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Molecular & Cellular Oncology Volume 9, 2022 - Issue 1
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Commentary

Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma

Daria Capecea Department of Immunology and Inflammation, Imperial College London, London, UK;b Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila, L’Aquila, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3126-2014View further author information
ORCID Icon &
Guido Franzosoa Department of Immunology and Inflammation, Imperial College London, London, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0778-988XView further author information
ORCID Icon
Article: 2024051 | Received 16 Nov 2021, Accepted 21 Dec 2021, Published online: 27 Jan 2022

References

  • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348(17):1625–4. doi:10.1056/NEJMoa021423.
  • Munir R, Lisec J, Swinnen JV, Zaidi N. Lipid metabolism in cancer cells under metabolic stress. Br J Cancer. 2019;120(12):1090–1098. doi:10.1038/s41416-019-0451-4.
  • Park J, Morley TS, Kim M, Clegg DJ, Scherer PE. Obesity and cancer–mechanisms underlying tumour progression and recurrence. Nat Rev Endocrinol. 2014;10(8):455–465. doi:10.1038/nrendo.2014.94.
  • Koundouros N, Poulogiannis G. Reprogramming of fatty acid metabolism in cancer. Br J Cancer. 2020;122(1):4–22. doi:10.1038/s41416-019-0650-z.
  • Kreuzaler P, Panina Y, Segal J, Yuneva M. Adapt and conquer: metabolic flexibility in cancer growth, invasion and evasion. Mol Metab. 2020;33:83–101. doi:10.1016/j.molmet.2019.08.021.
  • Butler LM, Perone Y, Dehairs J, Lupien, LE, de Laat, V, Talebi, A, Loda, M, Kinlaw, WB, Swinnen, JV. Lipids and cancer: emerging roles in pathogenesis, diagnosis and therapeutic intervention. Adv Drug Deliv Rev. 2020;159:245–293. doi:10.1016/j.addr.2020.07.013.
  • Carracedo A, Cantley LC, Pandolfi PP. Cancer metabolism: fatty acid oxidation in the limelight. Nat Rev Cancer. 2013;13(4):227–232. doi:10.1038/nrc3483.
  • Fernández LP, Gómez de Cedrón M, Ramírez de Molina A. Alterations of lipid metabolism in cancer: implications in prognosis and treatment. Front Oncol. 2020;10:577420. doi:10.3389/fonc.2020.577420.
  • Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, et al. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016;22(4):427–432. doi:10.1038/nm.4055.
  • Xiong X, Wen Y-A, Fairchild R, Zaytseva YY, Weiss HL, Evers BM, Gao T. Upregulation of CPT1A is essential for the tumor-promoting effect of adipocytes in colon cancer. Cell Death Dis. 2020;11(9):736. doi:10.1038/s41419-020-02936-6.
  • Tian W, Zhang W, Zhang Y, Zhu T, Hua Y, Li H, Zhang Q, Xia M. FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport. Cancer Cell Int. 2020;20(1):512. doi:10.1186/s12935-020-01582-4.
  • Zaytseva Y. Lipid metabolism as a targetable metabolic vulnerability in colorectal cancer. Cancers (Basel). 2021;13(2):301. doi:10.3390/cancers13020301.
  • Petan T. Lipid droplets in cancer. Rev Physiol Biochem Pharmacol. 2020. doi:10.1007/112_2020_51.
  • Wang YY, Attané C, Milhas D, Dirat B, Dauvillier S, Guerard A, Gilhodes J, Lazar I, Alet N, Laurent V, et al. Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells. JCI Insight. 2017;2(4):e87489. doi:10.1172/jci.insight.87489.
  • Guinney J, Dienstmann R, Wang X, De Reynies A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21(11):1350–1356. doi:10.1038/nm.3967.
  • Capece D, D’-Andrea D, Begalli F, Goracci L, Tornatore L, Alexander JL, Di Veroli A, Leow SC, Vaiyapuri TS, Ellis JK, et al. Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. J Clin Invest. 2021;131(11). doi:10.1172/JCI137845.
  • Lian J, Nelson R, Lehner R. Carboxylesterases in lipid metabolism: from mouse to human. Protein Cell. 2018;9(2):178–195. doi:10.1007/s13238-017-0437-z.
  • Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S, Tabernero J. Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat Rev Cancer. 2017;17(2):79–92. doi:10.1038/nrc.2016.126.

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