Is gentamicin necessary in the antimicrobial treatment for group B streptococcal infections in the elderly? An in vitro study with human blood products

References

• Phares CR, Lynfield R, Farley MM, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005. JAMA. 2008;299:2056–2065.
   PubMed Web of Science ®Google Scholar
• Skoff TH, Farley MM, Petit S, et al. Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990–2007. Clin Infect Dis. 2009;49:85–92.
   PubMed Web of Science ®Google Scholar
• Polin RA. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129:1006–1015.
   PubMed Web of Science ®Google Scholar
• Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351:1645–1654.
   PubMed Web of Science ®Google Scholar
• Westling K, Aufwerber E, Ekdahl C, et al. Swedish guidelines for diagnosis and treatment of infective endocarditis. Scand J Infect Dis. 2007;39:929–946.
   PubMed Web of Science ®Google Scholar
• Baker CN, Thornsberry C, Facklam RR. Synergism, killing kinetics, and antimicrobial susceptibility of group A and B streptococci. Antimicrob Agents Chemother. 1981;19:716–725.
   PubMed Web of Science ®Google Scholar
• Cooper MD, Keeney RE, Lyons SF, et al. Synergistic effects of ampicillin-aminoglycoside combinations on group B Streptococci. Antimicrob Agents Chemother. 1979;15:484–486.
   PubMed Web of Science ®Google Scholar
• Swingle HM, Bucciarelli RL, Ayoub EM. Synergy between penicillins and low concentrations of gentamicin in the killing of group B Streptococci. J Infect Dis. 1985;152:515–520.
   PubMed Web of Science ®Google Scholar
• Pillai SK, Moellering RC, Jr, Eliopoulos GM. Antimicrobial combinations. In: Lorian V, editor. Antibiotics in laboratory medicine. Philadelphia (PA): Lippincott Williams & Wilkins; 2005. p. 365–440.
   Google Scholar
• Gonzalez LS, 3rd, Spencer JP. Aminoglycosides: a practical review. Am Fam Phys. 1998;58:1811–1820.
   PubMed Web of Science ®Google Scholar
• Ballard MS, Schønheyder HC, Knudsen JD, et al. The changing epidemiology of group B streptococcus bloodstream infection: a multi-national population-based assessment. Infect Dis (Lond). 2016;48:386–391.
   PubMed Web of Science ®Google Scholar
• Hilmer SN, Tran K, Rubie P, et al. Gentamicin pharmacokinetics in old age and frailty. Br J Clin Pharmacol. 2011;71:224–231.
   PubMed Web of Science ®Google Scholar
• Schroder AK, Rink L. Neutrophil immunity of the elderly. Mech Ageing Dev. 2003;124:419–425.
   PubMed Web of Science ®Google Scholar
• Ginaldi L, De Martinis M, D'Ostilio A, et al. Immunological changes in the elderly. Aging (Milano). 1999;11:281–286.
   PubMedGoogle Scholar
• Butcher S, Chahel H, Lord JM. Review article: ageing and the neutrophil: no appetite for killing? Immunology. 2000;100:411–416.
   PubMed Web of Science ®Google Scholar
• Ruppen C, Lupo A, Decosterd L, et al. Is penicillin plus gentamicin synergistic against clinical group B Streptococcus isolates? An in-vitro study. Front Microbiol. 2016;7. doi:10.3389/fmicb.2016.01680.
   PubMed Web of Science ®Google Scholar
• Sendi P, Furitsch M, Mauerer S, et al. Chromosomally and extrachromosomally mediated high-level gentamicin resistance in Streptococcus agalactiae. Antimicrob Agents Chemother. 2016;60:1702–1707.
   PubMed Web of Science ®Google Scholar
• Rolinson GN, Sutherland R. The binding of antibiotics to serum proteins. Br J Pharmacol Chemother. 1965;25:638–650.
