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Review Article

Staphylococcus aureus bacteraemia and endocarditis – epidemiology and outcome: a review

ORCID Icon, &
Pages 175-192 | Received 04 Oct 2017, Accepted 07 Oct 2017, Published online: 06 Nov 2017

References

  • Ogston A. Micrococcus poisoning. J Anat Physiol. 1882;17:24–58.
  • Classics in infectious diseases. “On abscesses”. Alexander Ogston (1844–1929). Rev Infect Dis. 1984;6:122–128.
  • Skinner D, Keefer CS. Significance of bacteremia caused by Staphylococcus aureus: a study of one hundred and twenty-two cases and a review of the literature concerned with experimental infection in animals. Arch Intern Med (Chic). 1941;68:851–875.
  • Uslan DZ, Crane SJ, Steckelberg JM, et al. Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted County, Minnesota. Arch Intern Med. 2007;167:834–839.
  • Federspiel JJ, Stearns SC, Peppercorn AF, et al. Increasing US rates of endocarditis with Staphylococcus aureus: 1999–2008. Arch Intern Med. 2012;172:363–365.
  • Selton-Suty C, Célard M, Le Moing V, et al. Preeminence of Staphylococcus aureus in infective endocarditis: a 1-year population-based survey. Clin Infect Dis. 2012;54:1230–1239.
  • Murdoch DR, Corey GR, Hoen B, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med. 2009;169:463–473.
  • Tleyjeh IM, Abdel-Latif A, Rahbi H, et al. A systematic review of population-based studies of infective endocarditis. Chest. 2007;132:1025–1035.
  • Miro JM, Anguera I, Cabell CH, et al. Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database. Clin Infect Dis. 2005;41:507–514.
  • DeLeo FR, Diep BA, Otto M. Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin N Am. 2009;23:17–34.
  • Naber CK. Staphylococcus aureus bacteremia: epidemiology, pathophysiology, and management strategies. Clin Infect Dis. 2009;48 (Suppl 4):S231–S237.
  • Archer GL. Staphylococcus aureus: a well-armed pathogen. Clin Infect Dis. 1998;26:1179–1181.
  • Stryjewski ME, Corey GR. Methicillin-resistant Staphylococcus aureus: an evolving pathogen. Clin Infect Dis. 2014;58 (Suppl 1):S10–S19.
  • Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339:520–532.
  • Thwaites GE, Edgeworth JD, Gkrania-Klotsas E, et al. Clinical management of Staphylococcus aureus bacteraemia. Lancet Infect Dis. 2011;11:208–222.
  • Holland TL, Arnold C, Fowler VG. Clinical management of Staphylococcus aureus bacteremia: a review. JAMA. 2014;312:1330–1341.
  • Proctor RA. Challenges for a universal Staphylococcus aureus vaccine. Clin Infect Dis. 2012;54:1179–1186.
  • Wisplinghoff H, Bischoff T, Tallent SM, et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39:309–317.
  • Laupland KB. Incidence of bloodstream infection: a review of population-based studies. Clin Microbiol Infect. 2013;19:492–500.
  • Laupland KB, Gregson DB, Vanderkooi OG, et al. The changing burden of pediatric bloodstream infections in Calgary, Canada, 2000–2006. Pediatr Infect Dis J. 2009;28:114–117.
  • Henderson KL, Johnson AP, Muller-Pebody B, et al. The changing aetiology of paediatric bacteraemia in England and Wales, 1998–2007. J Med Microbiol. 2010;59:213–219.
  • Steckelberg JM, Melton LJ, Ilstrup DM, et al. Influence of referral bias on the apparent clinical spectrum of infective endocarditis. Am J Med. 1990;88:582–588.
  • Laupland KB. Population-based epidemiology of intensive care: critical importance of ascertainment of residency status. Crit Care. 2004;8:R431–R436.
  • Laupland KB. Defining the epidemiology of bloodstream infections: the ‘gold standard’ of population-based assessment. Epidemiol Infect. 2013;141:2149–2157.
  • Lyytikäinen O, Ruotsalainen E, Järvinen A, et al. Trends and outcome of nosocomial and community-acquired bloodstream infections due to Staphylococcus aureus in Finland, 1995–2001. Eur J Clin Microbiol Infect Dis. 2005;24:399–404.
  • Huggan PJ, Wells JE, Browne M, et al. Population-based epidemiology of Staphylococcus aureus bloodstream infection in Canterbury, New Zealand. Intern Med J. 2010;40:117–125.
  • Laupland KB, Ross T, Gregson DB. Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000–2006. J Infect Dis. 2008;198:336–343.
  • Mejer N, Westh H, Schønheyder HC, et al. Stable incidence and continued improvement in short term mortality of Staphylococcus aureus bacteraemia between 1995 and 2008. BMC Infect Dis. 2012;12:260.
  • Laupland KB, Lyytikäinen O, Søgaard M, et al. The changing epidemiology of Staphylococcus aureus bloodstream infection: a multinational population-based surveillance study. Clin Microbiol Infect. 2013;19:465–471.
  • Benfield T, Espersen F, Frimodt-Møller N, et al. Increasing incidence but decreasing in-hospital mortality of adult Staphylococcus aureus bacteraemia between 1981 and 2000. Clin Microbiol Infect. 2007;13:257–263.
