Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 7, 2020 - Issue 5
Submit an article Journal homepage
1,437
Views
8
CrossRef citations to date
0
Altmetric
Author’s views

Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye

Pavlos Msaouela Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA;b Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6505-8308View further author information
ORCID Icon,
Cheryl L. Walkerb Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA;c Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA;d Department of Medicine, Baylor College of Medicine, Houston, Texas, USA;e Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USAView further author information
,
Giannicola Genovesea Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA;f Department of Genomic Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USAView further author information
&
Nizar M. Tannira Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAView further author information
Article: 1777060 | Received 15 May 2020, Accepted 28 May 2020, Published online: 23 Jun 2020

References

  • Msaouel P, Hong AL, Mullen EA, Atkins MB, Walker CL, Lee CH, Carden MA, Genovese G, Linehan WM, Rao P, et al. Updated recommendations on the diagnosis, management, and clinical trial eligibility criteria for patients with renal medullary carcinoma. Clin Genitourin Cancer. 2019;17(1):1–3. doi:10.1016/j.clgc.2018.09.005.
  • Msaouel P, NM T, CL W. A model linking sickle cell hemoglobinopathies and SMARCB1 Loss in Renal Medullary Carcinoma. Clin Cancer Res. 2018;24(9):2044–2049. doi:10.1158/1078-0432.CCR-17-3296.
  • Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, et al. Comprehensive molecular characterization identifies distinct genomic and immune hallmarks of Renal Medullary Carcinoma. Cancer Cell. 2020;37(5):720–734.e13. doi:10.1016/j.ccell.2020.04.002.
  • Pawel BR. SMARCB1-deficient Tumors of childhood: a practical guide. Pediatr Dev Pathol. 2018;21(1):6–28. doi:10.1177/1093526617749671.
  • Shah AY, Karam JA, Malouf GG, Rao P, Lim ZD, Jonasch E, Xiao L, Gao J, Vaishampayan UN, Heng DY, et al. Management and outcomes of patients with renal medullary carcinoma: a multicentre collaborative study. BJU Int. 2017;120(6):782–792. doi:10.1111/bju.13705.
  • Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, et al. p53 is a master regulator of proteostasis in SMARCB1-deficient malignant Rhabdoid tumors. Cancer Cell. 2019;35(2):204–220 e209. doi:10.1016/j.ccell.2019.01.006.
  • Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542(7641):362–366. doi:10.1038/nature21064.
  • Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, et al. Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. Elife. 2019;8. doi:(doi:10.7554/eLife.44161.
  • Msaouel P, Carugo A, Genovese G. Targeting proteostasis and autophagy in SMARCB1-deficient malignancies: where next? Oncotarget. 2019;10(40):3979–3981. doi:10.18632/oncotarget.26970.
  • Hayashi T, Gust KM, Wyatt AW, Goriki A, Jager W, Awrey S, Li N, Oo HZ, Altamirano-Dimas M, Buttyan R, et al. Not all notch is created equal: the Oncogenic role of NOTCH2 in Bladder Cancer and its implications for targeted therapy. Clin Cancer Res. 2016;22(12):2981–2992. doi:10.1158/1078-0432.CCR-15-2360.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.