   PubMed Web of Science ®Google Scholar
• Habib G, Hoen B, Tornos P, et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J. 2009;30:2369–2413.
   PubMed Web of Science ®Google Scholar
• Dwyer M, Gadjeva M. Opsonophagocytic assay. Methods Mol Biol. 2014;1100:373–379.
   PubMedGoogle Scholar
• Sendi P, Johansson L, Dahesh S, et al. Bacterial phenotype variants in group B streptococcal toxic shock syndrome. Emerg Infect Dis. 2009;15:223–232.
   PubMed Web of Science ®Google Scholar
• Nahm MH, Burton RL. Protocol for opsonophagocytic killing assay for antibodies against group B Streptococcus (UAB GBS OPA). Bacterial Respiratory Pathogen Reference Laboratory [Internet]; 2013; [cited 2015 Aug 10]. Protocols and software. 24 pp. Available from: http://www.vaccine.uab.edu/UAB-MOPA.pdf.
   Google Scholar
• Sagar A, Klemm C, Hartjes L, et al. The β-hemolysin and intracellular survival of Streptococcus agalactiae in human macrophages. PLoS One. 2013;8:e60160.
   Google Scholar
• Geering B, Stoeckle C, Rozman S, et al. DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. J Leukoc Biol. 2014;95:293–303.
   PubMed Web of Science ®Google Scholar
• Tak T, Tesselaar K, Pillay J, et al. What's your age again? Determination of human neutrophil half-lives revisited. J Leukoc Biol. 2013;94:595–601.
   PubMed Web of Science ®Google Scholar
• Liu GY, Doran KS, Lawrence T, et al. Sword and shield: Linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense. Proc Natl Acad Sci USA. 2004;101:14491–14496.
   PubMed Web of Science ®Google Scholar
• Ruppen C, Sendi P. Time kill assays for Streptococcus agalactiae and synergy testing. Nature Protocol Exchange [Internet]; 2015 [cited 2015 Dec 28]. Protocols. Available from: http://www.nature.com/protocolexchange/protocols/4505.
   Google Scholar
• Garcia LS, editor. Clinical microbiology procedures handbook. 3rd ed. Vol. 2. Washington (DC): ASM Press; 2010. Moody J, Knapp C. Tests to assess bactericidal activity. p. 5.10.1.1–5.10.3.6.
   Google Scholar
• Sutton S. Accuracy of plate counts. J Validat Technol. 2011;17:42–46.
   Google Scholar
• Baron Barshak M, Madoff LC. Group B streptococcal infections in nonpregnant adults. UpToDate Wolters Kluwer Health [Internet]; 2016 [cited 2016 Sep 21]. Available from: http://www.uptodate.com/contents/group-b-streptococcal-infections-in-nonpregnant-adults?source=search_result&search=gbs&selectedTitle =6%7E107.
   Google Scholar
• Puttaswamy S, Lee BD, Sengupta S. Novel electrical method for early detection of viable bacteria in blood cultures. J Clin Microbiol. 2011;49:2286–2289.
   PubMed Web of Science ®Google Scholar
• Yagupsky P, Nolte FS. Quantitative aspects of septicemia. Clin Microbiol Rev. 1990;3:269–279.
   PubMed Web of Science ®Google Scholar
• Geddes AM, Gould IM. Benzylpenicillin (Penicillin G). In: Grayson ML, editor. Kucers' the use of antibiotics. Sixth edition: a clinical review of antibacterial, antifungal and antiviral drugs. London, UK: Hodder Arnold; 2010. p. 5–58.
   Google Scholar
• Li Y, Karlin A, Loike JD, et al. A critical concentration of neutrophils is required for effective bacterial killing in suspension. Proc Natl Acad Sci USA. 2002;99:8289–8294.
   PubMed Web of Science ®Google Scholar
• Brook I. Inoculum effect. Rev Infect Dis. 1989;11:361–368.
   PubMedGoogle Scholar