  • Hill PC, Birch M, Chambers S, et al. Prospective study of 424 cases of Staphylococcus aureus bacteraemia: determination of factors affecting incidence and mortality. Intern Med J. 2001;31:97–103.
  • Allard C, Carignan A, Bergevin M, et al. Secular changes in incidence and mortality associated with Staphylococcus aureus bacteraemia in Quebec, Canada, 1991–2005. Clin Microbiol Infect. 2008;14:421–428.
  • El Atrouni WI, Knoll BM, Lahr BD, et al. Temporal trends in the incidence of Staphylococcus aureus bacteremia in Olmsted County, Minnesota, 1998 to 2005: a population-based study. Clin Infect Dis. 2009;49:e130–e138.
  • Asgeirsson H, Gudlaugsson O, Kristinsson KG, et al. Staphylococcus aureus bacteraemia in Iceland, 1995–2008: changing incidence and mortality. Clin Microbiol Infect. 2011;17:513–518.
  • Blomfeldt A, Eskesen AN, Aamot HV, et al. Population-based epidemiology of Staphylococcus aureus bloodstream infection: clonal complex 30 genotype is associated with mortality. Eur J Clin Microbiol Infect Dis. 2016;35:803–813.
  • Frederiksen MS, Espersen F, Frimodt MN, et al. Changing epidemiology of pediatric Staphylococcus aureus bacteremia in Denmark from 1971 through 2000. Pediatr Infect Dis J. 2007;26:398–405.
  • Hill PC, Wong CG, Voss LM, et al. Prospective study of 125 cases of Staphylococcus aureus bacteremia in children in New Zealand. Pediatr Infect Dis J. 2001;20:868–873.
  • Vanderkooi OG, Gregson D, Kellner JD, et al. Staphylococcus aureus bloodstream infections in children: a population-based assessment. Paediatr Child Health. 2011;16:276–280.
  • Asgeirsson H, Gudlaugsson O, Kristinsson KG, et al. Low mortality of Staphylococcus aureus bacteremia in Icelandic children - Nationwide study on incidence and outcome. Pediatr Infect Dis J. 2015;34:140–144.
  • Frimodt-Møller N, Espersen F, Skinhøj P, et al. Epidemiology of Staphylococcus aureus bacteremia in Denmark from 1957 to 1990. Clin Microbiol Infect. 1997;3:297–305.
  • Morgan M, Salmon R, Keppie N, et al. All Wales surveillance of methicillin-resistant Staphylococcus aureus (MRSA): the first year's results. J Hosp Infect. 1999;41:173–179.
  • Morin CA, Hadler JL. Population-based incidence and characteristics of community-onset Staphylococcus aureus infections with bacteremia in 4 metropolitan Connecticut areas, 1998. J Infect Dis. 2001;184:1029–1034.
  • McDonald P, Mitchell E, Johnson H, et al. MRSA bacteraemia: North/South Study of MRSA in Ireland 1999. J Hosp Infect. 2002;52:288–291.
  • Griffiths C, Lamagni TL, Crowcroft NS, et al. Trends in MRSA in England and Wales: analysis of morbidity and mortality data for 1993–2002. Health Stat Q. 2004;(21):15–22.
  • Jacobsson G, Dashti S, Wahlberg T, et al. The epidemiology of and risk factors for invasive Staphylococcus aureus infections in western Sweden. Scand J Infect Dis. 2007;39:6–13.
  • Nielsen SL, Pedersen C, Jensen TG, et al. Decreasing incidence rates of bacteremia: a 9-year population-based study. J Infect. 2014;69:51–59.
  • Mehl A, Åsvold BO, Lydersen S, et al. Burden of bloodstream infection in an area of Mid-Norway 2002–2013: a prospective population-based observational study. BMC Infect Dis. 2017;17:205.
  • McMullan BJ, Bowen A, Blyth CC, et al. Epidemiology and mortality of Staphylococcus aureus bacteremia in Australian and New Zealand children. JAMA Pediatr. 2016;170:979–986.
  • Cobos-Carrascosa E, Soler-Palacín P, Nieves Larrosa M, et al. Staphylococcus aureus bacteremia in children: changes during eighteen years. Pediatr Infect Dis J. 2015;34:1329–1334.
  • Tong SY, Davis JS, Eichenberger E, et al. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28:603–661.
  • Abernethy J, Sharland M, Johnson AP, et al. How do the epidemiology of paediatric methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus bacteraemia differ? J Med Microbiol. 2017;66:737–743.
  • Fitzgerald SF, O'Gorman J, Morris-Downes MM, et al. A 12-year review of Staphylococcus aureus bloodstream infections in haemodialysis patients: more work to be done. J Hosp Infect. 2011;79:218–221.
  • Wang IK, Chang YC, Liang CC, et al. Bacteremia in hemodialysis and peritoneal dialysis patients. Intern Med. 2012;51:1015–1021.
  • Laupland KB, Church DL, Mucenski M, et al. Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections. J Infect Dis. 2003;187:1452–1459.
  • Smit J, Søgaard M, Schønheyder HC, et al. Diabetes and risk of community-acquired Staphylococcus aureus bacteremia: a population-based case-control study. Eur J Endocrinol. 2016;174:631–639.
  • Hansen MU, Gotland N, Mejer N, et al. Diabetes increases the risk of disease and death due to Staphylococcus aureus bacteremia. A matched case-control and cohort study. Infect Dis (Lond). 2017;49:689–697.
