Wang S, Krishnamoorthy J, Buchanan M, Aguilar-Mahecha A, Abdulkarim B, et al. An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy. Nat Commun. 2019;10(1):2139. doi:10.1038/s41467-019-10138-8.
  • Ignatiadis M, Van den Eynden G, Roberto S, Fornili M, Bareche Y, Desmedt C, Rothé F, Maetens M, Venet D, Holgado E, et al. Tumor-infiltrating lymphocytes in patients receiving trastuzumab/pertuzumab-based chemotherapy: A TRYPHAENA substudy. J Natl Cancer Inst. 2019;111(1):69–77. doi:10.1093/jnci/djy076.
  • Romaguera JE, Lee HJ, Tarapore R, Prabhu V, Allen J, Schalop L, Zloza A, Ok CY, Sadimin ET, Schenkel J, et al. Integrated stress response and immune cell infiltration in an ibrutinib-refractory mantle cell lymphoma patient following ONC 201 treatment. Br J Haematol. 2019;185(1):133–136. doi:10.1111/bjh.15271.

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