  • Larsen MV, Harboe ZB, Ladelund S, et al. Major but differential decline in the incidence of Staphylococcus aureus bacteraemia in HIV-infected individuals from 1995 to 2007: a nationwide cohort study. HIV Med. 2012;13:45–53.
  • Spijkerman IJ, van Ameijden EJ, Mientjes GH, et al. Human immunodeficiency virus infection and other risk factors for skin abscesses and endocarditis among injection drug users. J Clin Epidemiol. 1996;49:1149–1154.
  • Tuazon CU, Sheagren JN. Increased rate of carriage of Staphylococcus aureus among narcotic addicts. J Infect Dis. 1974;129:725–727.
  • Craven DE, Rixinger AI, Goularte TA, et al. Methicillin-resistant Staphylococcus aureus bacteremia linked to intravenous drug abusers using a “shooting gallery”. Am J Med. 1986;80:770–776.
  • Fagan RP, Edwards JR, Park BJ, et al. Incidence trends in pathogen-specific central line-associated bloodstream infections in US intensive care units, 1990–2010. Infect Control Hosp Epidemiol. 2013;34:893–899.
  • Burton DC, Edwards JR, Horan TC, et al. Methicillin-resistant Staphylococcus aureus central line-associated bloodstream infections in US intensive care units, 1997–2007. JAMA. 2009;301:727–736.
  • Wang A, Athan E, Pappas PA, et al. Contemporary clinical profile and outcome of prosthetic valve endocarditis. JAMA. 2007;297:1354–1361.
  • Huggan PJ, Murdoch DR, Gallagher K, et al. Concomitant Staphylococcus aureus bacteriuria is associated with poor clinical outcome in adults with S. aureus bacteraemia. J Hosp Infect. 2008;69:345–349.
  • Asgeirsson H, Thalme A, Kristjansson M, et al. Incidence and outcome of Staphylococcus aureus endocarditis—a 10-year single-centre northern European experience. Clin Microbiol Infect. 2015;21:772–778.
  • Asgeirsson H, Kristjansson M, Kristinsson KG, et al. Staphylococcus aureus bacteraemia–nationwide assessment of treatment adequacy and outcome. J Infect. 2011;62:339–346.
  • Murdoch F, Danial J, Morris AK, et al. The Scottish enhanced Staphylococcus aureus bacteraemia surveillance programme: the first 18 months of data in adults. J Hosp Infect. 2017;97:133–139.
  • Jensen AG, Wachmann CH, Espersen F, et al. Treatment and outcome of Staphylococcus aureus bacteremia: a prospective study of 278 cases. Arch Intern Med. 2002;162:25–32.
  • Fätkenheuer G, Preuss M, Salzberger B, et al. Long-term outcome and quality of care of patients with Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis. 2004;23:157–162.
  • Burke RE, Halpern MS, Baron EJ, et al. Pediatric and neonatal Staphylococcus aureus bacteremia: epidemiology, risk factors, and outcome. Infect Control Hosp Epidemiol. 2009;30:636–644.
  • Forsblom E, Ruotsalainen E, Mölkänen T, et al. Predisposing factors, disease progression and outcome in 430 prospectively followed patients of healthcare- and community-associated Staphylococcus aureus bacteraemia. J Hosp Infect. 2011;78:102–107.
  • Le Moing V, Alla F, Doco-Lecompte T, et al. Staphylococcus aureus bloodstream infection and endocarditis – a prospective cohort study. PLoS One. 2015;10:e0127385.
  • Suryati BA, Watson M. Staphylococcus aureus bacteraemia in children: a 5-year retrospective review. J Paediatr Child Health. 2002;38:290–294.
  • Barrado L, Brañas P, Rojo P, et al. Molecular epidemiology of Staphylococcus aureus bacteremia in children, Spain: low risk of methicillin resistance. J Infect. 2014;68:195–198.
  • Murdoch F, Danial J, Morris AK, et al. The Scottish enhanced Staphylococcus aureus bacteraemia surveillance programme: the first 18 months of data in children. J Hosp Infect. 2017;97:127–132.
  • Friedman ND, Kaye KS, Stout JE, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med. 2002;137:791–797.
  • Shorr AF, Tabak YP, Killian AD, et al. Healthcare-associated bloodstream infection: a distinct entity? Insights from a large U.S. database. Crit Care Med. 2006;34:2588–2595.
  • Lenz R, Leal JR, Church DL, et al. The distinct category of healthcare associated bloodstream infections. BMC Infect Dis. 2012;12:85.
  • Paulsen J, Mehl A, Askim Å, et al. Epidemiology and outcome of Staphylococcus aureus bloodstream infection and sepsis in a Norwegian county 1996–2011: an observational study. BMC Infect Dis. 2015;15:116.
  • Naidoo R, Nuttall J, Whitelaw A, et al. Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa. PLoS One. 2013;8:e78396.
  • Chang FY, MacDonald BB, Peacock JEJ, et al. A prospective multicenter study of Staphylococcus aureus bacteremia: incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistance. Medicine (Baltimore). 2003;82:322–332.
  • Fowler VG, Olsen MK, Corey GR, et al. Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch Intern Med. 2003;163:2066–2072.
  • Holden E, Bashir A, Das I, et al. Staphylococcus aureus bacteraemia in a UK tertiary referral centre: a 'transoesophageal echocardiogram for all' policy. J Antimicrob Chemother. 2014;69:1960–1965.
  • Kaasch AJ, Barlow G, Edgeworth JD, et al. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect. 2014;68:242–251.
  • Fowler VG, Li J, Corey GR, et al. Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients. J Am Coll Cardiol. 1997;30:1072–1078.
  • Rasmussen RV, Høst U, Arpi M, et al. Prevalence of infective endocarditis in patients with Staphylococcus aureus bacteraemia: the value of screening with echocardiography. Eur J Echocardiogr. 2011;12:414–420.
  • Incani A, Hair C, Purnell P, et al. Staphylococcus aureus bacteraemia: evaluation of the role of transoesophageal echocardiography in identifying clinically unsuspected endocarditis. Eur J Clin Microbiol Infect Dis. 2013;32:1003–1008.
  • van Hal SJ, Mathur G, Kelly J, et al. The role of transthoracic echocardiography in excluding left sided infective endocarditis in Staphylococcus aureus bacteraemia. J Infect. 2005;51:218–221.
  • Joseph JP, Meddows TR, Webster DP, et al. Prioritizing echocardiography in Staphylococcus aureus bacteraemia. J Antimicrob Chemother. 2013;68:444–449.
  • Kaasch AJ, Fowler VGJ, Rieg S, et al. Use of a simple criteria set for guiding echocardiography in nosocomial Staphylococcus aureus bacteremia. Clin Infect Dis. 2011;53:1–9.
  • Bai AD, Agarwal A, Steinberg M, et al. Clinical predictors and clinical prediction rules to estimate initial patient risk for infective endocarditis in Staphylococcus aureus bacteraemia: a systematic review and meta-analysis. Clin Microbiol Infect. 2017. pii: S1198-743X:30236–30237 [Epub ahead of print].
  • van Hal SJ, Jensen SO, Vaska VL, et al. Predictors of mortality in Staphylococcus aureus bacteremia. Clin Microbiol Rev. 2012;25:362–386.
  • Roediger JC, Outhred AC, Shadbolt B, et al. Paediatric Staphylococcus aureus bacteraemia: a single-centre retrospective cohort. J Paediatr Child Health. 2017;53:180–186.
  • Le J, Dam Q, Tran T, et al. Epidemiology and hospital readmission associated with complications of Staphylococcus aureus bacteremia in pediatrics over a 25-year period. Epidemiol Infect. 2017;145:2631–2639.
  • Valente AM, Jain R, Scheurer M, et al. Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia. Pediatrics. 2005;115:e15–e19.
  • Li JS, Sexton DJ, Mick N, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30:633–638.
  • Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. Am J Med. 1994;96:200–209.
  • Evangelista A, Gonzalez-Alujas MT. Echocardiography in infective endocarditis. Heart. 2004;90:614–617.
  • Thuny F, Grisoli D, Collart F, et al. Management of infective endocarditis: challenges and perspectives. Lancet. 2012;379:965–975.
  • Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis: the Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36:3075–3128.
  • Thalme A, Westling K, Julander I. In-hospital and long-term mortality in infective endocarditis in injecting drug users compared to non-drug users: a retrospective study of 192 episodes. Scand J Infect Dis. 2007;39:197–204.
  • Slipczuk L, Codolosa JN, Davila CD, et al. Infective endocarditis epidemiology over five decades: a systematic review. PLoS One. 2013;8:e82665.
  • Muñoz P, Kestler M, De Alarcon A, et al. Current epidemiology and outcome of infective endocarditis: a multicenter, prospective, cohort study. Medicine (Baltimore). 2015;94:e1816.
  • Mathew J, Addai T, Anand A, et al. Clinical features, site of involvement, bacteriologic findings, and outcome of infective endocarditis in intravenous drug users. Arch Intern Med. 1995;155:1641–1648.
  • Hogevik H, Olaison L, Andersson R, et al. Epidemiologic aspects of infective endocarditis in an urban population. A 5-year prospective study. Medicine (Baltimore). 1995;74:324–339.
  • Scudeller L, Badano L, Crapis M, et al. Population-based surveillance of infectious endocarditis in an Italian region. Arch Intern Med. 2009;169:1720–1723.
  • Fowler VG, Miro JM, Hoen B, et al. Staphylococcus aureus endocarditis: a consequence of medical progress. JAMA. 2005;293:3012–3021.
  • Fernández Guerrero ML, González López JJ, Goyenechea A, et al. Endocarditis caused by Staphylococcus aureus: a reappraisal of the epidemiologic, clinical, and pathologic manifestations with analysis of factors determining outcome. Medicine (Baltimore). 2009;88:1–22.
  • Hsu RB, Lin FY. Methicillin resistance and risk factors for embolism in Staphylococcus aureus infective endocarditis. Infect Control Hosp Epidemiol. 2007;28:860–866.
  • Remadi JP, Habib G, Nadji G, et al. Predictors of death and impact of surgery in Staphylococcus aureus infective endocarditis. Ann Thorac Surg. 2007;83:1295–1302.
  • Asgeirsson H, Thalme A, Weiland O. Low mortality but increasing incidence of Staphylococcus aureus endocarditis in people who inject drugs: experience from a Swedish referral hospital. Medicine (Baltimore). 2016;95:e5617.
  • Røder BL, Wandall DA, Frimodt-Møller N, et al. Clinical features of Staphylococcus aureus endocarditis: a 10-year experience in Denmark. Arch Intern Med. 1999;159:462–469.
  • Cervera C, Castañeda X, de la Maria CG, et al. Effect of vancomycin minimal inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus endocarditis. Clin Infect Dis. 2014;58:1668–1675.
  • Abdallah L, Remadi JP, Habib G, et al. Long-term prognosis of left-sided native-valve Staphylococcus aureus endocarditis. Arch Cardiovasc Dis. 2016;109:260–267.
  • Cherubin CE, Sapira JD. The medical complications of drug addiction and the medical assessment of the intravenous drug user: 25 years later. Ann Intern Med. 1993;119:1017–1028.
  • Scheidegger C, Zimmerli W. Infectious complications in drug addicts: seven-year review of 269 hospitalized narcotics abusers in Switzerland. Rev Infect Dis. 1989;11:486–493.
  • Tuazon CU, Sheagren JN. Staphlococcal endocarditis in parenteral drug abusers: source of the organism. Ann Intern Med. 1975;82:788–790.
  • Williams RE. Healthy carriage of Staphylococcus aureus: its prevalence and importance. Bacteriol Rev. 1963;27:56–71.
  • Noble WC, Valkenburg HA, Wolters CH. Carriage of Staphylococcus aureus in random samples of a normal population. J Hyg (Lond). 1967;65:567–573.
  • Nilsson P, Ripa T. Staphylococcus aureus throat colonization is more frequent than colonization in the anterior nares. J Clin Microbiol. 2006;44:3334–3339.
  • Wertheim HF, Melles DC, Vos MC, et al. The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis. 2005;5:751–762.
  • Lowy FD, Miller M. New methods to investigate infectious disease transmission and pathogenesis – Staphylococcus aureus disease in drug users. Lancet Infect Dis. 2002;2:605–612.
  • Quagliarello B, Cespedes C, Miller M, et al. Strains of Staphylococcus aureus obtained from drug-use networks are closely linked. Clin Infect Dis. 2002;35:671–677.
  • Moreillon P, Que YA. Infective endocarditis. Lancet. 2004;363:139–149.
  • McDonald JR. Acute infective endocarditis. Infect Dis Clin N Am. 2009;23:643–664.
  • Hoen B, Duval X. Clinical practice. Infective endocarditis. N Engl J Med. 2013;368:1425–1433.
  • Faber M, Frimodt-Møller N, Espersen F, et al. Staphylococcus aureus endocarditis in Danish intravenous drug users: high proportion of left-sided endocarditis. Scand J Infect Dis. 1995;27:483–487.
  • Ruotsalainen E, Sammalkorpi K, Laine J, et al. Clinical manifestations and outcome in Staphylococcus aureus endocarditis among injection drug users and nonaddicts: a prospective study of 74 patients. BMC Infect Dis. 2006;6:137.
  • Wilson LE, Thomas DL, Astemborski J, et al. Prospective study of infective endocarditis among injection drug users. J Infect Dis. 2002;185:1761–1766.
  • Cherubin CE, Baden M, Kavaler F, et al. Infective endocarditis in narcotic addicts. Ann Intern Med. 1968;69:1091–1098.
  • Banks T, Fletcher R, Ali N. Infective endocarditis in heroin addicts. Am J Med. 1973;55:444–451.
  • Tung MK, Light M, Giri R, et al. Evolving epidemiology of injecting drug use-associated infective endocarditis: a regional centre experience. Drug Alcohol Rev. 2015;34:412–417.
  • Cooper HL, Brady JE, Ciccarone D, et al. Nationwide increase in the number of hospitalizations for illicit injection drug use-related infective endocarditis. Clin Infect Dis. 2007;45:1200–1203.
  • Statens offentliga utredningar (SOU) 2011:35. Bättre insatser vid missbruk och beroende. Stockholm: Statens offentliga utredningar; 2011.
  • Chai LY, Khare CB, Chua A, et al. Buprenorphine diversion: a possible reason for increased incidence of infective endocarditis among injection drug users? The Singapore experience. Clin Infect Dis. 2008;46:953–955.
  • Kaech C, Elzi L, Sendi P, et al. Course and outcome of Staphylococcus aureus bacteraemia: a retrospective analysis of 308 episodes in a Swiss tertiary-care centre. Clin Microbiol Infect. 2006;12:345–352.
  • Wyllie DH, Crook DW, Peto TE. Mortality after Staphylococcus aureus bacteraemia in two hospitals in Oxfordshire, 1997–2003: cohort study. BMJ. 2006;333:281–284.
  • Conterno LO, Wey SB, Castelo A. Risk factors for mortality in Staphylococcus aureus bacteremia. Infect Control Hosp Epidemiol. 1998;19:32–37.
  • Ammerlaan H, Seifert H, Harbarth S, et al. Adequacy of antimicrobial treatment and outcome of Staphylococcus aureus bacteremia in 9 Western European countries. Clin Infect Dis. 2009;49:997–1005.
  • Yahav D, Shaked H, Goldberg E, et al. Time trends in Staphylococcus aureus bacteremia, 1988–2010, in a tertiary center with high methicillin resistance rates. Infection. 2017;45:51–57.
  • Gray JW. A 7-year study of bloodstream infections in an English children's hospital. Eur J Pediatr. 2004;163:530–535.
  • Yilmaz M, Elaldi N, Balkan İ, et al. Mortality predictors of Staphylococcus aureus bacteremia: a prospective multicenter study. Ann Clin Microbiol Antimicrob. 2016;15:7.
  • Rieg S, Joost I, Weisz V, et al. Combination antimicrobial therapy in patients with Staphylococcus aureus bacteraemia—a post hoc analysis in 964 prospectively evaluated patients. Clin Microbiol Infect. 2016;23:406.e1–406.e8.
  • Yahav D, Yassin S, Shaked H, et al. Risk factors for long-term mortality of Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis. 2016;35:785–790.
  • Kim SH, Kim KH, Kim HB, et al. Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2008;52:192–197.
  • Bassetti M, Peghin M, Trecarichi EM, et al. Characteristics of Staphylococcus aureus bacteraemia and predictors of early and late mortality. PLoS One. 2017;12:e0170236.
  • Smit J, López-Cortés LE, Kaasch AJ, et al. Gender differences in the outcome of community-acquired Staphylococcus aureus bacteraemia: a historical population-based cohort study. Clin Microbiol Infect. 2017;23:27–32.
  • Soriano A, Martínez JA, Mensa J, et al. Pathogenic significance of methicillin resistance for patients with Staphylococcus aureus bacteremia. Clin Infect Dis. 2000;30:368–373.
  • Mansur N, Hazzan R, Paul M, et al. Does sex affect 30-day mortality in Staphylococcus aureus bacteremia? Gend Med. 2012;9:463–470.
  • Holmes NE, Turnidge JD, Munckhof WJ, et al. Antibiotic choice may not explain poorer outcomes in patients with Staphylococcus aureus bacteremia and high vancomycin minimum inhibitory concentrations. J Infect Dis. 2011;204:340–347.
  • Rieg S, Peyerl-Hoffmann G, de With K, et al. Mortality of S. aureus bacteremia and infectious diseases specialist consultation – a study of 521 patients in Germany. J Infect. 2009;59:232–239.
  • Turnidge JD, Kotsanas D, Munckhof W, et al. Staphylococcus aureus bacteraemia: a major cause of mortality in Australia and New Zealand. Med J Aust. 2009;191:368–373.
  • Perez-Jorge EV, Burdette SD, Markert RJ, et al. Staphylococcus aureus bacteremia (SAB) with associated S. aureus bacteriuria (SABU) as a predictor of complications and mortality. J Hosp Med. 2010;5:208–211.
  • Asgeirsson H, Kristjansson M, Kristinsson KG, et al. Clinical significance of Staphylococcus aureus bacteriuria in a nationwide study of adults with S. aureus bacteraemia. J Infect. 2012;64:41–46.
  • Chihara S, Popovich KJ, Weinstein RA, et al. Staphylococcus aureus bacteriuria as a prognosticator for outcome of Staphylococcus aureus bacteremia: a case-control study. BMC Infect Dis. 2010;10:225.
  • Lodise TP, McKinnon PS, Swiderski L, et al. Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. Clin Infect Dis. 2003;36:1418–1423.
  • Robinson JO, Pearson JC, Christiansen KJ, et al. Community-associated versus healthcare-associated methicillin-resistant Staphylococcus aureus bacteraemia: a 10-year retrospective review. Eur J Clin Microbiol Infect Dis. 2009;28:353–361.
  • Paul M, Kariv G, Goldberg E, et al. Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother. 2010;65:2658–2665.
  • Cosgrove SE, Sakoulas G, Perencevich EN, et al. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis. 2003;36:53–59.
  • Shurland S, Zhan M, Bradham DD, et al. Comparison of mortality risk associated with bacteremia due to methicillin-resistant and methicillin-susceptible Staphylococcus aureus. Infect Control Hosp Epidemiol. 2007;28:273–279.
  • Jokinen E, Laine J, Huttunen R, et al. Comparison of outcome and clinical characteristics of bacteremia caused by methicillin-resistant, penicillin-resistant and penicillin-susceptible Staphylococcus aureus strains. Infect Dis (Lond). 2017;49:493–500.
  • Castón JJ, González-Gasca F, Porras L, et al. High vancomycin minimum inhibitory concentration is associated with poor outcome in patients with methicillin-susceptible Staphylococcus aureus bacteremia regardless of treatment. Scand J Infect Dis. 2014;46:783–786.
  • Bouiller K, Gbaguidi-Haore H, Hocquet D, et al. Clonal complex 398 methicillin-susceptible Staphylococcus aureus bloodstream infections are associated with high mortality. Clin Microbiol Infect. 2016;22:451–455.
  • Kempker RR, Farley MM, Ladson JL, et al. Association of methicillin-resistant Staphylococcus aureus (MRSA) USA300 genotype with mortality in MRSA bacteremia. J Infect. 2010;61:372–381.
  • Giannitsioti E, Damoraki G, Rokkas C, et al. Impact of haplotypes of TNF in the natural course of infective endocarditis. Clin Microbiol Infect. 2014;20:459–464.
  • Lee BK, Crossley K, Gerding DN. The association between Staphylococcus aureus bacteremia and bacteriuria. Am J Med. 1978;65:303–306.
  • Pulcini C, Matta M, Mondain V, et al. Concomitant Staphylococcus aureus bacteriuria is associated with complicated S. aureus bacteremia. J Infect. 2009;59:240–246.
  • Leibovici L, Samra Z, Konigsberger H, et al. Long-term survival following bacteremia or fungemia. JAMA. 1995;274:807–812.
  • Hanses F, Spaeth C, Ehrenstein BP, et al. Risk factors associated with long-term prognosis of patients with Staphylococcus aureus bacteremia. Infection. 2010;38:465–470.
  • Gotland N, Uhre ML, Mejer N, et al. Long-term mortality and causes of death associated with Staphylococcus aureus bacteremia. A matched cohort study. J Infect. 2016;73:346–357.
  • Kaasch AJ, Rieg S, Neumann S, et al. Measuring mortality in Staphylococcus aureus bloodstream infections: are 3 months of follow-up enough? Infection. 2011;39:281–282.
  • Winters BD, Eberlein M, Leung J, et al. Long-term mortality and quality of life in sepsis: a systematic review. Crit Care Med. 2010;38:1276–1283.
  • Nielsen SL, Lassen AT, Gradel KO, et al. Bacteremia is associated with excess long-term mortality: a 12-year population-based cohort study. J Infect. 2015;70:111–126.
  • Storgaard M, Hallas J, Gahrn-Hansen B, et al. Short- and long-term mortality in patients with community-acquired severe sepsis and septic shock. Scand J Infect Dis. 2013;45:577–583.
  • Laupland KB, Svenson LW, Gregson DB, et al. Long-term mortality associated with community-onset bloodstream infection. Infection. 2011;39:405–410.
  • Espersen F, Frimodt-Møller N. Staphylococcus aureus endocarditis. A review of 119 cases. Arch Intern Med. 1986;146:1118–1121.
  • Watanakunakorn C. Staphylococcus aureus endocarditis at a community teaching hospital, 1980 to 1991. An analysis of 106 cases. Arch Intern Med. 1994;154:2330–2335.
  • Rasmussen RV, Snygg-Martin U, Olaison L, et al. One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis. Scand J Infect Dis. 2009;41:456–461.
  • Lauridsen TK, Park L, Tong SY, et al. Echocardiographic findings predict in-hospital and 1-year mortality in left-sided native valve Staphylococcus aureus endocarditis: analysis from the international collaboration on endocarditis-prospective echo cohort study. Circ Cardiovasc Imaging. 2015;8:e003397.
  • Julander I. Unfavourable prognostic factors in Staphylococcus aureus septicemia and endocarditis. Scand J Infect Dis. 1985;17:179–187.
  • Cabell C, Jollis JG, Peterson GE, et al. Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med. 2002;162:90–94.
  • Kiefer T, Park L, Tribouilloy C, et al. Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure. JAMA. 2011;306:2239–2247.
  • Miró JM, del Río A, Mestres CA. Infective endocarditis and cardiac surgery in intravenous drug abusers and HIV-1 infected patients. Cardiol Clin. 2003;21:167–184.
  • Tuazon CU, Cardella TA, Sheagren JN. Staphylococcal endocarditis in drug users. Clinical and microbiologic aspects. Arch Intern Med. 1975;135:1555–1561.
  • Levine DP, Crane LR, Zervos MJ. Bacteremia in narcotic addicts at the Detroit Medical Center. II. Infectious endocarditis: a prospective comparative study. Rev Infect Dis. 1986;8:374–396.
  • Chambers HF, Korzeniowski OM, Sande MA. Staphylococcus aureus endocarditis: clinical manifestations in addicts and nonaddicts. Medicine (Baltimore). 1983;62:170–177.
  • Grumann D, Ruotsalainen E, Kolata J, et al. Characterization of infecting strains and superantigen-neutralizing antibodies in Staphylococcus aureus bacteremia. Clin Vaccine Immunol. 2011;18:487–493.
  • Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. Circulation. 2005;111:e394–e434.
  • García-Cabrera E, Fernández-Hidalgo N, Almirante B, et al. Neurological complications of infective endocarditis: risk factors, outcome, and impact of cardiac surgery: a multicenter observational study. Circulation. 2013;127:2272–2284.
  • Snygg-Martin U, Gustafsson L, Rosengren L, et al. Cerebrovascular complications in patients with left-sided infective endocarditis are common: a prospective study using magnetic resonance imaging and neurochemical brain damage markers. Clin Infect Dis. 2008;47:23–30.
  • Cooper HA, Thompson EC, Laureno R, et al. Subclinical brain embolization in left-sided infective endocarditis: results from the evaluation by MRI of the brains of patients with left-sided intracardiac solid masses (EMBOLISM) pilot study. Circulation. 2009;120:585–591.
  • Duval X, Iung B, Klein I, et al. Effect of early cerebral magnetic resonance imaging on clinical decisions in infective endocarditis: a prospective study. Ann Intern Med. 2010;152:497–504.
  • Iung B, Tubiana S, Klein I, et al. Determinants of cerebral lesions in endocarditis on systematic cerebral magnetic resonance imaging: a prospective study. Stroke. 2013;44:3056–3062.
  • Cabell CH, Pond KK, Peterson GE, et al. The risk of stroke and death in patients with aortic and mitral valve endocarditis. Am Heart J. 2001;142:75–80.
  • Durante Mangoni E, Adinolfi LE, Tripodi MF, et al. Risk factors for “major” embolic events in hospitalized patients with infective endocarditis. Am Heart J. 2003;146:311–316.
  • Di Salvo G, Habib G, Pergola V, et al. Echocardiography predicts embolic events in infective endocarditis. J Am Coll Cardiol. 2001;37:1069–1076.
  • Tischler MD, Vaitkus PT. The ability of vegetation size on echocardiography to predict clinical complications: a meta-analysis. J Am Soc Echocardiogr. 1997;10:562–568.
  • Durante-Mangoni E, Bradley S, Selton-Suty C, et al. Current features of infective endocarditis in elderly patients: results of the International Collaboration on Endocarditis Prospective Cohort Study. Arch Intern Med. 2008;168:2095–2103.
  • Fowler VG, Sanders LL, Sexton DJ, et al. Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients. Clin Infect Dis. 1998;27:478–486.
  • Johnson LB, Almoujahed MO, Ilg K, et al. Staphylococcus aureus bacteremia: compliance with standard treatment, long-term outcome and predictors of relapse. Scand J Infect Dis. 2003;35:782–789.
  • Nørskov-Lauritsen N, Marchandin H, Dowzicky MJ. Antimicrobial susceptibility of tigecycline and comparators against bacterial isolates collected as part of the TEST study in Europe (2004–2007). Int J Antimicrob Agents. 2009;34:121–130.
  • Jones RN, Ross JE, Bell JM, et al. Zyvox annual appraisal of potency and spectrum program: linezolid surveillance program results for 2008. Diagn Microbiol Infect Dis. 2009;65:404–413.
  • Sabater S, Moreno R. Staphylococcus aureus bacteremia in Castellón General Hospital (2001–2005). Rev Esp Quimioter. 2008;21:217–223.
  • Fortún J, Navas E, Martínez-Beltrán J, et al. Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers: cloxacillin versus glycopeptides in combination with gentamicin. Clin Infect Dis. 2001;33:120–125.
  • Calain P, Krause KH, Vaudaux P, et al. Early termination of a prospective, randomized trial comparing teicoplanin and flucloxacillin for treating severe staphylococcal infections. J Infect Dis. 1987;155:187–191.
  • Chang FY, Peacock JEJ, Musher DM, et al. Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter study. Medicine (Baltimore). 2003;82:333–339.
  • Khatib R, Johnson LB, Sharma M, et al. Persistent Staphylococcus aureus bacteremia: incidence and outcome trends over time. Scand J Infect Dis. 2009;41:4–9.
  • Rehm SJ, Tice A. Staphylococcus aureus: methicillin-susceptible S. aureus to methicillin-resistant S. aureus and vancomycin-resistant S. aureus. Clin Infect Dis. 2010;51 Suppl 2:S176–S182.
  • Limbago BM, Kallen AJ, Zhu W, et al. Report of the 13th vancomycin-resistant Staphylococcus aureus isolate from the United States. J Clin Microbiol. 2014;52:998–1002.
  • Wertheim HF, Vos MC, Boelens HA, et al. Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission in the Netherlands: the value of search and destroy and restrictive antibiotic use. J Hosp Infect. 2004;56:321–325.
  • Skov R, Gudlaugsson O, Hardardottir H, et al. Proposal for common Nordic epidemiological terms and definitions for methicillin-resistant Staphylococcus aureus (MRSA). Scand J Infect Dis. 2008;40:495–502.
  • Jokinen E, Laine J, Huttunen R, et al. Combined interventions are effective in MRSA control. Infect Dis (Lond). 2015;47:801–807.
  • Frimodt-Møller N, Espersen F, Rosdahl VT. Antibiotic treatment of Staphylococcus aureus endocarditis. A review of 119 cases. Acta Med Scand. 1987;222:175–182.
  • Blyth CC, Darragh H, Whelan A, et al. Evaluation of clinical guidelines for the management of Staphylococcus aureus bacteraemia. Intern Med J. 2002;32:224–232.
  • Mitchell DH, Howden BP. Diagnosis and management of Staphylococcus aureus bacteraemia. Intern Med J. 2005;35 (Suppl 2):S17–S24.
  • Habib G, Hoen B, Tornos P, et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J. 2009;30:2369–2413.
  • Corey GR. Staphylococcus aureus bloodstream infections: definitions and treatment. Clin Infect Dis. 2009;48 Suppl 4:S254–S259.
  • Chong YP, Moon SM, Bang KM, et al. Treatment duration for uncomplicated Staphylococcus aureus bacteremia to prevent relapse: analysis of a prospective observational cohort study. Antimicrob Agents Chemother. 2013;57:1150–1156.
  • Zimmerli W, Widmer AF, Blatter M, et al. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. JAMA. 1998;279:1537–1541.
  • Osmon S, Ward S, Fraser VJ, et al. Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa. Chest. 2004;125:607–616.
  • Verhagen DW, van der Meer JT, Hamming T, et al. Management of patients with Staphylococcus aureus bacteraemia in a university hospital: a retrospective study. Scand J Infect Dis. 2003;35:459–463.
  • Kaasch AJ, Fätkenheuer G, Prinz-Langenohl R, et al. Early oral switch therapy in low-risk Staphylococcus aureus bloodstream infection (SABATO): study protocol for a randomized controlled trial. Trials. 2015;16:450.
  • Chirouze C, Alla F, Fowler VGJ, et al. Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study. Clin Infect Dis. 2015;60:741–749.
  • Rabkin DG, Mokadam NA, Miller DW, et al. Long-term outcome for the surgical treatment of infective endocarditis with a focus on intravenous drug users. Ann Thorac Surg. 2012;93:51–57.

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